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The map label for this gene is thiD [C]

Identifier: 121609967

GI number: 121609967

Start: 3376736

End: 3377698

Strand: Direct

Name: thiD [C]

Synonym: Veis_3023

Alternate gene names: 121609967

Gene position: 3376736-3377698 (Clockwise)

Preceding gene: 121609957

Following gene: 121609968

Centisome position: 60.66

GC content: 65.94

Gene sequence:

>963_bases
ATGACCTCCCCCCCATTCCCTCCTGCGCCGGACCGCAGGGCACCCGACGATGACGAGCGGCAGGGTGCAGGTCCGGCCTG
TGTGCTGGTGTTCAACGCCAGCGACCCGAGCGGGGCCGGCGGGCTGACCGCAGACATCACCGCCATTGCCTCGGTTGGCG
GGCATCCGATTGCGGTGGTCACCGGCGCCTATGCCCGTGACACGGCCGAGATCTTCGATCATTTCAGCTTCGACGATGAG
GTGGTGGCCGAGCAGGCGCGCACGGTGCTCGAAGACCTTGCCGTGCAAGCCATCAAGGTCGGCTTCGTCGGCAGCCCGGA
AAACATCAGCGCCATCGCCAGAATCACCACCGACTACGATGAAGTCCCGGTGATCGCGTACATGCCCAACCTGTCCTGGT
GGCGCGATGAACTGATCGACGAGTATCTGAACGCCTTCCGGGAATTATTGTTACCACAGGCTTCGGTGTTGGTTGGAAAC
CACAGCACGCTGTGGCGCTGGCTGCTGCCGGACTGGAGCGGCCAGCGCAGCCCCACGGCGCGCGACATCGCCCGGGCGGC
GGCCGAGATGGGCGTGCCCTACACCCTGGTCACCGGGATTGCACTGCCCGAGCAGTTTGTCGAGAACATGCTGGCCTCGC
CCCAGGTGCTGCTCGGCGGTGGCAAGTTCGAGCTGTTCGATGCCAGTTTCTGTGGCGCCGGCGACACGCTGTCGGCCGCG
CTGACCGCCCTGGTGGCCTGCGGCAACGACCTGGGCGAAGCCACCGGCGAAGCGCTGGGCTACCTCGACCGGTGCCTGGA
CGCCGGCTTTCGCCCCGGAATGGGGCATATCCTTCCCGACCGCATGTTCTGGGCCGCGCCCGGCGCCGACGATGCCCGGG
ACGCCGAAGAAGACAATCCCACCATTGACGATGCACAGGCCCTGGAAGGCTTTGTGATGCCACCCCATGACACCAAACAC
TGA

Upstream 100 bases:

>100_bases
ATAGAATGCAACGATTGTATTGGCCAATGGGGCCTCGGCGGCGCAGTCGGCGCGTCGGCCTGCAACTTTCCTGCCACTGT
TCGGGCATGATCCACAGTCC

Downstream 100 bases:

>100_bases
TCTGAATATCCCGCTGTTCGAGCGCGCCAAGGCGCTCATTCCCGGTGGCGTGAACTCGCCAGTCCGGGCCTTCAAGGCAG
TCGGCGGCACGCCCCGCTTC

Product: phosphomethylpyrimidine kinase type-1

Products: ADP; 4-amino-5-phosphomethyl-2-methylpyrimidine

Alternate protein names: Hydroxymethylpyrimidine Kinase; Phosphomethylpyrimidine Kinase Family Protein; Bifunctional ThiED Protein; Hydroxymethylpyrimidine/Phosphomethylpyrimidine Kinase; Bifunctional ThiED; Bifunctional Thiamine Biosynthesis ThiD; Adenine Phosphoribosyltransferase; Phosphomethylpyrimidine Kinase ThiD; Phosphomethylpyrimidine Kinase Superfamily

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTSPPFPPAPDRRAPDDDERQGAGPACVLVFNASDPSGAGGLTADITAIASVGGHPIAVVTGAYARDTAEIFDHFSFDDE
VVAEQARTVLEDLAVQAIKVGFVGSPENISAIARITTDYDEVPVIAYMPNLSWWRDELIDEYLNAFRELLLPQASVLVGN
HSTLWRWLLPDWSGQRSPTARDIARAAAEMGVPYTLVTGIALPEQFVENMLASPQVLLGGGKFELFDASFCGAGDTLSAA
LTALVACGNDLGEATGEALGYLDRCLDAGFRPGMGHILPDRMFWAAPGADDARDAEEDNPTIDDAQALEGFVMPPHDTKH

Sequences:

>Translated_320_residues
MTSPPFPPAPDRRAPDDDERQGAGPACVLVFNASDPSGAGGLTADITAIASVGGHPIAVVTGAYARDTAEIFDHFSFDDE
VVAEQARTVLEDLAVQAIKVGFVGSPENISAIARITTDYDEVPVIAYMPNLSWWRDELIDEYLNAFRELLLPQASVLVGN
HSTLWRWLLPDWSGQRSPTARDIARAAAEMGVPYTLVTGIALPEQFVENMLASPQVLLGGGKFELFDASFCGAGDTLSAA
LTALVACGNDLGEATGEALGYLDRCLDAGFRPGMGHILPDRMFWAAPGADDARDAEEDNPTIDDAQALEGFVMPPHDTKH
>Mature_319_residues
TSPPFPPAPDRRAPDDDERQGAGPACVLVFNASDPSGAGGLTADITAIASVGGHPIAVVTGAYARDTAEIFDHFSFDDEV
VAEQARTVLEDLAVQAIKVGFVGSPENISAIARITTDYDEVPVIAYMPNLSWWRDELIDEYLNAFRELLLPQASVLVGNH
STLWRWLLPDWSGQRSPTARDIARAAAEMGVPYTLVTGIALPEQFVENMLASPQVLLGGGKFELFDASFCGAGDTLSAAL
TALVACGNDLGEATGEALGYLDRCLDAGFRPGMGHILPDRMFWAAPGADDARDAEEDNPTIDDAQALEGFVMPPHDTKH

Specific function: Catalyzes The Phosphorylation Of Hmp-P To Hmp-Pp. [C]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788420, Length=259, Percent_Identity=24.7104247104247, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.1.49; 2.7.4.7

Molecular weight: Translated: 34155; Mature: 34024

Theoretical pI: Translated: 4.00; Mature: 4.00

Prosite motif: PS00093 N4_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPPFPPAPDRRAPDDDERQGAGPACVLVFNASDPSGAGGLTADITAIASVGGHPIAVV
CCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEE
TGAYARDTAEIFDHFSFDDEVVAEQARTVLEDLAVQAIKVGFVGSPENISAIARITTDYD
ECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEECCCC
EVPVIAYMPNLSWWRDELIDEYLNAFRELLLPQASVLVGNHSTLWRWLLPDWSGQRSPTA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHEEECCCCCCCCCCHH
RDIARAAAEMGVPYTLVTGIALPEQFVENMLASPQVLLGGGKFELFDASFCGAGDTLSAA
HHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCEEEECCEEEEEECCCCCCCHHHHHH
LTALVACGNDLGEATGEALGYLDRCLDAGFRPGMGHILPDRMFWAAPGADDARDAEEDNP
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
TIDDAQALEGFVMPPHDTKH
CCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TSPPFPPAPDRRAPDDDERQGAGPACVLVFNASDPSGAGGLTADITAIASVGGHPIAVV
CCCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEE
TGAYARDTAEIFDHFSFDDEVVAEQARTVLEDLAVQAIKVGFVGSPENISAIARITTDYD
ECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHEEEECCCC
EVPVIAYMPNLSWWRDELIDEYLNAFRELLLPQASVLVGNHSTLWRWLLPDWSGQRSPTA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHEEECCCCCCCCCCHH
RDIARAAAEMGVPYTLVTGIALPEQFVENMLASPQVLLGGGKFELFDASFCGAGDTLSAA
HHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCEEEECCEEEEEECCCCCCCHHHHHH
LTALVACGNDLGEATGEALGYLDRCLDAGFRPGMGHILPDRMFWAAPGADDARDAEEDNP
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
TIDDAQALEGFVMPPHDTKH
CCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 4-amino-5-hydroxymethyl-2-methylpyrimidine

Specific reaction: ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA