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The map label for this gene is fruA [H]

Identifier: 120612886

GI number: 120612886

Start: 4707678

End: 4709486

Strand: Reverse

Name: fruA [H]

Synonym: Aave_4250

Alternate gene names: 120612886

Gene position: 4709486-4707678 (Counterclockwise)

Preceding gene: 120612887

Following gene: 120612881

Centisome position: 87.98

GC content: 72.86

Gene sequence:

>1809_bases
ATGGCCCAACTCATCGCCATCGCCGCGAGCCAGGCCGGCCCGGCGCACAGCTTCATGGTGGCCGAGGCGCTGCGCGCCGC
GGCCGAATCGCTCGGCCACCGCATCGCCGTGAGCGTACACAGCAGCCTGGGCACCCAGGGCGGCTTCAGCGACGGCGAAC
TGGCGGGCGCCGCGGCGGCCATCATCGCCGCCGACATGCCCGTGGACCGCCAGGACCTGCTGGGCACGGCCGCGGCTCCC
GTGCACGAAGCCGCCCCGCAGGAGGTGCTGGCCGATGCGGAGCGCGTGGTGCGCGCCGCGCTGGCCCGCGCGGGCGGTGC
GCCTGCACGGGTCGCTGCTTCGCTGCCACCCGCCGCGCCCGCTGCGGCTTCGCCCGCAACCGCCGCGCCCCAGGACGGCC
CCCTGCGCATCGTCGCCATCACGTCCTGCCCCACGGGCGTGGCCCACACCTTCATGGCCGCCGAGGCGCTGGAGCAGGGC
GCGCGCGCCCTGGGCCATACCATCAAGGTGGAGACGCAGGGCTCGGTGGGCGCGCAGAACGCGCTCACTGCCGGCGAGAT
CGCCGAGGCCGACCTCGTGGTGATCGCGGCCGATACGCAGGTCAACCGCGACCGCTTCGCCGGCAAGCGCCTCTACGCCA
CCTCCACCAAGGCCGCCATCCACGATGCGGCGGCGGTCTTCGCCCAGGCGCGGGCGCAGGCCCAGGCGTGGGGCGCTTCC
GCATCGCCCGCCCCGGCGGCCGGCGGCTCGGCGGCGGCCCTGGCAACGGCTGGCAAGCGTGAATCCTCCGGCGCCTACAA
GCACCTGATGACGGGCGTCTCCTTCATGCTGCCCTTCGTGGTGGCGGGCGGCCTGCTGATCGCGCTGGCCTTCGCGCTGG
GCGGCATCTACGTCTATGACGACGCCCACAAGGGCACGTTCGGCTGGGTGCTGTTCCAGGTCGGGGCCAAGGCGGGCTTC
GCGCTCATGCTGCCCGCGCTGGCGGGCTACATCGCCTACTCCATCGCCGACCGGCCCGGCATCGCGCCCGGCATGATCGG
CGGCATGCTGGCCGGCACCGTGGGAGCAGGCTTCCTGGGCGCCATCGCGGCAGGCTTCATCGCCGGCTATGCGGTGCACT
GGCTGAACCGCTTCATCCGCCTGCCGCGCGGGCTGGACGGGCTCAAGCCCGTGCTGATCCTGCCGCTGCTGGGCGCGGCC
ATCGTCGGCGTGCTGATGATGATGGTGATCGGCGCGCCCATGGCCGCCGTGATGGGCGCGCTGACGGACTGGCTCAAGGG
CCTGCAGACCGGCAGCGCCGTGCTGCTGGGCGTGATCCTGGGCGCCATGATGGCCTTCGACATGGGCGGGCCGGTGAACA
AGGCGGCCTACGTCTTCTCCACCACCCTGATCGCCAGCGGCGTGGCCAACCCCATGGCCGCCGCCATGGCCGCCGGCATG
ACGCCGCCGCTGGGCATCGCCCTGGCCTGCTGGCTGTTCAAGAACCGCTTCACCGCCGAAGAGCGCGAAGCCTCCAAGGC
CTCCGCCGTGCTGGGCCTGGCCTTCATCACCGAAGGCGCCATTCCCTTCGTGGCGCGCGATCCGCTGCGCGTGATCCCGG
CCTGCGTGCTGGGCTCCGCGGTGGCCGGGGGCCTCTCGATGGCCTGGAACATCGGCCTGCAGGCCCCGCACGGCGGCGTG
TTCGTGCTGGCCATTCCCAACGCCGTGAACCATGTGGTCCTGTATGCGGCCGCGATCCTGGCCGGCACCGTGGTGACGGC
CCTGGCGCTGGGCCTGTTCAAGAAAAAACTGCAGCCTTCCGCCCGCTGA

