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The map label for this gene is hexR [H]

Identifier: 121610271

GI number: 121610271

Start: 3715660

End: 3716577

Strand: Direct

Name: hexR [H]

Synonym: Veis_3330

Alternate gene names: 121610271

Gene position: 3715660-3716577 (Clockwise)

Preceding gene: 121610270

Following gene: 121610272

Centisome position: 66.75

GC content: 71.02

Gene sequence:

>918_bases
ATGACCCCCTGCCTGCTTCAGAAGATCGCGCAGATCCGCAGCGGCGCCCCGGCCACGCGGCGCGCGATTCTCGAGCTGAT
CCTGGAAGACCCCGACCGCGTGCTCGAAGAGAGCTTCGAGCAGTTGGCCGAGCGCTCGCGCAGCTCGGTGCCGACCATCA
TGCGCACCTGCCGCGACCTGGGCTTTGCGGGCCTGCGCGAGTTCAAGCTCGCGCTCGCGCAGGAGCTCGCGCTCGGCGGC
TCGCCGCTGCACCGCCGCGTCAACATCGAGGACGCGGCCGACGAAGTGGTCGGCAAGATCGCGCGCAGCGCCGCAGCCTC
GGTCTCCGGCGTGCGCGGCCAGCTCGACATGCAGGTGCTCGACGGCGCCGTGGCCGCCATCGCGGCCGCGCCGCATGTGG
ACCTGTACGGCGCGGGCGCCACTTCGTGGTTCATGGCCAACGACCTGCAGGCGCGACTGTTCCGCCTCGGCCTCTCGGCG
AACGCCTGGGCCGACTACCACCTGCAGCAGGTGGCCGGCGCGGCGCAGCGGCCGGGCGGCGTGGTCATCGCCATCTCGCA
CGTCGGCGGCATGCCCTCGCTGTTGGACGCGGTGGACATCGCGCGCGGGCAGGGCGCCAAGGTGGTTGCGCTGACGCGGC
CCGGCACCGCGCTTGCGGCCAAAGCCGACTTTTTGCTCGGACTCTCGGTGCCCGACGACGCGGTGATGCATGTGGGCATC
GATGCCTACCTCACGCACCTCACCGCCATCGAAATCCTCACGGTGCTGGTCGCGCAACGCCGTGGCGAACCCGCCGTGCA
GCGCCTGCAGCGCGCACGCGAAGCCTTCCAGCGCCATGGCATCGACGCCGCCACGCACCCGCTGCAAAGCTGGAACGGCG
GCGGCATCAACGACGAAAAAGGAGGGCGCGCATCGTGA

Upstream 100 bases:

>100_bases
CCCTGCACCACCTTCGACAAATGGCACTGGATGCCCATCGTCGAGAACGACTACCGCGTGAGCGACGCCGTCGCCATGCA
TTTCTGAACCGCTTGCACCG

Downstream 100 bases:

>100_bases
TCGACCCCCAAGCCGTATTGCTCGAAGCCGGCCTCGTGGTCGACGGTTCGGGCGGACCCGCGTGGCCCGGCGACGTGCTG
CTGCAGGGCGACCGCATCTT

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTPCLLQKIAQIRSGAPATRRAILELILEDPDRVLEESFEQLAERSRSSVPTIMRTCRDLGFAGLREFKLALAQELALGG
SPLHRRVNIEDAADEVVGKIARSAAASVSGVRGQLDMQVLDGAVAAIAAAPHVDLYGAGATSWFMANDLQARLFRLGLSA
NAWADYHLQQVAGAAQRPGGVVIAISHVGGMPSLLDAVDIARGQGAKVVALTRPGTALAAKADFLLGLSVPDDAVMHVGI
DAYLTHLTAIEILTVLVAQRRGEPAVQRLQRAREAFQRHGIDAATHPLQSWNGGGINDEKGGRAS

Sequences:

>Translated_305_residues
MTPCLLQKIAQIRSGAPATRRAILELILEDPDRVLEESFEQLAERSRSSVPTIMRTCRDLGFAGLREFKLALAQELALGG
SPLHRRVNIEDAADEVVGKIARSAAASVSGVRGQLDMQVLDGAVAAIAAAPHVDLYGAGATSWFMANDLQARLFRLGLSA
NAWADYHLQQVAGAAQRPGGVVIAISHVGGMPSLLDAVDIARGQGAKVVALTRPGTALAAKADFLLGLSVPDDAVMHVGI
DAYLTHLTAIEILTVLVAQRRGEPAVQRLQRAREAFQRHGIDAATHPLQSWNGGGINDEKGGRAS
>Mature_304_residues
TPCLLQKIAQIRSGAPATRRAILELILEDPDRVLEESFEQLAERSRSSVPTIMRTCRDLGFAGLREFKLALAQELALGGS
PLHRRVNIEDAADEVVGKIARSAAASVSGVRGQLDMQVLDGAVAAIAAAPHVDLYGAGATSWFMANDLQARLFRLGLSAN
AWADYHLQQVAGAAQRPGGVVIAISHVGGMPSLLDAVDIARGQGAKVVALTRPGTALAAKADFLLGLSVPDDAVMHVGID
AYLTHLTAIEILTVLVAQRRGEPAVQRLQRAREAFQRHGIDAATHPLQSWNGGGINDEKGGRAS

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=278, Percent_Identity=32.3741007194245, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI87082369, Length=260, Percent_Identity=24.2307692307692, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788767, Length=214, Percent_Identity=25.7009345794392, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082130, Length=272, Percent_Identity=25, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 32291; Mature: 32160

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPCLLQKIAQIRSGAPATRRAILELILEDPDRVLEESFEQLAERSRSSVPTIMRTCRDL
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GFAGLREFKLALAQELALGGSPLHRRVNIEDAADEVVGKIARSAAASVSGVRGQLDMQVL
CHHHHHHHHHHHHHHHHCCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DGAVAAIAAAPHVDLYGAGATSWFMANDLQARLFRLGLSANAWADYHLQQVAGAAQRPGG
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
VVIAISHVGGMPSLLDAVDIARGQGAKVVALTRPGTALAAKADFLLGLSVPDDAVMHVGI
EEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHEEECCCCCHHHHHHHH
DAYLTHLTAIEILTVLVAQRRGEPAVQRLQRAREAFQRHGIDAATHPLQSWNGGGINDEK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCCHHCCCCCCCCCCC
GGRAS
CCCCC
>Mature Secondary Structure 
TPCLLQKIAQIRSGAPATRRAILELILEDPDRVLEESFEQLAERSRSSVPTIMRTCRDL
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GFAGLREFKLALAQELALGGSPLHRRVNIEDAADEVVGKIARSAAASVSGVRGQLDMQVL
CHHHHHHHHHHHHHHHHCCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DGAVAAIAAAPHVDLYGAGATSWFMANDLQARLFRLGLSANAWADYHLQQVAGAAQRPGG
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
VVIAISHVGGMPSLLDAVDIARGQGAKVVALTRPGTALAAKADFLLGLSVPDDAVMHVGI
EEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHEEECCCCCHHHHHHHH
DAYLTHLTAIEILTVLVAQRRGEPAVQRLQRAREAFQRHGIDAATHPLQSWNGGGINDEK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCCHHCCCCCCCCCCC
GGRAS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]