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The map label for this gene is dtd

Identifier: 120612879

GI number: 120612879

Start: 4700721

End: 4701188

Strand: Reverse

Name: dtd

Synonym: Aave_4243

Alternate gene names: 120612879

Gene position: 4701188-4700721 (Counterclockwise)

Preceding gene: 120612880

Following gene: 120612876

Centisome position: 87.83

GC content: 72.86

Gene sequence:

>468_bases
ATGATGGGCCTGCTGCAGCGCGTGCGCGAGGCGCGCGTGGAGATCGACGGAGAGACCGTGGGCCGCATCGGCCCCGGCCT
GCTCGTGCTGGTGTGCGCCGAACGCGGCGACACGCAAGCGGAGGCCGACCGCCTCCTGGACAAGCTGCTCAGGCTGCGCA
TCTTCGCCGACGAGGCCGGCAAGATGAATCGCAGCGTGCAGGATACGGGCGGGGGCCTGTTGCTCGTGAGCCAGTTCACT
CTGGCGGCCGACACGCGCGGCGGCAACCGCCCGAGCTTCACGCAGGCGGCCGCGCCGGACGACGGCCGCCGGCTCTACGA
CCACTTCGTGGCGCGCGCCCGCGCCCTGCACCCGGTGGTGGAGACGGGGCGCTTCGCGGCCGAGATGCAGGTGCACCTCG
TCAACGACGGGCCGGTGACGATCCCGCTGCGGATCGCCCCGCCGGGCACGGTCCAGAACGGCCCATAG

Upstream 100 bases:

>100_bases
ATGCCGTGCCCGGCCTGCGCGCCACCATCGAACTGCTGCCCACGGGCATGGAAGCCGTGGCCACCCCCATGGAAGACGAC
GAAACGAGGAGCCCGCACCC

Downstream 100 bases:

>100_bases
AGCCCGGCGAAACGGTTCTGGCGAGGCGTCGCATCGGCAGGCAGTACGCCCGGTACGGCAAGATGCGGCAACGACGCCAG
AAGGGCTCTGTGGGCCGTTC

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MMGLLQRVREARVEIDGETVGRIGPGLLVLVCAERGDTQAEADRLLDKLLRLRIFADEAGKMNRSVQDTGGGLLLVSQFT
LAADTRGGNRPSFTQAAAPDDGRRLYDHFVARARALHPVVETGRFAAEMQVHLVNDGPVTIPLRIAPPGTVQNGP

Sequences:

>Translated_155_residues
MMGLLQRVREARVEIDGETVGRIGPGLLVLVCAERGDTQAEADRLLDKLLRLRIFADEAGKMNRSVQDTGGGLLLVSQFT
LAADTRGGNRPSFTQAAAPDDGRRLYDHFVARARALHPVVETGRFAAEMQVHLVNDGPVTIPLRIAPPGTVQNGP
>Mature_155_residues
MMGLLQRVREARVEIDGETVGRIGPGLLVLVCAERGDTQAEADRLLDKLLRLRIFADEAGKMNRSVQDTGGGLLLVSQFT
LAADTRGGNRPSFTQAAAPDDGRRLYDHFVARARALHPVVETGRFAAEMQVHLVNDGPVTIPLRIAPPGTVQNGP

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=158, Percent_Identity=39.873417721519, Blast_Score=113, Evalue=6e-26,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=54.4827586206897, Blast_Score=161, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI115533292, Length=146, Percent_Identity=39.7260273972603, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319982, Length=146, Percent_Identity=37.6712328767123, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281361569, Length=145, Percent_Identity=41.3793103448276, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_ACIAC (A1TUZ5)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972557.1
- ProteinModelPortal:   A1TUZ5
- SMR:   A1TUZ5
- STRING:   A1TUZ5
- GeneID:   4666490
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4243
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   A1TUZ5
- ProtClustDB:   PRK05273
- BioCyc:   AAVE397945:AAVE_4243-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16734; Mature: 16734

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGLLQRVREARVEIDGETVGRIGPGLLVLVCAERGDTQAEADRLLDKLLRLRIFADEAG
CHHHHHHHHHHHEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
KMNRSVQDTGGGLLLVSQFTLAADTRGGNRPSFTQAAAPDDGRRLYDHFVARARALHPVV
CCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ETGRFAAEMQVHLVNDGPVTIPLRIAPPGTVQNGP
HCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MMGLLQRVREARVEIDGETVGRIGPGLLVLVCAERGDTQAEADRLLDKLLRLRIFADEAG
CHHHHHHHHHHHEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
KMNRSVQDTGGGLLLVSQFTLAADTRGGNRPSFTQAAAPDDGRRLYDHFVARARALHPVV
CCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ETGRFAAEMQVHLVNDGPVTIPLRIAPPGTVQNGP
HCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA