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The map label for this gene is lip2 [H]

Identifier: 120612069

GI number: 120612069

Start: 3772005

End: 3773084

Strand: Reverse

Name: lip2 [H]

Synonym: Aave_3416

Alternate gene names: 120612069

Gene position: 3773084-3772005 (Counterclockwise)

Preceding gene: 120612070

Following gene: 120612068

Centisome position: 70.49

GC content: 72.41

Gene sequence:

>1080_bases
ATGATCGGCGATGCGCCGCAGTGCGTGTTCCCTGTCTGTCCCCGATCCGTGATTCCCGTGACCGCTCCACCTCTTTCGCC
GCCTCCGATATCCACCCCCCGCGCGCACCGCCTCACGCCGCAGATGCGCAGCGTGATCGACCGCATGCACCGCGCGCGCC
GTCCGCCGCTGGAAACCCTGTCCGTGCAGGAGGCCCGTGCCGCCTATGAACTGGGCGCGGGCGTGCTCGAGATTCCCAAG
CCTGCGCTGCCGCGCGTGGAGCCGCTGCGCATCCCGGCGCGCGACGGCCATGCGCTGCCGGCACGCCTGTACGCGCCGCA
CGCGGAGGGCGGTGCATTGCCGGTGCTGCTCTACCTGCATGGCGGCGGCTTCACCGTGGGCAGCATCGACACGCACGACA
CGCTGTGCCGCGAGCTGGCGCGCCGTGCCGGCTGCATGGTCGTGTCGCTGGGCTACCGGCTCGCGCCGGAGCACCGGTTC
CCCGCGGCGGTGGAGGACACCTGGGATGCCCTGGCCTGGCTGGCCGCTGAGGGTCGCGGCATCGGCGCCGACCCCTCGCG
CATCGCGGTGGGTGGCGACAGCGCGGGTGGCACGCTGGCCGCCGTGGCAGCCCTGCAGGCGCGCGATGCGGGCCTGCCGC
TGGCGTTGCAACTGCTGATCTACCCGGGTTGCGCCGCGCACCAGGACACGCCCTCGCACGCGCTGTACGCGCACGGGTTC
GTGCTGGAGGAGCCGGCCATCACCTGGTTCTTCAGCCACTATGTGACCCACGCCCAGCGCGACGACTGGCGCTTCGCTCC
GCTGCATGCTCCCGATGTGGACGGCGTGGCGCCCGCATGGGTCGGCCTGGCCGAATGCGATCCGCTCGTGGACGAGGGGA
TTGCCTACGCCGACAGGCTGCGTGCCGCGGGCGTCGCCGTGGACCTGGAGATCTATCGCGGCGTCACCCACGAATTCATC
AAGATGGGGCGCGCCATCCCCGAGGCGCGCACCGCCCACGGCCATGCTGCTGCCGCCCTGCGCGCGGCCTTCGGCCTGCC
CGGACCCCTGGACGAGGAGACCTCCGATGCGACGCGCTGA

Upstream 100 bases:

>100_bases
GCCGCGCCCGTGGAAGTGCGTTTCAGGTAAGAAGCTATGGCCGCGGCTGCGTCCTGCGCCCCGGTCGCGCAGGGCACTGC
AGGCGGCACCGGTTTCGGGG

Downstream 100 bases:

>100_bases
TTTCCCGTGTACCGAACGCCTGCGCGTGCGCTGGGCAGAGGTGGACATGCAGAAGATCGTCTTCAACGGCCACTACCTCA
TGTACATCGACACCGCCATG

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MIGDAPQCVFPVCPRSVIPVTAPPLSPPPISTPRAHRLTPQMRSVIDRMHRARRPPLETLSVQEARAAYELGAGVLEIPK
PALPRVEPLRIPARDGHALPARLYAPHAEGGALPVLLYLHGGGFTVGSIDTHDTLCRELARRAGCMVVSLGYRLAPEHRF
PAAVEDTWDALAWLAAEGRGIGADPSRIAVGGDSAGGTLAAVAALQARDAGLPLALQLLIYPGCAAHQDTPSHALYAHGF
VLEEPAITWFFSHYVTHAQRDDWRFAPLHAPDVDGVAPAWVGLAECDPLVDEGIAYADRLRAAGVAVDLEIYRGVTHEFI
KMGRAIPEARTAHGHAAAALRAAFGLPGPLDEETSDATR

Sequences:

