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The map label for this gene is metC [H]

Identifier: 121610341

GI number: 121610341

Start: 3780241

End: 3781521

Strand: Direct

Name: metC [H]

Synonym: Veis_3409

Alternate gene names: 121610341

Gene position: 3780241-3781521 (Clockwise)

Preceding gene: 121610340

Following gene: 121610342

Centisome position: 67.91

GC content: 66.51

Gene sequence:

>1281_bases
ATGGCAGGCATGAACCATACAGACGCCGACGATCTCAGCACCCGCATCGTCCACCACGACTACATCCCGCCAGCGGGATT
TGCGGCCTTGCAGCCCGGGGTTTACAAGGCTTCCACCGTGATCTTCCCGAACGTGGCGGCAATGCGCACCCGTGAGTGGA
AGGACAAGAGCAGTTACACCTACGGGCTGCATGGCACGCCCACCACGTTCACGCTCGAAGAGCGGTTGTGCATGTTGGAG
GGCGGCCTGCAATGCGTGCTGCAGCCCAGTGGTTTGGCGGCGATCGCCAATGTGGCGCTGGCGCTGCTCGAAACCGGCGA
TGAGGTGCTGCTTCCCGACAATGTCTACGGCCCGAGCCTGGCACTGGCCAATGGTGAACTGGCCCGTTTCGGCATCCGCC
ATGGCTTGTACGATCCGCTGGACAAGGCCGATTTGGCCGCGCGCATCACGCCTGCCACGCGGCTGGTGTGGCTGGAGGCG
CCGGGTTCGGTGACCATGGAGTTTCCCGATCTGTGCGGGCAGGTGCGCATCTGCCGTGCGCGGGGTGTGATCACGGCCCT
GGACAATACCTGGGGCGCCGGTTTGGCATTTGCGCCGTTTGACCTCACCGGCGACGGCAGCCGCAGCCTCGGGGTCGACA
TTTCGGCCCATGCGCTGACCAAATTCCCGAGCGGCAACGGCGATGTGCTGATGGGTAGCGTGATCACGCGCGACCCCGAA
CTGCACATGAAGATCAAGCTCACCCATATGCGGCTGGGCCTGGGTGTGGCGGGCAATGACGCCGAGGCGGTGCTGCGCGC
GCTGCCCAGCATCGGTCTGCGTTACCGTGCCCACGACGCGGCCGCGCGCCAGTTGGCGCTGTGGCTGCAGCAGCAGCCGG
CGATCGCGCAGGTGCTGCATCCGGCGCTGGCCGGTTCGCCCGGCCACGCGCACTGGCAGGCGCTGTGCGGCGCCGGTGTC
ACTGAAGCGCCATGCGGCGCCGATACGGCTACCCGGGGCGCTGCGGCGGGCTTGTTCAGCGTGATCATCGATGCGCGCTA
CACGCAGTCGCAGGTGGACGCCTTCTGCGATGGCTTGCGCCTGTTCAAAATCGGCTACAGCTGGGGCGGGCCGATGAGCC
TGGTGGTGCCCTACCACCTTGCCAGCATGCGCCTGCGCCCTGCCCCGCATCTGAAGCCGGGCACGTTGGTGCGGTTTTTC
ATCGGGCTGGAAGCGGTGCCGGATCTGCAGCAGGATTTGCAGCAGGCGCTCGAGCGCGCCTTCGCGGCGGATGGACCCTA
G

Upstream 100 bases:

>100_bases
ATATACATCGTATGTCTCGAATGACGATCGTTCAAAAGAAGTGCATCTCAAGCTGCTTTTCGTCGACCACGCGCCGGGAC
ATTTCCGCCGGCGCGCTACC

Downstream 100 bases:

>100_bases
TGTCGTGTCACTGATCAGATGTCGTAGGCTGCGCGCAGCCATCGGAGCGCAGCGCAAGGCGCATAGCGCGGCCAATACCG
AGCGTATTGGCAAGCGATGC

Product: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAGMNHTDADDLSTRIVHHDYIPPAGFAALQPGVYKASTVIFPNVAAMRTREWKDKSSYTYGLHGTPTTFTLEERLCMLE
GGLQCVLQPSGLAAIANVALALLETGDEVLLPDNVYGPSLALANGELARFGIRHGLYDPLDKADLAARITPATRLVWLEA
PGSVTMEFPDLCGQVRICRARGVITALDNTWGAGLAFAPFDLTGDGSRSLGVDISAHALTKFPSGNGDVLMGSVITRDPE
LHMKIKLTHMRLGLGVAGNDAEAVLRALPSIGLRYRAHDAAARQLALWLQQQPAIAQVLHPALAGSPGHAHWQALCGAGV
TEAPCGADTATRGAAAGLFSVIIDARYTQSQVDAFCDGLRLFKIGYSWGGPMSLVVPYHLASMRLRPAPHLKPGTLVRFF
IGLEAVPDLQQDLQQALERAFAADGP

Sequences:

>Translated_426_residues
MAGMNHTDADDLSTRIVHHDYIPPAGFAALQPGVYKASTVIFPNVAAMRTREWKDKSSYTYGLHGTPTTFTLEERLCMLE
GGLQCVLQPSGLAAIANVALALLETGDEVLLPDNVYGPSLALANGELARFGIRHGLYDPLDKADLAARITPATRLVWLEA
PGSVTMEFPDLCGQVRICRARGVITALDNTWGAGLAFAPFDLTGDGSRSLGVDISAHALTKFPSGNGDVLMGSVITRDPE
LHMKIKLTHMRLGLGVAGNDAEAVLRALPSIGLRYRAHDAAARQLALWLQQQPAIAQVLHPALAGSPGHAHWQALCGAGV
TEAPCGADTATRGAAAGLFSVIIDARYTQSQVDAFCDGLRLFKIGYSWGGPMSLVVPYHLASMRLRPAPHLKPGTLVRFF
IGLEAVPDLQQDLQQALERAFAADGP
>Mature_425_residues
AGMNHTDADDLSTRIVHHDYIPPAGFAALQPGVYKASTVIFPNVAAMRTREWKDKSSYTYGLHGTPTTFTLEERLCMLEG
GLQCVLQPSGLAAIANVALALLETGDEVLLPDNVYGPSLALANGELARFGIRHGLYDPLDKADLAARITPATRLVWLEAP
GSVTMEFPDLCGQVRICRARGVITALDNTWGAGLAFAPFDLTGDGSRSLGVDISAHALTKFPSGNGDVLMGSVITRDPEL
HMKIKLTHMRLGLGVAGNDAEAVLRALPSIGLRYRAHDAAARQLALWLQQQPAIAQVLHPALAGSPGHAHWQALCGAGVT
EAPCGADTATRGAAAGLFSVIIDARYTQSQVDAFCDGLRLFKIGYSWGGPMSLVVPYHLASMRLRPAPHLKPGTLVRFFI
GLEAVPDLQQDLQQALERAFAADGP

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=319, Percent_Identity=28.5266457680251, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI299473759, Length=319, Percent_Identity=25.3918495297806, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI25453487, Length=320, Percent_Identity=23.125, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1789383, Length=416, Percent_Identity=33.1730769230769, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1790375, Length=403, Percent_Identity=26.0545905707196, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71980708, Length=399, Percent_Identity=27.8195488721804, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17560056, Length=371, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17538055, Length=374, Percent_Identity=28.3422459893048, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321170, Length=346, Percent_Identity=31.5028901734104, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6323333, Length=438, Percent_Identity=23.7442922374429, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319307, Length=378, Percent_Identity=24.8677248677249, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922554, Length=420, Percent_Identity=28.8095238095238, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45409; Mature: 45277

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGMNHTDADDLSTRIVHHDYIPPAGFAALQPGVYKASTVIFPNVAAMRTREWKDKSSYT
CCCCCCCCHHHHHHHHEEECCCCCCCHHHCCCCCEEEEEEECCCHHHHHHHCCCCCCCEE
YGLHGTPTTFTLEERLCMLEGGLQCVLQPSGLAAIANVALALLETGDEVLLPDNVYGPSL
EECCCCCCEEEHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCE
ALANGELARFGIRHGLYDPLDKADLAARITPATRLVWLEAPGSVTMEFPDLCGQVRICRA
EECCCCHHHHHHHHCCCCCCCCHHHHEEECCCEEEEEEECCCCEEEECHHHCCCEEEEEC
RGVITALDNTWGAGLAFAPFDLTGDGSRSLGVDISAHALTKFPSGNGDVLMGSVITRDPE
CCEEEEECCCCCCCEEEECEECCCCCCCCCCCEEEHHHHEECCCCCCCEEECCEEECCCC
LHMKIKLTHMRLGLGVAGNDAEAVLRALPSIGLRYRAHDAAARQLALWLQQQPAIAQVLH
EEEEEEEEEEEEECCCCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHHCCCHHHHHHH
PALAGSPGHAHWQALCGAGVTEAPCGADTATRGAAAGLFSVIIDARYTQSQVDAFCDGLR
HHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCEE
LFKIGYSWGGPMSLVVPYHLASMRLRPAPHLKPGTLVRFFIGLEAVPDLQQDLQQALERA
EEEEECCCCCCEEEEECHHHHHEECCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
FAADGP
HCCCCC
>Mature Secondary Structure 
AGMNHTDADDLSTRIVHHDYIPPAGFAALQPGVYKASTVIFPNVAAMRTREWKDKSSYT
CCCCCCCHHHHHHHHEEECCCCCCCHHHCCCCCEEEEEEECCCHHHHHHHCCCCCCCEE
YGLHGTPTTFTLEERLCMLEGGLQCVLQPSGLAAIANVALALLETGDEVLLPDNVYGPSL
EECCCCCCEEEHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCE
ALANGELARFGIRHGLYDPLDKADLAARITPATRLVWLEAPGSVTMEFPDLCGQVRICRA
EECCCCHHHHHHHHCCCCCCCCHHHHEEECCCEEEEEEECCCCEEEECHHHCCCEEEEEC
RGVITALDNTWGAGLAFAPFDLTGDGSRSLGVDISAHALTKFPSGNGDVLMGSVITRDPE
CCEEEEECCCCCCCEEEECEECCCCCCCCCCCEEEHHHHEECCCCCCCEEECCEEECCCC
LHMKIKLTHMRLGLGVAGNDAEAVLRALPSIGLRYRAHDAAARQLALWLQQQPAIAQVLH
EEEEEEEEEEEEECCCCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHHCCCHHHHHHH
PALAGSPGHAHWQALCGAGVTEAPCGADTATRGAAAGLFSVIIDARYTQSQVDAFCDGLR
HHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCEE
LFKIGYSWGGPMSLVVPYHLASMRLRPAPHLKPGTLVRFFIGLEAVPDLQQDLQQALERA
EEEEECCCCCCEEEEECHHHHHEECCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
FAADGP
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]