Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 120612955

GI number: 120612955

Start: 4797219

End: 4798298

Strand: Reverse

Name: pyrC [H]

Synonym: Aave_4319

Alternate gene names: 120612955

Gene position: 4798298-4797219 (Counterclockwise)

Preceding gene: 120612956

Following gene: 120612954

Centisome position: 89.64

GC content: 69.26

Gene sequence:

>1080_bases
ATGACCGCTGCCGCACACCCCACCCCTTCCGCCCCCGTGGACACCCTCACCATCACCCGGCCCGACGACTGGCATCTGCA
CGTGCGCGATGGCGAGCCGCTGCTGACCGTGGTGCCCCACACGGCGGCGCAGTTCGGCCGCGCGGTCATCATGCCCAACC
TGCGCCCTCCGGTGACCACGGCGGCCCAGGCCATGGCGTACAAGGAGCGCATCCTGGCCGCCGTGCCGCAGGGAATGTCG
TTCGAGCCGCTGATGACGCTCTACCTCACCGACAACATCCCTCCCGAGGAGATGGCGCGCGCGAAGGAGGCCGGCATCGT
CGCCTGCAAGCTCTATCCCGCCGGGGCCACGACGAACAGCGATGCGGGCGTGACCGAACTGCGCAGGATCTATCCGGTGC
TGGAGGCGATGCAGAAGGCCGGCCTGCTGCTGCTGGTGCATGGCGAGGCCACGGGCAGCGAGATCGACCTCTTCGACCGC
GAGGCCGTGTTCATCGACCGCCAGCTCATCCCGCTGCGCCGCGATTTCCCGGAACTCAAGATCGTCTTCGAGCACATCAC
CACGCGCGAGGCCGCGCAGTACGTGGCCTCCAGCGACGCCTTCACGGCCGCCACCATCACGCCGCAGCACCTGCTCTACA
ACCGCAATGCCATCTTCACGGGCGGCATCCGGCCCCATTACTACTGCCTGCCGGTGCTCAAGCGCGAAACGCACCGGCTC
GCCCTCGTGGAGGCCGCCACCGGCGGCAGCCCGAAGTTCTTCCTGGGCACGGACAGCGCGCCGCATGCCGCCCACCTGAA
GGAGCACGCCACCGGCTGCGCGGGCTGCTACAGCGCGCATGCCGCCATGGAGCTGTATGCCGAGGCCTTCGACAGCGTGG
GTGCGCTGGGCAAGCTCGAAGGGTTCGCCAGCTTCCACGGTCCGGATTTCTACGGCCTGCCGCGCAACCAGGGCACGCTG
ACCCTGCGCCGCGAATCGTGGACGCCACCCGATAGCTTCCCCTTCGGCGAAGCGTTGCTCAAGCCGCTGCGCTCGGGCGA
AGCGCTGGCCTGGCGGGCGGTGGCTGGCGGAGCGGACTGA

Upstream 100 bases:

>100_bases
CGGAATCCCCCCCTCGCCCCAATGACTGGGGTTTCACCCTGTCCTCCTTCACGGCGGACAGGGTTTTTTATGGGCGCGCC
CGGTGGGAGAATCGGCATCC

Downstream 100 bases:

>100_bases
GCCATGGCGCCGGCGTCGGACCTGCAGGAGCGGCAACAACTGCGCATCGCGCTGCTTATCGATGCGGACAACGCACCCGC
GGAGATGATCGACGAGATCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTAAAHPTPSAPVDTLTITRPDDWHLHVRDGEPLLTVVPHTAAQFGRAVIMPNLRPPVTTAAQAMAYKERILAAVPQGMS
FEPLMTLYLTDNIPPEEMARAKEAGIVACKLYPAGATTNSDAGVTELRRIYPVLEAMQKAGLLLLVHGEATGSEIDLFDR
EAVFIDRQLIPLRRDFPELKIVFEHITTREAAQYVASSDAFTAATITPQHLLYNRNAIFTGGIRPHYYCLPVLKRETHRL
ALVEAATGGSPKFFLGTDSAPHAAHLKEHATGCAGCYSAHAAMELYAEAFDSVGALGKLEGFASFHGPDFYGLPRNQGTL
TLRRESWTPPDSFPFGEALLKPLRSGEALAWRAVAGGAD

Sequences:

>Translated_359_residues
MTAAAHPTPSAPVDTLTITRPDDWHLHVRDGEPLLTVVPHTAAQFGRAVIMPNLRPPVTTAAQAMAYKERILAAVPQGMS
FEPLMTLYLTDNIPPEEMARAKEAGIVACKLYPAGATTNSDAGVTELRRIYPVLEAMQKAGLLLLVHGEATGSEIDLFDR
EAVFIDRQLIPLRRDFPELKIVFEHITTREAAQYVASSDAFTAATITPQHLLYNRNAIFTGGIRPHYYCLPVLKRETHRL
ALVEAATGGSPKFFLGTDSAPHAAHLKEHATGCAGCYSAHAAMELYAEAFDSVGALGKLEGFASFHGPDFYGLPRNQGTL
TLRRESWTPPDSFPFGEALLKPLRSGEALAWRAVAGGAD
>Mature_358_residues
TAAAHPTPSAPVDTLTITRPDDWHLHVRDGEPLLTVVPHTAAQFGRAVIMPNLRPPVTTAAQAMAYKERILAAVPQGMSF
EPLMTLYLTDNIPPEEMARAKEAGIVACKLYPAGATTNSDAGVTELRRIYPVLEAMQKAGLLLLVHGEATGSEIDLFDRE
AVFIDRQLIPLRRDFPELKIVFEHITTREAAQYVASSDAFTAATITPQHLLYNRNAIFTGGIRPHYYCLPVLKRETHRLA
LVEAATGGSPKFFLGTDSAPHAAHLKEHATGCAGCYSAHAAMELYAEAFDSVGALGKLEGFASFHGPDFYGLPRNQGTLT
LRRESWTPPDSFPFGEALLKPLRSGEALAWRAVAGGAD

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=343, Percent_Identity=53.6443148688047, Blast_Score=378, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6323452, Length=353, Percent_Identity=33.7110481586402, Blast_Score=175, Evalue=1e-44,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38965; Mature: 38834

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAAHPTPSAPVDTLTITRPDDWHLHVRDGEPLLTVVPHTAAQFGRAVIMPNLRPPVTT
CCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCEEEECCCCHHHHCCEEECCCCCCCHHH
AAQAMAYKERILAAVPQGMSFEPLMTLYLTDNIPPEEMARAKEAGIVACKLYPAGATTNS
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCEEEEEEEECCCCCCC
DAGVTELRRIYPVLEAMQKAGLLLLVHGEATGSEIDLFDREAVFIDRQLIPLRRDFPELK
CCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEECCCEEEECCEECCHHCCCCHHH
IVFEHITTREAAQYVASSDAFTAATITPQHLLYNRNAIFTGGIRPHYYCLPVLKRETHRL
HHHHHHHHHHHHHHHHCCCCEEEEECCHHHHEECCCEEEECCCCCCEEEEEHHHCCCCEE
ALVEAATGGSPKFFLGTDSAPHAAHLKEHATGCAGCYSAHAAMELYAEAFDSVGALGKLE
EEEEECCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
GFASFHGPDFYGLPRNQGTLTLRRESWTPPDSFPFGEALLKPLRSGEALAWRAVAGGAD
CHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
>Mature Secondary Structure 
TAAAHPTPSAPVDTLTITRPDDWHLHVRDGEPLLTVVPHTAAQFGRAVIMPNLRPPVTT
CCCCCCCCCCCCCEEEEECCCCCEEEEECCCCEEEECCCCHHHHCCEEECCCCCCCHHH
AAQAMAYKERILAAVPQGMSFEPLMTLYLTDNIPPEEMARAKEAGIVACKLYPAGATTNS
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCEEEEEEEECCCCCCC
DAGVTELRRIYPVLEAMQKAGLLLLVHGEATGSEIDLFDREAVFIDRQLIPLRRDFPELK
CCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEECCCEEEECCEECCHHCCCCHHH
IVFEHITTREAAQYVASSDAFTAATITPQHLLYNRNAIFTGGIRPHYYCLPVLKRETHRL
HHHHHHHHHHHHHHHHCCCCEEEEECCHHHHEECCCEEEECCCCCCEEEEEHHHCCCCEE
ALVEAATGGSPKFFLGTDSAPHAAHLKEHATGCAGCYSAHAAMELYAEAFDSVGALGKLE
EEEEECCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
GFASFHGPDFYGLPRNQGTLTLRRESWTPPDSFPFGEALLKPLRSGEALAWRAVAGGAD
CHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA