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The map label for this gene is moeA2 [H]

Identifier: 121636352

GI number: 121636352

Start: 556958

End: 558175

Strand: Reverse

Name: moeA2 [H]

Synonym: BCG_0477c

Alternate gene names: 121636352

Gene position: 558175-556958 (Counterclockwise)

Preceding gene: 121636353

Following gene: 121636351

Centisome position: 12.76

GC content: 67.73

Gene sequence:

>1218_bases
GTGCGGTCAGTCCAGGAGCATCAACGTGTCGTAGCGGAGATGATCCGCGCCTGTCGCCCGATTACGGTTCCGCTGACCCA
GGCTCAAGGTCTGGTCCTGGGCGGCGACGTGGTCGCACCGCTGTCGCTGCCGGTTTTCGACAACTCCGCAATGGATGGCT
ATGCGGTGCGCGCCGAAGACACCTCAGGTGCCACACCGCAAAATCCGGTGATGTTGCCGGTCGCCGAGGACATTCCCGCC
GGGCGCGCCGACATGCTGACGCTGCAGCCTGTGACTGCGCACCGGATCATGACCGGTGCGCCAGTGCCCACCGGTGCGAC
GGCGATCGTGCCGGTCGAAGCCACCGACGGCGGCGTCGATTCGGTGGCGATCCGCCAACAGGCCACCCCAGGCAAGCACA
TCCGACGGTCGGGCGAAGACGTCGCCGCCGGTACCACGGTGCTGCACAACGGCCAGATCGTGACCCCGGCGGTGCTCGGC
CTGGCCGCCGCGCTGGGTTTGGCCGAGCTGCCGGTGCTCCCCCGTCAGCGGGTGCTGGTGATCTCCACAGGGTCGGAGCT
GGCGTCGCCAGGCACGCCCCTACAACCGGGTCAGATCTACGAGTCCAACTCGATCATGCTGGCCGCTGCCGTCCGCGATG
CGGGCGCCGCTGTGGTCGCCACCGCAACCGCCGGCGACGACGTCGCGCAGTTCGGCGCGATCCTTGACCGGTACGCGGTG
GACGCCGACCTGATCATCACCAGCGGCGGTGTCAGTGCCGGAGCCTACGAGGTGGTCAAAGACGCGTTCGGCAGCGCTGA
CTACCGGGGAGGCGACCACGGTGTCGAATTCGTCAAGGTGGCGATGCAACCCGGAATGCCCCAGGGCGTCGGGCGGGTGG
CAGGTACGCCGATCGTCACCCTTCCCGGCAACCCGGTCAGCGCGCTGGTGTCCTTCGAGGTGTTCATCCGTCCCCCGCTG
CGCATGGCCATGGGCCTGCCGGATCCGTACCGGCCGCACCGAAGCGCGGTACTCACCGCGAGCCTGACATCGCCGCGCGG
CAAACGTCAGTTCCGACGCGCAATACTCGATCACCAGGCAGGCACGGTCATCAGCTACGGCCCACCGGCGTCGCACCATT
TGCGTTGGTTGGCATCGGCCAACGGACTTCTGGACATCCCGGAGGACGTCGTGGAGGTGGCTGCCGGAACGCAGCTGCAA
GTCTGGGACTTGACCTAA

Upstream 100 bases:

>100_bases
CGCGCAGTCCCACGACAAAGATCTGCAGCGCCGCCTCTGGACCGTCTCCGAAGAACTCACCGGCGTCAGCTTCGGAGTCT
GAACGACCGATAATGGCCGG

Downstream 100 bases:

>100_bases
CCGGACCGATCCTAGTGCCGTGCACCCAACCTGCGGCACGAAGCTCCGTAAGATGACCCCGTGGCCAGACGCCCCCGCCC
CGACGGCCCGCAACATCTGC

Product: putative molybdopterin biosynthesis protein moeA2

Products: NA

Alternate protein names: MPT Mo-transferase 2 [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MRSVQEHQRVVAEMIRACRPITVPLTQAQGLVLGGDVVAPLSLPVFDNSAMDGYAVRAEDTSGATPQNPVMLPVAEDIPA
GRADMLTLQPVTAHRIMTGAPVPTGATAIVPVEATDGGVDSVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLG
LAAALGLAELPVLPRQRVLVISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAVVATATAGDDVAQFGAILDRYAV
DADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEFVKVAMQPGMPQGVGRVAGTPIVTLPGNPVSALVSFEVFIRPPL
RMAMGLPDPYRPHRSAVLTASLTSPRGKRQFRRAILDHQAGTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQLQ
VWDLT

Sequences:

>Translated_405_residues
MRSVQEHQRVVAEMIRACRPITVPLTQAQGLVLGGDVVAPLSLPVFDNSAMDGYAVRAEDTSGATPQNPVMLPVAEDIPA
GRADMLTLQPVTAHRIMTGAPVPTGATAIVPVEATDGGVDSVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLG
LAAALGLAELPVLPRQRVLVISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAVVATATAGDDVAQFGAILDRYAV
DADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEFVKVAMQPGMPQGVGRVAGTPIVTLPGNPVSALVSFEVFIRPPL
RMAMGLPDPYRPHRSAVLTASLTSPRGKRQFRRAILDHQAGTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQLQ
VWDLT
>Mature_405_residues
MRSVQEHQRVVAEMIRACRPITVPLTQAQGLVLGGDVVAPLSLPVFDNSAMDGYAVRAEDTSGATPQNPVMLPVAEDIPA
GRADMLTLQPVTAHRIMTGAPVPTGATAIVPVEATDGGVDSVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLG
LAAALGLAELPVLPRQRVLVISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAVVATATAGDDVAQFGAILDRYAV
DADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEFVKVAMQPGMPQGVGRVAGTPIVTLPGNPVSALVSFEVFIRPPL
RMAMGLPDPYRPHRSAVLTASLTSPRGKRQFRRAILDHQAGTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQLQ
VWDLT

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=400, Percent_Identity=36, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI66932975, Length=400, Percent_Identity=36, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1787049, Length=387, Percent_Identity=36.1757105943152, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI25147659, Length=391, Percent_Identity=28.6445012787724, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17562606, Length=354, Percent_Identity=24.8587570621469, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136978, Length=369, Percent_Identity=28.9972899728997, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24638841, Length=369, Percent_Identity=28.9972899728997, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42004; Mature: 42004

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVQEHQRVVAEMIRACRPITVPLTQAQGLVLGGDVVAPLSLPVFDNSAMDGYAVRAED
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCCEEECEEEEEECCCCCCCEEEEECC
TSGATPQNPVMLPVAEDIPAGRADMLTLQPVTAHRIMTGAPVPTGATAIVPVEATDGGVD
CCCCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHEEECCCCCCCCEEEEEEECCCCCCC
SVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLGLAAALGLAELPVLPRQRVLV
CEEEECCCCCCHHHHCCCCCCCCCEEEEECCEECHHHHHHHHHHHHHHHCCCCCCCCEEE
ISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAVVATATAGDDVAQFGAILDRYAV
EECCCHHCCCCCCCCCCEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHC
DADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEFVKVAMQPGMPQGVGRVAGTPIVT
CCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHCCCCEEE
LPGNPVSALVSFEVFIRPPLRMAMGLPDPYRPHRSAVLTASLTSPRGKRQFRRAILDHQA
ECCCCCEEEEEEEEEECCCHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCC
GTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQLQVWDLT
CCEEECCCCHHHHEEEEECCCCCCCCCHHHHHHHCCCEEEEEECC
>Mature Secondary Structure
MRSVQEHQRVVAEMIRACRPITVPLTQAQGLVLGGDVVAPLSLPVFDNSAMDGYAVRAED
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCCEEECEEEEEECCCCCCCEEEEECC
TSGATPQNPVMLPVAEDIPAGRADMLTLQPVTAHRIMTGAPVPTGATAIVPVEATDGGVD
CCCCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHEEECCCCCCCCEEEEEEECCCCCCC
SVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLGLAAALGLAELPVLPRQRVLV
CEEEECCCCCCHHHHCCCCCCCCCEEEEECCEECHHHHHHHHHHHHHHHCCCCCCCCEEE
ISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAVVATATAGDDVAQFGAILDRYAV
EECCCHHCCCCCCCCCCEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHC
DADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEFVKVAMQPGMPQGVGRVAGTPIVT
CCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCHHHCCCCEEE
LPGNPVSALVSFEVFIRPPLRMAMGLPDPYRPHRSAVLTASLTSPRGKRQFRRAILDHQA
ECCCCCEEEEEEEEEECCCHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCC
GTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQLQVWDLT
CCEEECCCCHHHHEEEEECCCCCCCCCHHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]