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The map label for this gene is prs [H]

Identifier: 120612257

GI number: 120612257

Start: 3983617

End: 3984576

Strand: Direct

Name: prs [H]

Synonym: Aave_3610

Alternate gene names: 120612257

Gene position: 3983617-3984576 (Clockwise)

Preceding gene: 120612256

Following gene: 120612258

Centisome position: 74.42

GC content: 64.58

Gene sequence:

>960_bases
ATGCAAGCCAATCACCCCGACTTCATGGTTTTCACCGGCAATGCCAATCCAGGCATGGCCGCTGATATCGCCCGGCATCT
CGGCACGAGCCTCGGCGCCATCGACGTGGCACGCTTCTCCGACGGGGAAGTCACCGTGGAAATCAAGCAAAACGTCCGTG
CCCGCGACGTGTTCGTGGTGCAGTCCACCTGCGCCCCCACGAACGAGAACCTCATGGAACTGCTGATCATGGTCGATGCG
CTCAAGCGCGCATCCGCCGAGCGCATCAGTGCCGTGATCCCCTACTTCGGCTATGCCCGCCAGGACCGCCGCCCGCGTTC
CACGCGCGTGCCGATATCGGCCAAGGTCGTGGCCAACATGCTGCAGGCCGTCGGCGTCGCCCGCGTGCTGACCATGGACC
TGCACGCCGACCAGATCCAGGGCTTCTTCGACATCCCCGTGGACAACATCTACGCGTCGCCCGTGCTGCTCGGCGACCTG
CGCCAGAAGAACTACGAAGACCTCATCGTCGTGTCGCCCGATGTCGGCGGCGTGGTGCGTGCGCGTGCGCTGGCCAAGCA
GCTCGGCTGCGATCTCGCCATCATCGACAAGCGCCGCCCGAAGGCCAACGTCTCGGAAGTGATGCACGTGATCGGCGAGA
TCGAAGGCCGCAACTGCGTGATCATGGACGACATGATCGACACGGCAGGCACCCTCGTGAAGGCGGCCGAGGTCCTCAAG
GAGCGCGGTGCCAAGAAGGTGTACGCCTATTGCACGCACCCGATCTTCTCGGGCCCCGCCATCGACCGCATCTCCCAGGG
CGACGCGCTCGACGAGGTGGTCGTCACCAACACCATCCCCCTGAGCGAAGCCGGCAAGGGATGCACCAAGATTCGCCAGC
TCTCCGTGGCGCCGCTGATCGCCGAGACGATCCAGCGCATCGCCAAGGGAGAGTCGGTGATGAGCCTGTTCTCGGACTGA

Upstream 100 bases:

>100_bases
AAGGCACCGGATTTTGATTCCGGCATGCGAAGGTTCGAATCCTTCTTCCCCTGCCAAAGCTTTCCGCTTCGGGCATTTAC
TTCAGACTGCTGGGTCTCGC

Downstream 100 bases:

>100_bases
GGATTCCATCCTCCCCTGCTCCCGCCTTCCAGCGGGGCAGTCGATGCCAAGCCTCCTTCGGGAGGCTTGCGCGTTCGGGA
ACCTTTACGGCCCGCGGCCT

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MQANHPDFMVFTGNANPGMAADIARHLGTSLGAIDVARFSDGEVTVEIKQNVRARDVFVVQSTCAPTNENLMELLIMVDA
LKRASAERISAVIPYFGYARQDRRPRSTRVPISAKVVANMLQAVGVARVLTMDLHADQIQGFFDIPVDNIYASPVLLGDL
RQKNYEDLIVVSPDVGGVVRARALAKQLGCDLAIIDKRRPKANVSEVMHVIGEIEGRNCVIMDDMIDTAGTLVKAAEVLK
ERGAKKVYAYCTHPIFSGPAIDRISQGDALDEVVVTNTIPLSEAGKGCTKIRQLSVAPLIAETIQRIAKGESVMSLFSD

Sequences:

>Translated_319_residues
MQANHPDFMVFTGNANPGMAADIARHLGTSLGAIDVARFSDGEVTVEIKQNVRARDVFVVQSTCAPTNENLMELLIMVDA
LKRASAERISAVIPYFGYARQDRRPRSTRVPISAKVVANMLQAVGVARVLTMDLHADQIQGFFDIPVDNIYASPVLLGDL
RQKNYEDLIVVSPDVGGVVRARALAKQLGCDLAIIDKRRPKANVSEVMHVIGEIEGRNCVIMDDMIDTAGTLVKAAEVLK
ERGAKKVYAYCTHPIFSGPAIDRISQGDALDEVVVTNTIPLSEAGKGCTKIRQLSVAPLIAETIQRIAKGESVMSLFSD
>Mature_319_residues
MQANHPDFMVFTGNANPGMAADIARHLGTSLGAIDVARFSDGEVTVEIKQNVRARDVFVVQSTCAPTNENLMELLIMVDA
LKRASAERISAVIPYFGYARQDRRPRSTRVPISAKVVANMLQAVGVARVLTMDLHADQIQGFFDIPVDNIYASPVLLGDL
RQKNYEDLIVVSPDVGGVVRARALAKQLGCDLAIIDKRRPKANVSEVMHVIGEIEGRNCVIMDDMIDTAGTLVKAAEVLK
ERGAKKVYAYCTHPIFSGPAIDRISQGDALDEVVVTNTIPLSEAGKGCTKIRQLSVAPLIAETIQRIAKGESVMSLFSD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=48.5714285714286, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=47.9495268138801, Blast_Score=304, Evalue=6e-83,
Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=48.5714285714286, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=48.8888888888889, Blast_Score=301, Evalue=4e-82,
Organism=Homo sapiens, GI194018537, Length=354, Percent_Identity=36.4406779661017, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI4506133, Length=348, Percent_Identity=35.3448275862069, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=32.2147651006711, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=32.2147651006711, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=32.2147651006711, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=32.2147651006711, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=63.8977635782748, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=47.3015873015873, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=47.3015873015873, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71989924, Length=315, Percent_Identity=47.3015873015873, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=47.588424437299, Blast_Score=299, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=33.7243401759531, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321776, Length=304, Percent_Identity=46.0526315789474, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=44.5512820512821, Blast_Score=266, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=44.0894568690096, Blast_Score=262, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=41.8367346938776, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=35.0877192982456, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355239, Length=321, Percent_Identity=47.9750778816199, Blast_Score=296, Evalue=9e-81,
Organism=Drosophila melanogaster, GI45551540, Length=343, Percent_Identity=44.6064139941691, Blast_Score=287, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24651458, Length=358, Percent_Identity=33.5195530726257, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24651456, Length=358, Percent_Identity=33.5195530726257, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI281362873, Length=358, Percent_Identity=33.5195530726257, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24651454, Length=358, Percent_Identity=33.5195530726257, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24651462, Length=203, Percent_Identity=36.9458128078818, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24651464, Length=203, Percent_Identity=36.9458128078818, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45552010, Length=203, Percent_Identity=36.9458128078818, Blast_Score=141, Evalue=5e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34601; Mature: 34601

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQANHPDFMVFTGNANPGMAADIARHLGTSLGAIDVARFSDGEVTVEIKQNVRARDVFVV
CCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCEEEEEEE
QSTCAPTNENLMELLIMVDALKRASAERISAVIPYFGYARQDRRPRSTRVPISAKVVANM
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHH
LQAVGVARVLTMDLHADQIQGFFDIPVDNIYASPVLLGDLRQKNYEDLIVVSPDVGGVVR
HHHHHHHHHHHHHCCHHHHCCEEECCHHHHCCCCHHHHHHHCCCCCCEEEECCCCCHHHH
ARALAKQLGCDLAIIDKRRPKANVSEVMHVIGEIEGRNCVIMDDMIDTAGTLVKAAEVLK
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
ERGAKKVYAYCTHPIFSGPAIDRISQGDALDEVVVTNTIPLSEAGKGCTKIRQLSVAPLI
HCCCCEEEEEECCCCCCCCHHHHCCCCCCHHHHHEECCCCHHHCCCHHHHHHHHHHHHHH
AETIQRIAKGESVMSLFSD
HHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MQANHPDFMVFTGNANPGMAADIARHLGTSLGAIDVARFSDGEVTVEIKQNVRARDVFVV
CCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCEEEEEEE
QSTCAPTNENLMELLIMVDALKRASAERISAVIPYFGYARQDRRPRSTRVPISAKVVANM
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHH
LQAVGVARVLTMDLHADQIQGFFDIPVDNIYASPVLLGDLRQKNYEDLIVVSPDVGGVVR
HHHHHHHHHHHHHCCHHHHCCEEECCHHHHCCCCHHHHHHHCCCCCCEEEECCCCCHHHH
ARALAKQLGCDLAIIDKRRPKANVSEVMHVIGEIEGRNCVIMDDMIDTAGTLVKAAEVLK
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
ERGAKKVYAYCTHPIFSGPAIDRISQGDALDEVVVTNTIPLSEAGKGCTKIRQLSVAPLI
HCCCCEEEEEECCCCCCCCHHHHCCCCCCHHHHHEECCCCHHHCCCHHHHHHHHHHHHHH
AETIQRIAKGESVMSLFSD
HHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]