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The map label for this gene is moeB [H]

Identifier: 120612501

GI number: 120612501

Start: 4286763

End: 4287518

Strand: Direct

Name: moeB [H]

Synonym: Aave_3860

Alternate gene names: 120612501

Gene position: 4286763-4287518 (Clockwise)

Preceding gene: 120612500

Following gene: 120612502

Centisome position: 80.08

GC content: 70.24

Gene sequence:

>756_bases
ATGAACGACGACCAGCTCCTGCGCTACTCCCGCCATATCCTGCTCGACGAGATCGGCATCGAAGGGCAGGAGCGCCTGCT
CGCGGCGCATGCGCTGGTCATCGGGGCCGGCGGCCTGGGATCGCCCGCGGCGCTCTTCCTGGCCTCGGCGGGCGTGGGCC
GCCTGACCCTGGTCGATGCCGACACCGTGGACCTGACCAATCTGCAGAGGCAGATCGCACACACCACGGAGCGTGTCGGC
CAGCCCAAGGTGGCGTCGGCCGCGCACGCCGTGCGAGCCATCAACCCCGGGGTGCAGGTGGACGGGCTGCCGCTGCGCGC
CGACGCGGCATGGCTCGATGCCCATGTGCCGCTCGCGGACGTGGTCCTCGACTGCAGCGACAACTATGCGACTCGGCAGG
CCGTCAATGCCGCGTGCGTGCGGCACCGCGTACCGCTGGTAGCCGGCGCGGCGATCCGCTTCGATGGCCAGATCACGGTG
ATCGACCCGCGCGCATCCGATGCGCCCTGCTATGCCTGCCTGTTCCCTCCGGACGCCGCCTTCGAGGAAGTACGCTGCTC
CACGATGGGGGTCTTCGCACCCATGGTCGGCATCGTCGGCGCCATGCAGGCCGCGGAGGCCCTCAAGCTGCTCTGCGGCG
CAGGCAAGCCGCTGGCAGGCAGGCTGCTCATGCTGGATGGACTGTCCATGGAGTGGACCACCATGCGCGCCCACCGCGAT
CCGTCCTGCCCGGTGTGCGGAAGCGGCGGCACGTGA

Upstream 100 bases:

>100_bases
GGGGGTCCGGCCTTTTTGCTTTGCGCCTTTGCGCGCCAGGCAAACCCACAACGGCTTCGCCCCAGCCCCTTCGCCAACGC
TACCGCCAGCACCACGCTCC

Downstream 100 bases:

>100_bases
GGCACCCTGCATGGCGAAGGGTGACGGTAGGAGAAATCCTACCGGGGTAACACCCTGCTGCTGGCAGAATGCCGGCTCTC
TCCCTATAAAGTAGAGCCGT

Product: UBA/THIF-type NAD/FAD-binding protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MNDDQLLRYSRHILLDEIGIEGQERLLAAHALVIGAGGLGSPAALFLASAGVGRLTLVDADTVDLTNLQRQIAHTTERVG
QPKVASAAHAVRAINPGVQVDGLPLRADAAWLDAHVPLADVVLDCSDNYATRQAVNAACVRHRVPLVAGAAIRFDGQITV
IDPRASDAPCYACLFPPDAAFEEVRCSTMGVFAPMVGIVGAMQAAEALKLLCGAGKPLAGRLLMLDGLSMEWTTMRAHRD
PSCPVCGSGGT

Sequences:

>Translated_251_residues
MNDDQLLRYSRHILLDEIGIEGQERLLAAHALVIGAGGLGSPAALFLASAGVGRLTLVDADTVDLTNLQRQIAHTTERVG
QPKVASAAHAVRAINPGVQVDGLPLRADAAWLDAHVPLADVVLDCSDNYATRQAVNAACVRHRVPLVAGAAIRFDGQITV
IDPRASDAPCYACLFPPDAAFEEVRCSTMGVFAPMVGIVGAMQAAEALKLLCGAGKPLAGRLLMLDGLSMEWTTMRAHRD
PSCPVCGSGGT
>Mature_251_residues
MNDDQLLRYSRHILLDEIGIEGQERLLAAHALVIGAGGLGSPAALFLASAGVGRLTLVDADTVDLTNLQRQIAHTTERVG
QPKVASAAHAVRAINPGVQVDGLPLRADAAWLDAHVPLADVVLDCSDNYATRQAVNAACVRHRVPLVAGAAIRFDGQITV
IDPRASDAPCYACLFPPDAAFEEVRCSTMGVFAPMVGIVGAMQAAEALKLLCGAGKPLAGRLLMLDGLSMEWTTMRAHRD
PSCPVCGSGGT

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=230, Percent_Identity=45.6521739130435, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI4885649, Length=153, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI38045948, Length=159, Percent_Identity=31.4465408805031, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI13376212, Length=258, Percent_Identity=27.5193798449612, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787048, Length=251, Percent_Identity=45.8167330677291, Blast_Score=223, Evalue=8e-60,
Organism=Escherichia coli, GI87082356, Length=247, Percent_Identity=48.582995951417, Blast_Score=210, Evalue=7e-56,
Organism=Escherichia coli, GI1789177, Length=141, Percent_Identity=36.8794326241135, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=262, Percent_Identity=39.6946564885496, Blast_Score=196, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI193203301, Length=162, Percent_Identity=30.2469135802469, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321903, Length=258, Percent_Identity=33.7209302325581, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320598, Length=165, Percent_Identity=28.4848484848485, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322639, Length=172, Percent_Identity=27.3255813953488, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24582879, Length=255, Percent_Identity=40.3921568627451, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24660640, Length=160, Percent_Identity=30, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641311, Length=258, Percent_Identity=30.6201550387597, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573937, Length=169, Percent_Identity=27.810650887574, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26280; Mature: 26280

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDQLLRYSRHILLDEIGIEGQERLLAAHALVIGAGGLGSPAALFLASAGVGRLTLVDA
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCEEEEEEC
DTVDLTNLQRQIAHTTERVGQPKVASAAHAVRAINPGVQVDGLPLRADAAWLDAHVPLAD
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEECCEEEECCCHHHCCCCCHHH
VVLDCSDNYATRQAVNAACVRHRVPLVAGAAIRFDGQITVIDPRASDAPCYACLFPPDAA
EEEECCCCHHHHHHHHHHHHHHCCCEEECEEEEECCEEEEECCCCCCCCEEEEECCCCHH
FEEVRCSTMGVFAPMVGIVGAMQAAEALKLLCGAGKPLAGRLLMLDGLSMEWTTMRAHRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCC
PSCPVCGSGGT
CCCCCCCCCCC
>Mature Secondary Structure
MNDDQLLRYSRHILLDEIGIEGQERLLAAHALVIGAGGLGSPAALFLASAGVGRLTLVDA
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCEEEEEEC
DTVDLTNLQRQIAHTTERVGQPKVASAAHAVRAINPGVQVDGLPLRADAAWLDAHVPLAD
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEECCEEEECCCHHHCCCCCHHH
VVLDCSDNYATRQAVNAACVRHRVPLVAGAAIRFDGQITVIDPRASDAPCYACLFPPDAA
EEEECCCCHHHHHHHHHHHHHHCCCEEECEEEEECCEEEEECCCCCCCCEEEEECCCCHH
FEEVRCSTMGVFAPMVGIVGAMQAAEALKLLCGAGKPLAGRLLMLDGLSMEWTTMRAHRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCC
PSCPVCGSGGT
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]