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The map label for this gene is yisK [H]

Identifier: 120612904

GI number: 120612904

Start: 4730794

End: 4731663

Strand: Direct

Name: yisK [H]

Synonym: Aave_4268

Alternate gene names: 120612904

Gene position: 4730794-4731663 (Clockwise)

Preceding gene: 120612903

Following gene: 120612905

Centisome position: 88.38

GC content: 70.0

Gene sequence:

>870_bases
ATGAAGCTTCTTTCCTTTCTCACAGGCGGCCAGGTACGCTGGGGCGCCGCCACGCCGGACGGCATCGTCGATCTGGGCCG
GCGCCTGCCCGCGTTCGGCAGCGTGCTCGCGCTGCTCGAAGGCGGCGAGGCGGCGCTGGCGCAGGCGCGCGAGGTGCTCG
CGGGCGCGACCGCTCCCGACCATGCGCTGGACAGCGTCACGCTGCTGCCGCCGGTCCCAGCGCCGCGCAAGATCTTCTGC
ATCGGCGTGAACTACGCGCACCGCAATGCCGAGTACCGCGACGGCAGCGATCTGCCGCGCTACCCGAGCATCTTCCTGCG
CGTGCCGGATTCGTTCGTCGGCCACGGAAGGCCGCTGCTGCAGCCGCACGAATCGCGGCAACTCGACTACGAGGGCGAGA
TCGGCCTCGTGATAGGCCGCGGCGGTCGGCGCATCGCGCGCGAGGACGCGCTGCGCCACATCGCCGGGCTCACCTGCGTG
AACGAGGGCACGGTGCGCGACTGGGTGCACCACGCCAAATTCAACGTCACGCAGGGCAAGAACTTCCATGCCTCCGGCGC
GATGGGCCCCTGGATCGCCACGGCCGACGAATTCCCGCAGGGCTACGGACGGCTGCGCGTGCGCACGCGCGTCAACGGCG
AGACACGGCAGGACGACACGACCGAGCACCTCATGTTCGATTTCGCGCAGCTCATCCACTACCTCTCCACCTTCACCACG
CTGGAGCCCGGCGACGTTGTCGTGACCGGCACGCCCACCGGCGCGGGCATCCGCTTCGATCCGCCGCGGTTCCTGCAACC
CGGCGACGTGGTCGAGGTGGAAGTGGACGGCGTGGGCGTGCTGCGCAATGCCGTGGAGGCCGAGGCATGA

Upstream 100 bases:

>100_bases
GCAGCCTGCTGGAACTGCTCTACCGCTTCGCGCCCGACGCCGCCGTGCGCGAGCGCATCCTCGTCACCAACCCGGCACGG
CTCTTCGGATTCGACACGCC

Downstream 100 bases:

>100_bases
GCGCCGCGTCCGCTGCATCCTCTCCTCCCGCACCCGCCCTGTCGGCAGACCAGCTCGGCGAAGCGGCGCGGCAACTCGAC
GAGGCCGAACGCACGCGCGT

Product: 5-carboxymethyl-2-hydroxymuconate delta-isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKLLSFLTGGQVRWGAATPDGIVDLGRRLPAFGSVLALLEGGEAALAQAREVLAGATAPDHALDSVTLLPPVPAPRKIFC
IGVNYAHRNAEYRDGSDLPRYPSIFLRVPDSFVGHGRPLLQPHESRQLDYEGEIGLVIGRGGRRIAREDALRHIAGLTCV
NEGTVRDWVHHAKFNVTQGKNFHASGAMGPWIATADEFPQGYGRLRVRTRVNGETRQDDTTEHLMFDFAQLIHYLSTFTT
LEPGDVVVTGTPTGAGIRFDPPRFLQPGDVVEVEVDGVGVLRNAVEAEA

Sequences:

>Translated_289_residues
MKLLSFLTGGQVRWGAATPDGIVDLGRRLPAFGSVLALLEGGEAALAQAREVLAGATAPDHALDSVTLLPPVPAPRKIFC
IGVNYAHRNAEYRDGSDLPRYPSIFLRVPDSFVGHGRPLLQPHESRQLDYEGEIGLVIGRGGRRIAREDALRHIAGLTCV
NEGTVRDWVHHAKFNVTQGKNFHASGAMGPWIATADEFPQGYGRLRVRTRVNGETRQDDTTEHLMFDFAQLIHYLSTFTT
LEPGDVVVTGTPTGAGIRFDPPRFLQPGDVVEVEVDGVGVLRNAVEAEA
>Mature_289_residues
MKLLSFLTGGQVRWGAATPDGIVDLGRRLPAFGSVLALLEGGEAALAQAREVLAGATAPDHALDSVTLLPPVPAPRKIFC
IGVNYAHRNAEYRDGSDLPRYPSIFLRVPDSFVGHGRPLLQPHESRQLDYEGEIGLVIGRGGRRIAREDALRHIAGLTCV
NEGTVRDWVHHAKFNVTQGKNFHASGAMGPWIATADEFPQGYGRLRVRTRVNGETRQDDTTEHLMFDFAQLIHYLSTFTT
LEPGDVVVTGTPTGAGIRFDPPRFLQPGDVVEVEVDGVGVLRNAVEAEA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI40786394, Length=269, Percent_Identity=36.4312267657993, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI156231349, Length=293, Percent_Identity=35.1535836177474, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI215422413, Length=184, Percent_Identity=32.0652173913043, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI66348062, Length=184, Percent_Identity=32.0652173913043, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI13654274, Length=184, Percent_Identity=32.0652173913043, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1787428, Length=204, Percent_Identity=32.843137254902, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17557057, Length=199, Percent_Identity=32.6633165829146, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324161, Length=236, Percent_Identity=27.1186440677966, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28572127, Length=225, Percent_Identity=35.5555555555556, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24663695, Length=276, Percent_Identity=29.3478260869565, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28571789, Length=216, Percent_Identity=28.2407407407407, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 31389; Mature: 31389

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLSFLTGGQVRWGAATPDGIVDLGRRLPAFGSVLALLEGGEAALAQAREVLAGATAPD
CCHHHHHCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
HALDSVTLLPPVPAPRKIFCIGVNYAHRNAEYRDGSDLPRYPSIFLRVPDSFVGHGRPLL
HHHCCEEECCCCCCCCEEEEEEECHHHCCCCCCCCCCCCCCCEEEEECCHHHHHCCCCCC
QPHESRQLDYEGEIGLVIGRGGRRIAREDALRHIAGLTCVNEGTVRDWVHHAKFNVTQGK
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCEEECCCHHHHHHHHHEEEECCCC
NFHASGAMGPWIATADEFPQGYGRLRVRTRVNGETRQDDTTEHLMFDFAQLIHYLSTFTT
CEECCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
LEPGDVVVTGTPTGAGIRFDPPRFLQPGDVVEVEVDGVGVLRNAVEAEA
CCCCCEEEECCCCCCCEEECCCCCCCCCCEEEEEECCHHHHHHHHHCCC
>Mature Secondary Structure
MKLLSFLTGGQVRWGAATPDGIVDLGRRLPAFGSVLALLEGGEAALAQAREVLAGATAPD
CCHHHHHCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
HALDSVTLLPPVPAPRKIFCIGVNYAHRNAEYRDGSDLPRYPSIFLRVPDSFVGHGRPLL
HHHCCEEECCCCCCCCEEEEEEECHHHCCCCCCCCCCCCCCCEEEEECCHHHHHCCCCCC
QPHESRQLDYEGEIGLVIGRGGRRIAREDALRHIAGLTCVNEGTVRDWVHHAKFNVTQGK
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCEEECCCHHHHHHHHHEEEECCCC
NFHASGAMGPWIATADEFPQGYGRLRVRTRVNGETRQDDTTEHLMFDFAQLIHYLSTFTT
CEECCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
LEPGDVVVTGTPTGAGIRFDPPRFLQPGDVVEVEVDGVGVLRNAVEAEA
CCCCCEEEECCCCCCCEEECCCCCCCCCCEEEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]