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The map label for this gene is pccB [H]

Identifier: 121610333

GI number: 121610333

Start: 3770767

End: 3772299

Strand: Direct

Name: pccB [H]

Synonym: Veis_3401

Alternate gene names: 121610333

Gene position: 3770767-3772299 (Clockwise)

Preceding gene: 121610332

Following gene: 121610334

Centisome position: 67.74

GC content: 62.49

Gene sequence:

>1533_bases
ATGCACGACATCCTTGCGCAGCTCGAAATCAAGCGCGAACGCGCGCGCCAGGGCGGTGGCGAGAAACGCATCGCCACCCA
GCACGCAAAAGGCAAGCTCACGGCGCGTGAGCGCCTGGAACTGTTGCTCGACGATGGCACGTTTGAAGAGTGGGACATGT
TTGTCGAGCACCGCTGCGTGGACTTTGGCATGCAGGAGCAGAAAGTGCCCGGCGACGGCGTGGTCACCGGCTACGGCATG
ATCAATGGCCGCCTGGTGTTCGTGTTCAGCCAGGACTTCACCGTGTTTGGCGGCGCGCTGTCGGAGGCGCACGCCGAGAA
GATTTGCAAGGTGATGGACCAGGCCATGAAGGTCGGCGCCCCCGTCATCGGCCTGAACGACTCGGGCGGTGCGCGCATAC
AGGAGGGCGTGGCGTCCCTGGGCGGCTATGCCGATGTGTTCCAGCGCAACGTGCTGGCCAGCGGCGTGATTCCGCAGATC
AGCATGATCATGGGACCGAGCGCCGGTGGCGCGGTATACAGCCCGGCCATGACCGACTTCATCTTCATGGTCAAGGATTC
CAGCTACATGTTCGTCACCGGCCCCGAAGTGGTCAAAACCGTGACGCATGAAGAAGTCAGCGCCGAAGAACTGGGCGGCG
CCATCACCCACTCCACCAAGAGCGGCGTGGCCGATCTGGCCTTCGACAACGATGTGCAAGCGCTGCTGATGCTGCGCCGC
CTGTACAACTACCTGCCGCTGAGCAACCGCGAGAAAGCGCCGGTGCGCCAAAGCGGCGACCCGATAGAGCGGCAGGAGCC
AAGCCTGGACACCCTGGTGCCCGAGCACCCGAACAAGCCATACGACATGCAGGAGTTGATCGTCAAAACCGTCGACGATG
GCGACTTCTTCGAGTTGCAGCCCGAGTACGCCAAGAACATCCTGATCGGCTTTGCCCGCATGGACGGCCAGACCGTCGGC
ATCGTGGCCAACCAGCCGCTGGTGCTGGCCGGCTGCCTGGACATCAAAAGCAGCATCAAGGCCGCGCGCTTCGTGCGCTT
TTGCGATGCGTTCAACATTCCCGTCGTCACCTTTGTCGATGTGCCCGGCTTCATGCCCGGCACCGGCCAAGAATACGGCG
GCATCATCAAGCATGGCGCCAAGCTGCTGTACGCCTATGCCGAGTGCACGGTGCCCAAGATCACCGTCATCACCCGCAAA
GCCTATGGCGGGGCCTACGATGTGATGAGCTCCAAGCACCTGCGCGGCGACGTGAACCTGGCCTGGCCGAGCGCCGAAAT
TGCCGTCATGGGCGCCAAGGGGGCGGTGGAAATCATCTTTCGCGAAGACAAGAACGACCCGGTCAAGCTCGCCGCCCGCG
AAGCCGGCTACAAGGAGCGCTTTGCCAACCCGTTCGTGGCCGGTGCCCGTGGCTTCATCGACGACGTGATCATGCCGCAC
GAGACGCGCAAACGCATCTGTCGCAGCCTGCTGATGCTGCGTGACAAAAAGCTGCAAAATCCTTGGCGCAAGCATGGCAA
CATCCCGCTGTAA

Upstream 100 bases:

>100_bases
AGATCGCGGCCAGCACGGCTGCGCGCCATCTGCTTGCGGCGGCCGTCGGCGAGGTCCCAACGGATTGAGCCGAAAAGATC
GAACCGCGGAGAAAGAAACC

Downstream 100 bases:

>100_bases
GGCGCCCCCTGCAGGCCGCCATCGAAAGGCATGCCATGTTTGAATTCCTCGCCGAATGGATCGGCATCGGCCTGGTGTTT
TGTGCGGATGTGTTTCTGCT

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MHDILAQLEIKRERARQGGGEKRIATQHAKGKLTARERLELLLDDGTFEEWDMFVEHRCVDFGMQEQKVPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVLASGVIPQI
SMIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHSTKSGVADLAFDNDVQALLMLRR
LYNYLPLSNREKAPVRQSGDPIERQEPSLDTLVPEHPNKPYDMQELIVKTVDDGDFFELQPEYAKNILIGFARMDGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVDVPGFMPGTGQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNLAWPSAEIAVMGAKGAVEIIFREDKNDPVKLAAREAGYKERFANPFVAGARGFIDDVIMPH
ETRKRICRSLLMLRDKKLQNPWRKHGNIPL

Sequences:

>Translated_510_residues
MHDILAQLEIKRERARQGGGEKRIATQHAKGKLTARERLELLLDDGTFEEWDMFVEHRCVDFGMQEQKVPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVLASGVIPQI
SMIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHSTKSGVADLAFDNDVQALLMLRR
LYNYLPLSNREKAPVRQSGDPIERQEPSLDTLVPEHPNKPYDMQELIVKTVDDGDFFELQPEYAKNILIGFARMDGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVDVPGFMPGTGQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNLAWPSAEIAVMGAKGAVEIIFREDKNDPVKLAAREAGYKERFANPFVAGARGFIDDVIMPH
ETRKRICRSLLMLRDKKLQNPWRKHGNIPL
>Mature_510_residues
MHDILAQLEIKRERARQGGGEKRIATQHAKGKLTARERLELLLDDGTFEEWDMFVEHRCVDFGMQEQKVPGDGVVTGYGM
INGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGAPVIGLNDSGGARIQEGVASLGGYADVFQRNVLASGVIPQI
SMIMGPSAGGAVYSPAMTDFIFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHSTKSGVADLAFDNDVQALLMLRR
LYNYLPLSNREKAPVRQSGDPIERQEPSLDTLVPEHPNKPYDMQELIVKTVDDGDFFELQPEYAKNILIGFARMDGQTVG
IVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVDVPGFMPGTGQEYGGIIKHGAKLLYAYAECTVPKITVITRK
AYGGAYDVMSSKHLRGDVNLAWPSAEIAVMGAKGAVEIIFREDKNDPVKLAAREAGYKERFANPFVAGARGFIDDVIMPH
ETRKRICRSLLMLRDKKLQNPWRKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=506, Percent_Identity=69.7628458498024, Blast_Score=738, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=526, Percent_Identity=67.1102661596958, Blast_Score=724, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=507, Percent_Identity=33.5305719921105, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679960, Length=404, Percent_Identity=25.7425742574257, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI38679971, Length=404, Percent_Identity=25.7425742574257, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679977, Length=404, Percent_Identity=25.7425742574257, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679967, Length=404, Percent_Identity=25.7425742574257, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679974, Length=404, Percent_Identity=25.7425742574257, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI134142062, Length=411, Percent_Identity=23.3576642335766, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788655, Length=194, Percent_Identity=26.8041237113402, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147359, Length=504, Percent_Identity=69.2460317460317, Blast_Score=750, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=504, Percent_Identity=69.2460317460317, Blast_Score=750, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=502, Percent_Identity=33.6653386454183, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24586065, Length=530, Percent_Identity=33.2075471698113, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56049; Mature: 56049

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDILAQLEIKRERARQGGGEKRIATQHAKGKLTARERLELLLDDGTFEEWDMFVEHRCV
CCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHH
DFGMQEQKVPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGA
HCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYADVFQRNVLASGVIPQISMIMGPSAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHEECCCCCCCEECCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHSTKSGVADLAFDNDVQALLMLRR
EEEEECCCEEEEECHHHHHHHHHHHCCHHHHCCEEECCCCCCCEEECCCCCHHHHHHHHH
LYNYLPLSNREKAPVRQSGDPIERQEPSLDTLVPEHPNKPYDMQELIVKTVDDGDFFELQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PEYAKNILIGFARMDGQTVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVD
HHHHHHHEEEEEECCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTGQEYGGIIKHGAKLLYAYAECTVPKITVITRKAYGGAYDVMSSKHLRGDVNL
CCCCCCCCCCHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCEEE
AWPSAEIAVMGAKGAVEIIFREDKNDPVKLAAREAGYKERFANPFVAGARGFIDDVIMPH
ECCCCEEEEEECCCEEEEEEECCCCCCEEEHHHHCCHHHHHCCCHHHCCHHHHHHHCCCC
ETRKRICRSLLMLRDKKLQNPWRKHGNIPL
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
>Mature Secondary Structure
MHDILAQLEIKRERARQGGGEKRIATQHAKGKLTARERLELLLDDGTFEEWDMFVEHRCV
CCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHH
DFGMQEQKVPGDGVVTGYGMINGRLVFVFSQDFTVFGGALSEAHAEKICKVMDQAMKVGA
HCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCC
PVIGLNDSGGARIQEGVASLGGYADVFQRNVLASGVIPQISMIMGPSAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHEECCCCCCCEECCHHHEE
IFMVKDSSYMFVTGPEVVKTVTHEEVSAEELGGAITHSTKSGVADLAFDNDVQALLMLRR
EEEEECCCEEEEECHHHHHHHHHHHCCHHHHCCEEECCCCCCCEEECCCCCHHHHHHHHH
LYNYLPLSNREKAPVRQSGDPIERQEPSLDTLVPEHPNKPYDMQELIVKTVDDGDFFELQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PEYAKNILIGFARMDGQTVGIVANQPLVLAGCLDIKSSIKAARFVRFCDAFNIPVVTFVD
HHHHHHHEEEEEECCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
VPGFMPGTGQEYGGIIKHGAKLLYAYAECTVPKITVITRKAYGGAYDVMSSKHLRGDVNL
CCCCCCCCCCHHCHHHHHHHHHEEHHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCEEE
AWPSAEIAVMGAKGAVEIIFREDKNDPVKLAAREAGYKERFANPFVAGARGFIDDVIMPH
ECCCCEEEEEECCCEEEEEEECCCCCCEEEHHHHCCHHHHHCCCHHHCCHHHHHHHCCCC
ETRKRICRSLLMLRDKKLQNPWRKHGNIPL
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]