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The map label for this gene is thiD

Identifier: 121636336

GI number: 121636336

Start: 538573

End: 539370

Strand: Reverse

Name: thiD

Synonym: BCG_0461c

Alternate gene names: 121636336

Gene position: 539370-538573 (Counterclockwise)

Preceding gene: 121636337

Following gene: 121636335

Centisome position: 12.33

GC content: 66.92

Gene sequence:

>798_bases
ATGACGCCGCCGCGGGTGTTGAGCATCGCCGGATCGGACTCCGGGGGCGGTGCCGGCATCCAAGCCGATATGCGCACGAT
GGCACTGCTAGGAGTGCACGCGTGCGTCGCAGTCACGGCGGTTACCGTACAGAACACGTTGGGAGTCAAGGATATTCATG
AAGTTCCCAACGATGTGGTGGCCGGCCAGATCGAGGCGGTCGTCACCGACATCGGCGTTCAAGCCGCCAAGACCGGGATG
CTGGCCTCGTCGCGCATCGTTGCGACCGTGGCCGCGACCTGGCGTCGGCTCGAGCTGTCCGTTCCGCTCGTCGTCGACCC
GGTATGCGCATCCATGCACGGAGACCCGCTGTTGGCACCGTCTGCCCTGGATTCGCTTCGCGGTCAGCTGTTCCCGTTGG
CGACGCTGCTGACCCCCAACCTTGACGAGGCGCGCCTGCTGGTAGATATCGAGGTAGTCGACGCCGAGTCGCAGCGTGCG
GCGGCCAAAGCCCTGCATGCGCTGGGGCCGCAGTGGGTGCTGGTCAAAGGCGGACACCTGCGCTCGTCGGACGGCAGCTG
CGACCTGCTCTATGACGGCGTCAGCTGCTACCAGTTCGACGCGCAGCGACTACCCACCGGCGATGACCATGGCGGTGGTG
ACACGCTGGCGACCGCGATCGCCGCCGCGTTGGCGCACGGCTTCACCGTGCCCGACGCGGTGGACTTCGGGAAGCGATGG
GTTACCGAATGCCTGCGCGCGGCCTATCCACTGGGCCGCGGCCACGGGCCCGTTTCGCCGCTGTTTCGGCTGTCATGA

Upstream 100 bases:

>100_bases
CCGCCGGAATGGCCGAAAAGTCACGTGAATTCGCAGAGCACGGCAATCGGGTGTATCTCCCGATAACCCAGTGAACTACC
TCCCGCTGGCACCGCCGGGA

Downstream 100 bases:

>100_bases
ACCTTGATCAGATCGCCGGCGTTGCACACCAACCGGCCGGCCCACCACACGGGGTAGTCGTCCTTACCCACGGCGCGGGC
GGTAGCCGCGAATCCACACT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGM
LASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRA
AAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRW
VTECLRAAYPLGRGHGPVSPLFRLS

Sequences:

>Translated_265_residues
MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGM
LASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRA
AAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRW
VTECLRAAYPLGRGHGPVSPLFRLS
>Mature_264_residues
TPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGML
ASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRAA
AKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRWV
TECLRAAYPLGRGHGPVSPLFRLS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family

Homologues:

Organism=Escherichia coli, GI1788420, Length=257, Percent_Identity=39.2996108949416, Blast_Score=166, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325378, Length=248, Percent_Identity=33.8709677419355, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324997, Length=247, Percent_Identity=33.6032388663968, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324517, Length=247, Percent_Identity=33.6032388663968, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THID_MYCBO (P66914)

Other databases:

- EMBL:   BX248335
- RefSeq:   NP_854093.1
- ProteinModelPortal:   P66914
- SMR:   P66914
- EnsemblBacteria:   EBMYCT00000018111
- GeneID:   1091436
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0430c
- GeneTree:   EBGT00050000016703
- HOGENOM:   HBG476673
- OMA:   ACALAHG
- ProtClustDB:   PRK06427
- BioCyc:   MBOV233413:MB0430C-MONOMER
- BRENDA:   2.7.4.7
- InterPro:   IPR013749
- InterPro:   IPR004399
- TIGRFAMs:   TIGR00097

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.49; =2.7.4.7

Molecular weight: Translated: 27511; Mature: 27380

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: BINDING 44-44

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVV
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
AGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCEEECHHHHHCCCCCCCCH
SALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRAAAKALHALGPQWVLVKGGHL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCEE
RSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRW
ECCCCCEEEEECCCEEEEECHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VTECLRAAYPLGRGHGPVSPLFRLS
HHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVV
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
AGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCEEECHHHHHCCCCCCCCH
SALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRAAAKALHALGPQWVLVKGGHL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCEE
RSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRW
ECCCCCEEEEECCCEEEEECHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VTECLRAAYPLGRGHGPVSPLFRLS
HHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972