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The map label for this gene is htpX

Identifier: 120612952

GI number: 120612952

Start: 4794515

End: 4795390

Strand: Reverse

Name: htpX

Synonym: Aave_4316

Alternate gene names: 120612952

Gene position: 4795390-4794515 (Counterclockwise)

Preceding gene: 120612953

Following gene: 120612950

Centisome position: 89.59

GC content: 67.35

Gene sequence:

>876_bases
ATGAAACGAATCGCGCTATTCCTGCTCACCAACCTTGCCGTCGTGGTGGTGCTGGGCATCGTCGCCAGCCTGCTCGGCGT
CAACCGCTACCTGACGGCCAACGGCCTCAACCTGGGGGCGCTGCTCGGCTTCGCCTTCATCATGGGCTTCGGCGGCGCCA
TCATCTCGCTGCTCATGAGCAAGCCGATCGCCAAGTGGAGTTCCGGCGTGCGCGTGATCGACGGCACGGGTTCGGCCGAC
GAGGCCTGGATCGTCCAGACCGTGCGCAAGTTCGCCGACCAGGCCGGCATCGGCATGCCCGAGGTCGGCATCTTCGAGGG
CGACCCGAACGCCTTCGCCACCGGCGCTTTCAAGAACAACGCCCTCGTGGCGGTGTCCACCGGCCTGCTGCAGGGCATGA
CCCGCGAGGAGGTCGAGGCCGTGATCGGCCACGAGGTGGCCCACATCGCCAACGGCGACATGGTCACGATGACGCTGATC
CAGGGCGTGATGAACACCTTCGTCGTGTTCCTCTCGCGCGTGATCGGCTATGCGGTGGACAGCTTCCTGCGCCGCAACGA
CGAGAACAGCTCCGGCCCCGGCATCGGCTACATGGTCACCACCATCGTGCTCGACATCGTGCTGGGTTTCCTCGCCTCGA
TGATCGTGGCCTGGTTCAGCCGCCAGCGCGAATTCCGCGCCGACGCGGGTGCCGCGCGCCTCATGGGTCGCCGCCAGCCG
ATGATCAACGCGCTGGCCCGCCTGGGCGGCATGCACCCGGCCGAACTGCCCAAGGGCCTGCAGGCCATGGGCATCGCCGG
CGGCATCGGCAAGCTGTTCAGCACCCATCCGCCGATCGAGGAGCGCATCGCCGCGCTGCAGAACGCGCAGGGCTGA

Upstream 100 bases:

>100_bases
TGAACGCCCGCCCGGCATCCCCAACTGACTGTCGGGTTCGAGACCAACCGCTTTACCTTCCCCCGCACCCAAACGCTTTC
CCCTCCGTGGAGAAACTTCG

Downstream 100 bases:

>100_bases
TACCTCCGCATGGCAGCCCGGTTACGGCTGCCGGCAGGAAAGAAGCAAGACGAAACCTCCGCCGTGGCGACATGGCGGGG
GTTTTTCTTTGCGGCGCTTT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKRIALFLLTNLAVVVVLGIVASLLGVNRYLTANGLNLGALLGFAFIMGFGGAIISLLMSKPIAKWSSGVRVIDGTGSAD
EAWIVQTVRKFADQAGIGMPEVGIFEGDPNAFATGAFKNNALVAVSTGLLQGMTREEVEAVIGHEVAHIANGDMVTMTLI
QGVMNTFVVFLSRVIGYAVDSFLRRNDENSSGPGIGYMVTTIVLDIVLGFLASMIVAWFSRQREFRADAGAARLMGRRQP
MINALARLGGMHPAELPKGLQAMGIAGGIGKLFSTHPPIEERIAALQNAQG

Sequences:

>Translated_291_residues
MKRIALFLLTNLAVVVVLGIVASLLGVNRYLTANGLNLGALLGFAFIMGFGGAIISLLMSKPIAKWSSGVRVIDGTGSAD
EAWIVQTVRKFADQAGIGMPEVGIFEGDPNAFATGAFKNNALVAVSTGLLQGMTREEVEAVIGHEVAHIANGDMVTMTLI
QGVMNTFVVFLSRVIGYAVDSFLRRNDENSSGPGIGYMVTTIVLDIVLGFLASMIVAWFSRQREFRADAGAARLMGRRQP
MINALARLGGMHPAELPKGLQAMGIAGGIGKLFSTHPPIEERIAALQNAQG
>Mature_291_residues
MKRIALFLLTNLAVVVVLGIVASLLGVNRYLTANGLNLGALLGFAFIMGFGGAIISLLMSKPIAKWSSGVRVIDGTGSAD
EAWIVQTVRKFADQAGIGMPEVGIFEGDPNAFATGAFKNNALVAVSTGLLQGMTREEVEAVIGHEVAHIANGDMVTMTLI
QGVMNTFVVFLSRVIGYAVDSFLRRNDENSSGPGIGYMVTTIVLDIVLGFLASMIVAWFSRQREFRADAGAARLMGRRQP
MINALARLGGMHPAELPKGLQAMGIAGGIGKLFSTHPPIEERIAALQNAQG

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=297, Percent_Identity=50.8417508417508, Blast_Score=261, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_ACIAC (A1TV68)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972630.1
- ProteinModelPortal:   A1TV68
- SMR:   A1TV68
- STRING:   A1TV68
- MEROPS:   M48.002
- GeneID:   4665305
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4316
- NMPDR:   fig|397945.5.peg.3708
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   NRFLTAN
- PhylomeDB:   A1TV68
- ProtClustDB:   PRK05457
- BioCyc:   AAVE397945:AAVE_4316-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 30802; Mature: 30802

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 145-145

Signals:

None

Transmembrane regions:

HASH(0x17a5b960)-; HASH(0x167e473c)-; HASH(0x18528400)-; HASH(0x18453740)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIALFLLTNLAVVVVLGIVASLLGVNRYLTANGLNLGALLGFAFIMGFGGAIISLLMS
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KPIAKWSSGVRVIDGTGSADEAWIVQTVRKFADQAGIGMPEVGIFEGDPNAFATGAFKNN
CCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEECCCCCC
ALVAVSTGLLQGMTREEVEAVIGHEVAHIANGDMVTMTLIQGVMNTFVVFLSRVIGYAVD
CEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFLRRNDENSSGPGIGYMVTTIVLDIVLGFLASMIVAWFSRQREFRADAGAARLMGRRQP
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
MINALARLGGMHPAELPKGLQAMGIAGGIGKLFSTHPPIEERIAALQNAQG
HHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCH
>Mature Secondary Structure
MKRIALFLLTNLAVVVVLGIVASLLGVNRYLTANGLNLGALLGFAFIMGFGGAIISLLMS
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KPIAKWSSGVRVIDGTGSADEAWIVQTVRKFADQAGIGMPEVGIFEGDPNAFATGAFKNN
CCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEECCCCCC
ALVAVSTGLLQGMTREEVEAVIGHEVAHIANGDMVTMTLIQGVMNTFVVFLSRVIGYAVD
CEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFLRRNDENSSGPGIGYMVTTIVLDIVLGFLASMIVAWFSRQREFRADAGAARLMGRRQP
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
MINALARLGGMHPAELPKGLQAMGIAGGIGKLFSTHPPIEERIAALQNAQG
HHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA