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The map label for this gene is argB

Identifier: 120612776

GI number: 120612776

Start: 4589119

End: 4590009

Strand: Reverse

Name: argB

Synonym: Aave_4139

Alternate gene names: 120612776

Gene position: 4590009-4589119 (Counterclockwise)

Preceding gene: 120612777

Following gene: 120612775

Centisome position: 85.75

GC content: 64.09

Gene sequence:

>891_bases
ATGACCGATCTGCAATCCATCGCCCCCCGGGACAAGGCCGAGATCCTGGCTCAGGCTCTGCCCTACATCCGCAAGTTCCA
CGGCAAGACCATCGTCATCAAGTACGGCGGCAATGCCATGACCGACCCGGCGCTGCAGGCCGATTTCGCGGAAGACGTGG
TCCTGCTCAAGCTGGTCGGCATGAACCCGGTGGTGGTGCATGGCGGAGGCCCCCAGATCGAGACCGCGCTCAAGCGGCTG
GGCAAGCAGGGACACTTCATCCAGGGCATGCGGGTGACCGATGCCGAGACGATGGAGGTGGTCGAATGGGTGCTGGCCGG
CGAGGTGCAGCAGGACATCGTGGGCCTGATCAACCAGGCCGGCGGCAAGGCCGTGGGCCTGACGGGCCGTGACGGGGGGC
TGATCCGTGCACGCAAGCTCAAGATGGTGGACAAGGACGATCCGAGCAAGGAGCATGACATCGGCCAGGTGGGCGACATC
GTGTCCATCGACCCCAGCGTGGTCAAGGCCCTTCAGGACGATGCCTTCATCCCGGTGATCAGCCCGCTCGGTTTCGGCGA
GGAAAACGAGAGCTACAACATCAACGCCGACGTGGTCGCCAGCAAGCTGGCCACGGTGCTCAAGGCGGAGAAGCTCATGA
TGCTCACCAACATTCCGGGCGTGCTCAACAAGTCCGGCGCGCTCATCCCGGAACTGACCGCGCGCGAGATCGACGAACTC
GTGGTGGACGGCACGATTTCCGGAGGCATGCTGCCCAAGATCGCTGGCGCCATCGATGCGGCCAAGAGCGGCGTCAATGC
AGTGCATATCGTGGACGGCCGCGTGCCCCACGCGATGCTGCTGGAGATCCTGACCGAGCAGGCCTACGGCACGATGATCC
GCAGCCATTGA

Upstream 100 bases:

>100_bases
CGGGGCGTGGCCTCCCGGCGCGCCGCAAGGCGCGGCAGAGCGGGCACAATGCGCACTTCTTCACTGACTGCCGCCCTGTT
TTTTCCACGTCGAGCGCTCC

Downstream 100 bases:

>100_bases
GCGCGGCGGCGGGCCTGCTGTTCCTTCCATGCGCCTGCTGCTCGTCGAAGACGACGTGATGCTGGCCAGCGGCATCAAGC
TGGGCCTCACCGACGCGGGC

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTDLQSIAPRDKAEILAQALPYIRKFHGKTIVIKYGGNAMTDPALQADFAEDVVLLKLVGMNPVVVHGGGPQIETALKRL
GKQGHFIQGMRVTDAETMEVVEWVLAGEVQQDIVGLINQAGGKAVGLTGRDGGLIRARKLKMVDKDDPSKEHDIGQVGDI
VSIDPSVVKALQDDAFIPVISPLGFGEENESYNINADVVASKLATVLKAEKLMMLTNIPGVLNKSGALIPELTAREIDEL
VVDGTISGGMLPKIAGAIDAAKSGVNAVHIVDGRVPHAMLLEILTEQAYGTMIRSH

Sequences:

>Translated_296_residues
MTDLQSIAPRDKAEILAQALPYIRKFHGKTIVIKYGGNAMTDPALQADFAEDVVLLKLVGMNPVVVHGGGPQIETALKRL
GKQGHFIQGMRVTDAETMEVVEWVLAGEVQQDIVGLINQAGGKAVGLTGRDGGLIRARKLKMVDKDDPSKEHDIGQVGDI
VSIDPSVVKALQDDAFIPVISPLGFGEENESYNINADVVASKLATVLKAEKLMMLTNIPGVLNKSGALIPELTAREIDEL
VVDGTISGGMLPKIAGAIDAAKSGVNAVHIVDGRVPHAMLLEILTEQAYGTMIRSH
>Mature_295_residues
TDLQSIAPRDKAEILAQALPYIRKFHGKTIVIKYGGNAMTDPALQADFAEDVVLLKLVGMNPVVVHGGGPQIETALKRLG
KQGHFIQGMRVTDAETMEVVEWVLAGEVQQDIVGLINQAGGKAVGLTGRDGGLIRARKLKMVDKDDPSKEHDIGQVGDIV
SIDPSVVKALQDDAFIPVISPLGFGEENESYNINADVVASKLATVLKAEKLMMLTNIPGVLNKSGALIPELTAREIDELV
VDGTISGGMLPKIAGAIDAAKSGVNAVHIVDGRVPHAMLLEILTEQAYGTMIRSH

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI1789181, Length=288, Percent_Identity=29.5138888888889, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI145693208, Length=245, Percent_Identity=29.3877551020408, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320913, Length=299, Percent_Identity=28.4280936454849, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGB_ACIAC (A1TUP2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972454.1
- ProteinModelPortal:   A1TUP2
- SMR:   A1TUP2
- STRING:   A1TUP2
- GeneID:   4669186
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4139
- NMPDR:   fig|397945.5.peg.3544
- eggNOG:   COG0548
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- PhylomeDB:   A1TUP2
- ProtClustDB:   PRK00942
- BioCyc:   AAVE397945:AAVE_4139-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 31506; Mature: 31375

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: BINDING 91-91 BINDING 193-193

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLQSIAPRDKAEILAQALPYIRKFHGKTIVIKYGGNAMTDPALQADFAEDVVLLKLVG
CCCCHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHEEEEEEEC
MNPVVVHGGGPQIETALKRLGKQGHFIQGMRVTDAETMEVVEWVLAGEVQQDIVGLINQA
CCEEEEECCCCCHHHHHHHHCCCCCEEECEEECCHHHHHHHHHHHHHHHHHHHHHHHHHC
GGKAVGLTGRDGGLIRARKLKMVDKDDPSKEHDIGQVGDIVSIDPSVVKALQDDAFIPVI
CCCEEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHCCCEEECCHHHHHHHHCCCCEEEE
SPLGFGEENESYNINADVVASKLATVLKAEKLMMLTNIPGVLNKSGALIPELTAREIDEL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHH
VVDGTISGGMLPKIAGAIDAAKSGVNAVHIVDGRVPHAMLLEILTEQAYGTMIRSH
HHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDLQSIAPRDKAEILAQALPYIRKFHGKTIVIKYGGNAMTDPALQADFAEDVVLLKLVG
CCCHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHEEEEEEEC
MNPVVVHGGGPQIETALKRLGKQGHFIQGMRVTDAETMEVVEWVLAGEVQQDIVGLINQA
CCEEEEECCCCCHHHHHHHHCCCCCEEECEEECCHHHHHHHHHHHHHHHHHHHHHHHHHC
GGKAVGLTGRDGGLIRARKLKMVDKDDPSKEHDIGQVGDIVSIDPSVVKALQDDAFIPVI
CCCEEEECCCCCCEEEEEEEEECCCCCCCCCCCCHHCCCEEECCHHHHHHHHCCCCEEEE
SPLGFGEENESYNINADVVASKLATVLKAEKLMMLTNIPGVLNKSGALIPELTAREIDEL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHH
VVDGTISGGMLPKIAGAIDAAKSGVNAVHIVDGRVPHAMLLEILTEQAYGTMIRSH
HHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA