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The map label for this gene is pncB1 [H]

Identifier: 121637261

GI number: 121637261

Start: 1525727

End: 1527073

Strand: Reverse

Name: pncB1 [H]

Synonym: BCG_1392c

Alternate gene names: 121637261

Gene position: 1527073-1525727 (Counterclockwise)

Preceding gene: 121637273

Following gene: 121637260

Centisome position: 34.91

GC content: 68.75

Gene sequence:

>1347_bases
GTGGGGCCACCCCCAGCCGCCAGGCGGCGAGAGGGAGAGCCCGACAATCAAGACCCAGCCGGGCTGTTGACCGACAAGTA
CGAGTTGACCATGCTGGCGGCTGCCCTGCGCGACGGCAGCGCCAATCGCCCCACCACATTCGAGGTGTTCGCTCGCCGAC
TCCCCACCGGCCGTCGCTACGGAGTTGTCGCCGGAACCGGCCGGTTGCTGGAAGCGTTGCCGCAGTTCAGGTTCGACGCT
GACGCGTGCGAGTTGCTGGCCCAATTCCTCGACCCGGCCACGGTGCGGTATCTTCGCGAATTCCGGTTCCGCGGCGATAT
CGACGGCTATGCCGAGGGGGAGCTGTATTTTCCCGGGTCACCGGTGCTCTCGGTACGCGGCAGCTTCGCCGAATGCGTCC
TGCTCGAAACGCTGGTGCTGTCAATCTTCAACCACGACACAGCGATCGCCTCGGCAGCGGCGCGCATGGTCAGCGCCGCC
GGGGGGCGCCCACTGATCGAGATGGGCTCGCGGCGCACCCACGAACGCGCCGCGGTGGCAGCGGCCCGGGCGGCGTATAT
CGCCGGTTTCGCCGCGTCATCCAACTTGGCGGCGCAGCGACGCTACGGAGTGCCCGCGCACGGCACCGCGGCACACGCAT
TCACCATGTTGCACGCCCAGCATGGCGGCCCCACCGAACTAGCCGAGCGAGCCGCATTCCGCGCCCAGGTCGAAGCGCTG
GGACCCGGTACCACGCTGCTGGTGGATACCTATGACGTCACGACCGGTGTGGCCAATGCCGTTGCCGCCGCCGGCGCTGA
GCTCGGCGCGATCCGCATCGATTCCGGTGAGCTTGGGGTACTGGCCCGCCAAGCGCGGGAGCAGCTCGACCGGCTAGGAG
CCACCCGGACGCGCATCGTGGTGTCCGGCGACCTTGACGAGTTCAGCATCGCCGCGTTGCGCGGTGAACCCGTCGACAGC
TACGGCGTGGGCACGTCGCTGGTCACCGGGTCGGGCGCGCCGACCGCCAACATGGTCTACAAACTGGTCGAGGTAGACGG
TGTACCGGTGCAAAAGCGCAGCAGCTACAAAGAATCCCCCGGCGGCCGCAAAGAGGCACTGCGGCGCTCCCGTGCGACGG
GCACCATCACCGAGGAGCTCGTGCATCCGGCGGGCCGTCCGCCGGTCATTGTCGAGCCGCACCGGGTTTTGACGCTGCCA
CTGGTCCGCGCCGGGCAACCGGTAGCCGATACCAGCCTGGCCGCGGCACGGCAGCTGGTGGCATCCGGATTGCGCAGCCT
GCCAGCCGACGGGCTGAAATTGGCACCCGGCGAGCCGGCGATTCCGACACGCACGATCCCGGCCTGA

Upstream 100 bases:

>100_bases
GCCCCAGGATACCCAGCGCACCGTGGCCGCGAGCCGATACCGTGGCGGTGTGAACGACTGGGTCCCAACCGGGCGACGCT
GCGGACCGCGTCGGACCGCT

Downstream 100 bases:

>100_bases
GCGCAAGGATGTGACCACGTCCCGTGTCCGAGTCGGTATCCATGTCTGTGCCTGAGCTGCTTGCCATCGCCGTGGCGGCA
CTTGGCGGCACCCGGCGTCG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDA
DACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAA
GGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL
GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDS
YGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLP
LVRAGQPVADTSLAAARQLVASGLRSLPADGLKLAPGEPAIPTRTIPA

Sequences:

>Translated_448_residues
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDA
DACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAA
GGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL
GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDS
YGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLP
LVRAGQPVADTSLAAARQLVASGLRSLPADGLKLAPGEPAIPTRTIPA
>Mature_447_residues
GPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDAD
ACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAG
GRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEALG
PGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSY
GVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPL
VRAGQPVADTSLAAARQLVASGLRSLPADGLKLAPGEPAIPTRTIPA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=442, Percent_Identity=33.710407239819, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71997952, Length=416, Percent_Identity=31.4903846153846, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71997947, Length=416, Percent_Identity=31.4903846153846, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71997955, Length=200, Percent_Identity=35, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24581587, Length=431, Percent_Identity=31.0904872389791, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI161076680, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24581595, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28574709, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24581593, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24581591, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 47241; Mature: 47110

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEE
GVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGS
EEEECCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEECCCC
PVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVA
CCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHH
AARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIV
CCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEE
VSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESP
EECCCCCEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCHHHCCCCCCC
GGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLV
CCHHHHHHHHCCCCCHHHHHHCCCCCCCEEECCCCEEEEEHHHCCCCCCHHHHHHHHHHH
ASGLRSLPADGLKLAPGEPAIPTRTIPA
HHHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRY
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEE
GVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGS
EEEECCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEECCCC
PVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVA
CCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHH
AARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIV
CCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEE
VSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESP
EECCCCCEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCHHHCCCCCCC
GGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLV
CCHHHHHHHHCCCCCHHHHHHCCCCCCCEEECCCCEEEEEHHHCCCCCCHHHHHHHHHHH
ASGLRSLPADGLKLAPGEPAIPTRTIPA
HHHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]