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The map label for this gene is pepE [H]

Identifier: 121610239

GI number: 121610239

Start: 3681847

End: 3682581

Strand: Direct

Name: pepE [H]

Synonym: Veis_3298

Alternate gene names: 121610239

Gene position: 3681847-3682581 (Clockwise)

Preceding gene: 121610238

Following gene: 121610240

Centisome position: 66.14

GC content: 59.59

Gene sequence:

>735_bases
ATGCGACTGCTATTGCTTTCCAATTCGATCAACCCTGGCGGCGCGTATTTGCAGCATGCGCTCGCGGCCGTTGAAAAAAT
CAACCGCCGGCGCGCCATCTTCATCCCCTACGCGGGCGTGACCATTGGCTGGGACGATTACCTGAACAAGGTCCGGCAAG
CCCTGGCGCCCATCGGCATTCATGTCGATGGCGTGCACCAGTCAGACGACCCGGTGGCAGCCATACAGGGAGCCGAACTG
ATTCTGGGCGGTGGCGGCAACACCTGGCGTCTGTTGCAACTCGTGCGTCAGCACGGTCTGCTGGAAGCAATCCGTGCCAA
GGTCGCCGTCGGCACGCCATACATCGGCTGGAGCGCGGGAACCAATCTGGCATGCCCAACGATACGCACCACCAACGACA
TGCCGATCGTCGATCCCAAAGGCTTTGATGCCTTGAATCTGCTGCCGTTTCAGATCAACCCGCACTACAACAACGAACTA
CCCGCAGGCCATCAGGGTGAAACGCGCTCGCAGCGCATCGCAGAATTCACGCGGATCAATCCGGACATGCCGGTGCTTGG
CTTGCCCGAAGGTGATTGGCTGGAGGTTGATGGGCAGCAGACGGTGCTGTGCGGCCCCAAGCCGGCGCTGCTGTTCAAGG
AAGGAAACGAGCCGCGTGAGATCCATGCTGGCGACCTTTCCTTTTTGATGGCACGACAAATTGAAGCAACCCCGGGTACG
AGAGGCACTGAATGA

Upstream 100 bases:

>100_bases
TTACTTCAATACCGAAGCAGAAATTGAGCGTGCCGTCGCCCTGATTCGAGAACTACTCTGACCACGGATTTGCCTTAGCA
TTTTTACAGGAACAACTGCC

Downstream 100 bases:

>100_bases
CAATGAAACAAACGCTGGACATCTACGAACTCCTCGATGGTGCGGGTGTCGATGGCAAGGAAATCAAGGCCATGTTTGCC
CCATTCGCCGCGCAAGGGGT

Product: peptidase E

Products: NA

Alternate protein names: Alpha-aspartyl dipeptidase; Asp-specific dipeptidase; Dipeptidase E [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MRLLLLSNSINPGGAYLQHALAAVEKINRRRAIFIPYAGVTIGWDDYLNKVRQALAPIGIHVDGVHQSDDPVAAIQGAEL
ILGGGGNTWRLLQLVRQHGLLEAIRAKVAVGTPYIGWSAGTNLACPTIRTTNDMPIVDPKGFDALNLLPFQINPHYNNEL
PAGHQGETRSQRIAEFTRINPDMPVLGLPEGDWLEVDGQQTVLCGPKPALLFKEGNEPREIHAGDLSFLMARQIEATPGT
RGTE

Sequences:

>Translated_244_residues
MRLLLLSNSINPGGAYLQHALAAVEKINRRRAIFIPYAGVTIGWDDYLNKVRQALAPIGIHVDGVHQSDDPVAAIQGAEL
ILGGGGNTWRLLQLVRQHGLLEAIRAKVAVGTPYIGWSAGTNLACPTIRTTNDMPIVDPKGFDALNLLPFQINPHYNNEL
PAGHQGETRSQRIAEFTRINPDMPVLGLPEGDWLEVDGQQTVLCGPKPALLFKEGNEPREIHAGDLSFLMARQIEATPGT
RGTE
>Mature_244_residues
MRLLLLSNSINPGGAYLQHALAAVEKINRRRAIFIPYAGVTIGWDDYLNKVRQALAPIGIHVDGVHQSDDPVAAIQGAEL
ILGGGGNTWRLLQLVRQHGLLEAIRAKVAVGTPYIGWSAGTNLACPTIRTTNDMPIVDPKGFDALNLLPFQINPHYNNEL
PAGHQGETRSQRIAEFTRINPDMPVLGLPEGDWLEVDGQQTVLCGPKPALLFKEGNEPREIHAGDLSFLMARQIEATPGT
RGTE

Specific function: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids [H]

COG id: COG3340

COG function: function code E; Peptidase E

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S51 family [H]

Homologues:

Organism=Escherichia coli, GI1790452, Length=226, Percent_Identity=56.6371681415929, Blast_Score=259, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24641669, Length=227, Percent_Identity=42.2907488986784, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005320
- InterPro:   IPR023172 [H]

Pfam domain/function: PF03575 Peptidase_S51 [H]

EC number: =3.4.13.21 [H]

Molecular weight: Translated: 26543; Mature: 26543

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLLSNSINPGGAYLQHALAAVEKINRRRAIFIPYAGVTIGWDDYLNKVRQALAPIGI
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCEEECHHHHHHHHHHHHCCCCE
HVDGVHQSDDPVAAIQGAELILGGGGNTWRLLQLVRQHGLLEAIRAKVAVGTPYIGWSAG
EEECCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHEECCCCCCCCCC
TNLACPTIRTTNDMPIVDPKGFDALNLLPFQINPHYNNELPAGHQGETRSQRIAEFTRIN
CCCCCCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCC
PDMPVLGLPEGDWLEVDGQQTVLCGPKPALLFKEGNEPREIHAGDLSFLMARQIEATPGT
CCCCEEECCCCCEEEECCCEEEEECCCCEEEEECCCCCCEEECCCHHHHHHHHHCCCCCC
RGTE
CCCC
>Mature Secondary Structure
MRLLLLSNSINPGGAYLQHALAAVEKINRRRAIFIPYAGVTIGWDDYLNKVRQALAPIGI
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCEEECHHHHHHHHHHHHCCCCE
HVDGVHQSDDPVAAIQGAELILGGGGNTWRLLQLVRQHGLLEAIRAKVAVGTPYIGWSAG
EEECCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHEECCCCCCCCCC
TNLACPTIRTTNDMPIVDPKGFDALNLLPFQINPHYNNELPAGHQGETRSQRIAEFTRIN
CCCCCCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCC
PDMPVLGLPEGDWLEVDGQQTVLCGPKPALLFKEGNEPREIHAGDLSFLMARQIEATPGT
CCCCEEECCCCCEEEECCCEEEEECCCCEEEEECCCCCCEEECCCHHHHHHHHHCCCCCC
RGTE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA