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The map label for this gene is fumC

Identifier: 121637029

GI number: 121637029

Start: 1257557

End: 1258981

Strand: Reverse

Name: fumC

Synonym: BCG_1158c

Alternate gene names: 121637029

Gene position: 1258981-1257557 (Counterclockwise)

Preceding gene: 121637030

Following gene: 121637028

Centisome position: 28.78

GC content: 65.61

Gene sequence:

>1425_bases
ATGGCCGTTGACGCCGACAGCGCCAATTACCGCATCGAGCACGACACCATGGGCGAAGTCCGGGTGCCGGCAAAAGCGTT
GTGGCGCGCGCAAACCCAGCGCGCGGTGGAGAACTTCCCGATATCCGGCCGCGGGTTGGAGCGCACCCAGATCCGCGCGC
TAGGCCTGCTGAAAGGCGCCTGCGCGCAGGTGAACTCCGACCTCGGGTTGCTGGCGCCGGAGAAAGCCGACGCCATCATC
GCCGCGGCCGCCGAGATCGCCGACGGTCAACACGACGACCAGTTTCCCATCGACGTCTTCCAGACCGGCTCGGGCACCAG
CTCCAACATGAACACCAACGAGGTGATTGCGTCCATCGCGGCCAAGGGCGGGGTCACGTTGCATCCCAACGACGACGTGA
ACATGTCGCAGTCGTCCAACGACACCTTCCCGACGGCCACCCACATCGCGGCCACCGAGGCCGCGGTCGCTCATCTCATC
CCAGCGCTGCAGCAGCTGCACGACGCATTGGCCGCCAAGGCTCTTGATTGGCACACGGTGGTGAAGTCGGGCCGAACGCA
TCTGATGGACGCCGTTCCGGTGACACTCGGCCAGGAGTTCAGCGGATATGCCCGCCAGATCGAGGCCGGCATCGAGCGGG
TGCGCGCGTGTCTGCCCAGGCTGGGCGAGCTGGCGATCGGCGGCACCGCGGTGGGTACCGGCCTCAACGCTCCCGACGAC
TTCGGCGTCAGAGTGGTCGCGGTGCTGGTCGCGCAGACCGGTCTGTCGGAATTGCGTACGGCGGCTAATTCTTTCGAAGC
TCAGGCTGCCCGCGACGGGCTGGTGGAGGCGTCCGGGGCGCTGCGCACGATCGCGGTATCGCTGACCAAGATCGCCAACG
ACATCCGCTGGATGGGATCGGGCCCATTGACCGGCCTGGCCGAGATCCAACTGCCAGATCTGCAGCCGGGCAGCTCGATC
ATGCCGGGAAAGGTGAATCCGGTTCTGCCGGAGGCGGTTACGCAGGTCGCCGCGCAGGTGATCGGAAACGACGCCGCCAT
CGCCTGGGGTGGGGCCAACGGCGCATTCGAACTCAACGTCTACATCCCGATGATGGCCCGCAACATCCTCGAGTCCTTCA
AGCTGCTGACCAATGTGTCACGGCTGTTCGCCCAGCGCTGCATAGCAGGGCTGACCGCCAACGTCGAGCACCTGCGGCGG
CTGGCCGAGTCCTCACCGTCGATCGTGACACCGTTGAATTCGGCCATCGGCTACGAGGAGGCGGCCGCCGTCGCCAAGCA
AGCACTCAAGGAACGCAAAACGATTCGCCAAACCGTGATCGACCGTGGCCTGATCGGCGACAGGCTGTCGATCGAGGATC
TGGACCGCCGTCTGGACGTGCTGGCAATGGCCAAGGCCGAGCAGCTCGACAGCGATCGGCTATGA

Upstream 100 bases:

>100_bases
TTCAAAGCTCAACGAATACTCCGCGATCGACTTCACCGGCGACAGCAGCGCCGTGTACCCATTGCCCTAACACACCCACG
ACACACAAGGAACCCGATCA

Downstream 100 bases:

>100_bases
CGGTTCCTCCCGCTGGCCCCTACGGCAACTACCCCTACGGCCCGAATACGTATGGGCAGGACCTGTATTGGGGAGGCCAA
CCGCAGGGCGGCTCCTATCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAII
AAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLI
PALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDD
FGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSI
MPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRR
LAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL

Sequences:

>Translated_474_residues
MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAII
AAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLI
PALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDD
FGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSI
MPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRR
LAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
>Mature_473_residues
AVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIA
AAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIP
ALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDF
GVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIM
PGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRL
AESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=450, Percent_Identity=52.2222222222222, Blast_Score=437, Evalue=1e-123,
Organism=Escherichia coli, GI1787896, Length=428, Percent_Identity=51.6355140186916, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI87082375, Length=463, Percent_Identity=40.3887688984881, Blast_Score=307, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI17553882, Length=448, Percent_Identity=50.8928571428571, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI32565146, Length=313, Percent_Identity=51.7571884984025, Blast_Score=316, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6324993, Length=451, Percent_Identity=49.6674057649667, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24640179, Length=452, Percent_Identity=49.7787610619469, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24640177, Length=452, Percent_Identity=49.7787610619469, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI78710009, Length=451, Percent_Identity=49.4456762749446, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24662684, Length=445, Percent_Identity=48.0898876404494, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24583245, Length=445, Percent_Identity=41.5730337078652, Blast_Score=338, Evalue=5e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_MYCBO (Q7U0N6)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854784.1
- ProteinModelPortal:   Q7U0N6
- SMR:   Q7U0N6
- EnsemblBacteria:   EBMYCT00000017834
- GeneID:   1090418
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1128c
- GeneTree:   EBGT00050000016253
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- ProtClustDB:   PRK00485
- BioCyc:   MBOV233413:MB1128C-MONOMER
- BRENDA:   4.2.1.2
- GO:   GO:0005737
- HAMAP:   MF_00743
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00149

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 50142; Mature: 50010

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGA
CCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
CAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIA
HHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHH
AKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTV
HCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDD
HHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCC
FGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGS
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCC
GPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNV
CCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEEE
YIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECCHHHHCCHHH
AAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGA
CCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
CAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIA
HHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHH
AKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTV
HCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDD
HHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCC
FGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGS
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCC
GPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNV
CCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEEE
YIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECCHHHHCCHHH
AAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972