Upstream 100 bases:

>100_bases
CCAGCGCATCGCGCCGGGACTGCCCCCGCGCGCCGAGGTGGATGCCCTGGCCGCATCCATCCAGGCCACGCCGCTCTAAA
GCAATCAGGAGACACACCCC

Downstream 100 bases:

>100_bases
GGCGCCTGCCGGGGCTGCCGCCACGGCGGCAGCTGCACCGGCCGGATCCTGCTACTTGCGCTTCCGCGCGCCGACTTCGC
CCAGGCGGTAGCTCCCACCC

Product: PTS system, fructose subfamily, IIC subunit

Products: NA

Alternate protein names: EIIBC-Fru; EII-Fru; Fructose-specific phosphotransferase enzyme IIB component; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MAQLIAIAASQAGPAHSFMVAEALRAAAESLGHRIAVSVHSSLGTQGGFSDGELAGAAAAIIAADMPVDRQDLLGTAAAP
VHEAAPQEVLADAERVVRAALARAGGAPARVAASLPPAAPAAASPATAAPQDGPLRIVAITSCPTGVAHTFMAAEALEQG
ARALGHTIKVETQGSVGAQNALTAGEIAEADLVVIAADTQVNRDRFAGKRLYATSTKAAIHDAAAVFAQARAQAQAWGAS
ASPAPAAGGSAAALATAGKRESSGAYKHLMTGVSFMLPFVVAGGLLIALAFALGGIYVYDDAHKGTFGWVLFQVGAKAGF
ALMLPALAGYIAYSIADRPGIAPGMIGGMLAGTVGAGFLGAIAAGFIAGYAVHWLNRFIRLPRGLDGLKPVLILPLLGAA
IVGVLMMMVIGAPMAAVMGALTDWLKGLQTGSAVLLGVILGAMMAFDMGGPVNKAAYVFSTTLIASGVANPMAAAMAAGM
TPPLGIALACWLFKNRFTAEEREASKASAVLGLAFITEGAIPFVARDPLRVIPACVLGSAVAGGLSMAWNIGLQAPHGGV
FVLAIPNAVNHVVLYAAAILAGTVVTALALGLFKKKLQPSAR

Sequences:

>Translated_602_residues
MAQLIAIAASQAGPAHSFMVAEALRAAAESLGHRIAVSVHSSLGTQGGFSDGELAGAAAAIIAADMPVDRQDLLGTAAAP
VHEAAPQEVLADAERVVRAALARAGGAPARVAASLPPAAPAAASPATAAPQDGPLRIVAITSCPTGVAHTFMAAEALEQG
ARALGHTIKVETQGSVGAQNALTAGEIAEADLVVIAADTQVNRDRFAGKRLYATSTKAAIHDAAAVFAQARAQAQAWGAS
ASPAPAAGGSAAALATAGKRESSGAYKHLMTGVSFMLPFVVAGGLLIALAFALGGIYVYDDAHKGTFGWVLFQVGAKAGF
ALMLPALAGYIAYSIADRPGIAPGMIGGMLAGTVGAGFLGAIAAGFIAGYAVHWLNRFIRLPRGLDGLKPVLILPLLGAA
IVGVLMMMVIGAPMAAVMGALTDWLKGLQTGSAVLLGVILGAMMAFDMGGPVNKAAYVFSTTLIASGVANPMAAAMAAGM
TPPLGIALACWLFKNRFTAEEREASKASAVLGLAFITEGAIPFVARDPLRVIPACVLGSAVAGGLSMAWNIGLQAPHGGV
FVLAIPNAVNHVVLYAAAILAGTVVTALALGLFKKKLQPSAR
>Mature_601_residues
AQLIAIAASQAGPAHSFMVAEALRAAAESLGHRIAVSVHSSLGTQGGFSDGELAGAAAAIIAADMPVDRQDLLGTAAAPV
HEAAPQEVLADAERVVRAALARAGGAPARVAASLPPAAPAAASPATAAPQDGPLRIVAITSCPTGVAHTFMAAEALEQGA
RALGHTIKVETQGSVGAQNALTAGEIAEADLVVIAADTQVNRDRFAGKRLYATSTKAAIHDAAAVFAQARAQAQAWGASA
SPAPAAGGSAAALATAGKRESSGAYKHLMTGVSFMLPFVVAGGLLIALAFALGGIYVYDDAHKGTFGWVLFQVGAKAGFA
LMLPALAGYIAYSIADRPGIAPGMIGGMLAGTVGAGFLGAIAAGFIAGYAVHWLNRFIRLPRGLDGLKPVLILPLLGAAI
VGVLMMMVIGAPMAAVMGALTDWLKGLQTGSAVLLGVILGAMMAFDMGGPVNKAAYVFSTTLIASGVANPMAAAMAAGMT
PPLGIALACWLFKNRFTAEEREASKASAVLGLAFITEGAIPFVARDPLRVIPACVLGSAVAGGLSMAWNIGLQAPHGGVF
VLAIPNAVNHVVLYAAAILAGTVVTALALGLFKKKLQPSAR

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=464, Percent_Identity=52.5862068965517, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI87082348, Length=445, Percent_Identity=38.876404494382, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1786951, Length=433, Percent_Identity=38.3371824480369, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1790386, Length=273, Percent_Identity=47.985347985348, Blast_Score=232, Evalue=5e-62,
Organism=Escherichia coli, GI1788729, Length=407, Percent_Identity=28.009828009828, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1790387, Length=99, Percent_Identity=46.4646464646465, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1788730, Length=95, Percent_Identity=42.1052631578947, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 60295; Mature: 60164

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLIAIAASQAGPAHSFMVAEALRAAAESLGHRIAVSVHSSLGTQGGFSDGELAGAAAA
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEHHHCCCCCCCCCCHHHHHHHH
IIAADMPVDRQDLLGTAAAPVHEAAPQEVLADAERVVRAALARAGGAPARVAASLPPAAP
HHHCCCCCCHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
AAASPATAAPQDGPLRIVAITSCPTGVAHTFMAAEALEQGARALGHTIKVETQGSVGAQN
CCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCC
ALTAGEIAEADLVVIAADTQVNRDRFAGKRLYATSTKAAIHDAAAVFAQARAQAQAWGAS
CCCCCCCCCCCEEEEEECCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
ASPAPAAGGSAAALATAGKRESSGAYKHLMTGVSFMLPFVVAGGLLIALAFALGGIYVYD
CCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DAHKGTFGWVLFQVGAKAGFALMLPALAGYIAYSIADRPGIAPGMIGGMLAGTVGAGFLG
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AIAAGFIAGYAVHWLNRFIRLPRGLDGLKPVLILPLLGAAIVGVLMMMVIGAPMAAVMGA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LTDWLKGLQTGSAVLLGVILGAMMAFDMGGPVNKAAYVFSTTLIASGVANPMAAAMAAGM
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
TPPLGIALACWLFKNRFTAEEREASKASAVLGLAFITEGAIPFVARDPLRVIPACVLGSA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
VAGGLSMAWNIGLQAPHGGVFVLAIPNAVNHVVLYAAAILAGTVVTALALGLFKKKLQPS
HHCCHHHHEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AR
CC
>Mature Secondary Structure 
AQLIAIAASQAGPAHSFMVAEALRAAAESLGHRIAVSVHSSLGTQGGFSDGELAGAAAA
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEHHHCCCCCCCCCCHHHHHHHH
IIAADMPVDRQDLLGTAAAPVHEAAPQEVLADAERVVRAALARAGGAPARVAASLPPAAP
HHHCCCCCCHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
AAASPATAAPQDGPLRIVAITSCPTGVAHTFMAAEALEQGARALGHTIKVETQGSVGAQN
CCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCC
ALTAGEIAEADLVVIAADTQVNRDRFAGKRLYATSTKAAIHDAAAVFAQARAQAQAWGAS
CCCCCCCCCCCEEEEEECCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
ASPAPAAGGSAAALATAGKRESSGAYKHLMTGVSFMLPFVVAGGLLIALAFALGGIYVYD
CCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DAHKGTFGWVLFQVGAKAGFALMLPALAGYIAYSIADRPGIAPGMIGGMLAGTVGAGFLG
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AIAAGFIAGYAVHWLNRFIRLPRGLDGLKPVLILPLLGAAIVGVLMMMVIGAPMAAVMGA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LTDWLKGLQTGSAVLLGVILGAMMAFDMGGPVNKAAYVFSTTLIASGVANPMAAAMAAGM
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
TPPLGIALACWLFKNRFTAEEREASKASAVLGLAFITEGAIPFVARDPLRVIPACVLGSA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
VAGGLSMAWNIGLQAPHGGVFVLAIPNAVNHVVLYAAAILAGTVVTALALGLFKKKLQPS
HHCCHHHHEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1655739; 12024217; 1650911 [H]