Click here to switch to the map view.

The map label for this gene is fadE7 [H]

Identifier: 121636312

GI number: 121636312

Start: 509381

End: 510568

Strand: Reverse

Name: fadE7 [H]

Synonym: BCG_0437c

Alternate gene names: 121636312

Gene position: 510568-509381 (Counterclockwise)

Preceding gene: 121636314

Following gene: 121636311

Centisome position: 11.67

GC content: 68.18

Gene sequence:

>1188_bases
ATGAGCACCCCGACACCACCCGCCCTTGACCGCGACGACCCGCTGGGACTGGACGCGTCGCTATCCAGCGACGAGATCGC
CGTCCGCGACACCGTCAGGCGGTTCTGCGCCGAACACGTCACCCCGCACGTCGCGGCGTGGTTCGAGGACGGCGACCTAC
CGGTCGCGCGCGATTTGGCCAAACAGTTCGGCGAACTCGGACTGCTGGGAATGCAGCTGCACGGCCACGGCTGTGGCGGC
GCGTCGGCGGTGCACTATGGCCTGGCCTGCCGGGAGCTGGAGGCCGCCGACTCCGGCATCCGGTCGCTGGTGTCGGTACA
GGGTTCGCTGGCGATGTTCGCCATCGCGAGCTTTGGCTCCGACGAGCAAAAGCGGCAGTGGCTGCCCGGCATGGCCACCG
GTGACCTGCTCGGCTGCTTCGGGCTCACCGAGCCCGACGTCGGCTCCGACCCGGCCGCGATGAAAACCCGGGCGCGACGC
GATGGTCCGGACTGGGTGATCACCGGGGGCAAGATGTGGATCACCAACGGCTCGGTCGCCGACGTGGCGATCGTGTGGGC
CGCCACCGACGACGGAATCCGCGGATTCATCGTGCCCACCGACACCCCGGGTTTCACCGCCAACACCATCGGTCACAAGC
TGTCGCTGCGGGCGTCGATCACCAGCGAGCTGGTGCTCGACAATGTCCGGCTGCCCGCCGACGCCATGCTGCCCGGCGCG
ACCGGCCTCAGGGCGCCGCTGGCATGCCTGTCGGAGGCGCGCTACGGGATCGTCTGGGGAGCGATGGGCGCGGCCAGGTC
GGCCTGGCAGTGCGCGCTCGACTACGCGAGACAGCGCACCCAGTTCGGACGTCCGATCGCCGGCTTCCAGCTGACCCAGG
CCAAGCTCGTCGACATGGCCGTGGAACTGCACAAGGGTCAGCTGCTGTCGTTGCATCTGGGGCGCCTCAAAGACAGGGTG
GGCCTGCGCCCCGATCAGGTCAGCTTCGGCAAGCTCAACAACACCCGGGAAGCGCTCAAAATCTGCCGGACCGCTCGAAC
AATACTGGGCGGCAACGGGATATCGCTGGAGTACCCGGTCATCCGGCACATGGTCAACCTGGAGTCGGTGCTCACCTACG
AGGGCACGCCCGAGATGCATCAGCTGGTGCTCGGTCAGGCCTTCACGGGCTTGGCCGCCTTCCGGTAG

Upstream 100 bases:

>100_bases
GCGCAGAACACCAGCACGGCGACGACGTCGGCGGCCAGCCCCGCCAGCGCGCGCCGTGGTCGCATGCCGCGAGGCTACCG
GGCCGGGGCAGTATTGAGTG

Downstream 100 bases:

>100_bases
GACCGTCGCATGCCCGTCTTGCGGCGCCTCGGGTGTTCGGTCCTGGCTCTCGGGCTGCTGGCCGGCTGCGCCCCACCCCG
CACCGGGCCGGCTTCGTCGC

Product: putative acyl-CoA dehydrogenase fadE7

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAAWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGG
ASAVHYGLACRELEAADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARR
DGPDWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAMLPGA
TGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRV
GLRPDQVSFGKLNNTREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR

Sequences:

>Translated_395_residues
MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAAWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGG
ASAVHYGLACRELEAADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARR
DGPDWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAMLPGA
TGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRV
GLRPDQVSFGKLNNTREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR
>Mature_394_residues
STPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAAWFEDGDLPVARDLAKQFGELGLLGMQLHGHGCGGA
SAVHYGLACRELEAADSGIRSLVSVQGSLAMFAIASFGSDEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARRD
GPDWVITGGKMWITNGSVADVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAMLPGAT
GLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRPIAGFQLTQAKLVDMAVELHKGQLLSLHLGRLKDRVG
LRPDQVSFGKLNNTREALKICRTARTILGGNGISLEYPVIRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=47.8589420654912, Blast_Score=370, Evalue=1e-103,
Organism=Homo sapiens, GI7669494, Length=377, Percent_Identity=47.4801061007958, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI4557233, Length=363, Percent_Identity=36.6391184573003, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4501857, Length=393, Percent_Identity=29.7709923664122, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=28.6089238845144, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4501859, Length=368, Percent_Identity=28.5326086956522, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4557231, Length=396, Percent_Identity=28.5353535353535, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI187960098, Length=396, Percent_Identity=28.5353535353535, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=28.9855072463768, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI21361497, Length=376, Percent_Identity=28.1914893617021, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI76496475, Length=397, Percent_Identity=27.2040302267003, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557235, Length=397, Percent_Identity=27.2040302267003, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=25.2631578947368, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI38505218, Length=390, Percent_Identity=24.6153846153846, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI48976061, Length=351, Percent_Identity=23.0769230769231, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI211971008, Length=351, Percent_Identity=23.0769230769231, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786223, Length=275, Percent_Identity=26.9090909090909, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI87081958, Length=302, Percent_Identity=27.1523178807947, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=43.9276485788114, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=32.1808510638298, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17508101, Length=387, Percent_Identity=30.749354005168, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17506239, Length=385, Percent_Identity=30.1298701298701, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=29.6103896103896, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=29.6587926509186, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=360, Percent_Identity=30.5555555555556, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=26.2599469496021, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71990804, Length=260, Percent_Identity=33.8461538461538, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=295, Percent_Identity=31.5254237288136, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=26.7015706806283, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=222, Percent_Identity=34.2342342342342, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17551932, Length=281, Percent_Identity=29.8932384341637, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=276, Percent_Identity=29.3478260869565, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=278, Percent_Identity=29.8561151079137, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=284, Percent_Identity=25.3521126760563, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920834, Length=400, Percent_Identity=48.5, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=32.620320855615, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=31.266846361186, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24660351, Length=390, Percent_Identity=31.2820512820513, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=30.0531914893617, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=30.1587301587302, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281363737, Length=343, Percent_Identity=27.1137026239067, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 42298; Mature: 42167

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAAWFEDGDLPVARDLA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
KQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRSLVSVQGSLAMFAIASFGS
HHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
DEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARRDGPDWVITGGKMWITNGSVA
CHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCEEEEECCCEE
DVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAMLPGA
EEEEEEEECCCCCEEEEEECCCCCCCHHHCCCEEEEEHHHHHHHHHHCCCCCHHHCCCCC
TGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRPIAGFQLTQAKLVDMA
CCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNNTREALKICRTARTILGGNGISLEYPV
HHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECHHH
IRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR
HHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STPTPPALDRDDPLGLDASLSSDEIAVRDTVRRFCAEHVTPHVAAWFEDGDLPVARDLA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
KQFGELGLLGMQLHGHGCGGASAVHYGLACRELEAADSGIRSLVSVQGSLAMFAIASFGS
HHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
DEQKRQWLPGMATGDLLGCFGLTEPDVGSDPAAMKTRARRDGPDWVITGGKMWITNGSVA
CHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCEEEEECCCEE
DVAIVWAATDDGIRGFIVPTDTPGFTANTIGHKLSLRASITSELVLDNVRLPADAMLPGA
EEEEEEEECCCCCEEEEEECCCCCCCHHHCCCEEEEEHHHHHHHHHHCCCCCHHHCCCCC
TGLRAPLACLSEARYGIVWGAMGAARSAWQCALDYARQRTQFGRPIAGFQLTQAKLVDMA
CCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VELHKGQLLSLHLGRLKDRVGLRPDQVSFGKLNNTREALKICRTARTILGGNGISLEYPV
HHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECHHH
IRHMVNLESVLTYEGTPEMHQLVLGQAFTGLAAFR
HHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]