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The map label for this gene is cbf2 [H]

Identifier: 120612784

GI number: 120612784

Start: 4600034

End: 4600933

Strand: Reverse

Name: cbf2 [H]

Synonym: Aave_4147

Alternate gene names: 120612784

Gene position: 4600933-4600034 (Counterclockwise)

Preceding gene: 120612785

Following gene: 120612783

Centisome position: 85.95

GC content: 61.0

Gene sequence:

>900_bases
ATGAAACGTTCCGCTTTCCGCCTCTGCGCCGGTGCCATGCTCTCCGCATTGATGTTGTCTGCCCATGCCCAGGAAACCGT
GCTGATCCAGGGGCCGCACATCGCGATCGACAGCAGCGATATGCGGGCCGATGCACTGCGCATGCCTCCGGAAATGCGCG
ATACGGTGCTGTCCCGTCCACAGACAGTGACCCAGATCGCGTCCAACCTGTATGCACGTCGCGCCATGGCGCAGCGCGCC
GAAGCTGCTGGACTGGAGAAGGATCCAGAGGTCGCGGCTGCATTGCGTGTAGCGCGCGACAAGGTGCTGTCCGATGCCTA
CCTGGCCAAGGTGGACAAGGACAACATGCTTTCGGACTCGGCTGCCGAAGGTCTGGCCCGCAATATCTACAAGGCCAAGC
CGGAACGCTTCAAGGTACCTGAGCAGGTGCAGGTGCGGCACATCCTGATTGCAGGCAAGGGGGCGGATTCCCGTGCGCAG
ATCGAGAAGATCGAGCAGGAACTCAAGGGCGGCGCGGACTTCGCGCAACTGGCCAAGGAGCGTTCCGCGGACAAGGGCAG
TGCCGCGAAGGGCGGTGATCTGGGCTTCTTTGAGGCTGGAAAGATGGTTCCCGAATTTGACAAGGCGGCATTTGCCTTGA
CCAAGCCAGGAGAGTTGAGCGGCATCGTGGAGAGCAAGTTCGGCTATCACATCCTGCAACTCGAAGGCCGCCATGCCCCG
AGAACGCGCAGCTTCGATGAGGTGCGCAGCGAACTGATGCAGGAAGTCCGTGCGAACGTGCAGCAGGAAGCGCGCGTTGC
CGACGCGCAGGCAATGCAGAAGGAAGCAAAAATCAACAAGGAAGCCATCGAAGCTTTTGCAGCTGGCTACAACCCGCAGC
CGGTGAAGACGGCCCCGTAA

Upstream 100 bases:

>100_bases
TAATTCACTGCTGCTACGGCACTTTTCACAGCAATGTGATCCAAAAAAGGCGGGGGTCTCCCCCGCCTTTTTTCATTTCT
CACTGATGGTTGACTCCTAC

Downstream 100 bases:

>100_bases
CGCGTAAGCTCTGCGTTTGTGTTCGGGGCGCAGGCCATTCGGGGTCTGTGCCGTTGCCTGGCGGGCAGCGCCCGCCGCTG
ATGGTTTTCTTCATGCAGAC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: Major antigen peb4A [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKRSAFRLCAGAMLSALMLSAHAQETVLIQGPHIAIDSSDMRADALRMPPEMRDTVLSRPQTVTQIASNLYARRAMAQRA
EAAGLEKDPEVAAALRVARDKVLSDAYLAKVDKDNMLSDSAAEGLARNIYKAKPERFKVPEQVQVRHILIAGKGADSRAQ
IEKIEQELKGGADFAQLAKERSADKGSAAKGGDLGFFEAGKMVPEFDKAAFALTKPGELSGIVESKFGYHILQLEGRHAP
RTRSFDEVRSELMQEVRANVQQEARVADAQAMQKEAKINKEAIEAFAAGYNPQPVKTAP

Sequences:

>Translated_299_residues
MKRSAFRLCAGAMLSALMLSAHAQETVLIQGPHIAIDSSDMRADALRMPPEMRDTVLSRPQTVTQIASNLYARRAMAQRA
EAAGLEKDPEVAAALRVARDKVLSDAYLAKVDKDNMLSDSAAEGLARNIYKAKPERFKVPEQVQVRHILIAGKGADSRAQ
IEKIEQELKGGADFAQLAKERSADKGSAAKGGDLGFFEAGKMVPEFDKAAFALTKPGELSGIVESKFGYHILQLEGRHAP
RTRSFDEVRSELMQEVRANVQQEARVADAQAMQKEAKINKEAIEAFAAGYNPQPVKTAP
>Mature_299_residues
MKRSAFRLCAGAMLSALMLSAHAQETVLIQGPHIAIDSSDMRADALRMPPEMRDTVLSRPQTVTQIASNLYARRAMAQRA
EAAGLEKDPEVAAALRVARDKVLSDAYLAKVDKDNMLSDSAAEGLARNIYKAKPERFKVPEQVQVRHILIAGKGADSRAQ
IEKIEQELKGGADFAQLAKERSADKGSAAKGGDLGFFEAGKMVPEFDKAAFALTKPGELSGIVESKFGYHILQLEGRHAP
RTRSFDEVRSELMQEVRANVQQEARVADAQAMQKEAKINKEAIEAFAAGYNPQPVKTAP

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=100, Percent_Identity=42, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786645, Length=131, Percent_Identity=33.587786259542, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786238, Length=154, Percent_Identity=33.7662337662338, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17537235, Length=100, Percent_Identity=43, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 32574; Mature: 32574

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSAFRLCAGAMLSALMLSAHAQETVLIQGPHIAIDSSDMRADALRMPPEMRDTVLSRP
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCHHHHHCCCHHHHHHHHCCC
QTVTQIASNLYARRAMAQRAEAAGLEKDPEVAAALRVARDKVLSDAYLAKVDKDNMLSDS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
AAEGLARNIYKAKPERFKVPEQVQVRHILIAGKGADSRAQIEKIEQELKGGADFAQLAKE
HHHHHHHHHHHCCHHHCCCCHHHCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHH
RSADKGSAAKGGDLGFFEAGKMVPEFDKAAFALTKPGELSGIVESKFGYHILQLEGRHAP
HCCCCCCCCCCCCCCHHHHCCCCCCHHHHHEEECCCCCHHHHHHHCCCEEEEEECCCCCC
RTRSFDEVRSELMQEVRANVQQEARVADAQAMQKEAKINKEAIEAFAAGYNPQPVKTAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKRSAFRLCAGAMLSALMLSAHAQETVLIQGPHIAIDSSDMRADALRMPPEMRDTVLSRP
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCHHHHHCCCHHHHHHHHCCC
QTVTQIASNLYARRAMAQRAEAAGLEKDPEVAAALRVARDKVLSDAYLAKVDKDNMLSDS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
AAEGLARNIYKAKPERFKVPEQVQVRHILIAGKGADSRAQIEKIEQELKGGADFAQLAKE
HHHHHHHHHHHCCHHHCCCCHHHCEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHH
RSADKGSAAKGGDLGFFEAGKMVPEFDKAAFALTKPGELSGIVESKFGYHILQLEGRHAP
HCCCCCCCCCCCCCCHHHHCCCCCCHHHHHEEECCCCCHHHHHHHCCCEEEEEECCCCCC
RTRSFDEVRSELMQEVRANVQQEARVADAQAMQKEAKINKEAIEAFAAGYNPQPVKTAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]