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The map label for this gene is gltA [H]

Identifier: 121636819

GI number: 121636819

Start: 1029946

End: 1031241

Strand: Direct

Name: gltA [H]

Synonym: BCG_0948

Alternate gene names: 121636819

Gene position: 1029946-1031241 (Clockwise)

Preceding gene: 121636818

Following gene: 121636822

Centisome position: 23.54

GC content: 62.5

Gene sequence:

>1296_bases
GTGGCCGACACCGACGACACCGCAACCCTCCGTTACCCGGGAGGCGAGATCGACCTGCAGATCGTGCACGCCACCGAAGG
CGCCGACGGCATTGCGCTCGGGCCGCTGCTGGCAAAAACCGGGCACACCACGTTCGACGTCGGCTTCGCCAACACGGCCG
CCGCTAAAAGCTCCATCACCTACATCGACGGAGATGCCGGCATTCTGCGTTATCGCGGCTACCCGATCGACCAACTGGCG
GAGAAGTCAACCTTCATCGAGGTCTGCTACCTGTTGATTTACGGCGAGCTGCCCGATACCGACCAGCTTGCCCAGTTCAC
CGGCCGGATCCAGCGCCACACCATGCTGCACGAGGATCTCAAGCGGTTCTTCGACGGCTTTCCGCGCAATGCCCACCCGA
TGCCGGTGTTGTCCAGCGTGGTCAATGCGCTGTCGGCGTACTACCAGGATGCTCTGGACCCCATGGACAACGGTCAAGTC
GAGCTGTCGACCATTCGGCTGCTGGCCAAGCTGCCCACCATCGCCGCGTACGCCTACAAGAAATCGGTCGGCCAGCCCTT
CCTCTACCCAGATAACTCACTGACGCTGGTGGAGAACTTCCTACGGTTGACGTTCGGATTTCCCGCCGAGCCCTACCAGG
CCGACCCCGAGGTGGTGCGGGCGCTGGACATGTTGTTCATCTTGCACGCCGACCACGAGCAGAACTGCTCGACGTCGACG
GTTCGGCTGGTTGGCTCGTCGCGAGCCAACCTGTTCACCTCGATCTCGGGTGGCATCAACGCACTATGGGGTCCGCTTCA
TGGCGGCGCCAATCAGGCTGTCCTGGAGATGCTCGAGGGCATTCGCGACAGCGGCGACGACGTCAGCGAGTTTGTACGCA
AGGTCAAGAACCGCGAGGCCGGGGTCAAATTGATGGGTTTCGGTCATCGTGTCTACAAGAACTACGATCCGCGGGCCCGC
ATCGTCAAGGAACAGGCCGACAAGATCCTGGCCAAGCTCGGCGGCGATGACTCCTTGCTGGGCATCGCCAAGGAGCTCGA
AGAGGCGGCGCTGACCGACGACTACTTCATCGAACGCAAGCTTTACCCCAACGTCGACTTCTACACCGGCCTGATCTACC
GGGCCCTCGGCTTCCCGACCAGGATGTTCACCGTGTTGTTTGCCCTGGGCAGGCTTCCCGGCTGGATCGCGCACTGGCGT
GAGATGCACGACGAGGGCGACAGCAAGATCGGCCGGCCCCGCCAGATCTACACCGGCTACGCGGAGCGCGACTACGTCAC
CATAGACGCGCGGTAG

Upstream 100 bases:

>100_bases
GGCGGGTCATCCCGATAGCGACTACCTTCAGCTATAAGCACTTATCAGCTATAAGCACTTAGTGGGGCAGCCATATCAGC
CAAAGCGCGAAGGGGTTCTC

Downstream 100 bases:

>100_bases
GCCGGCGAGCAGACGCAAAAGCCCCCTAAACCGGCAGGTATTAGGGGCTTTTGCGTCTGCTCGCCAGGCAAGCCAGCACT
GCCATCGCGGCGTTGTGACC

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAKSSITYIDGDAGILRYRGYPIDQLA
EKSTFIEVCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQV
ELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTST
VRLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRAR
IVKEQADKILAKLGGDDSLLGIAKELEEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWR
EMHDEGDSKIGRPRQIYTGYAERDYVTIDAR

Sequences:

>Translated_431_residues
MADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAKSSITYIDGDAGILRYRGYPIDQLA
EKSTFIEVCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQV
ELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTST
VRLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRAR
IVKEQADKILAKLGGDDSLLGIAKELEEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWR
EMHDEGDSKIGRPRQIYTGYAERDYVTIDAR
>Mature_430_residues
ADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAKSSITYIDGDAGILRYRGYPIDQLAE
KSTFIEVCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQVE
LSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTSTV
RLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRARI
VKEQADKILAKLGGDDSLLGIAKELEEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWRE
MHDEGDSKIGRPRQIYTGYAERDYVTIDAR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=392, Percent_Identity=28.0612244897959, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1786939, Length=425, Percent_Identity=52.9411764705882, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1786527, Length=387, Percent_Identity=31.5245478036176, Blast_Score=188, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17555174, Length=380, Percent_Identity=27.8947368421053, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324328, Length=366, Percent_Identity=28.4153005464481, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=328, Percent_Identity=26.5243902439024, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6325257, Length=377, Percent_Identity=25.9946949602122, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24640126, Length=388, Percent_Identity=28.8659793814433, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24640124, Length=388, Percent_Identity=28.8659793814433, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21356863, Length=370, Percent_Identity=27.5675675675676, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47949; Mature: 47818

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAKSSIT
CCCCCCCEEEEECCCCEEEEEEEECCCCCCCEECHHHHHCCCCEEEECCCCHHHCCCCEE
YIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDL
EEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
KRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYK
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
KSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTST
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCE
VRLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVKNREA
EEEECCCCCHHEEECCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
GVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDSLLGIAKELEEAALTDDYFIERK
CEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHC
LYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWREMHDEGDSKIGRPRQIYTGY
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHEEECC
AERDYVTIDAR
CCCCEEEEECC
>Mature Secondary Structure 
ADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAKSSIT
CCCCCCEEEEECCCCEEEEEEEECCCCCCCEECHHHHHCCCCEEEECCCCHHHCCCCEE
YIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDL
EEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
KRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYK
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
KSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTST
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCE
VRLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVKNREA
EEEECCCCCHHEEECCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
GVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDSLLGIAKELEEAALTDDYFIERK
CEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHC
LYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWREMHDEGDSKIGRPRQIYTGY
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHEEECC
AERDYVTIDAR
CCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]