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The map label for this gene is tmk

Identifier: 120612065

GI number: 120612065

Start: 3768253

End: 3768918

Strand: Reverse

Name: tmk

Synonym: Aave_3412

Alternate gene names: 120612065

Gene position: 3768918-3768253 (Counterclockwise)

Preceding gene: 120612066

Following gene: 120612064

Centisome position: 70.41

GC content: 73.27

Gene sequence:

>666_bases
ATGCAGCGACGGGGTTGGTTCATCACATTCGAGGGCATCGACGGGGCGGGAAAGTCCTCCCACATCGAGGCCGTGGCCGA
GGCGCTGCGCCGCGAGGGCCGCACGGTCACCGTGACCCGCGAGCCCGGGGGAACGCCCCTGGCCGAGACCCTGCGCTCGC
TGCTGCTGAACGAGGCCATGGACGCGCTCACCGAGTCGCTGGTCGTCTTCGCCGGCCGCCGCGACCACCTGCGCTCGGTG
ATCGCGCCTGCGCTCGTGCGCGGCGAGGTCGTGCTGTGCGACCGCTTCACCGACGCCACGTTCGCCTACCAGGGCGCGGG
GCGGGGCTTCGACCGGGCCGTGCTCGCCCAGCTCGAGCGCATCACCCAGTCGGGCCTGCAGGAAGGCACGGATGCCGTCC
TCCATCCCCACCTGACACTCTGGTTCGACCTGGCACCGGACGTGGCCGCAGCGCGGCTCGAAGGCGCGCGCGCGCCGGAC
CGGTTCGAGGCGCAGCCCGTGGAGTTCTTCCGCCGCGTGGCGCAGGGCTATGCCGACCGGGCGGCGGCCGACCCCGGTCG
CTTCGCGCGGCTCGATGCCGACCAGCCGCGCGAGGCGGTGCGTGCGCAGCTCATGGAAATCCTCCACCGGCGTGGCGTGC
TGGATGCGGCGCAGGAGGGCGGATGA

Upstream 100 bases:

>100_bases
GAACACAACCGCGCGGTGAACCGCTACCAGCGCGGCCAGCCGGCGCCGCAGGGGCAGTAAACCGCACCGGCAGCGCACGC
ACCACAAAGGTCTTTCTTCC

Downstream 100 bases:

>100_bases
GCGCGGCCGCCGTGTCTCCCTGGATCGCTGCCCAGCGCCGCAGGCTCCTGGCCCAGCGCGGCCATGCCTGGCTGCTCAGC
GGCCCCTCCGGGCTGGGGCA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MQRRGWFITFEGIDGAGKSSHIEAVAEALRREGRTVTVTREPGGTPLAETLRSLLLNEAMDALTESLVVFAGRRDHLRSV
IAPALVRGEVVLCDRFTDATFAYQGAGRGFDRAVLAQLERITQSGLQEGTDAVLHPHLTLWFDLAPDVAAARLEGARAPD
RFEAQPVEFFRRVAQGYADRAAADPGRFARLDADQPREAVRAQLMEILHRRGVLDAAQEGG

Sequences:

>Translated_221_residues
MQRRGWFITFEGIDGAGKSSHIEAVAEALRREGRTVTVTREPGGTPLAETLRSLLLNEAMDALTESLVVFAGRRDHLRSV
IAPALVRGEVVLCDRFTDATFAYQGAGRGFDRAVLAQLERITQSGLQEGTDAVLHPHLTLWFDLAPDVAAARLEGARAPD
RFEAQPVEFFRRVAQGYADRAAADPGRFARLDADQPREAVRAQLMEILHRRGVLDAAQEGG
>Mature_221_residues
MQRRGWFITFEGIDGAGKSSHIEAVAEALRREGRTVTVTREPGGTPLAETLRSLLLNEAMDALTESLVVFAGRRDHLRSV
IAPALVRGEVVLCDRFTDATFAYQGAGRGFDRAVLAQLERITQSGLQEGTDAVLHPHLTLWFDLAPDVAAARLEGARAPD
RFEAQPVEFFRRVAQGYADRAAADPGRFARLDADQPREAVRAQLMEILHRRGVLDAAQEGG

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=207, Percent_Identity=40.0966183574879, Blast_Score=120, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_ACIAC (A1TSN1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971743.1
- ProteinModelPortal:   A1TSN1
- SMR:   A1TSN1
- STRING:   A1TSN1
- GeneID:   4668471
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3412
- NMPDR:   fig|397945.5.peg.2914
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   A1TSN1
- BioCyc:   AAVE397945:AAVE_3412-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24216; Mature: 24216

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRRGWFITFEGIDGAGKSSHIEAVAEALRREGRTVTVTREPGGTPLAETLRSLLLNEAM
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHH
DALTESLVVFAGRRDHLRSVIAPALVRGEVVLCDRFTDATFAYQGAGRGFDRAVLAQLER
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHH
ITQSGLQEGTDAVLHPHLTLWFDLAPDVAAARLEGARAPDRFEAQPVEFFRRVAQGYADR
HHHHHHHHCCHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
AAADPGRFARLDADQPREAVRAQLMEILHRRGVLDAAQEGG
HCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MQRRGWFITFEGIDGAGKSSHIEAVAEALRREGRTVTVTREPGGTPLAETLRSLLLNEAM
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHH
DALTESLVVFAGRRDHLRSVIAPALVRGEVVLCDRFTDATFAYQGAGRGFDRAVLAQLER
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHH
ITQSGLQEGTDAVLHPHLTLWFDLAPDVAAARLEGARAPDRFEAQPVEFFRRVAQGYADR
HHHHHHHHCCHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
AAADPGRFARLDADQPREAVRAQLMEILHRRGVLDAAQEGG
HCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA