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The map label for this gene is aroA [H]

Identifier: 121610065

GI number: 121610065

Start: 3470421

End: 3472538

Strand: Direct

Name: aroA [H]

Synonym: Veis_3123

Alternate gene names: 121610065

Gene position: 3470421-3472538 (Clockwise)

Preceding gene: 121610064

Following gene: 121610066

Centisome position: 62.34

GC content: 68.04

Gene sequence:

>2118_bases
ATGTACAGCACCGCCTTCATTGACCTTCCCGCATTGGATGCGGCAGCCGGCGAGGTCCGGTTGCCCGGCTCCAAGAGCAT
TTCCAACCGGGTGCTGCTGCTGGCCGCGCTCAGCAACGGCACCACCACCGTGCATCAACTGCTGGCGTCCGACGACACCC
GCGTGATGCTCGACGCATTGCGCCAGATCGGCTGCGCCGTCGATGAAGCGGGCAGCAGCGTGCACATCACGGGCCTGGGC
GGCCGCGCCCCGCGCGCACCGGCCAAACTCTTTCTGGGCAATGCCGGCACCGCGATGCGCCCGCTGACGGCAGCGCTGGC
TCTGCTCGGCGGCGAGTTCGAGCTCTCGGGCGTGGCGCGCATGCACCAGCGCCCGATCGGTGATCTGGTCGATGCGCTGC
GCCAACTCGGTTGCCGGATCGACTACCTCGGCAACGACGGCTACCCGCCGCTGCGCATCGCACATGCCGCATGTGCCCCG
GCCCCGGATGTTCCGGCCCTGGTCCCGGGCGTCCCGCCCCTGGCGTTGGCCGAACCGATCCGCGTTCGTGGCGATGTCTC
CAGCCAGTTTTTGACCGCCTTGCTGATGGCGTTGCCGCTGGCGGCCGGCAGACAAAGCATCGTGATCGAAGTCTTGGGCG
AGTTGATCTCCAAGCCCTATATCGCAATCACCCTGGAACTGCTGGCCCGCTTCGGCATCGTGGTCGAGCGCCAGGGCTGG
CAGCGGTTCACGATTGCCGCAGGCAGCCGCTACCAGTCGCCGGGCAGCATCCATGTCGAGGCAGACGCCTCATCGGCCAG
CTATTTCATCGCGCTGGGCGCCATTGCCTCTGGCGCCGGTGGCCCGAACGGCGCCCAGGGCATCAGGATTGCCGGTCTGG
GCCTGGATTCGATACAGGGCGACATCCGCTTCGTCGAAGCCGCCCGGGCGATGGGCGCCGTGGTGACCGGCGGCCCCCAT
TGGCTGCATGTCCAGCGCGGAGCGCCCGGACAGGGATGGCCGCTCAAGGCCATCGACATCGACTGCAACCACATCCCGGA
CGCCGCGATGACCCTGGCCGTGATGGCGCTGTACGCCCAGGGCAGCAGCCGCTTGCGCAACATCGCCAGTTGGCGCGTGA
AGGAGACCGACCGCATCGCCGCCATGGCCGCCGGGCTGCGCCAACTCGGCGCCAGCGTCGAGGAAGGCGCAGACTTCATC
CGCATCACCCCACCGCCACGGACCGAGGACTGGAAAGCCGCCAGCATCGACACCCATGACGACCACCGCGTGGCCATGTG
CTTCGCACTGGCGGCCTTCAACCCCGCCGGCTTGCCGATCCGCATTCAGGATCCGAAATGCGTGGCCAAGACCTTCCCGG
ACTACTTCGAGGCCCTGTTCTCGGTCGCGCAACTGGCGGCCGAGCGCATTCCGGTGATCTGCATCGACGGCCCCACGGCC
TCGGGCAAAGGAACGCTGGCCGCCGCGCTGGCCCGGCAACTGGGCTACCGCTTCCTGGACTCGGGCGCGCTCTACCGCAT
CACCGCGCTGGTCGCGCTGCGGTCGGGTCTGCGGATCGACGCCGGGCACGAAGAGCGCATCGCCGCGCTGGCCCGAACGC
TGCCCGTGCGCTTCGAAAGCGACCGGGTGTTGCTGGGCAGCGATGACTTGACCGAGGCCATCCGCAGCGAAGAGGTCGGC
ATGAACGCCTCCCGCGTATCGGCCCTGCCCGCCGTGCGCGCGGCCCTGGTCGCGCTGCAACACAGCTTTCGGCGCCTGCC
CGGGCTGGTGGCCGATGGCCGCGACATGGGCACGGTGATCTTCCCGGCCGCAGCGCTGAAGGTCTACCTGACGGCAAGCC
TCGCCTGCCGTGCGGAGCGCCGTTATAAGCAGTTGATTTCAAAGGGTTTTTCAGCTAACATCGCGGATCTTTGCGCAGAC
TTGCAAGAGCGCGATGCGCGCGATGGCACGCGCAGCGTCGCGCCGCTCAAGCCCGCGCAGGACGCTCTGCTGCTGGACAA
CTCCTGCCAGACGATGGATCAAACCGTCGCCTTGGTGTTGGCTTGGTGGCAAGAGAAGCAGTTTGGTGCCGTTTCTGCGC
CAGGGCGACAGCCCGGCGCCGTGACCGCGCCGGGCTGA

Upstream 100 bases:

>100_bases
GAAGCCCGCGCCCACTGGCGCATGGGCGCACAGAAAACGGCCAAGCTGCGCTCCTCCCCCGTAGACCCGTAGCCCCCCGT
AGCCCGCAGACCACCGCGCC

Downstream 100 bases:

>100_bases
AACCATGCGGGGCCGCAAGGCCCCGCGCAACAGTCCCACGCAGTCGCGCATAGCGCTGTGTGGATCATTCACCCGACCTG
CGGTCGATCCGCAAAAAAAC

Product: bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MYSTAFIDLPALDAAAGEVRLPGSKSISNRVLLLAALSNGTTTVHQLLASDDTRVMLDALRQIGCAVDEAGSSVHITGLG
GRAPRAPAKLFLGNAGTAMRPLTAALALLGGEFELSGVARMHQRPIGDLVDALRQLGCRIDYLGNDGYPPLRIAHAACAP
APDVPALVPGVPPLALAEPIRVRGDVSSQFLTALLMALPLAAGRQSIVIEVLGELISKPYIAITLELLARFGIVVERQGW
QRFTIAAGSRYQSPGSIHVEADASSASYFIALGAIASGAGGPNGAQGIRIAGLGLDSIQGDIRFVEAARAMGAVVTGGPH
WLHVQRGAPGQGWPLKAIDIDCNHIPDAAMTLAVMALYAQGSSRLRNIASWRVKETDRIAAMAAGLRQLGASVEEGADFI
RITPPPRTEDWKAASIDTHDDHRVAMCFALAAFNPAGLPIRIQDPKCVAKTFPDYFEALFSVAQLAAERIPVICIDGPTA
SGKGTLAAALARQLGYRFLDSGALYRITALVALRSGLRIDAGHEERIAALARTLPVRFESDRVLLGSDDLTEAIRSEEVG
MNASRVSALPAVRAALVALQHSFRRLPGLVADGRDMGTVIFPAAALKVYLTASLACRAERRYKQLISKGFSANIADLCAD
LQERDARDGTRSVAPLKPAQDALLLDNSCQTMDQTVALVLAWWQEKQFGAVSAPGRQPGAVTAPG

Sequences:

>Translated_705_residues
MYSTAFIDLPALDAAAGEVRLPGSKSISNRVLLLAALSNGTTTVHQLLASDDTRVMLDALRQIGCAVDEAGSSVHITGLG
GRAPRAPAKLFLGNAGTAMRPLTAALALLGGEFELSGVARMHQRPIGDLVDALRQLGCRIDYLGNDGYPPLRIAHAACAP
APDVPALVPGVPPLALAEPIRVRGDVSSQFLTALLMALPLAAGRQSIVIEVLGELISKPYIAITLELLARFGIVVERQGW
QRFTIAAGSRYQSPGSIHVEADASSASYFIALGAIASGAGGPNGAQGIRIAGLGLDSIQGDIRFVEAARAMGAVVTGGPH
WLHVQRGAPGQGWPLKAIDIDCNHIPDAAMTLAVMALYAQGSSRLRNIASWRVKETDRIAAMAAGLRQLGASVEEGADFI
RITPPPRTEDWKAASIDTHDDHRVAMCFALAAFNPAGLPIRIQDPKCVAKTFPDYFEALFSVAQLAAERIPVICIDGPTA
SGKGTLAAALARQLGYRFLDSGALYRITALVALRSGLRIDAGHEERIAALARTLPVRFESDRVLLGSDDLTEAIRSEEVG
MNASRVSALPAVRAALVALQHSFRRLPGLVADGRDMGTVIFPAAALKVYLTASLACRAERRYKQLISKGFSANIADLCAD
LQERDARDGTRSVAPLKPAQDALLLDNSCQTMDQTVALVLAWWQEKQFGAVSAPGRQPGAVTAPG
>Mature_705_residues
MYSTAFIDLPALDAAAGEVRLPGSKSISNRVLLLAALSNGTTTVHQLLASDDTRVMLDALRQIGCAVDEAGSSVHITGLG
GRAPRAPAKLFLGNAGTAMRPLTAALALLGGEFELSGVARMHQRPIGDLVDALRQLGCRIDYLGNDGYPPLRIAHAACAP
APDVPALVPGVPPLALAEPIRVRGDVSSQFLTALLMALPLAAGRQSIVIEVLGELISKPYIAITLELLARFGIVVERQGW
QRFTIAAGSRYQSPGSIHVEADASSASYFIALGAIASGAGGPNGAQGIRIAGLGLDSIQGDIRFVEAARAMGAVVTGGPH
WLHVQRGAPGQGWPLKAIDIDCNHIPDAAMTLAVMALYAQGSSRLRNIASWRVKETDRIAAMAAGLRQLGASVEEGADFI
RITPPPRTEDWKAASIDTHDDHRVAMCFALAAFNPAGLPIRIQDPKCVAKTFPDYFEALFSVAQLAAERIPVICIDGPTA
SGKGTLAAALARQLGYRFLDSGALYRITALVALRSGLRIDAGHEERIAALARTLPVRFESDRVLLGSDDLTEAIRSEEVG
MNASRVSALPAVRAALVALQHSFRRLPGLVADGRDMGTVIFPAAALKVYLTASLACRAERRYKQLISKGFSANIADLCAD
LQERDARDGTRSVAPLKPAQDALLLDNSCQTMDQTVALVLAWWQEKQFGAVSAPGRQPGAVTAPG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=453, Percent_Identity=49.0066225165563, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1787139, Length=220, Percent_Identity=48.6363636363636, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320332, Length=548, Percent_Identity=33.3941605839416, Blast_Score=226, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 74401; Mature: 74401

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSTAFIDLPALDAAAGEVRLPGSKSISNRVLLLAALSNGTTTVHQLLASDDTRVMLDAL
CCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHH
RQIGCAVDEAGSSVHITGLGGRAPRAPAKLFLGNAGTAMRPLTAALALLGGEFELSGVAR
HHHCCHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHH
MHQRPIGDLVDALRQLGCRIDYLGNDGYPPLRIAHAACAPAPDVPALVPGVPPLALAEPI
HHCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCCC
RVRGDVSSQFLTALLMALPLAAGRQSIVIEVLGELISKPYIAITLELLARFGIVVERQGW
EECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCC
QRFTIAAGSRYQSPGSIHVEADASSASYFIALGAIASGAGGPNGAQGIRIAGLGLDSIQG
CEEEEECCCCCCCCCCEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCEEEEECCHHHHCC
DIRFVEAARAMGAVVTGGPHWLHVQRGAPGQGWPLKAIDIDCNHIPDAAMTLAVMALYAQ
HHHHHHHHHHHCEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHC
GSSRLRNIASWRVKETDRIAAMAAGLRQLGASVEEGADFIRITPPPRTEDWKAASIDTHD
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCCEEEECCCCCCCCCCCCCCCCCC
DHRVAMCFALAAFNPAGLPIRIQDPKCVAKTFPDYFEALFSVAQLAAERIPVICIDGPTA
CCHHHHHHHHHHCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCC
SGKGTLAAALARQLGYRFLDSGALYRITALVALRSGLRIDAGHEERIAALARTLPVRFES
CCCHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCEECC
DRVLLGSDDLTEAIRSEEVGMNASRVSALPAVRAALVALQHSFRRLPGLVADGRDMGTVI
CEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEE
FPAAALKVYLTASLACRAERRYKQLISKGFSANIADLCADLQERDARDGTRSVAPLKPAQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
DALLLDNSCQTMDQTVALVLAWWQEKQFGAVSAPGRQPGAVTAPG
CCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYSTAFIDLPALDAAAGEVRLPGSKSISNRVLLLAALSNGTTTVHQLLASDDTRVMLDAL
CCCEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCHHHHHHHH
RQIGCAVDEAGSSVHITGLGGRAPRAPAKLFLGNAGTAMRPLTAALALLGGEFELSGVAR
HHHCCHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHH
MHQRPIGDLVDALRQLGCRIDYLGNDGYPPLRIAHAACAPAPDVPALVPGVPPLALAEPI
HHCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCCC
RVRGDVSSQFLTALLMALPLAAGRQSIVIEVLGELISKPYIAITLELLARFGIVVERQGW
EECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCC
QRFTIAAGSRYQSPGSIHVEADASSASYFIALGAIASGAGGPNGAQGIRIAGLGLDSIQG
CEEEEECCCCCCCCCCEEEEECCCCCEEEEEEEHHHCCCCCCCCCCCEEEEECCHHHHCC
DIRFVEAARAMGAVVTGGPHWLHVQRGAPGQGWPLKAIDIDCNHIPDAAMTLAVMALYAQ
HHHHHHHHHHHCEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHC
GSSRLRNIASWRVKETDRIAAMAAGLRQLGASVEEGADFIRITPPPRTEDWKAASIDTHD
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCCEEEECCCCCCCCCCCCCCCCCC
DHRVAMCFALAAFNPAGLPIRIQDPKCVAKTFPDYFEALFSVAQLAAERIPVICIDGPTA
CCHHHHHHHHHHCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCC
SGKGTLAAALARQLGYRFLDSGALYRITALVALRSGLRIDAGHEERIAALARTLPVRFES
CCCHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCEECC
DRVLLGSDDLTEAIRSEEVGMNASRVSALPAVRAALVALQHSFRRLPGLVADGRDMGTVI
CEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEE
FPAAALKVYLTASLACRAERRYKQLISKGFSANIADLCADLQERDARDGTRSVAPLKPAQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
DALLLDNSCQTMDQTVALVLAWWQEKQFGAVSAPGRQPGAVTAPG
CCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA