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The map label for this gene is trxC [C]

Identifier: 120612845

GI number: 120612845

Start: 4664386

End: 4664841

Strand: Reverse

Name: trxC [C]

Synonym: Aave_4209

Alternate gene names: 120612845

Gene position: 4664841-4664386 (Counterclockwise)

Preceding gene: 120612849

Following gene: 120612843

Centisome position: 87.15

GC content: 74.12

Gene sequence:

>456_bases
ATGCCCGAATCCCTGCACATCGTCTGCCCGCACTGCCACACCACCAACCGCATCGCGGCCGACCGGCTGGCCGCGCCGCC
CGGCACGGTCGAGGCGGACTGCGGGCAGTGCCACCGGCCGCTTTTCACGGGCGAGCCCGTGGCGCTCGACGATGCCTCCT
TCGGGCGCCATACCGAACGCAGCCACATTCCGGTGGTGGTGGATTTCTGGGCGCCATGGTGCGGTCCCTGCCGCACCATG
GCCCCGGCCTTCGCGCAGGCGGCCCGGGCGCTCGAGCCGGGCGTGCGGCTCGCCAAGCTCGACACCGAGGCGCATCCCGC
CATCGGCGCGCGCCTGGGCATCCGCAGCATCCCGACGATGGTGATGTTCCGCCAGGGGCGGGAAGTCGCGCGCATCTCGG
GGGCGATGGGCGCCGCCGACATCGCGCGCTGGGTGCGGACGGCCGGCGGCGCCTGA

Upstream 100 bases:

>100_bases
ATTGCCGAGCCTGTAGTCCGCGAGGCTGGCGCCCTGTAGGCGTGCCCAGCCGCCATGCGCGCGCCTTGAAAACCCAGGCA
GCGCCGCGCATCTGCCGCCC

Downstream 100 bases:

>100_bases
GGCCGCGGGCCCGCGGCACGGGGCCGTCAGGTTCCGGCCGCGGGCGGCTGCGCCGCCATCCACTCCTGCACCGCGTCGCC
GCGCGCCCGGCGGATCCATT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MPESLHIVCPHCHTTNRIAADRLAAPPGTVEADCGQCHRPLFTGEPVALDDASFGRHTERSHIPVVVDFWAPWCGPCRTM
APAFAQAARALEPGVRLAKLDTEAHPAIGARLGIRSIPTMVMFRQGREVARISGAMGAADIARWVRTAGGA

Sequences:

>Translated_151_residues
MPESLHIVCPHCHTTNRIAADRLAAPPGTVEADCGQCHRPLFTGEPVALDDASFGRHTERSHIPVVVDFWAPWCGPCRTM
APAFAQAARALEPGVRLAKLDTEAHPAIGARLGIRSIPTMVMFRQGREVARISGAMGAADIARWVRTAGGA
>Mature_150_residues
PESLHIVCPHCHTTNRIAADRLAAPPGTVEADCGQCHRPLFTGEPVALDDASFGRHTERSHIPVVVDFWAPWCGPCRTMA
PAFAQAARALEPGVRLAKLDTEAHPAIGARLGIRSIPTMVMFRQGREVARISGAMGAADIARWVRTAGGA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI20070125, Length=95, Percent_Identity=33.6842105263158, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI94966757, Length=102, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1788936, Length=144, Percent_Identity=38.8888888888889, Blast_Score=118, Evalue=1e-28,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=32.3232323232323, Blast_Score=78, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32566189, Length=89, Percent_Identity=34.8314606741573, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=104, Percent_Identity=34.6153846153846, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=89, Percent_Identity=34.8314606741573, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=89, Percent_Identity=34.8314606741573, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=84, Percent_Identity=36.9047619047619, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=89, Percent_Identity=34.8314606741573, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=27.9569892473118, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17647799, Length=89, Percent_Identity=40.4494382022472, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921434, Length=102, Percent_Identity=32.3529411764706, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573567, Length=110, Percent_Identity=30.9090909090909, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 16155; Mature: 16024

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESLHIVCPHCHTTNRIAADRLAAPPGTVEADCGQCHRPLFTGEPVALDDASFGRHTER
CCCCCEEECCCCCCCCCHHHHHHCCCCCCCCCCCHHCCCCCCCCCCEEECCCCCCCCCCC
SHIPVVVDFWAPWCGPCRTMAPAFAQAARALEPGVRLAKLDTEAHPAIGARLGIRSIPTM
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCHHHHHHH
VMFRQGREVARISGAMGAADIARWVRTAGGA
HHHHCCCHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
PESLHIVCPHCHTTNRIAADRLAAPPGTVEADCGQCHRPLFTGEPVALDDASFGRHTER
CCCCEEECCCCCCCCCHHHHHHCCCCCCCCCCCHHCCCCCCCCCCEEECCCCCCCCCCC
SHIPVVVDFWAPWCGPCRTMAPAFAQAARALEPGVRLAKLDTEAHPAIGARLGIRSIPTM
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCHHHHHHH
VMFRQGREVARISGAMGAADIARWVRTAGGA
HHHHCCCHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8652661 [H]