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The map label for this gene is ruvA

Identifier: 120612876

GI number: 120612876

Start: 4698574

End: 4699146

Strand: Reverse

Name: ruvA

Synonym: Aave_4240

Alternate gene names: 120612876

Gene position: 4699146-4698574 (Counterclockwise)

Preceding gene: 120612879

Following gene: 120612875

Centisome position: 87.79

GC content: 65.97

Gene sequence:

>573_bases
ATGATAGGCAAACTCACCGGCACGCTGCTGGAGAAAAACCCGCCCGAGGTGCTGGTGGACTGCCATGGCGTGGGCTATGA
AGTGCAGGTGCCGATGAGCACCTTCTACAACCTGCCCGCCGTGGGCGAGCGCGTGCAGTTGCTCACGCAGTTCATCGTAC
GCGAGGATGCGCAATTGCTCTATGGCTTTGGCAGCGCGCCGGAGCGCCAGGCGTTCCGCGAACTCATCAAGATCTCGGGC
GTGGGGCCGCGCACGGCGCTGTCCATCCTCTCCGGCATGGGCGTGGACGACCTGGCCCAGGCCGTGTCGCTGCAGGAGGC
CGGGCGCCTCGTGAAGGTGCCCGGCATCGGCAAGAAGACCGCCGAGCGCCTGCTGCTGGAACTCAAGGGCAAGCTGGGCG
TGGACATCGGTGCCCGCCCCGAGGCCGCGAACGATGCGCAGGCCGACATCCTGCAGGCCCTGCTGGCCCTGGGATACAAC
GATAAGGAAGGCACCGCCGCGCTCAAGGCATTGCCGAAGGACGTGGGGGTCAGCGAGGGCATCAAATTGGCGCTCAAGGC
ACTGGCGAAGTGA

Upstream 100 bases:

>100_bases
GGTGCGTGAGCCGGATGTTGTTGTGGGGAGTGAAGGTATGGCGCAGGATCACGCGGATAATTCCGGTTGGACGTCAGCAG
GACGAAAAGACAGGACGAAG

Downstream 100 bases:

>100_bases
AGTCAGCCCTTCCCGGCACGCCAGTGCCGGACGCTGTGGGATGGGCGAAAAATGAACCAAAACATGAAAAATCACAGGGT
TTCCAAATGGAAGATCGCGC

Product: Holliday junction DNA helicase RuvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MIGKLTGTLLEKNPPEVLVDCHGVGYEVQVPMSTFYNLPAVGERVQLLTQFIVREDAQLLYGFGSAPERQAFRELIKISG
VGPRTALSILSGMGVDDLAQAVSLQEAGRLVKVPGIGKKTAERLLLELKGKLGVDIGARPEAANDAQADILQALLALGYN
DKEGTAALKALPKDVGVSEGIKLALKALAK

Sequences:

>Translated_190_residues
MIGKLTGTLLEKNPPEVLVDCHGVGYEVQVPMSTFYNLPAVGERVQLLTQFIVREDAQLLYGFGSAPERQAFRELIKISG
VGPRTALSILSGMGVDDLAQAVSLQEAGRLVKVPGIGKKTAERLLLELKGKLGVDIGARPEAANDAQADILQALLALGYN
DKEGTAALKALPKDVGVSEGIKLALKALAK
>Mature_190_residues
MIGKLTGTLLEKNPPEVLVDCHGVGYEVQVPMSTFYNLPAVGERVQLLTQFIVREDAQLLYGFGSAPERQAFRELIKISG
VGPRTALSILSGMGVDDLAQAVSLQEAGRLVKVPGIGKKTAERLLLELKGKLGVDIGARPEAANDAQADILQALLALGYN
DKEGTAALKALPKDVGVSEGIKLALKALAK

Specific function: The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday

COG id: COG0632

COG function: function code L; Holliday junction resolvasome, DNA-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvA family

Homologues:

Organism=Escherichia coli, GI1788168, Length=202, Percent_Identity=46.5346534653465, Blast_Score=172, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVA_ACIAC (A1TUZ2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972554.1
- ProteinModelPortal:   A1TUZ2
- SMR:   A1TUZ2
- STRING:   A1TUZ2
- GeneID:   4668127
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4240
- NMPDR:   fig|397945.5.peg.3639
- eggNOG:   COG0632
- HOGENOM:   HBG635309
- OMA:   LSIETYV
- PhylomeDB:   A1TUZ2
- ProtClustDB:   PRK00116
- BioCyc:   AAVE397945:AAVE_4240-MONOMER
- HAMAP:   MF_00031
- InterPro:   IPR011114
- InterPro:   IPR013849
- InterPro:   IPR003583
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR000085
- InterPro:   IPR010994
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00278
- TIGRFAMs:   TIGR00084

Pfam domain/function: PF07499 RuvA_C; PF01330 RuvA_N; SSF50249 Nucleic_acid_OB; SSF47781 RuvA_2_like; SSF46929 RuvA_C-like

EC number: =3.6.4.12

Molecular weight: Translated: 20101; Mature: 20101

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGKLTGTLLEKNPPEVLVDCHGVGYEVQVPMSTFYNLPAVGERVQLLTQFIVREDAQLL
CCCCHHHHHHCCCCCCEEEEECCCCEEEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
YGFGSAPERQAFRELIKISGVGPRTALSILSGMGVDDLAQAVSLQEAGRLVKVPGIGKKT
HCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCCHHH
AERLLLELKGKLGVDIGARPEAANDAQADILQALLALGYNDKEGTAALKALPKDVGVSEG
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHH
IKLALKALAK
HHHHHHHHCC
>Mature Secondary Structure
MIGKLTGTLLEKNPPEVLVDCHGVGYEVQVPMSTFYNLPAVGERVQLLTQFIVREDAQLL
CCCCHHHHHHCCCCCCEEEEECCCCEEEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
YGFGSAPERQAFRELIKISGVGPRTALSILSGMGVDDLAQAVSLQEAGRLVKVPGIGKKT
HCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCCHHH
AERLLLELKGKLGVDIGARPEAANDAQADILQALLALGYNDKEGTAALKALPKDVGVSEG
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHH
IKLALKALAK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA