Click here to switch to the map view.

The map label for this gene is vvpD [H]

Identifier: 120612326

GI number: 120612326

Start: 4060187

End: 4061074

Strand: Direct

Name: vvpD [H]

Synonym: Aave_3682

Alternate gene names: 120612326

Gene position: 4060187-4061074 (Clockwise)

Preceding gene: 120612325

Following gene: 120612327

Centisome position: 75.85

GC content: 70.38

Gene sequence:

>888_bases
ATGGGGTTCGAGCCCTGGCTGCAGGCCGCGGTGTTCGGCCTCGTCGGCCTGCTGATCGGCAGTTTTCTCAACGTCGTCAT
CCACCGCCTTCCGCGCATGATGGAGGCCGACTGGGCCGCCGAGTGCGAGGACTACCTGCGCTCGCAACCGGGTTCCACCA
CGACCACGGCCCCCGTGGCGAAGCCGGAGGCGGAGCCCTTCAACCTGGTGACGCCGCGCTCGCGGTGCCCGGCCTGCGGC
CACGCGGTGCGGTGGCACGAGAACATTCCGGTGCTGAGCTACCTCTGGCTGGGCGGCAAATGCTCGGCCTGCAAGACCCG
CATCAGCCCGCGCTATCCGGCCGTCGAGCTCGCGACCGGGCTGCTGTTCTGGTTCTGCGCCCGGCACTGGGGCGCGACGC
CGACGGCGGCGGCCTGGTGCGCCTTCTCCGCCGCGCTGGTCACGCTGGCCTGCATCGACTGGGACACCACCCTGCTGCCG
GACGACATCACGCTGCCGCTGCTGTGGGGCGGGCTGCTCGGCTCGGCCTTCCAGTGGACTTCCGTGCCGCTCTTCGCCTC
GGTGGCGGGCGCGGCTGCCGGCTACCTGTCGCTCTGGGCGGTGTATTGGGCGTTCAAGCTGGCCACGGGCAAGGAGGGCA
TGGGCTATGGCGATTTCAAGCTGTTCGCGGCCCTCGGCGCCTGGTTCGGCTGGCAGGCCCTGGTGCCCATCATCCTGATG
GCGTCGGTCATCGGGGCGCTGGTCGGCATCGGCATGAAGTTCACCCGGGGCCTGCGCGAGGGCAACTACATCCCCTTCGG
CCCGTTCCTCGCCGGCGCCGGGCTCGCCGCCATGCTGTTCGGGCCCGACCGCATATTGAACGGCATCCTGGGAGCGCTGG
GCCTGTGA

Upstream 100 bases:

>100_bases
GCCTCATGGAGCCGATCATCATCGTGTTCCTGGGCACCATCATCGGCGGCATCGTGGTGTCGATGTACCTGCCCATCTTC
AAGCTGGGACAGGTGATCTG

Downstream 100 bases:

>100_bases
CGGATGCGGCGCCCCGCCCTGCCCCGCTGCGGCTGGGCCTGACGGGCGGCATCGGCAGCGGCAAGACGACCGTCGGCCAG
TGGCTGCAGGAGTTCGGGGC

Product: type 4 prepilin peptidase 1

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MGFEPWLQAAVFGLVGLLIGSFLNVVIHRLPRMMEADWAAECEDYLRSQPGSTTTTAPVAKPEAEPFNLVTPRSRCPACG
HAVRWHENIPVLSYLWLGGKCSACKTRISPRYPAVELATGLLFWFCARHWGATPTAAAWCAFSAALVTLACIDWDTTLLP
DDITLPLLWGGLLGSAFQWTSVPLFASVAGAAAGYLSLWAVYWAFKLATGKEGMGYGDFKLFAALGAWFGWQALVPIILM
ASVIGALVGIGMKFTRGLREGNYIPFGPFLAGAGLAAMLFGPDRILNGILGALGL

Sequences:

>Translated_295_residues
MGFEPWLQAAVFGLVGLLIGSFLNVVIHRLPRMMEADWAAECEDYLRSQPGSTTTTAPVAKPEAEPFNLVTPRSRCPACG
HAVRWHENIPVLSYLWLGGKCSACKTRISPRYPAVELATGLLFWFCARHWGATPTAAAWCAFSAALVTLACIDWDTTLLP
DDITLPLLWGGLLGSAFQWTSVPLFASVAGAAAGYLSLWAVYWAFKLATGKEGMGYGDFKLFAALGAWFGWQALVPIILM
ASVIGALVGIGMKFTRGLREGNYIPFGPFLAGAGLAAMLFGPDRILNGILGALGL
>Mature_294_residues
GFEPWLQAAVFGLVGLLIGSFLNVVIHRLPRMMEADWAAECEDYLRSQPGSTTTTAPVAKPEAEPFNLVTPRSRCPACGH
AVRWHENIPVLSYLWLGGKCSACKTRISPRYPAVELATGLLFWFCARHWGATPTAAAWCAFSAALVTLACIDWDTTLLPD
DITLPLLWGGLLGSAFQWTSVPLFASVAGAAAGYLSLWAVYWAFKLATGKEGMGYGDFKLFAALGAWFGWQALVPIILMA
SVIGALVGIGMKFTRGLREGNYIPFGPFLAGAGLAAMLFGPDRILNGILGALGL

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=263, Percent_Identity=35.361216730038, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789732, Length=219, Percent_Identity=37.4429223744292, Blast_Score=85, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 31674; Mature: 31543

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFEPWLQAAVFGLVGLLIGSFLNVVIHRLPRMMEADWAAECEDYLRSQPGSTTTTAPVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KPEAEPFNLVTPRSRCPACGHAVRWHENIPVLSYLWLGGKCSACKTRISPRYPAVELATG
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHCCCCCHHHHHCCCCCCCHHHHHHH
LLFWFCARHWGATPTAAAWCAFSAALVTLACIDWDTTLLPDDITLPLLWGGLLGSAFQWT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHH
SVPLFASVAGAAAGYLSLWAVYWAFKLATGKEGMGYGDFKLFAALGAWFGWQALVPIILM
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASVIGALVGIGMKFTRGLREGNYIPFGPFLAGAGLAAMLFGPDRILNGILGALGL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GFEPWLQAAVFGLVGLLIGSFLNVVIHRLPRMMEADWAAECEDYLRSQPGSTTTTAPVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KPEAEPFNLVTPRSRCPACGHAVRWHENIPVLSYLWLGGKCSACKTRISPRYPAVELATG
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHCCCCCHHHHHCCCCCCCHHHHHHH
LLFWFCARHWGATPTAAAWCAFSAALVTLACIDWDTTLLPDDITLPLLWGGLLGSAFQWT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHH
SVPLFASVAGAAAGYLSLWAVYWAFKLATGKEGMGYGDFKLFAALGAWFGWQALVPIILM
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ASVIGALVGIGMKFTRGLREGNYIPFGPFLAGAGLAAMLFGPDRILNGILGALGL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9826339 [H]