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The map label for this gene is ddc [H]

Identifier: 120612857

GI number: 120612857

Start: 4678164

End: 4679630

Strand: Direct

Name: ddc [H]

Synonym: Aave_4221

Alternate gene names: 120612857

Gene position: 4678164-4679630 (Clockwise)

Preceding gene: 120612856

Following gene: 120612861

Centisome position: 87.4

GC content: 63.05

Gene sequence:

>1467_bases
GTGACGGAATCGTGGAAAGAGCACTTCATCCGGACGGGCTGCGGAGGTGCTGATCGTTATCGTGCCGTGATGGAGTCCTG
CGTGGAGGAACTGTCGAGTCTTTTCGAGACTGCGGTGCGCCCCTATTCGGGCAGGGAGCCGTCCGATCTGCGCGAGCAGG
TCTTCCTGCGTGACCTCGGAGTGCAAGCGGTAGCACCGCTGCAGCAGGTGATCCGGGAAGTACGCCAGGACATCGCTGCG
CATGCAATCATCGTCCAGCACCCGCATTGCATCGCCCACCTGCACACGCCACCACTCCTGAGCGGCATCGCTGCGGAAAG
CTTCATCGCGGCACAGAACCTTTCGATGGATTCTTGGGACCAATCGGGCTCCGCCACTTTTGTCGAGCAGCGGGTCGTGG
ACCACCTCTGCACACTGTTCGGATATCTCCCCGAGGCGGACGGTGTGTTTACCAGCGGAGGCACCCAGGGCAACATCATG
GCCCTGCTCACGGCACGGGACTGGTTCCTGTGGACGCACCACGGGCACCGGGCCAGGCGTGACGGCATGCCCGATTTTTT
CCCCAGGCTGAGGATCATCGCCTCGGCCAAGAGCCACTTCACGGTGGACAAGGCAGCCTTCATCATGGGGCTGGGACAGC
GCGGCGTGGTGAAGGTGCGGACGGGAAACGACGGTGCCATGGACATGGAGGAGCTGGCATCAACGGTCGAGTCTCTGCGG
CAGGAGGGTCTGATCCCCTTCGCCGTGGTGGGAACGGCGGGCACCACGGACCATGGCGCCATCGACGATCTGCAGCGCAT
CGGCGAAATCTCCCGGGCGCACGGCTTATGGTTCCATGTGGATGGCGCCTACGGCTCTGCCCTGGTGCTGGGCCGCCACA
GGCACCGGCTCGCCGGTATCGAGCAGGCCGATTCGATGGTGGCCGATTTCCACAAGCTGTGGTTTCAGCCCGTGAGTTGC
GGGGCCCTGCTGTTCCGCGAAGGGGAACGCTTCAGGCACCTGCTCTACCAGGCTGAATACCTGAACCGCGAGACCGATGA
TCTTCCCAACCTCGTGGACAAGACGATCTCCACGACGAGACGCTTCGACGCCTTGAAGGTCTACATGATGCTACGGGCGG
TCGGCACCGAAGTGCTGGGAGAGATGATCGACCACCTGCTTGGACAGGCGCGCGAGGTTGCCGAGGCCATCCGACGCCGC
AGCATGTTCGAGCTTCTGGCCGAGCCGAGCCTGACAACCATTCTTTTCAGGTACACCGGCCCCATGCCCGGTACTGATAT
CGACGCTTTCAACCGCAGGCTTCGCGCCGGACTTCTCAAGCACGGCATAGCCGTACTGGGGGAGACGACTGTCCAGCAGC
GCGCTGCGCTGAAGCTGACTCTGCTGAACCCCTGCCTTGCCGCGGAGGACTTCGACAGCCTCCTGGACAACATTGCCGCC
TTCGCAGCCCGCGTCTACAGCGAGTAG

Upstream 100 bases:

>100_bases
CGGTCTTGCGCTTTCTCCCCCCCTTGAACATCACGGATGATCAGATCGATTTCGCGGCCCGGGCCTTCACACACGCCATG
CAGGCCACGGAGCAGGCACG

Downstream 100 bases:

>100_bases
CCGAGCATCATCGCCACACCCGCCTCCTTGTTGGGACGGCTGAAGCTATCGCGCGTCAGCCGGCCCACCGGGATGGCGAT
CTGGTTGTTCAGGAACCACT

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTESWKEHFIRTGCGGADRYRAVMESCVEELSSLFETAVRPYSGREPSDLREQVFLRDLGVQAVAPLQQVIREVRQDIAA
HAIIVQHPHCIAHLHTPPLLSGIAAESFIAAQNLSMDSWDQSGSATFVEQRVVDHLCTLFGYLPEADGVFTSGGTQGNIM
ALLTARDWFLWTHHGHRARRDGMPDFFPRLRIIASAKSHFTVDKAAFIMGLGQRGVVKVRTGNDGAMDMEELASTVESLR
QEGLIPFAVVGTAGTTDHGAIDDLQRIGEISRAHGLWFHVDGAYGSALVLGRHRHRLAGIEQADSMVADFHKLWFQPVSC
GALLFREGERFRHLLYQAEYLNRETDDLPNLVDKTISTTRRFDALKVYMMLRAVGTEVLGEMIDHLLGQAREVAEAIRRR
SMFELLAEPSLTTILFRYTGPMPGTDIDAFNRRLRAGLLKHGIAVLGETTVQQRAALKLTLLNPCLAAEDFDSLLDNIAA
FAARVYSE

Sequences:

>Translated_488_residues
MTESWKEHFIRTGCGGADRYRAVMESCVEELSSLFETAVRPYSGREPSDLREQVFLRDLGVQAVAPLQQVIREVRQDIAA
HAIIVQHPHCIAHLHTPPLLSGIAAESFIAAQNLSMDSWDQSGSATFVEQRVVDHLCTLFGYLPEADGVFTSGGTQGNIM
ALLTARDWFLWTHHGHRARRDGMPDFFPRLRIIASAKSHFTVDKAAFIMGLGQRGVVKVRTGNDGAMDMEELASTVESLR
QEGLIPFAVVGTAGTTDHGAIDDLQRIGEISRAHGLWFHVDGAYGSALVLGRHRHRLAGIEQADSMVADFHKLWFQPVSC
GALLFREGERFRHLLYQAEYLNRETDDLPNLVDKTISTTRRFDALKVYMMLRAVGTEVLGEMIDHLLGQAREVAEAIRRR
SMFELLAEPSLTTILFRYTGPMPGTDIDAFNRRLRAGLLKHGIAVLGETTVQQRAALKLTLLNPCLAAEDFDSLLDNIAA
FAARVYSE
>Mature_487_residues
TESWKEHFIRTGCGGADRYRAVMESCVEELSSLFETAVRPYSGREPSDLREQVFLRDLGVQAVAPLQQVIREVRQDIAAH
AIIVQHPHCIAHLHTPPLLSGIAAESFIAAQNLSMDSWDQSGSATFVEQRVVDHLCTLFGYLPEADGVFTSGGTQGNIMA
LLTARDWFLWTHHGHRARRDGMPDFFPRLRIIASAKSHFTVDKAAFIMGLGQRGVVKVRTGNDGAMDMEELASTVESLRQ
EGLIPFAVVGTAGTTDHGAIDDLQRIGEISRAHGLWFHVDGAYGSALVLGRHRHRLAGIEQADSMVADFHKLWFQPVSCG
ALLFREGERFRHLLYQAEYLNRETDDLPNLVDKTISTTRRFDALKVYMMLRAVGTEVLGEMIDHLLGQAREVAEAIRRRS
MFELLAEPSLTTILFRYTGPMPGTDIDAFNRRLRAGLLKHGIAVLGETTVQQRAALKLTLLNPCLAAEDFDSLLDNIAAF
AARVYSE

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=488, Percent_Identity=29.5081967213115, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI194294551, Length=450, Percent_Identity=28.2222222222222, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI58331246, Length=433, Percent_Identity=26.0969976905312, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI197276620, Length=422, Percent_Identity=27.2511848341232, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4503875, Length=422, Percent_Identity=27.2511848341232, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI92110055, Length=467, Percent_Identity=25.0535331905782, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI4503281, Length=401, Percent_Identity=26.6832917705736, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI132814448, Length=401, Percent_Identity=26.6832917705736, Blast_Score=111, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71993062, Length=428, Percent_Identity=29.6728971962617, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17555682, Length=422, Percent_Identity=29.8578199052133, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71993058, Length=341, Percent_Identity=32.258064516129, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI133931025, Length=370, Percent_Identity=26.7567567567568, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17534817, Length=401, Percent_Identity=26.6832917705736, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534819, Length=399, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71981211, Length=486, Percent_Identity=23.4567901234568, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17551992, Length=275, Percent_Identity=28, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71981217, Length=298, Percent_Identity=26.1744966442953, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17136594, Length=494, Percent_Identity=28.3400809716599, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21356415, Length=364, Percent_Identity=29.6703296703297, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24657193, Length=380, Percent_Identity=30, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24657185, Length=380, Percent_Identity=30, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24657188, Length=380, Percent_Identity=30, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28573972, Length=379, Percent_Identity=27.4406332453826, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24586044, Length=477, Percent_Identity=26.6247379454927, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24652373, Length=374, Percent_Identity=28.6096256684492, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI221476190, Length=230, Percent_Identity=32.6086956521739, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585143, Length=230, Percent_Identity=32.6086956521739, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585139, Length=230, Percent_Identity=32.6086956521739, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17136190, Length=354, Percent_Identity=25.1412429378531, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585135, Length=322, Percent_Identity=25.4658385093168, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 54264; Mature: 54132

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESWKEHFIRTGCGGADRYRAVMESCVEELSSLFETAVRPYSGREPSDLREQVFLRDLG
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
VQAVAPLQQVIREVRQDIAAHAIIVQHPHCIAHLHTPPLLSGIAAESFIAAQNLSMDSWD
HHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCC
QSGSATFVEQRVVDHLCTLFGYLPEADGVFTSGGTQGNIMALLTARDWFLWTHHGHRARR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEEEECCEEEEECCCCHHHH
DGMPDFFPRLRIIASAKSHFTVDKAAFIMGLGQRGVVKVRTGNDGAMDMEELASTVESLR
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
QEGLIPFAVVGTAGTTDHGAIDDLQRIGEISRAHGLWFHVDGAYGSALVLGRHRHRLAGI
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHCCHHHHHHCH
EQADSMVADFHKLWFQPVSCGALLFREGERFRHLLYQAEYLNRETDDLPNLVDKTISTTR
HHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RFDALKVYMMLRAVGTEVLGEMIDHLLGQAREVAEAIRRRSMFELLAEPSLTTILFRYTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECC
PMPGTDIDAFNRRLRAGLLKHGIAVLGETTVQQRAALKLTLLNPCLAAEDFDSLLDNIAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
FAARVYSE
HHHHHHCC
>Mature Secondary Structure 
TESWKEHFIRTGCGGADRYRAVMESCVEELSSLFETAVRPYSGREPSDLREQVFLRDLG
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
VQAVAPLQQVIREVRQDIAAHAIIVQHPHCIAHLHTPPLLSGIAAESFIAAQNLSMDSWD
HHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCC
QSGSATFVEQRVVDHLCTLFGYLPEADGVFTSGGTQGNIMALLTARDWFLWTHHGHRARR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEEEECCEEEEECCCCHHHH
DGMPDFFPRLRIIASAKSHFTVDKAAFIMGLGQRGVVKVRTGNDGAMDMEELASTVESLR
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
QEGLIPFAVVGTAGTTDHGAIDDLQRIGEISRAHGLWFHVDGAYGSALVLGRHRHRLAGI
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHCCHHHHHHCH
EQADSMVADFHKLWFQPVSCGALLFREGERFRHLLYQAEYLNRETDDLPNLVDKTISTTR
HHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RFDALKVYMMLRAVGTEVLGEMIDHLLGQAREVAEAIRRRSMFELLAEPSLTTILFRYTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECC
PMPGTDIDAFNRRLRAGLLKHGIAVLGETTVQQRAALKLTLLNPCLAAEDFDSLLDNIAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
FAARVYSE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]