Click here to switch to the map view.

The map label for this gene is acsA [H]

Identifier: 121610159

GI number: 121610159

Start: 3591801

End: 3593795

Strand: Direct

Name: acsA [H]

Synonym: Veis_3218

Alternate gene names: 121610159

Gene position: 3591801-3593795 (Clockwise)

Preceding gene: 121610158

Following gene: 121610160

Centisome position: 64.52

GC content: 66.97

Gene sequence:

>1995_bases
ATGAGCGCGCCCACATCTGCCATCGAGTCCGTGCTGATCGAAAACCGCGTATTCCCACCGTCGGACGCCATCGTCAACGC
GGCCCGCGTGTCCGGCATGTCCGGCTATGAGGCGCTGTGCGCCGAGGCCGACCAGGATATCGAGGGCTTCTGGGCGCGCC
AGGCGCGCAGCCACCTGCAGTGGAGCCGGCCCTTCACCCGCACGCTCGACGCATCGAATGCGCCGTTTTTCCAGTGGTTT
GCCGACGGCCAGCTCAATGCCTCGGCCAATTGCCTGGACCGCCATATCGGCACGCCGACCGAGCACAAATGCGCCATCAT
CTTCGAGGCCGACGATGGCACGGTCACCCGCATCAGCTACCGCGAGCTGCTCGCGCGCGTGGGCCAGTTTGCCAATGCGC
TCAAAGCCCATGGCGTGGCCAAGGGCGACCGGGTCCTGATCTACATGCCGATGACCATCGAGGGCGTGATCGCGATGCAG
GCTTGCGCCCGCATTGGCGCCACGCACAGCGTGGTGTTTGGCGGCTTCAGCGCCAAGGCCGTGCACGAGCGCATCATCGA
CGCCGGCGCCGTGGCCGTGATCACTGCCAACTACCAGATGCGTGGCGGCAAGGAACTGCCCCTGAAAGCCATCATCGACC
AGGCCCTGGCCCTGGGTGGCTGCGACAGCGTTGGCACCGTCTTCGTCCATCAACGCACTGCCAGCGCCTGCCCGATGCTG
GCCGGGCGCGACAAGACCTTTGCCCAGGCGCTCGCGGGCCAGAGCAGCGACTGCGCCGCGCTCGCGCTGGAGGCCGAGCA
TCCGCTGTTCATCCTGTACACCAGCGGCTCCACCGGCAAGCCCAAGGGCGTGCAGCACAGCACCGGCGGCTATCTGCTGT
GGGCCAAGATGACTATGGACTGGACCTTCGACCTGCGCCCGGACGACATCTTCTGGTGCACGGCCGATATCGGCTGGATC
ACCGGCCACACCTACGTGGCCTATGGCCCGCTGGCCGCAGGCGCGACGCAGATCATCTTCGAGGGCATTCCCACCTTTCC
CGACGCGGGGCGCTTTTGGCAGATGATCGAGCGGCACAGGTGCACGATCTTCTACACCGCCCCCACGGCCATCCGCTCGC
TGATCAAGGCCGCCGAGGCCGACGCTGCGGTGCACCCGGCGCGCTCGGATCTGAGCAGCCTGCGCATCCTGGGCAGCGTC
GGCGAGCCGATCAACCCCGAAGCCTGGATGTGGTACCACAAGAACGTGGGCGGCGAGCGCTGCCCCATCGTCGACACCTT
CTGGCAGACCGAAACCGGCGGCCATGTGATCGCGCCGCTGCCCGGCGCCACCCCGCTGGTGCCCGGTAGCTGCACGCTGG
CGCTGCCCGGCATCGCGGCCGCCGTGGTCGATGAAACGGGCCACGACATGCCCCACGGCGCGGGCGGCATTCTGGTCATC
AAGCGTCCCTGGCCCAGCATGATCCGCACCATCTGGAACGACCCCGAGCGCTTCAAAAAGAGCTACTTCCCGCAGGAGCT
CAAAGGCTACTACCTGGCCGGCGACGGCGCCGTGCGCAGCACCGACCGTGGCTACTTTCGCATCACCGGCCGCATCGATG
ACGTGCTCAACGTCTCAGGCCACCGCATGGGCACGATGGAGATCGAATCGGCCCTGGTGGCCAAGACCGACCTGGTGGCC
GAGGCCGCCGTGGTCGGCCGCCCCGACGAGGTGACGGGCGAGGCCATCTGCGCCTTCGTGGTGCTCAAGCGCCTGCGCCC
GACCGGCGAAGAGGCCCGGCAAATCGCCAACGAGCTGCGCAACTGGGTGGCCAAGGAAATCGGCCCGATCGCCAAGCCCC
GGGACATCCGCTTTGGCGACAACCTGCCCAAGACCCGCAGCGGCAAGATCATGCGCCGCCTGCTGCGCAGCATTGCCAAG
GGCGAAGCCATCACGCAAGACACCAGCACGCTGGAGAATCCGGCCATCCTCGATCAATTGGCCCAAATCAACTGA

Upstream 100 bases:

>100_bases
TCCAGCGTCCCGGCATTGTCTGTAAGCTGCGTCAGTGGCCTGTAAGTACCGGGTCCGACAGTACCGGCCAATTTTTCTTT
GGACCCAGGAGACCATCACC

Downstream 100 bases:

>100_bases
AGGAGACTCTCATGCATTTGCGTTCCATCGTTTTGCTCGTGACCGTGCTGGCCATCGCCGCACTGGCGGCCCTGAACTGG
CCCGCGCTGGCCGCTCCCGC

Product: acetate--CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSAPTSAIESVLIENRVFPPSDAIVNAARVSGMSGYEALCAEADQDIEGFWARQARSHLQWSRPFTRTLDASNAPFFQWF
ADGQLNASANCLDRHIGTPTEHKCAIIFEADDGTVTRISYRELLARVGQFANALKAHGVAKGDRVLIYMPMTIEGVIAMQ
ACARIGATHSVVFGGFSAKAVHERIIDAGAVAVITANYQMRGGKELPLKAIIDQALALGGCDSVGTVFVHQRTASACPML
AGRDKTFAQALAGQSSDCAALALEAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKMTMDWTFDLRPDDIFWCTADIGWI
TGHTYVAYGPLAAGATQIIFEGIPTFPDAGRFWQMIERHRCTIFYTAPTAIRSLIKAAEADAAVHPARSDLSSLRILGSV
GEPINPEAWMWYHKNVGGERCPIVDTFWQTETGGHVIAPLPGATPLVPGSCTLALPGIAAAVVDETGHDMPHGAGGILVI
KRPWPSMIRTIWNDPERFKKSYFPQELKGYYLAGDGAVRSTDRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLVA
EAAVVGRPDEVTGEAICAFVVLKRLRPTGEEARQIANELRNWVAKEIGPIAKPRDIRFGDNLPKTRSGKIMRRLLRSIAK
GEAITQDTSTLENPAILDQLAQIN

Sequences:

>Translated_664_residues
MSAPTSAIESVLIENRVFPPSDAIVNAARVSGMSGYEALCAEADQDIEGFWARQARSHLQWSRPFTRTLDASNAPFFQWF
ADGQLNASANCLDRHIGTPTEHKCAIIFEADDGTVTRISYRELLARVGQFANALKAHGVAKGDRVLIYMPMTIEGVIAMQ
ACARIGATHSVVFGGFSAKAVHERIIDAGAVAVITANYQMRGGKELPLKAIIDQALALGGCDSVGTVFVHQRTASACPML
AGRDKTFAQALAGQSSDCAALALEAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKMTMDWTFDLRPDDIFWCTADIGWI
TGHTYVAYGPLAAGATQIIFEGIPTFPDAGRFWQMIERHRCTIFYTAPTAIRSLIKAAEADAAVHPARSDLSSLRILGSV
GEPINPEAWMWYHKNVGGERCPIVDTFWQTETGGHVIAPLPGATPLVPGSCTLALPGIAAAVVDETGHDMPHGAGGILVI
KRPWPSMIRTIWNDPERFKKSYFPQELKGYYLAGDGAVRSTDRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLVA
EAAVVGRPDEVTGEAICAFVVLKRLRPTGEEARQIANELRNWVAKEIGPIAKPRDIRFGDNLPKTRSGKIMRRLLRSIAK
GEAITQDTSTLENPAILDQLAQIN
>Mature_663_residues
SAPTSAIESVLIENRVFPPSDAIVNAARVSGMSGYEALCAEADQDIEGFWARQARSHLQWSRPFTRTLDASNAPFFQWFA
DGQLNASANCLDRHIGTPTEHKCAIIFEADDGTVTRISYRELLARVGQFANALKAHGVAKGDRVLIYMPMTIEGVIAMQA
CARIGATHSVVFGGFSAKAVHERIIDAGAVAVITANYQMRGGKELPLKAIIDQALALGGCDSVGTVFVHQRTASACPMLA
GRDKTFAQALAGQSSDCAALALEAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKMTMDWTFDLRPDDIFWCTADIGWIT
GHTYVAYGPLAAGATQIIFEGIPTFPDAGRFWQMIERHRCTIFYTAPTAIRSLIKAAEADAAVHPARSDLSSLRILGSVG
EPINPEAWMWYHKNVGGERCPIVDTFWQTETGGHVIAPLPGATPLVPGSCTLALPGIAAAVVDETGHDMPHGAGGILVIK
RPWPSMIRTIWNDPERFKKSYFPQELKGYYLAGDGAVRSTDRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLVAE
AAVVGRPDEVTGEAICAFVVLKRLRPTGEEARQIANELRNWVAKEIGPIAKPRDIRFGDNLPKTRSGKIMRRLLRSIAKG
EAITQDTSTLENPAILDQLAQIN

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=683, Percent_Identity=44.5095168374817, Blast_Score=550, Evalue=1e-156,
Organism=Homo sapiens, GI253970489, Length=696, Percent_Identity=43.9655172413793, Blast_Score=549, Evalue=1e-156,
Organism=Homo sapiens, GI28416953, Length=634, Percent_Identity=46.8454258675079, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI13375727, Length=638, Percent_Identity=36.2068965517241, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI31982927, Length=654, Percent_Identity=25.8409785932722, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI38505220, Length=535, Percent_Identity=28.785046728972, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI42544132, Length=533, Percent_Identity=27.9549718574109, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI122937307, Length=534, Percent_Identity=26.7790262172285, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI58082049, Length=539, Percent_Identity=28.7569573283859, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI115511026, Length=545, Percent_Identity=27.5229357798165, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI157311624, Length=539, Percent_Identity=28.3858998144712, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI157311622, Length=539, Percent_Identity=28.3858998144712, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI187761345, Length=406, Percent_Identity=26.8472906403941, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI187761343, Length=406, Percent_Identity=26.8472906403941, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI156151445, Length=602, Percent_Identity=23.2558139534884, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1790505, Length=633, Percent_Identity=51.0268562401264, Blast_Score=609, Evalue=1e-175,
Organism=Escherichia coli, GI1786529, Length=624, Percent_Identity=37.9807692307692, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI145693145, Length=512, Percent_Identity=24.8046875, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI221142682, Length=546, Percent_Identity=24.1758241758242, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788107, Length=568, Percent_Identity=25.5281690140845, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1786810, Length=531, Percent_Identity=22.5988700564972, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71982997, Length=668, Percent_Identity=42.0658682634731, Blast_Score=481, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71983001, Length=665, Percent_Identity=42.2556390977444, Blast_Score=480, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17569507, Length=642, Percent_Identity=22.5856697819315, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17558820, Length=535, Percent_Identity=24.2990654205607, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=568, Percent_Identity=26.056338028169, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=572, Percent_Identity=25, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=572, Percent_Identity=24.8251748251748, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=572, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=401, Percent_Identity=25.6857855361596, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=47.1228615863142, Blast_Score=569, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319264, Length=658, Percent_Identity=45.7446808510638, Blast_Score=537, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6319699, Length=546, Percent_Identity=22.3443223443223, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667955, Length=671, Percent_Identity=45.75260804769, Blast_Score=570, Evalue=1e-162,
Organism=Drosophila melanogaster, GI62472339, Length=558, Percent_Identity=50.5376344086022, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24667959, Length=527, Percent_Identity=49.9051233396584, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI21355225, Length=617, Percent_Identity=33.387358184765, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24648260, Length=399, Percent_Identity=25.5639097744361, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355181, Length=384, Percent_Identity=26.3020833333333, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581924, Length=554, Percent_Identity=23.4657039711191, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72026; Mature: 71895

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPTSAIESVLIENRVFPPSDAIVNAARVSGMSGYEALCAEADQDIEGFWARQARSHLQ
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHCC
WSRPFTRTLDASNAPFFQWFADGQLNASANCLDRHIGTPTEHKCAIIFEADDGTVTRISY
CCCCHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEEHH
RELLARVGQFANALKAHGVAKGDRVLIYMPMTIEGVIAMQACARIGATHSVVFGGFSAKA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
VHERIIDAGAVAVITANYQMRGGKELPLKAIIDQALALGGCDSVGTVFVHQRTASACPML
HHHHHHCCCCEEEEEECEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCC
AGRDKTFAQALAGQSSDCAALALEAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKMTMD
CCCCHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEE
WTFDLRPDDIFWCTADIGWITGHTYVAYGPLAAGATQIIFEGIPTFPDAGRFWQMIERHR
EEEECCCCCEEEEECCCCEEECCCEEEECCHHCCHHHHHHCCCCCCCCCHHHHHHHHHCC
CTIFYTAPTAIRSLIKAAEADAAVHPARSDLSSLRILGSVGEPINPEAWMWYHKNVGGER
CEEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
CPIVDTFWQTETGGHVIAPLPGATPLVPGSCTLALPGIAAAVVDETGHDMPHGAGGILVI
CCEEECCCCCCCCCEEEEECCCCCCCCCCCCEEECCCHHEEHHHCCCCCCCCCCCCEEEE
KRPWPSMIRTIWNDPERFKKSYFPQELKGYYLAGDGAVRSTDRGYFRITGRIDDVLNVSG
ECCCHHHHHHHCCCHHHHHHHCCCHHHCCEEEECCCCEECCCCCEEEEECCCCHHHCCCC
HRMGTMEIESALVAKTDLVAEAAVVGRPDEVTGEAICAFVVLKRLRPTGEEARQIANELR
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
NWVAKEIGPIAKPRDIRFGDNLPKTRSGKIMRRLLRSIAKGEAITQDTSTLENPAILDQL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHH
AQIN
HHCC
>Mature Secondary Structure 
SAPTSAIESVLIENRVFPPSDAIVNAARVSGMSGYEALCAEADQDIEGFWARQARSHLQ
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHCC
WSRPFTRTLDASNAPFFQWFADGQLNASANCLDRHIGTPTEHKCAIIFEADDGTVTRISY
CCCCHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCEEEEHH
RELLARVGQFANALKAHGVAKGDRVLIYMPMTIEGVIAMQACARIGATHSVVFGGFSAKA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
VHERIIDAGAVAVITANYQMRGGKELPLKAIIDQALALGGCDSVGTVFVHQRTASACPML
HHHHHHCCCCEEEEEECEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCC
AGRDKTFAQALAGQSSDCAALALEAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKMTMD
CCCCHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEE
WTFDLRPDDIFWCTADIGWITGHTYVAYGPLAAGATQIIFEGIPTFPDAGRFWQMIERHR
EEEECCCCCEEEEECCCCEEECCCEEEECCHHCCHHHHHHCCCCCCCCCHHHHHHHHHCC
CTIFYTAPTAIRSLIKAAEADAAVHPARSDLSSLRILGSVGEPINPEAWMWYHKNVGGER
CEEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
CPIVDTFWQTETGGHVIAPLPGATPLVPGSCTLALPGIAAAVVDETGHDMPHGAGGILVI
CCEEECCCCCCCCCEEEEECCCCCCCCCCCCEEECCCHHEEHHHCCCCCCCCCCCCEEEE
KRPWPSMIRTIWNDPERFKKSYFPQELKGYYLAGDGAVRSTDRGYFRITGRIDDVLNVSG
ECCCHHHHHHHCCCHHHHHHHCCCHHHCCEEEECCCCEECCCCCEEEEECCCCHHHCCCC
HRMGTMEIESALVAKTDLVAEAAVVGRPDEVTGEAICAFVVLKRLRPTGEEARQIANELR
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
NWVAKEIGPIAKPRDIRFGDNLPKTRSGKIMRRLLRSIAKGEAITQDTSTLENPAILDQL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHH
AQIN
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA