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The map label for this gene is acdA [H]

Identifier: 120613001

GI number: 120613001

Start: 4850497

End: 4851627

Strand: Reverse

Name: acdA [H]

Synonym: Aave_4365

Alternate gene names: 120613001

Gene position: 4851627-4850497 (Counterclockwise)

Preceding gene: 120613002

Following gene: 120612998

Centisome position: 90.64

GC content: 68.44

Gene sequence:

>1131_bases
ATGTTGCTGACCCAGGACCAGGAGATGATCCGCGACGCGGTGCGCGAGTTCGCGCAGACGGAGCTGTGGCCGCATGCGGC
CCGCTGGGACAAGGAGCACCTGTTTCCCCGCGATGCGCACCGCGGCCTCGCCGCGCTGGGGGCGTATGGCATTTGCGTGC
CGGAGGAGTACGGCGGCGCAGGGCTGGACTACCTGTCGCTGGCACTGGTTCTGGAGGAAATCGCGGCAGGCGACGGTGGC
ACGAGCACGGCGATCAGCGTGACCAACTGTCCGGTCAATGCGATCCTGATGCGCTACGGCAGCGAGGCGCAGAAGCGCCG
GTGGCTCGAGCCCCTGGCGCGCGGCGAGATGCTGGGGGCTTTCTGCCTGACGGAGCCCCACGTCGGCTCGGATGCCTCGG
CGCTGCGTACCACGGCGGTGCGGCATGGGGACGAATACGCCATCGACGGCGTGAAGCAGTTCATCACGAGCGGCAGGAAT
GGCCAGGTGGCGATCGTGATCGCGGTGACCGACCGTGCCGCCGGCAAGCGCGGCATGAGCGCATTCCTCGTGCCCACCGA
CACCCCCGGCTACGTCGTGGCGCGGCTGGAGGACAAGCTGGGCCAGCGCAGCAGCGATACGGCGCAGATCATGTTCGAGG
GATGCCGCATCCCGGTGGAGAACCGGATCGGCGCAGAGGGCGAGGGCTACAAGATCGCGCTGGGCGCTCTGGAAGGGGGG
CGCATCGGCATCGCGGCGCAGAGCGTGGGCATGGCGCGCAGCGCCTTCGACGTGGCCGTGCAGTATGCGAAGGAGCGCGA
GAGTTTCGGCCAGCCGATCTTCCAGCACCAAGCCGTGGGATTCCGGCTGGCCGATTGCGCCACGCAGCTCGAGGCCGCTC
GCCAACTGATCTGGCATGCGGCGACCCTGCGGGACGCGGGGCGCCCCTGCCTGAAGGAGGCCGCCATGGCCAAGCTGTTC
GCGAGCGAGATGGCCGAGCGCGTGTGCAGCGCAGCCATACAGACGCTGGGATGGTACGGCGTGGTCAACGACTTCCCGGT
AGAACGCATCTACCGCGACGTGCGCGTGTGCCAGATCTACGAGGGCACGAGCGACGTGCAGAAGATTCTCATCACCCGCG
CGCTGGCCTGA

Upstream 100 bases:

>100_bases
CCTGCGCCCGGTGCTCCGGAACCCGGCCTCCTGAAGACGGTGCACCGCTCCTTTTTTGCGCAGCCTTTTCCCACTTTCGA
TCAATGACGGAGACAAAAGC

Downstream 100 bases:

>100_bases
GACCGGCTCGCCCGGACCGGGGCTTCAGGCCCGTGGCAGCTCCAAGGGGCCGGGGCCCTGGAGGCGTGCCGGCGCGGCGC
CCAGGAACAGGCGCACGGGT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MLLTQDQEMIRDAVREFAQTELWPHAARWDKEHLFPRDAHRGLAALGAYGICVPEEYGGAGLDYLSLALVLEEIAAGDGG
TSTAISVTNCPVNAILMRYGSEAQKRRWLEPLARGEMLGAFCLTEPHVGSDASALRTTAVRHGDEYAIDGVKQFITSGRN
GQVAIVIAVTDRAAGKRGMSAFLVPTDTPGYVVARLEDKLGQRSSDTAQIMFEGCRIPVENRIGAEGEGYKIALGALEGG
RIGIAAQSVGMARSAFDVAVQYAKERESFGQPIFQHQAVGFRLADCATQLEAARQLIWHAATLRDAGRPCLKEAAMAKLF
ASEMAERVCSAAIQTLGWYGVVNDFPVERIYRDVRVCQIYEGTSDVQKILITRALA

Sequences:

>Translated_376_residues
MLLTQDQEMIRDAVREFAQTELWPHAARWDKEHLFPRDAHRGLAALGAYGICVPEEYGGAGLDYLSLALVLEEIAAGDGG
TSTAISVTNCPVNAILMRYGSEAQKRRWLEPLARGEMLGAFCLTEPHVGSDASALRTTAVRHGDEYAIDGVKQFITSGRN
GQVAIVIAVTDRAAGKRGMSAFLVPTDTPGYVVARLEDKLGQRSSDTAQIMFEGCRIPVENRIGAEGEGYKIALGALEGG
RIGIAAQSVGMARSAFDVAVQYAKERESFGQPIFQHQAVGFRLADCATQLEAARQLIWHAATLRDAGRPCLKEAAMAKLF
ASEMAERVCSAAIQTLGWYGVVNDFPVERIYRDVRVCQIYEGTSDVQKILITRALA
>Mature_376_residues
MLLTQDQEMIRDAVREFAQTELWPHAARWDKEHLFPRDAHRGLAALGAYGICVPEEYGGAGLDYLSLALVLEEIAAGDGG
TSTAISVTNCPVNAILMRYGSEAQKRRWLEPLARGEMLGAFCLTEPHVGSDASALRTTAVRHGDEYAIDGVKQFITSGRN
GQVAIVIAVTDRAAGKRGMSAFLVPTDTPGYVVARLEDKLGQRSSDTAQIMFEGCRIPVENRIGAEGEGYKIALGALEGG
RIGIAAQSVGMARSAFDVAVQYAKERESFGQPIFQHQAVGFRLADCATQLEAARQLIWHAATLRDAGRPCLKEAAMAKLF
ASEMAERVCSAAIQTLGWYGVVNDFPVERIYRDVRVCQIYEGTSDVQKILITRALA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=369, Percent_Identity=47.4254742547426, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=40.2144772117962, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=37.2340425531915, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=37.1657754010695, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=37.1657754010695, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=36.2433862433862, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=37.5, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=30.8510638297872, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI21361497, Length=356, Percent_Identity=35.3932584269663, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI76496475, Length=373, Percent_Identity=33.2439678284182, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4557235, Length=373, Percent_Identity=33.2439678284182, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=29.2553191489362, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI211971008, Length=381, Percent_Identity=31.758530183727, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI48976061, Length=381, Percent_Identity=31.758530183727, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI38505218, Length=338, Percent_Identity=32.5443786982249, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=29.0055248618785, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI218563752, Length=257, Percent_Identity=24.124513618677, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786223, Length=374, Percent_Identity=28.3422459893048, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87081958, Length=367, Percent_Identity=30.7901907356948, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082384, Length=275, Percent_Identity=30.9090909090909, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081702, Length=384, Percent_Identity=24.4791666666667, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=37.1657754010695, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17508101, Length=365, Percent_Identity=38.3561643835616, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=38.2978723404255, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17569725, Length=376, Percent_Identity=37.2340425531915, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=37.0666666666667, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17570075, Length=376, Percent_Identity=36.968085106383, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=35.0923482849604, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=40.5797101449275, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=33.9031339031339, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17551932, Length=379, Percent_Identity=30.8707124010554, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=252, Percent_Identity=37.3015873015873, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=379, Percent_Identity=29.287598944591, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=28.6472148541114, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=268, Percent_Identity=30.9701492537313, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=299, Percent_Identity=32.4414715719064, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17562446, Length=386, Percent_Identity=30.5699481865285, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=32.7800829875519, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17531913, Length=171, Percent_Identity=35.0877192982456, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=276, Percent_Identity=29.3478260869565, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=276, Percent_Identity=29.3478260869565, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356377, Length=369, Percent_Identity=43.0894308943089, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=42.627345844504, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=39.0374331550802, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=37.4005305039788, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=34.6560846560847, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI281363737, Length=354, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI19920834, Length=380, Percent_Identity=29.4736842105263, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40839; Mature: 40839

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTQDQEMIRDAVREFAQTELWPHAARWDKEHLFPRDAHRGLAALGAYGICVPEEYGGA
CCCCCHHHHHHHHHHHHHHHHCCCCHHCCCHHHCCCCHHHHHHHHHHHCCEECCCCCCCC
GLDYLSLALVLEEIAAGDGGTSTAISVTNCPVNAILMRYGSEAQKRRWLEPLARGEMLGA
CHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCHHHHH
FCLTEPHVGSDASALRTTAVRHGDEYAIDGVKQFITSGRNGQVAIVIAVTDRAAGKRGMS
HCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCE
AFLVPTDTPGYVVARLEDKLGQRSSDTAQIMFEGCRIPVENRIGAEGEGYKIALGALEGG
EEEEECCCCCEEEEEEHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCC
RIGIAAQSVGMARSAFDVAVQYAKERESFGQPIFQHQAVGFRLADCATQLEAARQLIWHA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ATLRDAGRPCLKEAAMAKLFASEMAERVCSAAIQTLGWYGVVNDFPVERIYRDVRVCQIY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEE
EGTSDVQKILITRALA
CCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLTQDQEMIRDAVREFAQTELWPHAARWDKEHLFPRDAHRGLAALGAYGICVPEEYGGA
CCCCCHHHHHHHHHHHHHHHHCCCCHHCCCHHHCCCCHHHHHHHHHHHCCEECCCCCCCC
GLDYLSLALVLEEIAAGDGGTSTAISVTNCPVNAILMRYGSEAQKRRWLEPLARGEMLGA
CHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCHHHHH
FCLTEPHVGSDASALRTTAVRHGDEYAIDGVKQFITSGRNGQVAIVIAVTDRAAGKRGMS
HCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCE
AFLVPTDTPGYVVARLEDKLGQRSSDTAQIMFEGCRIPVENRIGAEGEGYKIALGALEGG
EEEEECCCCCEEEEEEHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCC
RIGIAAQSVGMARSAFDVAVQYAKERESFGQPIFQHQAVGFRLADCATQLEAARQLIWHA
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ATLRDAGRPCLKEAAMAKLFASEMAERVCSAAIQTLGWYGVVNDFPVERIYRDVRVCQIY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEE
EGTSDVQKILITRALA
CCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]