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The map label for this gene is menA

Identifier: 121636452

GI number: 121636452

Start: 656454

End: 657332

Strand: Reverse

Name: menA

Synonym: BCG_0578c

Alternate gene names: 121636452

Gene position: 657332-656454 (Counterclockwise)

Preceding gene: 121636455

Following gene: 121636451

Centisome position: 15.03

GC content: 69.74

Gene sequence:

>879_bases
GTGGCCAGTTTCGCACAGTGGGTCTCCGGCGCGCGGCCCCGAACGCTGCCGAACGCGATCGCGCCAGTGGTTGCCGGCAC
CGGCGCCGCGGCCTGGCTGCACGCGGCCGTGTGGTGGAAAGCGCTGTTGGCACTGGCTGTTGCGGTGGCGCTGGTCATTG
GGGTCAATTACGCCAATGACTACTCCGACGGCATCCGCGGCACCGATGACGACAGGGTGGGTCCGGTGCGGTTGGTGGGC
TCGCGGCTGGCGACCCCGCGCTCGGTGCTGACCGCTGCCATGACGAGCCTGGCGCTCGGTGCGCTGGCCGGGCTGGTTTT
GGCGCTGCTCAGCGCGCCGTGGCTGATTGCGGTGGGTGCGATCTGCATCGCCGGGGCCTGGCTCTACACCGGCGGGTCAA
AACCCTACGGCTATGCGGGCTTCGGCGAACTGGCGGTGTTTGTGTTCTTCGGGCCGGTCGCCGTGCTCGGTACCCAGTAC
ACGCAGGCATTGCGGGTGGACTGGGTGGGGCTGGCACAGGCGGTAGCAACGGGTGCGTTGTCGTGCTCGGTGCTGGTGGC
CAACAACCTGCGCGACATCCCCACCGACGCGCGGGCCGACAAGATCACGCTGGCGGTGCGGCTGGGAGACGCCCGGACCC
GGATGCTTTACCAGGGCCTGCTGGCGGTCGCCGGGGTGCTGACGTTCGTGCTAATGCTGGCCACGCCGTGGTGTGTGGTG
GGCTTGGTGGCCGCGCCTTTGGCGCTGCGCGCTGCCGGACCGGTGCGATCCGGGCGCGGCGGGCGCGAGCTGATCCCGGT
ACTGCGTGACACTGGGCTGGCCATGCTGGTGTGGGCGTTGGCGGTGGCGGGGGCATTGGCGTTTGGTCAGTTGAGCTAA

Upstream 100 bases:

>100_bases
ATTGACTGTGCGGGTGTCCGACCCAAAGAAGGTGTAGAAGCCGCTGCCGCCGATCACTCCGAGCATGCGCCCATTGTTGT
GCATAGGGCAGGATGCCCTG

Downstream 100 bases:

>100_bases
CTTCGAACGTGCACTCAGGGCGGGCTCCGTCGGCGTGTCGTCGCCGTAGGTGCACACTCGACGAGAACAGATAGGACGGG
TATGACGGAGATCGCCACGA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLALAVAVALVIGVNYANDYSDGIRGTDDDRVGPVRLVG
SRLATPRSVLTAAMTSLALGALAGLVLALLSAPWLIAVGAICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQY
TQALRVDWVGLAQAVATGALSCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVV
GLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS

Sequences:

>Translated_292_residues
MASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLALAVAVALVIGVNYANDYSDGIRGTDDDRVGPVRLVG
SRLATPRSVLTAAMTSLALGALAGLVLALLSAPWLIAVGAICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQY
TQALRVDWVGLAQAVATGALSCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVV
GLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS
>Mature_291_residues
ASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLALAVAVALVIGVNYANDYSDGIRGTDDDRVGPVRLVGS
RLATPRSVLTAAMTSLALGALAGLVLALLSAPWLIAVGAICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQYT
QALRVDWVGLAQAVATGALSCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVVG
LVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family

Homologues:

Organism=Homo sapiens, GI7019551, Length=261, Percent_Identity=29.5019157088123, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1790365, Length=271, Percent_Identity=37.2693726937269, Blast_Score=138, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17737429, Length=262, Percent_Identity=27.8625954198473, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENA_MYCBO (P65651)

Other databases:

- EMBL:   BX248335
- RefSeq:   NP_854209.1
- EnsemblBacteria:   EBMYCT00000016257
- GeneID:   1091620
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0548c
- GeneTree:   EBGT00050000017548
- HOGENOM:   HBG313998
- OMA:   RVTQSGM
- ProtClustDB:   PRK06080
- BioCyc:   MBOV233413:MB0548C-MONOMER
- InterPro:   IPR004657
- InterPro:   IPR000537
- TIGRFAMs:   TIGR00751

Pfam domain/function: PF01040 UbiA

EC number: =2.5.1.74

Molecular weight: Translated: 30015; Mature: 29883

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x40962620)-; HASH(0x12c3d5c4)-; HASH(0x141ba3a0)-; HASH(0x1389a278)-; HASH(0x1433367c)-; HASH(0x13dc1898)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLALAVAVALVIGVNYAND
CCCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YSDGIRGTDDDRVGPVRLVGSRLATPRSVLTAAMTSLALGALAGLVLALLSAPWLIAVGA
CCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQYTQALRVDWVGLAQAVATGAL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVV
HHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
ASFAQWVSGARPRTLPNAIAPVVAGTGAAAWLHAAVWWKALLALAVAVALVIGVNYAND
CCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YSDGIRGTDDDRVGPVRLVGSRLATPRSVLTAAMTSLALGALAGLVLALLSAPWLIAVGA
CCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQYTQALRVDWVGLAQAVATGAL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVV
HHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972