>Translated_359_residues
MIGDAPQCVFPVCPRSVIPVTAPPLSPPPISTPRAHRLTPQMRSVIDRMHRARRPPLETLSVQEARAAYELGAGVLEIPK
PALPRVEPLRIPARDGHALPARLYAPHAEGGALPVLLYLHGGGFTVGSIDTHDTLCRELARRAGCMVVSLGYRLAPEHRF
PAAVEDTWDALAWLAAEGRGIGADPSRIAVGGDSAGGTLAAVAALQARDAGLPLALQLLIYPGCAAHQDTPSHALYAHGF
VLEEPAITWFFSHYVTHAQRDDWRFAPLHAPDVDGVAPAWVGLAECDPLVDEGIAYADRLRAAGVAVDLEIYRGVTHEFI
KMGRAIPEARTAHGHAAAALRAAFGLPGPLDEETSDATR
>Mature_359_residues
MIGDAPQCVFPVCPRSVIPVTAPPLSPPPISTPRAHRLTPQMRSVIDRMHRARRPPLETLSVQEARAAYELGAGVLEIPK
PALPRVEPLRIPARDGHALPARLYAPHAEGGALPVLLYLHGGGFTVGSIDTHDTLCRELARRAGCMVVSLGYRLAPEHRF
PAAVEDTWDALAWLAAEGRGIGADPSRIAVGGDSAGGTLAAVAALQARDAGLPLALQLLIYPGCAAHQDTPSHALYAHGF
VLEEPAITWFFSHYVTHAQRDDWRFAPLHAPDVDGVAPAWVGLAECDPLVDEGIAYADRLRAAGVAVDLEIYRGVTHEFI
KMGRAIPEARTAHGHAAAALRAAFGLPGPLDEETSDATR

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=179, Percent_Identity=35.7541899441341, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI206597554, Length=174, Percent_Identity=36.2068965517241, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI157041239, Length=168, Percent_Identity=35.1190476190476, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI68051721, Length=270, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI61966717, Length=131, Percent_Identity=37.4045801526718, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI226423947, Length=278, Percent_Identity=26.6187050359712, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI157041237, Length=136, Percent_Identity=33.8235294117647, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI21328446, Length=98, Percent_Identity=34.6938775510204, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786682, Length=309, Percent_Identity=27.1844660194175, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17567059, Length=319, Percent_Identity=26.9592476489028, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71996133, Length=164, Percent_Identity=33.5365853658537, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17540028, Length=164, Percent_Identity=32.3170731707317, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI72001146, Length=138, Percent_Identity=34.0579710144928, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533412, Length=124, Percent_Identity=32.258064516129, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI115533410, Length=124, Percent_Identity=32.258064516129, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24656084, Length=98, Percent_Identity=34.6938775510204, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656076, Length=98, Percent_Identity=34.6938775510204, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20130169, Length=98, Percent_Identity=34.6938775510204, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 38279; Mature: 38279

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01173 LIPASE_GDXG_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGDAPQCVFPVCPRSVIPVTAPPLSPPPISTPRAHRLTPQMRSVIDRMHRARRPPLETL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
SVQEARAAYELGAGVLEIPKPALPRVEPLRIPARDGHALPARLYAPHAEGGALPVLLYLH
HHHHHHHHHHHCCCCEECCCCCCCCCCCEECCCCCCCCCCHHEECCCCCCCCCEEEEEEE
GGGFTVGSIDTHDTLCRELARRAGCMVVSLGYRLAPEHRFPAAVEDTWDALAWLAAEGRG
CCCEEECCCCCHHHHHHHHHHHCCEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHCCCC
IGADPSRIAVGGDSAGGTLAAVAALQARDAGLPLALQLLIYPGCAAHQDTPSHALYAHGF
CCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEEHHHHCCCCCCCCCCCCCEEEECCE
VLEEPAITWFFSHYVTHAQRDDWRFAPLHAPDVDGVAPAWVGLAECDPLVDEGIAYADRL
EECCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
RAAGVAVDLEIYRGVTHEFIKMGRAIPEARTAHGHAAAALRAAFGLPGPLDEETSDATR
HHCCEEEEHHHHHCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIGDAPQCVFPVCPRSVIPVTAPPLSPPPISTPRAHRLTPQMRSVIDRMHRARRPPLETL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
SVQEARAAYELGAGVLEIPKPALPRVEPLRIPARDGHALPARLYAPHAEGGALPVLLYLH
HHHHHHHHHHHCCCCEECCCCCCCCCCCEECCCCCCCCCCHHEECCCCCCCCCEEEEEEE
GGGFTVGSIDTHDTLCRELARRAGCMVVSLGYRLAPEHRFPAAVEDTWDALAWLAAEGRG
CCCEEECCCCCHHHHHHHHHHHCCEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHCCCC
IGADPSRIAVGGDSAGGTLAAVAALQARDAGLPLALQLLIYPGCAAHQDTPSHALYAHGF
CCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEEHHHHCCCCCCCCCCCCCEEEECCE
VLEEPAITWFFSHYVTHAQRDDWRFAPLHAPDVDGVAPAWVGLAECDPLVDEGIAYADRL
EECCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
RAAGVAVDLEIYRGVTHEFIKMGRAIPEARTAHGHAAAALRAAFGLPGPLDEETSDATR
HHCCEEEEHHHHHCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]