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The map label for this gene is coaX

Identifier: 120612806

GI number: 120612806

Start: 4621836

End: 4622600

Strand: Reverse

Name: coaX

Synonym: Aave_4169

Alternate gene names: 120612806

Gene position: 4622600-4621836 (Counterclockwise)

Preceding gene: 120612809

Following gene: 120612803

Centisome position: 86.36

GC content: 69.41

Gene sequence:

>765_bases
ATGACTTTTCTGGCCATCGACGTCGGCAACACCCGCCTGAAATGGGCGATGTATGACGCTCCCAAGCCGGGCGCCGCCGT
GCTGGCCCACGGCGCCGAATTCCTCGACCACATCGAGCGCCTCGCGGACAGCGCCTGGGCAGGGCTGCCCGCGCCCACGC
GCATGCTCGGCTGCGTGGTGGCCGGCGATGCCGTGCGCCGGCGCGTCATGGAGCAGATGGAATGGTGGGACGTGCCCTCC
CACTGGGTGGTGCCTTCCGCCGAGGAGGCGGGGCTCGTCAATGGCTACGACCATCCCACGCGCCTGGGTTCGGACCGCTG
GGTGGCCATGATCGGCGCGCGCCACCGGCTGCTGCGGCAGGGCCCGGCCCGGCCCCTGGTGGTGGTGATGGTCGGAACGG
CGGTGACCGTGGAAGCCATCGATGCCGAAGGCCGCTTCCTCGGAGGCCTCATCCTGCCGGGGCACGGCATCATGCTGCGG
GCCCTGGAATCCGGCACCGCGGGGCTGCACGTTCCCACCGGCGAAGTGAAGCTGTTCCCCACCAACACCAGCGATGCGCT
CACCAGCGGCGGCACCTACGCCATCGCCGGCGCCGTCGAGCGCATGGTGCAGCATGTCATCCAGCACTGCGGCGAAGAGC
CCGCGTGCATGATGACCGGGGGGGCAGGCTGGAAAATGGCGCCCAGCATGACCCGGCCGTTCGATCTCATCGAAAACCTG
ATCTTCGAGGGATTGCTCGCCATCGCGGCGGAGCGGTTCCGCTAG

Upstream 100 bases:

>100_bases
TCGGACATCGGCCCGAGCCCGGCCGTGGATCCAGGCAGGGCGCAACCGCGGTGTGCCGCACGGAACAGCCGCGTTTGTAA
AACTCGTGATAATCCGCCGC

Downstream 100 bases:

>100_bases
CCTTCGGCGAGTTCCAGCCGCGCCAGTTCCACGGCCAGCCGCTCCGCCGCGTCGGCGGCCTCGGCGCCTGCCGCCTCCTC
GTAGAGCTTGGCGGCCAGGT

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTFLAIDVGNTRLKWAMYDAPKPGAAVLAHGAEFLDHIERLADSAWAGLPAPTRMLGCVVAGDAVRRRVMEQMEWWDVPS
HWVVPSAEEAGLVNGYDHPTRLGSDRWVAMIGARHRLLRQGPARPLVVVMVGTAVTVEAIDAEGRFLGGLILPGHGIMLR
ALESGTAGLHVPTGEVKLFPTNTSDALTSGGTYAIAGAVERMVQHVIQHCGEEPACMMTGGAGWKMAPSMTRPFDLIENL
IFEGLLAIAAERFR

Sequences:

>Translated_254_residues
MTFLAIDVGNTRLKWAMYDAPKPGAAVLAHGAEFLDHIERLADSAWAGLPAPTRMLGCVVAGDAVRRRVMEQMEWWDVPS
HWVVPSAEEAGLVNGYDHPTRLGSDRWVAMIGARHRLLRQGPARPLVVVMVGTAVTVEAIDAEGRFLGGLILPGHGIMLR
ALESGTAGLHVPTGEVKLFPTNTSDALTSGGTYAIAGAVERMVQHVIQHCGEEPACMMTGGAGWKMAPSMTRPFDLIENL
IFEGLLAIAAERFR
>Mature_253_residues
TFLAIDVGNTRLKWAMYDAPKPGAAVLAHGAEFLDHIERLADSAWAGLPAPTRMLGCVVAGDAVRRRVMEQMEWWDVPSH
WVVPSAEEAGLVNGYDHPTRLGSDRWVAMIGARHRLLRQGPARPLVVVMVGTAVTVEAIDAEGRFLGGLILPGHGIMLRA
LESGTAGLHVPTGEVKLFPTNTSDALTSGGTYAIAGAVERMVQHVIQHCGEEPACMMTGGAGWKMAPSMTRPFDLIENLI
FEGLLAIAAERFR

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_ACIAC (A1TUS2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972484.1
- ProteinModelPortal:   A1TUS2
- SMR:   A1TUS2
- STRING:   A1TUS2
- GeneID:   4667817
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4169
- NMPDR:   fig|397945.5.peg.3570
- eggNOG:   COG1521
- HOGENOM:   HBG634537
- OMA:   RTTIRSR
- ProtClustDB:   PRK13329
- BioCyc:   AAVE397945:AAVE_4169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 27369; Mature: 27238

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: ACT_SITE 105-105 BINDING 96-96 BINDING 133-133 BINDING 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLAIDVGNTRLKWAMYDAPKPGAAVLAHGAEFLDHIERLADSAWAGLPAPTRMLGCVV
CEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AGDAVRRRVMEQMEWWDVPSHWVVPSAEEAGLVNGYDHPTRLGSDRWVAMIGARHRLLRQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHC
GPARPLVVVMVGTAVTVEAIDAEGRFLGGLILPGHGIMLRALESGTAGLHVPTGEVKLFP
CCCCCEEEEEECCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCCCEEECCCCEEEEE
TNTSDALTSGGTYAIAGAVERMVQHVIQHCGEEPACMMTGGAGWKMAPSMTRPFDLIENL
CCCCHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHH
IFEGLLAIAAERFR
HHHHHHHHHHHHCC
>Mature Secondary Structure 
TFLAIDVGNTRLKWAMYDAPKPGAAVLAHGAEFLDHIERLADSAWAGLPAPTRMLGCVV
EEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AGDAVRRRVMEQMEWWDVPSHWVVPSAEEAGLVNGYDHPTRLGSDRWVAMIGARHRLLRQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHC
GPARPLVVVMVGTAVTVEAIDAEGRFLGGLILPGHGIMLRALESGTAGLHVPTGEVKLFP
CCCCCEEEEEECCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCCCEEECCCCEEEEE
TNTSDALTSGGTYAIAGAVERMVQHVIQHCGEEPACMMTGGAGWKMAPSMTRPFDLIENL
CCCCHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHH
IFEGLLAIAAERFR
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA