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The map label for this gene is echA6

Identifier: 121636828

GI number: 121636828

Start: 1038681

End: 1039412

Strand: Direct

Name: echA6

Synonym: BCG_0957

Alternate gene names: 121636828

Gene position: 1038681-1039412 (Clockwise)

Preceding gene: 121636824

Following gene: 121636829

Centisome position: 23.74

GC content: 64.75

Gene sequence:

>732_bases
ATGATCGGTATCACCCAGGCAGAAGCCGTGCTGACCATTGAGCTGCAACGCCCGGAGCGCCGCAACGCCTTAAATTCCCA
GCTGGTCGAGGAGCTTACGCAGGCCATCCGGAAAGCCGGGGATGGATCGGCTCGGGCGATCGTGCTGACCGGCCAAGGCA
CCGCGTTCTGCGCTGGCGCGGACCTGAGCGGAGACGCATTCGCCGCCGATTATCCCGACCGGCTCATCGAGCTGCACAAG
GCGATGGACGCCTCCCCGATGCCAGTGGTCGGCGCGATCAACGGTCCCGCCATCGGCGCCGGCTTGCAGCTTGCCATGCA
ATGCGACCTGCGGGTTGTCGCGCCCGATGCCTTCTTCCAGTTTCCGACGTCGAAATACGGTCTGGCCCTGGATAACTGGA
GCATCCGCCGGCTGTCGTCGTTGGTTGGGCACGGACGTGCCCGCGCGATGCTGCTCAGCGCGGAAAAGCTGACCGCCGAG
ATCGCACTGCACACCGGAATGGCGAATCGCATTGGCACTTTGGCCGACGCCCAGGCCTGGGCCGCCGAGATCGCCAGGCT
GGCACCACTGGCTATCCAGCACGCCAAGCGGGTGCTCAACGACGACGGCGCTATCGAGGAAGCGTGGCCGGCCCATAAGG
AACTCTTCGACAAAGCCTGGGGCAGCCAGGATGTCATCGAAGCGCAGGTTGCCCGGATGGAAAAGCGGCCGCCGAAGTTC
CAAGGGGCTTAA

Upstream 100 bases:

>100_bases
TCGCTATCCCAGCTGACGAAAGATCCCCGGTCTAGCACCGCGTGCCGCAGTTGGTCGGTCGTGATACGACTCACGCGATG
AGGCTATATAGGCTGACCCA

Downstream 100 bases:

>100_bases
CCGCCATGGTGCGCCGAGCGCTACGACTGGCGGCCGGCACCGCCTCGCTGGCCGCCGGCACGTGGCTGTTGCGTGCGCTG
CACGGCACGCCGGCCGCGCT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHK
AMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAE
IALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKF
QGA

Sequences:

>Translated_243_residues
MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHK
AMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAE
IALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKF
QGA
>Mature_243_residues
MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHK
AMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAE
IALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKF
QGA

Specific function: Could possibly oxidize fatty acids using specific components

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family

Homologues:

Organism=Homo sapiens, GI70995211, Length=262, Percent_Identity=30.9160305343511, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI194097323, Length=239, Percent_Identity=31.3807531380753, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI25453481, Length=239, Percent_Identity=25.1046025104602, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI51538573, Length=239, Percent_Identity=25.1046025104602, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI4757968, Length=239, Percent_Identity=25.9414225941423, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI49355787, Length=239, Percent_Identity=25.9414225941423, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI4757966, Length=227, Percent_Identity=25.5506607929515, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI51538581, Length=227, Percent_Identity=25.5506607929515, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI221136756, Length=241, Percent_Identity=25.3112033195021, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI221136753, Length=241, Percent_Identity=25.3112033195021, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI221307494, Length=241, Percent_Identity=25.3112033195021, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI45643119, Length=212, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI260275230, Length=212, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI260274832, Length=212, Percent_Identity=25, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI31542718, Length=188, Percent_Identity=26.5957446808511, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI116235487, Length=159, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI157694516, Length=237, Percent_Identity=22.7848101265823, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI213417737, Length=237, Percent_Identity=22.7848101265823, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=33.7349397590361, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788597, Length=251, Percent_Identity=28.6852589641434, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI221142681, Length=256, Percent_Identity=29.6875, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082183, Length=258, Percent_Identity=25.1937984496124, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787660, Length=251, Percent_Identity=30.6772908366534, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=263, Percent_Identity=27.7566539923954, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=31.496062992126, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=29.8387096774194, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560910, Length=243, Percent_Identity=27.5720164609054, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=204, Percent_Identity=27.4509803921569, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=222, Percent_Identity=25.6756756756757, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=238, Percent_Identity=25.2100840336134, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=205, Percent_Identity=28.2926829268293, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25141363, Length=220, Percent_Identity=22.7272727272727, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20129971, Length=245, Percent_Identity=28.9795918367347, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653477, Length=245, Percent_Identity=28.9795918367347, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19920382, Length=214, Percent_Identity=31.3084112149533, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357171, Length=207, Percent_Identity=29.4685990338164, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24653139, Length=254, Percent_Identity=24.8031496062992, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650670, Length=247, Percent_Identity=26.7206477732794, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24654903, Length=222, Percent_Identity=24.7747747747748, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922422, Length=256, Percent_Identity=24.609375, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECHA6_MYCBO (P64015)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854586.1
- ProteinModelPortal:   P64015
- SMR:   P64015
- EnsemblBacteria:   EBMYCT00000016005
- GeneID:   1092860
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0929
- GeneTree:   EBGT00050000015506
- HOGENOM:   HBG748731
- OMA:   WPEHKEL
- ProtClustDB:   PRK07854
- BioCyc:   MBOV233413:MB0929-MONOMER
- BRENDA:   4.2.1.17
- InterPro:   IPR001753
- InterPro:   IPR018376

Pfam domain/function: PF00378 ECH

EC number: =4.2.1.17

Molecular weight: Translated: 26029; Mature: 26029

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGA
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECC
DLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQ
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHEEEECCEEEECCHHHHC
FPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEIALHTGMANRIGTLADAQAW
CCCCCCCEEECCCHHHHHHHHHCCCHHHHEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKF
HHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
QGA
CCC
>Mature Secondary Structure
MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGA
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECC
DLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQ
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHEEEECCEEEECCHHHHC
FPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEIALHTGMANRIGTLADAQAW
CCCCCCCEEECCCHHHHHHHHHCCCHHHHEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKF
HHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
QGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972