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The map label for this gene is mutT [H]

Identifier: 120612330

GI number: 120612330

Start: 4062856

End: 4063311

Strand: Reverse

Name: mutT [H]

Synonym: Aave_3686

Alternate gene names: 120612330

Gene position: 4063311-4062856 (Counterclockwise)

Preceding gene: 120612331

Following gene: 120612322

Centisome position: 75.91

GC content: 69.74

Gene sequence:

>456_bases
ATGGCTGAGTCCGTCGCATCCGGCGCCCAGCGCGCCCACACCGAGGTGGCGGTCGGCATCCTGTTCCGCCCCGATGGCGC
CATGCTGCTGTCCACGCGGCCGCCCGGCAAGCCCTATGCGGGCTACTGGGAGTTTCCCGGCGGCAAGCTGGAGGCCGGCG
AAACCGTCGAGCAGGCCCTGCGCCGCGAGCTCATCGAGGAACTGGGCGTCACCATCGGCCCGGCGTCCGTCTGGAAGGTC
ACCGAGCACGACTATCCCCATGCCCTCGTGCGCCTGCACTGGTGCAAGGTGCATGCATGGACGGGCGAGTTCGAGATGCG
TGAAGGCCAGTCCATGGCCTGGCAGCAGTGGCCGCTGGACGTGTCGCCGGTGCTGCCGGGCGCCTACCCGGTACTGCAGT
GGCTGGCGGAAGAGCGCGGCCTGCCGTTCGATCCGGACCTGCTGCCCAAGGCATAG

Upstream 100 bases:

>100_bases
GAGGCGGCCCGCCCCGCCGCGCTGGTCTGGGCGCTGGAGCGCGGCTCGCGCAGCGGCCGGGTGGCCTACCAGTTCGCGCG
GGACTTCGCGGGGCGCGCCG

Downstream 100 bases:

>100_bases
CGGCCTGCAGACGCATGGCGGGCCGCCGCAGACCAGAGGCGGAGTGCCGGCGGGCCTTCAGTGTTCCGGTGGACGCTGCA
GGTGGTCGCCGAAGGCGTCC

Product: NUDIX hydrolase

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MAESVASGAQRAHTEVAVGILFRPDGAMLLSTRPPGKPYAGYWEFPGGKLEAGETVEQALRRELIEELGVTIGPASVWKV
TEHDYPHALVRLHWCKVHAWTGEFEMREGQSMAWQQWPLDVSPVLPGAYPVLQWLAEERGLPFDPDLLPKA

Sequences:

>Translated_151_residues
MAESVASGAQRAHTEVAVGILFRPDGAMLLSTRPPGKPYAGYWEFPGGKLEAGETVEQALRRELIEELGVTIGPASVWKV
TEHDYPHALVRLHWCKVHAWTGEFEMREGQSMAWQQWPLDVSPVLPGAYPVLQWLAEERGLPFDPDLLPKA
>Mature_150_residues
AESVASGAQRAHTEVAVGILFRPDGAMLLSTRPPGKPYAGYWEFPGGKLEAGETVEQALRRELIEELGVTIGPASVWKVT
EHDYPHALVRLHWCKVHAWTGEFEMREGQSMAWQQWPLDVSPVLPGAYPVLQWLAEERGLPFDPDLLPKA

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=119, Percent_Identity=35.2941176470588, Blast_Score=68, Evalue=3e-13,
Organism=Escherichia coli, GI1788056, Length=101, Percent_Identity=36.6336633663366, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 16812; Mature: 16681

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESVASGAQRAHTEVAVGILFRPDGAMLLSTRPPGKPYAGYWEFPGGKLEAGETVEQAL
CCCCHHHHHHHHHCEEEEEEEECCCCCEEEECCCCCCCCCCEEECCCCCCCCCHHHHHHH
RRELIEELGVTIGPASVWKVTEHDYPHALVRLHWCKVHAWTGEFEMREGQSMAWQQWPLD
HHHHHHHCCCEECCCCEEEECCCCCCCHHEEEEEEEEEEECCCEECCCCCCCCCCCCCCC
VSPVLPGAYPVLQWLAEERGLPFDPDLLPKA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AESVASGAQRAHTEVAVGILFRPDGAMLLSTRPPGKPYAGYWEFPGGKLEAGETVEQAL
CCCHHHHHHHHHCEEEEEEEECCCCCEEEECCCCCCCCCCEEECCCCCCCCCHHHHHHH
RRELIEELGVTIGPASVWKVTEHDYPHALVRLHWCKVHAWTGEFEMREGQSMAWQQWPLD
HHHHHHHCCCEECCCCEEEECCCCCCCHHEEEEEEEEEEECCCEECCCCCCCCCCCCCCC
VSPVLPGAYPVLQWLAEERGLPFDPDLLPKA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]