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The map label for this gene is ipk

Identifier: 120612256

GI number: 120612256

Start: 3982607

End: 3983464

Strand: Direct

Name: ipk

Synonym: Aave_3609

Alternate gene names: 120612256

Gene position: 3982607-3983464 (Clockwise)

Preceding gene: 120612255

Following gene: 120612257

Centisome position: 74.4

GC content: 63.87

Gene sequence:

>858_bases
ATGCGCACGCTCCACGACCTGCCTGCCCCGGCCAAGCTCAACCTGTTCCTGCACATCACCGGGCGCAGGCCCGACGGCTA
CCACCTGCTGCAGTCGGTCTTCATGCTGATCGACTGGTGCGACACGCTGCATATCGAGTTGCGCCCGGACGGCGGAATCA
GCCGGGAAGACATGGGCGCCGGGCTGCCTGCCGACGACCTCTGCACGCGCGCGGCCCGCGCGCTGCAGGCGGCCACGGGC
ACGCGGCAGGGTGCGCACATCGTCCTGGAGAAGTCCATCCCAGCGCAGGCCGGGATGGGCGGCGGCTCTTCGGACGCGGC
GACCACGCTGCTCGCCCTCAACCGGCTCTGGGGGCTGGGCCTGGGCCGCACGGCGCTCGAGCGCATCGGACTGTCGCTCG
GGGCCGACATTCCCTTCTTCTTGCGCGGCAGGAACGCCTGGGTCGAGGGAATCGGTGAGACAATCATGCCGCTCGAGAAC
GTGCACGCGCTGCCGCAGAGCCGGTTCGTGGTGGTCAAGCCCGAAGCCGGACTGGATACGAAATCGATTTTTTCGTCTCC
TTCGCTGGAACGCAATTCAGAGCGTGCTACAATCTCAGGCTTTGCTGCAGCACACTACCAATTTGGTAAGAACGTTCTGC
AGCCGGTCGCAGAAACGCTCTGCCCCGAGGTCTCCGAAGCCATCCGCTGGCTGGAGCACAAGGGATTGCAGGCACGAATG
ACCGGCTCGGGAAGTGCGGTGTTTGCGCAAATGACACATGCGATCGATTTATTCGATCTGCCCACCGGATGGAGGGCAAA
AGTATGTGATAATCTGAGGCTCCACCCCCTAGCAGGGTGGGCAGCAGATGAAGATTGA

Upstream 100 bases:

>100_bases
TCGATACCAGCAGGCTGGACGACGGCCGGCTGACCGCGCACCGCCAGAGCCCGCTGCCGGAGGCCACGCTGCGCATCGTG
CTGGACCGCTGACCCGATCC

Downstream 100 bases:

>100_bases
GGTGGATTGCCATCAGGCAGTCAACCTGTGTAGGGGAGTCGCCAAGCTGGTTAAGGCACCGGATTTTGATTCCGGCATGC
GAAGGTTCGAATCCTTCTTC

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRTLHDLPAPAKLNLFLHITGRRPDGYHLLQSVFMLIDWCDTLHIELRPDGGISREDMGAGLPADDLCTRAARALQAATG
TRQGAHIVLEKSIPAQAGMGGGSSDAATTLLALNRLWGLGLGRTALERIGLSLGADIPFFLRGRNAWVEGIGETIMPLEN
VHALPQSRFVVVKPEAGLDTKSIFSSPSLERNSERATISGFAAAHYQFGKNVLQPVAETLCPEVSEAIRWLEHKGLQARM
TGSGSAVFAQMTHAIDLFDLPTGWRAKVCDNLRLHPLAGWAADED

Sequences:

>Translated_285_residues
MRTLHDLPAPAKLNLFLHITGRRPDGYHLLQSVFMLIDWCDTLHIELRPDGGISREDMGAGLPADDLCTRAARALQAATG
TRQGAHIVLEKSIPAQAGMGGGSSDAATTLLALNRLWGLGLGRTALERIGLSLGADIPFFLRGRNAWVEGIGETIMPLEN
VHALPQSRFVVVKPEAGLDTKSIFSSPSLERNSERATISGFAAAHYQFGKNVLQPVAETLCPEVSEAIRWLEHKGLQARM
TGSGSAVFAQMTHAIDLFDLPTGWRAKVCDNLRLHPLAGWAADED
>Mature_285_residues
MRTLHDLPAPAKLNLFLHITGRRPDGYHLLQSVFMLIDWCDTLHIELRPDGGISREDMGAGLPADDLCTRAARALQAATG
TRQGAHIVLEKSIPAQAGMGGGSSDAATTLLALNRLWGLGLGRTALERIGLSLGADIPFFLRGRNAWVEGIGETIMPLEN
VHALPQSRFVVVKPEAGLDTKSIFSSPSLERNSERATISGFAAAHYQFGKNVLQPVAETLCPEVSEAIRWLEHKGLQARM
TGSGSAVFAQMTHAIDLFDLPTGWRAKVCDNLRLHPLAGWAADED

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=258, Percent_Identity=40.6976744186046, Blast_Score=168, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_ACIAC (A1TT72)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971934.1
- ProteinModelPortal:   A1TT72
- SMR:   A1TT72
- STRING:   A1TT72
- GeneID:   4666546
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3609
- eggNOG:   COG1947
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- PhylomeDB:   A1TT72
- ProtClustDB:   PRK00343
- BioCyc:   AAVE397945:AAVE_3609-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 30830; Mature: 30830

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: ACT_SITE 12-12 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLHDLPAPAKLNLFLHITGRRPDGYHLLQSVFMLIDWCDTLHIELRPDGGISREDMGA
CCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCC
GLPADDLCTRAARALQAATGTRQGAHIVLEKSIPAQAGMGGGSSDAATTLLALNRLWGLG
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
LGRTALERIGLSLGADIPFFLRGRNAWVEGIGETIMPLENVHALPQSRFVVVKPEAGLDT
CCHHHHHHHHHHHCCCCCEEEECCHHHHHHCCHHHHCHHHHHCCCCCCEEEECCCCCCCH
KSIFSSPSLERNSERATISGFAAAHYQFGKNVLQPVAETLCPEVSEAIRWLEHKGLQARM
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEE
TGSGSAVFAQMTHAIDLFDLPTGWRAKVCDNLRLHPLAGWAADED
CCCCCHHHHHHHHHHHEEECCCCCHHHHHCCCEEEECCCCCCCCC
>Mature Secondary Structure
MRTLHDLPAPAKLNLFLHITGRRPDGYHLLQSVFMLIDWCDTLHIELRPDGGISREDMGA
CCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCC
GLPADDLCTRAARALQAATGTRQGAHIVLEKSIPAQAGMGGGSSDAATTLLALNRLWGLG
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
LGRTALERIGLSLGADIPFFLRGRNAWVEGIGETIMPLENVHALPQSRFVVVKPEAGLDT
CCHHHHHHHHHHHCCCCCEEEECCHHHHHHCCHHHHCHHHHHCCCCCCEEEECCCCCCCH
KSIFSSPSLERNSERATISGFAAAHYQFGKNVLQPVAETLCPEVSEAIRWLEHKGLQARM
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEE
TGSGSAVFAQMTHAIDLFDLPTGWRAKVCDNLRLHPLAGWAADED
CCCCCHHHHHHHHHHHEEECCCCCHHHHHCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA