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The map label for this gene is mmsB [H]

Identifier: 121636674

GI number: 121636674

Start: 874130

End: 875014

Strand: Reverse

Name: mmsB [H]

Synonym: BCG_0802c

Alternate gene names: 121636674

Gene position: 875014-874130 (Counterclockwise)

Preceding gene: 121636675

Following gene: 121636672

Centisome position: 20.0

GC content: 68.93

Gene sequence:

>885_bases
ATGACGACCATCGCCTTCCTAGGTTTGGGCAACATGGGTGCGCCGATGTCGGCGAATCTGGTTGGTGCGGGCCACGTCGT
GCGTGGATTCGACCCGGCACCCACGGCGGCGTCCGGCGCCGCCGCGCACGGTGTCGCGGTGTTTCGTAGCGCGCCCGAAG
CGGTGGCCGAGGCCGACGTGGTCATCACCATGCTGCCCACCGGCGAGGTGGTCCGGCGCTGCTACACCGACGTGCTGGCC
GCCGCGCGTCCGGCAACGCTGTTCATCGACAGCTCCACGATCTCGGTCACCGATGCCCGTGAGGTGCACGCGCTGGCCGA
ATCGCACGGCATGCTCCAACTGGATGCGCCGGTCTCCGGCGGGGTGAAGGGCGCCGCCGCCGCGACGCTGGCATTCATGG
TCGGCGGCGACGAGTCCACGCTACGGCGGGCACGCCCGGTACTAGAGCCCATGGCGGGCAAGATCATTCACTGCGGCGCC
GCCGGTGCCGGACAGGCCGCCAAGGTGTGCAACAACATGGTGCTGGCGGTGCAGCAGATCGCGATCGCCGAGGCGTTCGT
GCTGGCCGAGAAGCTCGGGCTGTCCGCACAATCGTTGTTCGACGTCATCACCGGCGCGACCGGCAATTGCTGGGCGGTGC
ACACCAATTGCCCGGTGCCGGGCCCGGTGCCCACCTCACCGGCCAACAACGACTTCAAGCCCGGGTTTTCGACCGCGTTG
ATGAACAAGGACCTGGGCCTGGCGATGGATGCGGTGGCCGCCACCGGTGCGACGGCCCCGCGGGGCAGCCACGCCGCCGA
CATCTACGCCAAATTCGCCGCCGACCACGCCGACCTGGACTTCAGCGCGGTGATCCACACGTTGCGCGCGCGAGCAGACG
CATAA

Upstream 100 bases:

>100_bases
CGGGTGCATCGCATCCTGGAAGGGACCAACGAGATCATGCGGCTGGTCATCGGTCGGGCCGAGGCCGCGCGGTTCCGCGC
CACCGTTTAGAGAGGCTCAG

Downstream 100 bases:

>100_bases
GCGCCCATTTCGACACGAAATTGGGCGCTTATGCGTCTGCTCGCCCTCAGAGGTCGCCGGCACACCCATCAGCCCTCGGC
GGCGTCTTTCGGGTCCGACA

Product: putative 3-hydroxyisobutyrate dehydrogenase mmsB

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLA
AARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGA
AGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTAL
MNKDLGLAMDAVAATGATAPRGSHAADIYAKFAADHADLDFSAVIHTLRARADA

Sequences:

>Translated_294_residues
MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLA
AARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGA
AGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTAL
MNKDLGLAMDAVAATGATAPRGSHAADIYAKFAADHADLDFSAVIHTLRARADA
>Mature_293_residues
TTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLAA
ARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAA
GAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALM
NKDLGLAMDAVAATGATAPRGSHAADIYAKFAADHADLDFSAVIHTLRARADA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=40.0684931506849, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI40556376, Length=287, Percent_Identity=25.7839721254355, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI145693186, Length=275, Percent_Identity=32.7272727272727, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790315, Length=297, Percent_Identity=31.3131313131313, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786719, Length=300, Percent_Identity=31, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789092, Length=291, Percent_Identity=29.553264604811, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=38.047138047138, Blast_Score=187, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=43.9862542955326, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=43.9862542955326, Blast_Score=234, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29722; Mature: 29591

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADV
CCEEEEEECCCCCCCCCCCEEECCCEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCE
VITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSG
EEEECCCHHHHHHHHHHHHHHCCCCEEEEECCEEEECCHHHHHHHHHHCCEEEECCCCCC
GVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQI
CCCHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTAL
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
MNKDLGLAMDAVAATGATAPRGSHAADIYAKFAADHADLDFSAVIHTLRARADA
HCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADV
CEEEEEECCCCCCCCCCCEEECCCEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCE
VITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSG
EEEECCCHHHHHHHHHHHHHHCCCCEEEEECCEEEECCHHHHHHHHHHCCEEEECCCCCC
GVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQI
CCCHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTAL
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHH
MNKDLGLAMDAVAATGATAPRGSHAADIYAKFAADHADLDFSAVIHTLRARADA
HCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]