Click here to switch to the map view.

The map label for this gene is gntR [H]

Identifier: 120612271

GI number: 120612271

Start: 3998407

End: 3999462

Strand: Direct

Name: gntR [H]

Synonym: Aave_3625

Alternate gene names: 120612271

Gene position: 3998407-3999462 (Clockwise)

Preceding gene: 120612267

Following gene: 120612272

Centisome position: 74.7

GC content: 72.16

Gene sequence:

>1056_bases
ATGGCCCTGCTCCCCGACTCCCCTTCCCTGCCCCCCGGTGCGGCCGCCCGTGCAGGGTCGTCTGCCCGCGCGGCCGTCAC
CCTGCGTGAAGTGGCCGACCGTGCGGGGGTATCGATGATCACGGTATCGCGCGCGCTGAAGACCCCGCAGCAGGTCAGCG
AGGCCACCCGGGCCCGCGTGGAGGAAGCCGTGTCCGCCCTGGGCTACGTGCCCAACCTGCTGGCGGGCGGCCTGCGCTCC
GCGCGCAGCCACCTCGTCATGGCCCTGGTGCCCACCATCCGCGGCCAGCTGTTCGGGGAAATGATCCAGTCGCTCACCGA
TGCGCTGCATGCGCGAGGGTTCCAGGTGGTATTCGGCGAAGTGGGCTACGCAGCGTCGCGCGAGGACGAACTGCTGCGCG
CCATCGTCGGGCGGCGCCCGGACGGCATCGTGCTCACGGGCGTGATGCATTCCCCCGAGGGACGGCGCCTGCTGCTCGCT
TCGGGCATTCCCGTAGTGGAAACCTGGGACACCACGCCCACGCCCATCGACATGCTGGTCGGGCTGTCGCACGAGCGGCT
GGGCGAGGCCGTGTGCCGCTACCTGCATGGTCGCGGCCGGCGCCGGCTGGCGCTCATCAGCGGTGACGACGAGCGCGCCG
CGCGACGCCAGCGGGGCTTTTCCGAGGCCGCCCGGCAACTGGGCCTGCAGGAGCCGGTCCTGCGGTGGGTCCCCGCCCCC
ACGTCGCATGCCCAGGGGCGCGAAGGACTGGCTGCGCTGCGGAAGGACGCCCCCGACATCGATGCCGTGTTCTGCAGTTC
CGACATGCTGGCGCTCGGGGTGCTCACGGAGGCCCGCGAGCACGCCATCACGGTGCCGCAGGACCTGGCCGTGGTGGGTT
TCGGCGACATCGAGTTCGCTGCCACGCTGGCGCCCAGCCTGACCACCGTGCGCATCGACGGCACGCGCATCGGCCGCACG
GCAGCGGCCTTCATTGCCGACCGGGCGGAGGGCCGCGCCGTGCCCGAACCCCGGGTGGACATCGGGTTCTCGATCGTGGA
GCGCGAGAGCGTTTGA

Upstream 100 bases:

>100_bases
GTTAACATCCACCGAACGCAGAGGGTAAACCCTGCACGATGGATCGGCAGTTACGTCACCCGGCGCCATCGCTCGGAGCA
GCACCCCCTAGACTCACCGG

Downstream 100 bases:

>100_bases
TGCGATGCAGGCAGGCGCGGGCGCGCAGTGCGTGTTGCGCTTCGCGGTATCGCAAGGCTCTGCGCTCCTCCATCCGGCAA
CTGGCGGCGTTCGCGCAGGA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MALLPDSPSLPPGAAARAGSSARAAVTLREVADRAGVSMITVSRALKTPQQVSEATRARVEEAVSALGYVPNLLAGGLRS
ARSHLVMALVPTIRGQLFGEMIQSLTDALHARGFQVVFGEVGYAASREDELLRAIVGRRPDGIVLTGVMHSPEGRRLLLA
SGIPVVETWDTTPTPIDMLVGLSHERLGEAVCRYLHGRGRRRLALISGDDERAARRQRGFSEAARQLGLQEPVLRWVPAP
TSHAQGREGLAALRKDAPDIDAVFCSSDMLALGVLTEAREHAITVPQDLAVVGFGDIEFAATLAPSLTTVRIDGTRIGRT
AAAFIADRAEGRAVPEPRVDIGFSIVERESV

Sequences:

>Translated_351_residues
MALLPDSPSLPPGAAARAGSSARAAVTLREVADRAGVSMITVSRALKTPQQVSEATRARVEEAVSALGYVPNLLAGGLRS
ARSHLVMALVPTIRGQLFGEMIQSLTDALHARGFQVVFGEVGYAASREDELLRAIVGRRPDGIVLTGVMHSPEGRRLLLA
SGIPVVETWDTTPTPIDMLVGLSHERLGEAVCRYLHGRGRRRLALISGDDERAARRQRGFSEAARQLGLQEPVLRWVPAP
TSHAQGREGLAALRKDAPDIDAVFCSSDMLALGVLTEAREHAITVPQDLAVVGFGDIEFAATLAPSLTTVRIDGTRIGRT
AAAFIADRAEGRAVPEPRVDIGFSIVERESV
>Mature_350_residues
ALLPDSPSLPPGAAARAGSSARAAVTLREVADRAGVSMITVSRALKTPQQVSEATRARVEEAVSALGYVPNLLAGGLRSA
RSHLVMALVPTIRGQLFGEMIQSLTDALHARGFQVVFGEVGYAASREDELLRAIVGRRPDGIVLTGVMHSPEGRRLLLAS
GIPVVETWDTTPTPIDMLVGLSHERLGEAVCRYLHGRGRRRLALISGDDERAARRQRGFSEAARQLGLQEPVLRWVPAPT
SHAQGREGLAALRKDAPDIDAVFCSSDMLALGVLTEAREHAITVPQDLAVVGFGDIEFAATLAPSLTTVRIDGTRIGRTA
AAFIADRAEGRAVPEPRVDIGFSIVERESV

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=319, Percent_Identity=31.974921630094, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1790715, Length=327, Percent_Identity=29.6636085626911, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1790369, Length=319, Percent_Identity=28.8401253918495, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1790194, Length=328, Percent_Identity=28.0487804878049, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787948, Length=331, Percent_Identity=27.190332326284, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789068, Length=302, Percent_Identity=29.1390728476821, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788474, Length=331, Percent_Identity=27.190332326284, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789202, Length=328, Percent_Identity=24.0853658536585, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787906, Length=255, Percent_Identity=28.2352941176471, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786540, Length=337, Percent_Identity=25.5192878338279, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789456, Length=338, Percent_Identity=26.3313609467456, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37418; Mature: 37287

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLPDSPSLPPGAAARAGSSARAAVTLREVADRAGVSMITVSRALKTPQQVSEATRARV
CCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHH
EEAVSALGYVPNLLAGGLRSARSHLVMALVPTIRGQLFGEMIQSLTDALHARGFQVVFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
VGYAASREDELLRAIVGRRPDGIVLTGVMHSPEGRRLLLASGIPVVETWDTTPTPIDMLV
CCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCEEEECCCCCCCHHHHH
GLSHERLGEAVCRYLHGRGRRRLALISGDDERAARRQRGFSEAARQLGLQEPVLRWVPAP
CCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCHHHHHHHCCCCCCHHHHCCCC
TSHAQGREGLAALRKDAPDIDAVFCSSDMLALGVLTEAREHAITVPQDLAVVGFGDIEFA
CCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHH
ATLAPSLTTVRIDGTRIGRTAAAFIADRAEGRAVPEPRVDIGFSIVERESV
HHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure 
ALLPDSPSLPPGAAARAGSSARAAVTLREVADRAGVSMITVSRALKTPQQVSEATRARV
CCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHH
EEAVSALGYVPNLLAGGLRSARSHLVMALVPTIRGQLFGEMIQSLTDALHARGFQVVFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
VGYAASREDELLRAIVGRRPDGIVLTGVMHSPEGRRLLLASGIPVVETWDTTPTPIDMLV
CCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCEEEECCCCCCCHHHHH
GLSHERLGEAVCRYLHGRGRRRLALISGDDERAARRQRGFSEAARQLGLQEPVLRWVPAP
CCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCHHHHHHHCCCCCCHHHHCCCC
TSHAQGREGLAALRKDAPDIDAVFCSSDMLALGVLTEAREHAITVPQDLAVVGFGDIEFA
CCCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHH
ATLAPSLTTVRIDGTRIGRTAAAFIADRAEGRAVPEPRVDIGFSIVERESV
HHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]