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The map label for this gene is uvrY [H]

Identifier: 121610244

GI number: 121610244

Start: 3685975

End: 3686643

Strand: Direct

Name: uvrY [H]

Synonym: Veis_3303

Alternate gene names: 121610244

Gene position: 3685975-3686643 (Clockwise)

Preceding gene: 121610243

Following gene: 121610250

Centisome position: 66.21

GC content: 59.94

Gene sequence:

>669_bases
ATGAACACTGAAACCATCCGCACCTTGATCGTTGACGACCATGCCGTGGTGCGTTCGGGCTACCGCAGCTATCTGGAGCA
GGTGCCCGGTTTCCAGGTGGTGGCGGAGGCCGATTGCGCCAACGAGGCCTACGCACAGTACAAACGGATGCACCCGGATG
TGGTGATCATGGACATCATGCTGCAAGGCGCCAGCGGTATCGATGCCAGCCGCAGGATATTGTCGAACCATCCGGGGGCG
AAGATTCTCATCTTCTCGATGTATGTCAGCCCGGTATTGCTGCAGCAGGCGCTCAATGTCGGGGTGCTTGGCGCTGTCGG
CAAACAATGCGATCCCGACACCCTGCGTGAAGCGGCGATTGCCGTGGCCGGCGGCGATCGATATCTCGACGCGAGCATGG
CGCAGTCGCTGGTATTTTCCAGATACGATCGCGGCCAGAAGATTTTCGATGCACTCTCACCGCGCGAGTTCGAGATATTC
CTGCTGCTGATTTCCGGCGCGCCGGTCAAGGAAATCGCGCAAGCGCTCAACCTGAGCGCAAAAACCGTCGCCAACCGGGC
CAGCATGATTCGCCAGAAGCTCGGCGTGTCATCGGACATCCAACTCGTCAAACTGGCCGTTGCCGCCGATATCGTACCCT
GGATCCGGCCCGATCGGGCGACGAGCTGA

Upstream 100 bases:

>100_bases
TGGGCGGCAGCTTTGCCGCAGGAGCGCTGCACGACGATAAGGTGTGGTGCGTGCGCATGCACCTGCCGCTGGATGCGGCT
GCGCGAAACGATAGCCATGT

Downstream 100 bases:

>100_bases
TTCCATCTCCAAATCGTCCGATTCAGAAATGGAATCAGTCACTTCGTTTGCAATTTCACCATCACATGGCGCGCACAGGT
ATATTCCTCCAAGGCAAACA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MNTETIRTLIVDDHAVVRSGYRSYLEQVPGFQVVAEADCANEAYAQYKRMHPDVVIMDIMLQGASGIDASRRILSNHPGA
KILIFSMYVSPVLLQQALNVGVLGAVGKQCDPDTLREAAIAVAGGDRYLDASMAQSLVFSRYDRGQKIFDALSPREFEIF
LLLISGAPVKEIAQALNLSAKTVANRASMIRQKLGVSSDIQLVKLAVAADIVPWIRPDRATS

Sequences:

>Translated_222_residues
MNTETIRTLIVDDHAVVRSGYRSYLEQVPGFQVVAEADCANEAYAQYKRMHPDVVIMDIMLQGASGIDASRRILSNHPGA
KILIFSMYVSPVLLQQALNVGVLGAVGKQCDPDTLREAAIAVAGGDRYLDASMAQSLVFSRYDRGQKIFDALSPREFEIF
LLLISGAPVKEIAQALNLSAKTVANRASMIRQKLGVSSDIQLVKLAVAADIVPWIRPDRATS
>Mature_222_residues
MNTETIRTLIVDDHAVVRSGYRSYLEQVPGFQVVAEADCANEAYAQYKRMHPDVVIMDIMLQGASGIDASRRILSNHPGA
KILIFSMYVSPVLLQQALNVGVLGAVGKQCDPDTLREAAIAVAGGDRYLDASMAQSLVFSRYDRGQKIFDALSPREFEIF
LLLISGAPVKEIAQALNLSAKTVANRASMIRQKLGVSSDIQLVKLAVAADIVPWIRPDRATS

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=204, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=38, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788546, Length=212, Percent_Identity=28.7735849056604, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788521, Length=193, Percent_Identity=31.0880829015544, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=28.2926829268293, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787473, Length=185, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24190; Mature: 24190

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTETIRTLIVDDHAVVRSGYRSYLEQVPGFQVVAEADCANEAYAQYKRMHPDVVIMDIM
CCCHHEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEHHH
LQGASGIDASRRILSNHPGAKILIFSMYVSPVLLQQALNVGVLGAVGKQCDPDTLREAAI
HCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHH
AVAGGDRYLDASMAQSLVFSRYDRGQKIFDALSPREFEIFLLLISGAPVKEIAQALNLSA
EEECCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHCCHH
KTVANRASMIRQKLGVSSDIQLVKLAVAADIVPWIRPDRATS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNTETIRTLIVDDHAVVRSGYRSYLEQVPGFQVVAEADCANEAYAQYKRMHPDVVIMDIM
CCCHHEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEHHH
LQGASGIDASRRILSNHPGAKILIFSMYVSPVLLQQALNVGVLGAVGKQCDPDTLREAAI
HCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHH
AVAGGDRYLDASMAQSLVFSRYDRGQKIFDALSPREFEIFLLLISGAPVKEIAQALNLSA
EEECCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHCCHH
KTVANRASMIRQKLGVSSDIQLVKLAVAADIVPWIRPDRATS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]