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The map label for this gene is lrp [H]

Identifier: 120611976

GI number: 120611976

Start: 3669425

End: 3669937

Strand: Reverse

Name: lrp [H]

Synonym: Aave_3320

Alternate gene names: 120611976

Gene position: 3669937-3669425 (Counterclockwise)

Preceding gene: 120611978

Following gene: 120611975

Centisome position: 68.56

GC content: 64.13

Gene sequence:

>513_bases
ATGAATGTTTCACTATGGATCGGAGGTAACGTGGATGAAATCGATAGGGTGGACCGCAGAATCCTGGCAATCCTGCAGGA
CGACGGCCGCATCTCCAACATCAAGCTCGCCGAACGAGTCGCCCTGTCGCCCACCGCCGTGCTCGCGCGGGTGCAGCGGC
TCACGCGCGAGGGCTACATCCTGGGCTACGAGGCGCGGCTCAATCCGCAGAAACTCGGCGCCGGCATGCTCGTGTTCGTC
GAGGTGCTGCTGGACCGCACCACGCCCAACGTGTTCGACCAGTTCAAGGCCGCGGTGCAGGTCCACCCGGCCATCATGGA
GTGCCACATGGTGGCGGGCGGTTTCGATTACCTGCTCAAGACCCGGCAGGCCGACATGAACGCCTACCGGCAGTTCGCCG
GAGAGGTGCTGTGGCAACTGCCCGGCGTGCGCGAAACGCGCACCTATGCGGTGATGGAAGAGGTCAAGCACTCCTTCCAT
CTCGCGCTGGACGAACGCGCCGCGCGCTCCTGA

Upstream 100 bases:

>100_bases
TTCATGGCAGAGCGGTCCGGGGGCGGGACGAAGGTGGAGTGAATGCCTGCGATCATCTCGCCGAGTCGGTTGAATTAATG
CGCAAAAATACCGATCATGA

Downstream 100 bases:

>100_bases
GTCCCTGGCCGGCCCGCGCATGCCGCAAAGTCCGCAATAATCGGCGTCGCGCCGACCGGTTCCGGCCCGTCCCGCCACCC
CTACCCAGGAGCTCTGCCGA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNVSLWIGGNVDEIDRVDRRILAILQDDGRISNIKLAERVALSPTAVLARVQRLTREGYILGYEARLNPQKLGAGMLVFV
EVLLDRTTPNVFDQFKAAVQVHPAIMECHMVAGGFDYLLKTRQADMNAYRQFAGEVLWQLPGVRETRTYAVMEEVKHSFH
LALDERAARS

Sequences:

>Translated_170_residues
MNVSLWIGGNVDEIDRVDRRILAILQDDGRISNIKLAERVALSPTAVLARVQRLTREGYILGYEARLNPQKLGAGMLVFV
EVLLDRTTPNVFDQFKAAVQVHPAIMECHMVAGGFDYLLKTRQADMNAYRQFAGEVLWQLPGVRETRTYAVMEEVKHSFH
LALDERAARS
>Mature_170_residues
MNVSLWIGGNVDEIDRVDRRILAILQDDGRISNIKLAERVALSPTAVLARVQRLTREGYILGYEARLNPQKLGAGMLVFV
EVLLDRTTPNVFDQFKAAVQVHPAIMECHMVAGGFDYLLKTRQADMNAYRQFAGEVLWQLPGVRETRTYAVMEEVKHSFH
LALDERAARS

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=154, Percent_Identity=59.0909090909091, Blast_Score=189, Evalue=7e-50,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=31.1258278145695, Blast_Score=95, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19226; Mature: 19226

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSLWIGGNVDEIDRVDRRILAILQDDGRISNIKLAERVALSPTAVLARVQRLTREGYI
CCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEE
LGYEARLNPQKLGAGMLVFVEVLLDRTTPNVFDQFKAAVQVHPAIMECHMVAGGFDYLLK
EEEECCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
TRQADMNAYRQFAGEVLWQLPGVRETRTYAVMEEVKHSFHLALDERAARS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVSLWIGGNVDEIDRVDRRILAILQDDGRISNIKLAERVALSPTAVLARVQRLTREGYI
CCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEE
LGYEARLNPQKLGAGMLVFVEVLLDRTTPNVFDQFKAAVQVHPAIMECHMVAGGFDYLLK
EEEECCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
TRQADMNAYRQFAGEVLWQLPGVRETRTYAVMEEVKHSFHLALDERAARS
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]