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The map label for this gene is mcl1 [H]

Identifier: 121609992

GI number: 121609992

Start: 3401062

End: 3401928

Strand: Direct

Name: mcl1 [H]

Synonym: Veis_3048

Alternate gene names: 121609992

Gene position: 3401062-3401928 (Clockwise)

Preceding gene: 121609988

Following gene: 121609993

Centisome position: 61.1

GC content: 70.47

Gene sequence:

>867_bases
ATGAAAAGCAAGCTCTTCGTGCCGGCCTCCCGCCCCGAACTGTTCGCCAAGGCCCTGGCCGGAGAAGCCGAGGCCATCAG
CCTGGACCTGGAAGACGCCGTTGCCGAATCGCGCAAGGCCCAGGCGCGCGCAGCCGTCACGGCGTTCCTGCAAAGTGACG
CAGCGCTGCGCACGCGCAAGACCCTCATCGTGCGCGTCAACGCGATCGACACGCCGCATTTTGCGCACGACATGGCCGCC
GTGGTCCGGCCCGGCCTGCGCCTGATCAACCTGCCCAAGATCGAGAGCGCCGCCCAGGTGCGCGCAGCGGCAGCGGTGCT
GGCGCAGGCCGAGCGGGCGCATGGCCTGCGGCATCCGATCGGCCTGTTGCTGAACATCGAGACGCCGCGCGCGTTGCGCA
TGGCCGCCGATCTGGCACTGTCGGAGCCGCGCGTGCGCGGCCTGCAACTGGGCCTGGGGGACCTGTTCGAGCCGCTGGGC
ATCGAGCGGCGCGGCGCGGCGGCCGTGGCACAGGCCCTGTTCGCCGTGCGCCTGGCGGCGGGCGAGGCCGGCATCGCGGC
CTACGACGCCGCGTTTGCCGACATCCACGACATCGACGGCTTTCGCGCCGAGGCCGAGCTATCGCGGCGGCTCGGCTTTC
AAGGCAAGTCCTGCATCCACCCCAGCCAGGTCGCTGTGGCCAATGCGGTGTACCGCCCCTCTGACTGCGAGATAGCGCAG
GCCCGCAAAGTGCTCGACGCCGCCCGCGTGGCAGACGCCCAGGGTACGGGCGCTTACCTGGTGGACGCACAGATGGTCGA
CAAACCGTTCGTCGCGCGCGCACAGGCCATCGTGGACAGCGCACGGGCGCTGGATTTGCCGCCCTGA

Upstream 100 bases:

>100_bases
GCTGCGCAGGTAATTGGTTTCCATGAAGATGGATTTTCTGTGATCTGATCATAGAGAGCATGTGTTTTTCTTTTGTCATC
GGGCGCCGAGACTGCGCTCC

Downstream 100 bases:

>100_bases
CGCCGATTCATGGCCGAGACGATTTCAACCCCCACGGAGACCAGCCACCATGCCACGCAGCACCCGTTTGTCGGCGCGCG
CCGCCGCACTTTGCGCCATC

Product: Citryl-CoA lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MKSKLFVPASRPELFAKALAGEAEAISLDLEDAVAESRKAQARAAVTAFLQSDAALRTRKTLIVRVNAIDTPHFAHDMAA
VVRPGLRLINLPKIESAAQVRAAAAVLAQAERAHGLRHPIGLLLNIETPRALRMAADLALSEPRVRGLQLGLGDLFEPLG
IERRGAAAVAQALFAVRLAAGEAGIAAYDAAFADIHDIDGFRAEAELSRRLGFQGKSCIHPSQVAVANAVYRPSDCEIAQ
ARKVLDAARVADAQGTGAYLVDAQMVDKPFVARAQAIVDSARALDLPP

Sequences:

>Translated_288_residues
MKSKLFVPASRPELFAKALAGEAEAISLDLEDAVAESRKAQARAAVTAFLQSDAALRTRKTLIVRVNAIDTPHFAHDMAA
VVRPGLRLINLPKIESAAQVRAAAAVLAQAERAHGLRHPIGLLLNIETPRALRMAADLALSEPRVRGLQLGLGDLFEPLG
IERRGAAAVAQALFAVRLAAGEAGIAAYDAAFADIHDIDGFRAEAELSRRLGFQGKSCIHPSQVAVANAVYRPSDCEIAQ
ARKVLDAARVADAQGTGAYLVDAQMVDKPFVARAQAIVDSARALDLPP
>Mature_288_residues
MKSKLFVPASRPELFAKALAGEAEAISLDLEDAVAESRKAQARAAVTAFLQSDAALRTRKTLIVRVNAIDTPHFAHDMAA
VVRPGLRLINLPKIESAAQVRAAAAVLAQAERAHGLRHPIGLLLNIETPRALRMAADLALSEPRVRGLQLGLGDLFEPLG
IERRGAAAVAQALFAVRLAAGEAGIAAYDAAFADIHDIDGFRAEAELSRRLGFQGKSCIHPSQVAVANAVYRPSDCEIAQ
ARKVLDAARVADAQGTGAYLVDAQMVDKPFVARAQAIVDSARALDLPP

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=294, Percent_Identity=25.8503401360544, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI87081764, Length=285, Percent_Identity=35.4385964912281, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17557458, Length=294, Percent_Identity=27.2108843537415, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 30510; Mature: 30510

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKLFVPASRPELFAKALAGEAEAISLDLEDAVAESRKAQARAAVTAFLQSDAALRTRK
CCCCEECCCCCHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCE
TLIVRVNAIDTPHFAHDMAAVVRPGLRLINLPKIESAAQVRAAAAVLAQAERAHGLRHPI
EEEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GLLLNIETPRALRMAADLALSEPRVRGLQLGLGDLFEPLGIERRGAAAVAQALFAVRLAA
EEEEECCCCHHHHHHHHHHHCCCCHHHEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
GEAGIAAYDAAFADIHDIDGFRAEAELSRRLGFQGKSCIHPSQVAVANAVYRPSDCEIAQ
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCHHHH
ARKVLDAARVADAQGTGAYLVDAQMVDKPFVARAQAIVDSARALDLPP
HHHHHHHHHHCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKSKLFVPASRPELFAKALAGEAEAISLDLEDAVAESRKAQARAAVTAFLQSDAALRTRK
CCCCEECCCCCHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCE
TLIVRVNAIDTPHFAHDMAAVVRPGLRLINLPKIESAAQVRAAAAVLAQAERAHGLRHPI
EEEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GLLLNIETPRALRMAADLALSEPRVRGLQLGLGDLFEPLGIERRGAAAVAQALFAVRLAA
EEEEECCCCHHHHHHHHHHHCCCCHHHEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
GEAGIAAYDAAFADIHDIDGFRAEAELSRRLGFQGKSCIHPSQVAVANAVYRPSDCEIAQ
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCHHHH
ARKVLDAARVADAQGTGAYLVDAQMVDKPFVARAQAIVDSARALDLPP
HHHHHHHHHHCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA