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The map label for this gene is htpG [H]

Identifier: 120612925

GI number: 120612925

Start: 4758995

End: 4761001

Strand: Reverse

Name: htpG [H]

Synonym: Aave_4289

Alternate gene names: 120612925

Gene position: 4761001-4758995 (Counterclockwise)

Preceding gene: 120612927

Following gene: 120612918

Centisome position: 88.94

GC content: 65.32

Gene sequence:

>2007_bases
ATGGCCGGGCGTTCCCCTTTCGTTGCGAAACTCTCACAAAAGAGCCATCCACCAACCATGAGCAAGCAAACCCATTCCTT
CCAGGCCGAAGTGGCGCAACTGCTGCACCTGGTCACCCACTCGCTGTATTCCAACCAGGAAATCTTCCTGCGCGAGCTGA
TCTCGAATGCGTCCGACGCCTGCGACAAGCTGCGCTTCGAGGCGCTGAACAACGCCGCGCTGTACGAGGACGCGCCCAAC
CTCGAAGTGCGCGTGTCCTTTGACAAGGCCGCCAGGACGCTCACGATCACCGACAACGGCATCGGCATGAGCGAGCAGGA
AGCGATCGACCACCTGGGCACGATCGCCAAGAGCGGCACCAAGGACTTCATGAGCCGCCTGTCGGGCGACCAGAAGCAGG
ACGCCCAGCTCATCGGCCAGTTCGGCGTGGGCTTCTACTCGGGCTTCATCGTGGCCGACAGGATCACCGTGGAATCGCGC
CGCGCGGGCCTGAAGCCCGAAGAGGGCGTGCGCTGGACCAGCGGCGGCACGGGCGACTTCGAGGTGGAGACCATCACGCG
CGCCGAGCGCGGCACCAGCATCATCCTGCACCTGCGCGAGGAGGCCGAGGAATTCCTGAACGCCTGGAAACTCAAGCAGG
TCATCGGCAAGTACTCCGACCACATCAGCCTGCCCATCCTGATGGAGAAGGAAGAGTGGAAGGACGGCGAGAAGGAGGGC
GACCCCGGCCAGATGGTGAAGACCGGCGAGTGGGAGGCCGTGAACAAGGCCAGCGCCCTGTGGACGCGCCCCAGGAAGGA
CATCACGGACGAGCAGTACCAGGAGTTCTACAAGGCCATCAGCCACGACCACGAGAACCCGCTCACCTGGAGCCACAACC
GCGTGGAAGGCAACACCGAGTACACGCAGCTGCTCTACATCCCCGCCAAGGCGCCGTTCGACCTGTGGAACCGCGACAAG
AAGGCCGGCGTGAAGCTCTATGTGAAGCGCGTCTTCATCATGGACGACGCCGAGGCGCTCATGCCCACCTACCTGCGCTT
CGTGAAGGGCGTGATCGACTCGGCCGACCTGCCGCTCAACGTGAGCCGCGAGCTGCTGCAGGAAAGCCGCGACGTGCGCG
CCATCCGCGAAGGCTCCACCAAGCGCGTGCTCTCCATGCTCGAGGACCTGGCCAAGCACGACAAGCATGCCGCGGGCGAG
GGCGCCGACGGCGTGACCGACGTGGTGAGCGAGGAGGACAAGGCCAAGGAGGGCAAGTACACGCAGTTCTATGCCGAGTT
CGGCGCGGTGCTCAAGGAAGGCCTGGGCGAGGACTTCGGCAACCGCGAGCGCATCGCCAGGTTGCTGCGCTTCGCTTCCA
GCACGACCGACAGCGTGACCGTCTCGCTGGCCGACTACAAGGCCCGCATGAAGGAGGGCCAGGAGGCCATCTACTACATC
ACCGCCGACACCCTGGCCGCCGCGAAGAACAGCCCGCAGCTCGAGGTCTTCAAGAAGAAGGGCATCGAGGTGCTGCTGAT
GACCGACCGCGTGGACGAGTGGGCGCTCAACTACCTGCACGACTTCGACGGCACGCCGCTGCAATCCGTGGCCAAGGGCG
CGGTGGACCTGGGCAAGCTGCAGGACGAGGCCGAGAAGAAGGCCGCCGAAGAGGCCGCCGAGGCGTTCAAGCCCGTGCTG
GCCCAGCTCAAGGAAGCCCTCAAGGACAAGGCCGAGGACGTGCGCGTGACCACGCGCCTCGTCGATTCGCCCGCCTGCCT
GGTGGTGCAGGAGCACGGCATGAGCACCCAGCTCGCGCGCCTGATGAAGCAGGCCGGCCAGTCCCTGCCCGATGCCAAGC
CCGTGCTGGAGGTGAACCCGGAGCACGCGCTGGTGAAAAAGCTGGACGGCAGCGTGCACTTCCACGACCTCGCCCACATC
CTTTTCGACCAGGCCCTGCTGGCCGAGGGCGGGCTGCCGGACGACCCGGCCGCGTACGTGAAGCGGGTGAATGCGCTGCT
GGTGTAA

Upstream 100 bases:

>100_bases
GTAGGGCTGTCACGCAACGTTGTGAGCCCCGTGTACTGAGGCAGGCTCCGCTCGCTCGGCCTCACCCCGCAGGCCTTGAT
AATCCGCGGCCGGCCCCCAG

Downstream 100 bases:

>100_bases
GACCGGGACCGTGAGCTGACGGCCTGCGCTGCAATCATGCAGGCCGCGCACCGGAGCCGCGGAAGGCAGGCATGCCTTTC
GCGGCTTTTTCGTAGGTGCG

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MAGRSPFVAKLSQKSHPPTMSKQTHSFQAEVAQLLHLVTHSLYSNQEIFLRELISNASDACDKLRFEALNNAALYEDAPN
LEVRVSFDKAARTLTITDNGIGMSEQEAIDHLGTIAKSGTKDFMSRLSGDQKQDAQLIGQFGVGFYSGFIVADRITVESR
RAGLKPEEGVRWTSGGTGDFEVETITRAERGTSIILHLREEAEEFLNAWKLKQVIGKYSDHISLPILMEKEEWKDGEKEG
DPGQMVKTGEWEAVNKASALWTRPRKDITDEQYQEFYKAISHDHENPLTWSHNRVEGNTEYTQLLYIPAKAPFDLWNRDK
KAGVKLYVKRVFIMDDAEALMPTYLRFVKGVIDSADLPLNVSRELLQESRDVRAIREGSTKRVLSMLEDLAKHDKHAAGE
GADGVTDVVSEEDKAKEGKYTQFYAEFGAVLKEGLGEDFGNRERIARLLRFASSTTDSVTVSLADYKARMKEGQEAIYYI
TADTLAAAKNSPQLEVFKKKGIEVLLMTDRVDEWALNYLHDFDGTPLQSVAKGAVDLGKLQDEAEKKAAEEAAEAFKPVL
AQLKEALKDKAEDVRVTTRLVDSPACLVVQEHGMSTQLARLMKQAGQSLPDAKPVLEVNPEHALVKKLDGSVHFHDLAHI
LFDQALLAEGGLPDDPAAYVKRVNALLV

Sequences:

>Translated_668_residues
MAGRSPFVAKLSQKSHPPTMSKQTHSFQAEVAQLLHLVTHSLYSNQEIFLRELISNASDACDKLRFEALNNAALYEDAPN
LEVRVSFDKAARTLTITDNGIGMSEQEAIDHLGTIAKSGTKDFMSRLSGDQKQDAQLIGQFGVGFYSGFIVADRITVESR
RAGLKPEEGVRWTSGGTGDFEVETITRAERGTSIILHLREEAEEFLNAWKLKQVIGKYSDHISLPILMEKEEWKDGEKEG
DPGQMVKTGEWEAVNKASALWTRPRKDITDEQYQEFYKAISHDHENPLTWSHNRVEGNTEYTQLLYIPAKAPFDLWNRDK
KAGVKLYVKRVFIMDDAEALMPTYLRFVKGVIDSADLPLNVSRELLQESRDVRAIREGSTKRVLSMLEDLAKHDKHAAGE
GADGVTDVVSEEDKAKEGKYTQFYAEFGAVLKEGLGEDFGNRERIARLLRFASSTTDSVTVSLADYKARMKEGQEAIYYI
TADTLAAAKNSPQLEVFKKKGIEVLLMTDRVDEWALNYLHDFDGTPLQSVAKGAVDLGKLQDEAEKKAAEEAAEAFKPVL
AQLKEALKDKAEDVRVTTRLVDSPACLVVQEHGMSTQLARLMKQAGQSLPDAKPVLEVNPEHALVKKLDGSVHFHDLAHI
LFDQALLAEGGLPDDPAAYVKRVNALLV
>Mature_667_residues
AGRSPFVAKLSQKSHPPTMSKQTHSFQAEVAQLLHLVTHSLYSNQEIFLRELISNASDACDKLRFEALNNAALYEDAPNL
EVRVSFDKAARTLTITDNGIGMSEQEAIDHLGTIAKSGTKDFMSRLSGDQKQDAQLIGQFGVGFYSGFIVADRITVESRR
AGLKPEEGVRWTSGGTGDFEVETITRAERGTSIILHLREEAEEFLNAWKLKQVIGKYSDHISLPILMEKEEWKDGEKEGD
PGQMVKTGEWEAVNKASALWTRPRKDITDEQYQEFYKAISHDHENPLTWSHNRVEGNTEYTQLLYIPAKAPFDLWNRDKK
AGVKLYVKRVFIMDDAEALMPTYLRFVKGVIDSADLPLNVSRELLQESRDVRAIREGSTKRVLSMLEDLAKHDKHAAGEG
ADGVTDVVSEEDKAKEGKYTQFYAEFGAVLKEGLGEDFGNRERIARLLRFASSTTDSVTVSLADYKARMKEGQEAIYYIT
ADTLAAAKNSPQLEVFKKKGIEVLLMTDRVDEWALNYLHDFDGTPLQSVAKGAVDLGKLQDEAEKKAAEEAAEAFKPVLA
QLKEALKDKAEDVRVTTRLVDSPACLVVQEHGMSTQLARLMKQAGQSLPDAKPVLEVNPEHALVKKLDGSVHFHDLAHIL
FDQALLAEGGLPDDPAAYVKRVNALLV

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI20149594, Length=709, Percent_Identity=38.3638928067701, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI4507677, Length=706, Percent_Identity=36.5439093484419, Blast_Score=411, Evalue=1e-114,
Organism=Homo sapiens, GI155722983, Length=667, Percent_Identity=35.3823088455772, Blast_Score=378, Evalue=1e-104,
Organism=Homo sapiens, GI154146191, Length=434, Percent_Identity=39.4009216589862, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI153792590, Length=434, Percent_Identity=39.4009216589862, Blast_Score=286, Evalue=4e-77,
Organism=Escherichia coli, GI1786679, Length=652, Percent_Identity=57.5153374233129, Blast_Score=751, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559162, Length=690, Percent_Identity=38.695652173913, Blast_Score=460, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17542208, Length=694, Percent_Identity=37.463976945245, Blast_Score=407, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI115535205, Length=674, Percent_Identity=33.2344213649852, Blast_Score=311, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI115535167, Length=458, Percent_Identity=34.4978165938865, Blast_Score=253, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6323840, Length=701, Percent_Identity=37.5178316690442, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6325016, Length=707, Percent_Identity=37.0579915134371, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI17647529, Length=710, Percent_Identity=38.4507042253521, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI21357739, Length=697, Percent_Identity=37.0157819225251, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24586016, Length=674, Percent_Identity=34.86646884273, Blast_Score=357, Evalue=1e-98,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 74407; Mature: 74276

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRSPFVAKLSQKSHPPTMSKQTHSFQAEVAQLLHLVTHSLYSNQEIFLRELISNASDA
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
CDKLRFEALNNAALYEDAPNLEVRVSFDKAARTLTITDNGIGMSEQEAIDHLGTIAKSGT
HHHHHHHHHCCCEEECCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCH
KDFMSRLSGDQKQDAQLIGQFGVGFYSGFIVADRITVESRRAGLKPEEGVRWTSGGTGDF
HHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEEEEEEHHHHCCCCCCCCEEECCCCCCCE
EVETITRAERGTSIILHLREEAEEFLNAWKLKQVIGKYSDHISLPILMEKEEWKDGEKEG
EEHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCC
DPGQMVKTGEWEAVNKASALWTRPRKDITDEQYQEFYKAISHDHENPLTWSHNRVEGNTE
CCCCCEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
YTQLLYIPAKAPFDLWNRDKKAGVKLYVKRVFIMDDAEALMPTYLRFVKGVIDSADLPLN
EEEEEEECCCCCHHHHCCCHHCCHHEEEEEHEEECCHHHHHHHHHHHHHHHHCCCCCCCC
VSRELLQESRDVRAIREGSTKRVLSMLEDLAKHDKHAAGEGADGVTDVVSEEDKAKEGKY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHCCCCH
TQFYAEFGAVLKEGLGEDFGNRERIARLLRFASSTTDSVTVSLADYKARMKEGQEAIYYI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCEEEEE
TADTLAAAKNSPQLEVFKKKGIEVLLMTDRVDEWALNYLHDFDGTPLQSVAKGAVDLGKL
EEHHHHHCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
QDEAEKKAAEEAAEAFKPVLAQLKEALKDKAEDVRVTTRLVDSPACLVVQEHGMSTQLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
LMKQAGQSLPDAKPVLEVNPEHALVKKLDGSVHFHDLAHILFDQALLAEGGLPDDPAAYV
HHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KRVNALLV
HHHHHHCC
>Mature Secondary Structure 
AGRSPFVAKLSQKSHPPTMSKQTHSFQAEVAQLLHLVTHSLYSNQEIFLRELISNASDA
CCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
CDKLRFEALNNAALYEDAPNLEVRVSFDKAARTLTITDNGIGMSEQEAIDHLGTIAKSGT
HHHHHHHHHCCCEEECCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCH
KDFMSRLSGDQKQDAQLIGQFGVGFYSGFIVADRITVESRRAGLKPEEGVRWTSGGTGDF
HHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEEEEEEHHHHCCCCCCCCEEECCCCCCCE
EVETITRAERGTSIILHLREEAEEFLNAWKLKQVIGKYSDHISLPILMEKEEWKDGEKEG
EEHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCC
DPGQMVKTGEWEAVNKASALWTRPRKDITDEQYQEFYKAISHDHENPLTWSHNRVEGNTE
CCCCCEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
YTQLLYIPAKAPFDLWNRDKKAGVKLYVKRVFIMDDAEALMPTYLRFVKGVIDSADLPLN
EEEEEEECCCCCHHHHCCCHHCCHHEEEEEHEEECCHHHHHHHHHHHHHHHHCCCCCCCC
VSRELLQESRDVRAIREGSTKRVLSMLEDLAKHDKHAAGEGADGVTDVVSEEDKAKEGKY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHCCCCH
TQFYAEFGAVLKEGLGEDFGNRERIARLLRFASSTTDSVTVSLADYKARMKEGQEAIYYI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCEEEEE
TADTLAAAKNSPQLEVFKKKGIEVLLMTDRVDEWALNYLHDFDGTPLQSVAKGAVDLGKL
EEHHHHHCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
QDEAEKKAAEEAAEAFKPVLAQLKEALKDKAEDVRVTTRLVDSPACLVVQEHGMSTQLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
LMKQAGQSLPDAKPVLEVNPEHALVKKLDGSVHFHDLAHILFDQALLAEGGLPDDPAAYV
HHHHHCCCCCCCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KRVNALLV
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA