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The map label for this gene is catF [H]

Identifier: 120612583

GI number: 120612583

Start: 4369758

End: 4370966

Strand: Reverse

Name: catF [H]

Synonym: Aave_3944

Alternate gene names: 120612583

Gene position: 4370966-4369758 (Counterclockwise)

Preceding gene: 120612584

Following gene: 120612582

Centisome position: 81.66

GC content: 71.71

Gene sequence:

>1209_bases
ATGACCTCTTCGCAAGCCTTCATCTGCGACGCCATCCGCACGCCCTTCGGCCGCTACGGCGGCGCGCTCTCCAGCGTGCG
CACCGACGACCTGGGCGCCACTCCTCTCAAGGCGCTGATGGCGCGCAACCCCCGGGTCGATTGGGCCGCGGTGACGGACG
TGCTCTACGGCTGCGCCAACCAGGCCGGCGAGGACAACCGCAATGTGGCCCGCATGAGCGCGCTGCTGGCCGGCCTGCCC
ATCGACGTGCCGGGCGCCACCATCAACCGCCTGTGCGGCTCGGGCCTGGATGCGGTGGGCACGGCGGCGCGCGCCATCAA
GGCGGGCGAGGCGGGCCTGATGATTGCGGGCGGCGTGGAAAGCATGAGCCGGGCGCCTTTCGTGATGCCGAAGGCCGAAA
CCGCCTTCAGTCGCAGCAACGCGGTCTATGACACGACCATCGGCTGGCGCTTCGTGAACAAGCTCATGAAGGCGCAGTAC
GGCGTGGATTCCATGCCGGAAACGGCCGAGAACGTGGCCGACGACTACCAGATCGAGCGCGAGGCGCAGGACCGCATGGC
CCTGGCCAGCCAGCTCAAGGCCGTGGCCGCGCAGAAGGCCGGCCACCTGGCGCGCGAGATCACCGCCGTCACCATCCCCC
AGAAGAAGGGCGACGCGGTGGTGGTGGACAAGGACGAACACCCGCGCGAGACCAGTCTGGAGGCGCTGGCCCGGCTCAAG
GGCGTGGTGCGCGAGGGCGGCACGGTGACGGCCGGCAACGCCAGCGGCGTGAACGACGGCGCCTGCGCGCTGCTGCTGGC
CGATGAGGCCTCGGCCGCCAAGCATGGCCTGGCGCCGAAGGCCCGCGTGGTCGGCATGGCCACGGCCGGCGTGGCCCCGC
GCGTGATGGGCATCGGCCCCGCGCCCGCCACGCAGAAGGTGCTGGCGCAGACCGGCCTCACGCTGGAGCAGCTCGACGTG
ATCGAGCTGAACGAAGCCTTCGCCGCGCAGGGCCTGGCCGTGCTGCGCATGCTGGGCCTGAAAGACGACGACGAGCGCGT
GAACGCCTGGGGCGGCGCCATCGCCCTGGGCCACCCGCTGGGCGCCAGCGGCGCGCGCCTGGCCACCACGGCCGTCAACC
GGCTGCATGCCACGGGCGGGCGCTATGCGCTGTGCACGATGTGCATCGGCGTGGGGCAGGGCATCGCCGTGATCCTGGAG
CGCGTGTGA

Upstream 100 bases:

>100_bases
CGTGCAGGGCCTGGAGCACGGGGAACTCGAACGCCTCGTCGGCCTGTCCATCCGCGCCGCCTGAAACGCCGCGCCCTCAA
CCCCAAGGAGACAAGACACC

Downstream 100 bases:

>100_bases
GCGGGGGGGCCATGACCGGCGAAACGCTGCAGACCGCCGCCGGGAGCTTCCGCGTACGGGTCGAAGGGCCCGCGGGCGCG
CCGGCGCTGGTGTTGTCCAA

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTSSQAFICDAIRTPFGRYGGALSSVRTDDLGATPLKALMARNPRVDWAAVTDVLYGCANQAGEDNRNVARMSALLAGLP
IDVPGATINRLCGSGLDAVGTAARAIKAGEAGLMIAGGVESMSRAPFVMPKAETAFSRSNAVYDTTIGWRFVNKLMKAQY
GVDSMPETAENVADDYQIEREAQDRMALASQLKAVAAQKAGHLAREITAVTIPQKKGDAVVVDKDEHPRETSLEALARLK
GVVREGGTVTAGNASGVNDGACALLLADEASAAKHGLAPKARVVGMATAGVAPRVMGIGPAPATQKVLAQTGLTLEQLDV
IELNEAFAAQGLAVLRMLGLKDDDERVNAWGGAIALGHPLGASGARLATTAVNRLHATGGRYALCTMCIGVGQGIAVILE
RV

Sequences:

>Translated_402_residues
MTSSQAFICDAIRTPFGRYGGALSSVRTDDLGATPLKALMARNPRVDWAAVTDVLYGCANQAGEDNRNVARMSALLAGLP
IDVPGATINRLCGSGLDAVGTAARAIKAGEAGLMIAGGVESMSRAPFVMPKAETAFSRSNAVYDTTIGWRFVNKLMKAQY
GVDSMPETAENVADDYQIEREAQDRMALASQLKAVAAQKAGHLAREITAVTIPQKKGDAVVVDKDEHPRETSLEALARLK
GVVREGGTVTAGNASGVNDGACALLLADEASAAKHGLAPKARVVGMATAGVAPRVMGIGPAPATQKVLAQTGLTLEQLDV
IELNEAFAAQGLAVLRMLGLKDDDERVNAWGGAIALGHPLGASGARLATTAVNRLHATGGRYALCTMCIGVGQGIAVILE
RV
>Mature_401_residues
TSSQAFICDAIRTPFGRYGGALSSVRTDDLGATPLKALMARNPRVDWAAVTDVLYGCANQAGEDNRNVARMSALLAGLPI
DVPGATINRLCGSGLDAVGTAARAIKAGEAGLMIAGGVESMSRAPFVMPKAETAFSRSNAVYDTTIGWRFVNKLMKAQYG
VDSMPETAENVADDYQIEREAQDRMALASQLKAVAAQKAGHLAREITAVTIPQKKGDAVVVDKDEHPRETSLEALARLKG
VVREGGTVTAGNASGVNDGACALLLADEASAAKHGLAPKARVVGMATAGVAPRVMGIGPAPATQKVLAQTGLTLEQLDVI
ELNEAFAAQGLAVLRMLGLKDDDERVNAWGGAIALGHPLGASGARLATTAVNRLHATGGRYALCTMCIGVGQGIAVILER
V

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=41.75, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI148539872, Length=408, Percent_Identity=39.7058823529412, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI4557237, Length=410, Percent_Identity=34.8780487804878, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4501853, Length=338, Percent_Identity=42.0118343195266, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=32.3185011709602, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI194353979, Length=334, Percent_Identity=31.437125748503, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=66.9172932330827, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=46.7336683417085, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI48994986, Length=407, Percent_Identity=43.2432432432432, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI87082165, Length=396, Percent_Identity=44.6969696969697, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=31.6784869976359, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=407, Percent_Identity=42.014742014742, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI25147385, Length=408, Percent_Identity=32.1078431372549, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=410, Percent_Identity=33.4146341463415, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=31.5294117647059, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=411, Percent_Identity=28.4671532846715, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325229, Length=406, Percent_Identity=36.4532019704434, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=35.929648241206, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24655093, Length=400, Percent_Identity=44, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI17648125, Length=406, Percent_Identity=40.3940886699507, Blast_Score=257, Evalue=8e-69,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=33.2512315270936, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=31.4814814814815, Blast_Score=175, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 41640; Mature: 41509

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSQAFICDAIRTPFGRYGGALSSVRTDDLGATPLKALMARNPRVDWAAVTDVLYGCAN
CCCCCHHHHHHHHCCHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
QAGEDNRNVARMSALLAGLPIDVPGATINRLCGSGLDAVGTAARAIKAGEAGLMIAGGVE
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHH
SMSRAPFVMPKAETAFSRSNAVYDTTIGWRFVNKLMKAQYGVDSMPETAENVADDYQIER
HHCCCCEECCCCHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EAQDRMALASQLKAVAAQKAGHLAREITAVTIPQKKGDAVVVDKDEHPRETSLEALARLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHH
GVVREGGTVTAGNASGVNDGACALLLADEASAAKHGLAPKARVVGMATAGVAPRVMGIGP
HHHHCCCEEEECCCCCCCCCEEEEEEECCCHHHHHCCCCCHHEEEEECCCCCCCEEECCC
APATQKVLAQTGLTLEQLDVIELNEAFAAQGLAVLRMLGLKDDDERVNAWGGAIALGHPL
CCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEECCCC
GASGARLATTAVNRLHATGGRYALCTMCIGVGQGIAVILERV
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure 
TSSQAFICDAIRTPFGRYGGALSSVRTDDLGATPLKALMARNPRVDWAAVTDVLYGCAN
CCCCHHHHHHHHCCHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
QAGEDNRNVARMSALLAGLPIDVPGATINRLCGSGLDAVGTAARAIKAGEAGLMIAGGVE
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCHH
SMSRAPFVMPKAETAFSRSNAVYDTTIGWRFVNKLMKAQYGVDSMPETAENVADDYQIER
HHCCCCEECCCCHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EAQDRMALASQLKAVAAQKAGHLAREITAVTIPQKKGDAVVVDKDEHPRETSLEALARLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHH
GVVREGGTVTAGNASGVNDGACALLLADEASAAKHGLAPKARVVGMATAGVAPRVMGIGP
HHHHCCCEEEECCCCCCCCCEEEEEEECCCHHHHHCCCCCHHEEEEECCCCCCCEEECCC
APATQKVLAQTGLTLEQLDVIELNEAFAAQGLAVLRMLGLKDDDERVNAWGGAIALGHPL
CCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEECCCC
GASGARLATTAVNRLHATGGRYALCTMCIGVGQGIAVILERV
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]