Click here to switch to the map view.

The map label for this gene is adrA [H]

Identifier: 120612883

GI number: 120612883

Start: 4705262

End: 4706449

Strand: Direct

Name: adrA [H]

Synonym: Aave_4247

Alternate gene names: 120612883

Gene position: 4705262-4706449 (Clockwise)

Preceding gene: 120612882

Following gene: 120612884

Centisome position: 87.9

GC content: 74.16

Gene sequence:

>1188_bases
ATGCCGCCGATGGCACTGGATTTCGTCACGCTGCTGGCCGTCACGGCCACCAACCTGTTCATGCTCTCGATCGCCCTGCC
GCTCATCATGGGGCGGGAGGTGAGCCGTGCCGCGCGCTTCGCGCAGGCCAGCGTGGCGCTGCAGGCCCTGTCCTGGGGCG
CCATCATCGCCTCCTCCCGGCTGTGGGACCAGGCCCTGTCCACGCTCTCCGTCGGTTGCGCGGCGGCGGCGCAATGGGCC
TTGTTCGCGGCCCTGCAGGAATGGCTGGGGCCACGGCCCGGGCGCCGCTGGCTGCCCTGGCTGGTCGCCGCGATACCGAT
CGGCTACACCCTGGGTTTCGGCAGCTACCCCTTCCGCGTGGGCTGGGCCAACCTGCTGCTGGCCGTGCTGCTCGCCACCG
TCGCGCGGGCCACGCTCGCGCCCTGGCGGCCGTCGCCCCGGCACTGGCGCGTGCTGCTGTGCGCCTGCCTCGTCGCCATG
GCCGGCTTCACGGCCGCGCGCGGCGTGCTCGGCGCCTTCACCGAAGCGTATCCGAGCTTCCGCGCGCCGCATCCCGTGAA
CATCGCCGCCGCGCTCGCCGCCAACGTGACACTGGTGCTGGGCACCATGGCAGTGCTCGTGGCATGGCGCACCGAGGCCG
AGGACAAGCTGCGCGCGCTGGCCAAGACGGATGCGCTCACCGGCGTGCTCAACCGGCGCGGCTTCGACGTGCGGGGCCGC
GCGCTGCTGGCGCATGCGCTGCGGCACGGCCTGCGCGTCACCGCCGTGATGCTGGACGTGGACCACTTCAAGCGCGTGAA
CGACACCCATGGGCACGGCACGGGCGACCACGTGCTCGCGTTCTTCGCGCGGCTGCTGCAGGACGCGACACGCACGGGCG
ACGTGGCGGGCCGCATCGGCGGCGAGGAGTTCGCCGTTCTGCTCGCGCATGCGCCGGGCGACCGCGCCGCCGAGAGCTTC
GACCGCCGGCTGCGCGCGCGGCTGGCCGCCGACAGTCCGCAGGCCGTGGGATTCCCGGTCAGCTACAGCGCGGGGGCCGC
CACCCTGGAGGCCGGCCTGCCGGACCCCGGCGCCATGGCCGTCGCCCCGCTGCTCGCGGACCTCATGGCGCGCGCCGATG
CGACTCTCTACGAGGCCAAGCGCGCGGGGCGGGGGCGGCTGCAGGTGCAGCAGGGCACCACAGGCTGA

Upstream 100 bases:

>100_bases
CGCCGGCGGCGTGAGCCGCCTGCACAGCCGCAAGCTGCGCAGCTTCGCGGAAGTCGCCTTCCAGTAGGCGGGACGCCGCG
GCGGCCACGCCACCACGCCG

Downstream 100 bases:

>100_bases
ACACCCGGCGATCACGGCGCCTCGATGTATCCACCGGCAAGGTTATGCAACTTCAGGAAACAGATGTTTACACATCGAGT
CACGCCGATAGCATGGCCCG

Product: diguanylate cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MPPMALDFVTLLAVTATNLFMLSIALPLIMGREVSRAARFAQASVALQALSWGAIIASSRLWDQALSTLSVGCAAAAQWA
LFAALQEWLGPRPGRRWLPWLVAAIPIGYTLGFGSYPFRVGWANLLLAVLLATVARATLAPWRPSPRHWRVLLCACLVAM
AGFTAARGVLGAFTEAYPSFRAPHPVNIAAALAANVTLVLGTMAVLVAWRTEAEDKLRALAKTDALTGVLNRRGFDVRGR
ALLAHALRHGLRVTAVMLDVDHFKRVNDTHGHGTGDHVLAFFARLLQDATRTGDVAGRIGGEEFAVLLAHAPGDRAAESF
DRRLRARLAADSPQAVGFPVSYSAGAATLEAGLPDPGAMAVAPLLADLMARADATLYEAKRAGRGRLQVQQGTTG

Sequences:

>Translated_395_residues
MPPMALDFVTLLAVTATNLFMLSIALPLIMGREVSRAARFAQASVALQALSWGAIIASSRLWDQALSTLSVGCAAAAQWA
LFAALQEWLGPRPGRRWLPWLVAAIPIGYTLGFGSYPFRVGWANLLLAVLLATVARATLAPWRPSPRHWRVLLCACLVAM
AGFTAARGVLGAFTEAYPSFRAPHPVNIAAALAANVTLVLGTMAVLVAWRTEAEDKLRALAKTDALTGVLNRRGFDVRGR
ALLAHALRHGLRVTAVMLDVDHFKRVNDTHGHGTGDHVLAFFARLLQDATRTGDVAGRIGGEEFAVLLAHAPGDRAAESF
DRRLRARLAADSPQAVGFPVSYSAGAATLEAGLPDPGAMAVAPLLADLMARADATLYEAKRAGRGRLQVQQGTTG
>Mature_394_residues
PPMALDFVTLLAVTATNLFMLSIALPLIMGREVSRAARFAQASVALQALSWGAIIASSRLWDQALSTLSVGCAAAAQWAL
FAALQEWLGPRPGRRWLPWLVAAIPIGYTLGFGSYPFRVGWANLLLAVLLATVARATLAPWRPSPRHWRVLLCACLVAMA
GFTAARGVLGAFTEAYPSFRAPHPVNIAAALAANVTLVLGTMAVLVAWRTEAEDKLRALAKTDALTGVLNRRGFDVRGRA
LLAHALRHGLRVTAVMLDVDHFKRVNDTHGHGTGDHVLAFFARLLQDATRTGDVAGRIGGEEFAVLLAHAPGDRAAESFD
RRLRARLAADSPQAVGFPVSYSAGAATLEAGLPDPGAMAVAPLLADLMARADATLYEAKRAGRGRLQVQQGTTG

Specific function: Unknown

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1786584, Length=178, Percent_Identity=32.5842696629214, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1787262, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI145693134, Length=172, Percent_Identity=36.046511627907, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081881, Length=182, Percent_Identity=34.0659340659341, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082007, Length=168, Percent_Identity=35.7142857142857, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787541, Length=179, Percent_Identity=33.5195530726257, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787802, Length=167, Percent_Identity=32.3353293413174, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788381, Length=186, Percent_Identity=32.7956989247312, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081974, Length=164, Percent_Identity=28.6585365853659, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787816, Length=169, Percent_Identity=33.1360946745562, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081977, Length=180, Percent_Identity=30.5555555555556, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR007894 [H]

Pfam domain/function: PF00990 GGDEF; PF05230 MASE2 [H]

EC number: NA

Molecular weight: Translated: 42001; Mature: 41870

Theoretical pI: Translated: 11.01; Mature: 11.01

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPMALDFVTLLAVTATNLFMLSIALPLIMGREVSRAARFAQASVALQALSWGAIIASSR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWDQALSTLSVGCAAAAQWALFAALQEWLGPRPGRRWLPWLVAAIPIGYTLGFGSYPFRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEECCCCCCHHH
GWANLLLAVLLATVARATLAPWRPSPRHWRVLLCACLVAMAGFTAARGVLGAFTEAYPSF
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RAPHPVNIAAALAANVTLVLGTMAVLVAWRTEAEDKLRALAKTDALTGVLNRRGFDVRGR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ALLAHALRHGLRVTAVMLDVDHFKRVNDTHGHGTGDHVLAFFARLLQDATRTGDVAGRIG
HHHHHHHHCCCEEEHHEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCC
GEEFAVLLAHAPGDRAAESFDRRLRARLAADSPQAVGFPVSYSAGAATLEAGLPDPGAMA
CHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHH
VAPLLADLMARADATLYEAKRAGRGRLQVQQGTTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC
>Mature Secondary Structure 
PPMALDFVTLLAVTATNLFMLSIALPLIMGREVSRAARFAQASVALQALSWGAIIASSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWDQALSTLSVGCAAAAQWALFAALQEWLGPRPGRRWLPWLVAAIPIGYTLGFGSYPFRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEECCCCCCHHH
GWANLLLAVLLATVARATLAPWRPSPRHWRVLLCACLVAMAGFTAARGVLGAFTEAYPSF
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RAPHPVNIAAALAANVTLVLGTMAVLVAWRTEAEDKLRALAKTDALTGVLNRRGFDVRGR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ALLAHALRHGLRVTAVMLDVDHFKRVNDTHGHGTGDHVLAFFARLLQDATRTGDVAGRIG
HHHHHHHHCCCEEEHHEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCC
GEEFAVLLAHAPGDRAAESFDRRLRARLAADSPQAVGFPVSYSAGAATLEAGLPDPGAMA
CHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHH
VAPLLADLMARADATLYEAKRAGRGRLQVQQGTTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]