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The map label for this gene is gyaR [H]

Identifier: 120611961

GI number: 120611961

Start: 3656543

End: 3657523

Strand: Reverse

Name: gyaR [H]

Synonym: Aave_3305

Alternate gene names: 120611961

Gene position: 3657523-3656543 (Counterclockwise)

Preceding gene: 120611962

Following gene: 120611960

Centisome position: 68.33

GC content: 70.64

Gene sequence:

>981_bases
ATGACCCGACCCCGCATCCTCGTTGCCCGTGCCATCTTCCCCGACGTGGTGAACCGCCTCGCCGGGCACTTCGAGGTGGA
GGCCAACCCGGAGGACGTGATCTGGAGCCCGGCCGAACTGGCCGAGCGCCTCGCCGACAAGGACGGCGCCCTCACCACCG
GCAGCCAGCGCATCGACGCGGCGCTGGTCGCGGCATGCCCGCGCCTGCGCATCGTCGCCAACATGGCCGTGGGCTACAAC
AACTTCGACGTGGACGCGCTCACTGCCGCAGGGGTGCAGGCCACGAATACGCCCGACGTGTTGACGGAGACCACGGCGGA
TTTCGGCTTCGCGCTGCTCATGGCCACGGCCCGGCGCGTGACCGAGAGCGAGATCTACCTGCGCGAAGGCCGCTGGAGCA
AGTGGAGCTACGACATGTTCGCGGGCTCGGACGTGCACGGCTCCACGCTGGGCATCCTGGGCATGGGGCGCATCGGACAG
GGCATCGCGCGCCGCGGCGCGCACGGCTTCGGCATGAACGTGATCTACCACAACCGCTCGCGCCTCCCGCCGGAGCTCGA
GGCCGGGTGCAAGGCCCGGTATGTGTCCAAGGAGGAGCTGCTGCGCGAGGCGGACCACCTCGTGCTCGTGCTGCCGTACA
CGCCCGAATCGCACCACGCCATCGGCGCGGCCGAGCTCGCGCAGATGAAGCCCACGGCCAACCTCATCAACATCGCGCGC
GGCGGCATCGTGGATGACGCCGCGCTGGCGCAGGCGCTGCGCGAGCGGCGCATCGCCGCCGCAGGCCTGGACGTGTTCGA
GGGCGAGCCGAAGGTGCATCCGGACCTGCTGACGGTGCCCAACGTGGTGCTCACGCCGCACATCGCGAGCGCGACGGTGC
CCACCCGGCGTGCGATGGCCAACCTCGCGGCGGACAACCTGATCGCGTTCTTCGATGGGCGCGGCGCGCTCACGCCCGTG
AACACGCCCCGGCCCCGTTGA

Upstream 100 bases:

>100_bases
GGCCTGATCCGCCGCGCTTCGGCGCACCGCGCGTCCGTCCGTCCGTCAGTCCGCTCCACGCGGTTCGGCCCCGTCCTTCT
TTCACCAGGAATCCACGTCC

Downstream 100 bases:

>100_bases
GGGCCGCTCCATCGCCCGCCGGTCCCCGGGGCCGGCAGTTGACAACGAAACGTCTGGATTGGCATGTCGATTGAATGGCT
GGCGGTGTTCGCGTTGCTCG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTRPRILVARAIFPDVVNRLAGHFEVEANPEDVIWSPAELAERLADKDGALTTGSQRIDAALVAACPRLRIVANMAVGYN
NFDVDALTAAGVQATNTPDVLTETTADFGFALLMATARRVTESEIYLREGRWSKWSYDMFAGSDVHGSTLGILGMGRIGQ
GIARRGAHGFGMNVIYHNRSRLPPELEAGCKARYVSKEELLREADHLVLVLPYTPESHHAIGAAELAQMKPTANLINIAR
GGIVDDAALAQALRERRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRRAMANLAADNLIAFFDGRGALTPV
NTPRPR

Sequences:

>Translated_326_residues
MTRPRILVARAIFPDVVNRLAGHFEVEANPEDVIWSPAELAERLADKDGALTTGSQRIDAALVAACPRLRIVANMAVGYN
NFDVDALTAAGVQATNTPDVLTETTADFGFALLMATARRVTESEIYLREGRWSKWSYDMFAGSDVHGSTLGILGMGRIGQ
GIARRGAHGFGMNVIYHNRSRLPPELEAGCKARYVSKEELLREADHLVLVLPYTPESHHAIGAAELAQMKPTANLINIAR
GGIVDDAALAQALRERRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRRAMANLAADNLIAFFDGRGALTPV
NTPRPR
>Mature_325_residues
TRPRILVARAIFPDVVNRLAGHFEVEANPEDVIWSPAELAERLADKDGALTTGSQRIDAALVAACPRLRIVANMAVGYNN
FDVDALTAAGVQATNTPDVLTETTADFGFALLMATARRVTESEIYLREGRWSKWSYDMFAGSDVHGSTLGILGMGRIGQG
IARRGAHGFGMNVIYHNRSRLPPELEAGCKARYVSKEELLREADHLVLVLPYTPESHHAIGAAELAQMKPTANLINIARG
GIVDDAALAQALRERRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRRAMANLAADNLIAFFDGRGALTPVN
TPRPR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=296, Percent_Identity=38.5135135135135, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI23308577, Length=277, Percent_Identity=30.3249097472924, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI61743967, Length=232, Percent_Identity=35.3448275862069, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI4557497, Length=232, Percent_Identity=35.3448275862069, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=33.852140077821, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=33.852140077821, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=33.852140077821, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI87082289, Length=324, Percent_Identity=43.5185185185185, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1789279, Length=269, Percent_Identity=31.5985130111524, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787645, Length=253, Percent_Identity=28.4584980237154, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788660, Length=255, Percent_Identity=26.6666666666667, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=317, Percent_Identity=29.6529968454259, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=291, Percent_Identity=26.8041237113402, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=37.7952755905512, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320925, Length=299, Percent_Identity=27.7591973244147, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=314, Percent_Identity=26.7515923566879, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321253, Length=285, Percent_Identity=25.9649122807018, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=29.8850574712644, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571528, Length=278, Percent_Identity=40.6474820143885, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=38.2456140350877, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=38.2456140350877, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=38.2456140350877, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=38.2456140350877, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=38.2456140350877, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI28574286, Length=284, Percent_Identity=37.6760563380282, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24585516, Length=283, Percent_Identity=31.4487632508834, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19921140, Length=279, Percent_Identity=32.258064516129, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24646446, Length=242, Percent_Identity=35.1239669421488, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=242, Percent_Identity=35.1239669421488, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=242, Percent_Identity=35.1239669421488, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=242, Percent_Identity=35.1239669421488, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=228, Percent_Identity=35.5263157894737, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35181; Mature: 35049

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPRILVARAIFPDVVNRLAGHFEVEANPEDVIWSPAELAERLADKDGALTTGSQRIDA
CCCCCEEEHHHHHHHHHHHHHCCEEEECCCCCCEECHHHHHHHHHCCCCCCCCCCHHHHH
ALVAACPRLRIVANMAVGYNNFDVDALTAAGVQATNTPDVLTETTADFGFALLMATARRV
HHHHHCCCCEEEEHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TESEIYLREGRWSKWSYDMFAGSDVHGSTLGILGMGRIGQGIARRGAHGFGMNVIYHNRS
HHHHEEEECCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEEEECCC
RLPPELEAGCKARYVSKEELLREADHLVLVLPYTPESHHAIGAAELAQMKPTANLINIAR
CCCHHHHCCCCEECCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHC
GGIVDDAALAQALRERRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRRAMA
CCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHH
NLAADNLIAFFDGRGALTPVNTPRPR
HHHHCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRPRILVARAIFPDVVNRLAGHFEVEANPEDVIWSPAELAERLADKDGALTTGSQRIDA
CCCCEEEHHHHHHHHHHHHHCCEEEECCCCCCEECHHHHHHHHHCCCCCCCCCCHHHHH
ALVAACPRLRIVANMAVGYNNFDVDALTAAGVQATNTPDVLTETTADFGFALLMATARRV
HHHHHCCCCEEEEHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TESEIYLREGRWSKWSYDMFAGSDVHGSTLGILGMGRIGQGIARRGAHGFGMNVIYHNRS
HHHHEEEECCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCEEEEEECCC
RLPPELEAGCKARYVSKEELLREADHLVLVLPYTPESHHAIGAAELAQMKPTANLINIAR
CCCHHHHCCCCEECCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHC
GGIVDDAALAQALRERRIAAAGLDVFEGEPKVHPDLLTVPNVVLTPHIASATVPTRRAMA
CCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHH
NLAADNLIAFFDGRGALTPVNTPRPR
HHHHCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA