Click here to switch to the map view.

The map label for this gene is mutY [H]

Identifier: 120612251

GI number: 120612251

Start: 3976291

End: 3977382

Strand: Reverse

Name: mutY [H]

Synonym: Aave_3604

Alternate gene names: 120612251

Gene position: 3977382-3976291 (Counterclockwise)

Preceding gene: 120612252

Following gene: 120612247

Centisome position: 74.31

GC content: 71.25

Gene sequence:

>1092_bases
ATGAAGCGCGAGGTCCCCGACATCGCCACCGAAGTGGTGCGCTGGCAGGCCGTGCACGGCCGCAACCACCTGCCGTGGCA
GCAGACGCGCGACCCCTACCGGGTCTGGCTGTCCGAAATCATGCTGCAGCAGACGCAGGTCAACACGGTGCTGGACTATT
ACACCCGGTTCCTGGAGCGGTTCCCCGACGTGCGCGCCCTGGCCGCGGCGCCGGAGGACGACGTCATGGCCCTCTGGAGC
GGGCTGGGCTACTACAGCCGCGCCCGCAACCTGCACCGCTGCGCCAGGGAGGTCGTGGATCGGTACGGCGGGGAATTTCC
GCGCTCCGCCGAGGCCCTGGCCGGCCTGCCTGGCATCGGCCGTTCCACGGCCGGCGCGATCGCCTCCTTCTGCTTCGCGG
AGCGCGTGCCCATTCTGGACGCCAATGTCCGGCGGGTGCTCACGCGGGTGCTCGGCTTCGATGCCGACCTGGCCGTCGCC
CGCAACGAGCGTGACCTGTGGGACCGTGCCAGCGAACTCCTGCCGCACGACGATCTGCAGGAGGCCATGCCCCGCTACAC
GCAGGGCCTGATGGATCTGGGCGCGAGCCTCTGCACGCCCCGCAAGCCCGCCTGCATTCTCTGCCCCCTGCAACCGCAAT
GCGTGGCCGCCGTGGCCGGCAATCCCGAGGATTACCCCGTGCGCACGCGCAAGCTGCTGCGGCGGGCGCAGGCATGGTGG
TTTCCGCTGCTGCACGACGGCGAGGGGCGCCTCTGGCTGCAGCGCAGGCCTTCCGAGGGCATCTGGGCCGGCCTGCATTG
CCCGCCCATGTTCGACAGCCGGGAGGATGCGCTGCAATGGCTCGCGCAGCGCGGCGCGGGCCGCACGCCGCGGGAACTGG
ACACCGTGTTCCATGTCCTCACGCACCGGGACCTGCACCTGCATCCCCTGCTGGTGCGCGGGCCGGAAACTGCCGCGCCC
GGCCAGGCCGAAGCGGCGCAGGAGGGCGGCTGGTACACAGCCGCGCAATGGAAGGCGCTGGGATTGCCGGCCCCCGTGCG
CAAGCTGCTGGAACAGTTGCAGCTGCCCGCTGCGGGAGCCGTGGAGGCCTGA

Upstream 100 bases:

>100_bases
AACTCGCGCAACTGGAGGCGCGCCTGCACGAGCTGACGGAGCAACTGGCTTCCCTGCCGGCGGAAAACGGCAAGCCCCAG
CCCCGGGCGCCGCTGTCCGC

Downstream 100 bases:

>100_bases
GCCGGGGTGCCCGGGCAGGGCGGCCGTCTAGCGCCCGTCGAGTTCCCGGTGCCGTCGCAGCGTCGTCCAGCGGTCTGAAA
ATTCCGCTGCGAGCTGCTCG

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MKREVPDIATEVVRWQAVHGRNHLPWQQTRDPYRVWLSEIMLQQTQVNTVLDYYTRFLERFPDVRALAAAPEDDVMALWS
GLGYYSRARNLHRCAREVVDRYGGEFPRSAEALAGLPGIGRSTAGAIASFCFAERVPILDANVRRVLTRVLGFDADLAVA
RNERDLWDRASELLPHDDLQEAMPRYTQGLMDLGASLCTPRKPACILCPLQPQCVAAVAGNPEDYPVRTRKLLRRAQAWW
FPLLHDGEGRLWLQRRPSEGIWAGLHCPPMFDSREDALQWLAQRGAGRTPRELDTVFHVLTHRDLHLHPLLVRGPETAAP
GQAEAAQEGGWYTAAQWKALGLPAPVRKLLEQLQLPAAGAVEA

Sequences:

>Translated_363_residues
MKREVPDIATEVVRWQAVHGRNHLPWQQTRDPYRVWLSEIMLQQTQVNTVLDYYTRFLERFPDVRALAAAPEDDVMALWS
GLGYYSRARNLHRCAREVVDRYGGEFPRSAEALAGLPGIGRSTAGAIASFCFAERVPILDANVRRVLTRVLGFDADLAVA
RNERDLWDRASELLPHDDLQEAMPRYTQGLMDLGASLCTPRKPACILCPLQPQCVAAVAGNPEDYPVRTRKLLRRAQAWW
FPLLHDGEGRLWLQRRPSEGIWAGLHCPPMFDSREDALQWLAQRGAGRTPRELDTVFHVLTHRDLHLHPLLVRGPETAAP
GQAEAAQEGGWYTAAQWKALGLPAPVRKLLEQLQLPAAGAVEA
>Mature_363_residues
MKREVPDIATEVVRWQAVHGRNHLPWQQTRDPYRVWLSEIMLQQTQVNTVLDYYTRFLERFPDVRALAAAPEDDVMALWS
GLGYYSRARNLHRCAREVVDRYGGEFPRSAEALAGLPGIGRSTAGAIASFCFAERVPILDANVRRVLTRVLGFDADLAVA
RNERDLWDRASELLPHDDLQEAMPRYTQGLMDLGASLCTPRKPACILCPLQPQCVAAVAGNPEDYPVRTRKLLRRAQAWW
FPLLHDGEGRLWLQRRPSEGIWAGLHCPPMFDSREDALQWLAQRGAGRTPRELDTVFHVLTHRDLHLHPLLVRGPETAAP
GQAEAAQEGGWYTAAQWKALGLPAPVRKLLEQLQLPAAGAVEA

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=226, Percent_Identity=42.0353982300885, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI115298648, Length=226, Percent_Identity=42.0353982300885, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI115298654, Length=226, Percent_Identity=42.0353982300885, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI115298652, Length=226, Percent_Identity=42.0353982300885, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI6912520, Length=226, Percent_Identity=42.0353982300885, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI190358497, Length=226, Percent_Identity=42.0353982300885, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1789331, Length=357, Percent_Identity=42.5770308123249, Blast_Score=275, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40848; Mature: 40848

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREVPDIATEVVRWQAVHGRNHLPWQQTRDPYRVWLSEIMLQQTQVNTVLDYYTRFLER
CCCCCHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPDVRALAAAPEDDVMALWSGLGYYSRARNLHRCAREVVDRYGGEFPRSAEALAGLPGIG
CCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
RSTAGAIASFCFAERVPILDANVRRVLTRVLGFDADLAVARNERDLWDRASELLPHDDLQ
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHCCCCCHHH
EAMPRYTQGLMDLGASLCTPRKPACILCPLQPQCVAAVAGNPEDYPVRTRKLLRRAQAWW
HHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
FPLLHDGEGRLWLQRRPSEGIWAGLHCPPMFDSREDALQWLAQRGAGRTPRELDTVFHVL
CCEEECCCCCEEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
THRDLHLHPLLVRGPETAAPGQAEAAQEGGWYTAAQWKALGLPAPVRKLLEQLQLPAAGA
HCCCCCCCEEEEECCCCCCCCCCHHHHCCCCEEHHCCCCCCCCHHHHHHHHHHCCCCCCC
VEA
CCC
>Mature Secondary Structure
MKREVPDIATEVVRWQAVHGRNHLPWQQTRDPYRVWLSEIMLQQTQVNTVLDYYTRFLER
CCCCCHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPDVRALAAAPEDDVMALWSGLGYYSRARNLHRCAREVVDRYGGEFPRSAEALAGLPGIG
CCCHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
RSTAGAIASFCFAERVPILDANVRRVLTRVLGFDADLAVARNERDLWDRASELLPHDDLQ
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHCCCCCHHH
EAMPRYTQGLMDLGASLCTPRKPACILCPLQPQCVAAVAGNPEDYPVRTRKLLRRAQAWW
HHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
FPLLHDGEGRLWLQRRPSEGIWAGLHCPPMFDSREDALQWLAQRGAGRTPRELDTVFHVL
CCEEECCCCCEEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
THRDLHLHPLLVRGPETAAPGQAEAAQEGGWYTAAQWKALGLPAPVRKLLEQLQLPAAGA
HCCCCCCCEEEEECCCCCCCCCCHHHHCCCCEEHHCCCCCCCCHHHHHHHHHHCCCCCCC
VEA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]