Click here to switch to the map view.

The map label for this gene is yegE [H]

Identifier: 120611908

GI number: 120611908

Start: 3590105

End: 3592411

Strand: Direct

Name: yegE [H]

Synonym: Aave_3250

Alternate gene names: 120611908

Gene position: 3590105-3592411 (Clockwise)

Preceding gene: 120611907

Following gene: 120611913

Centisome position: 67.07

GC content: 69.48

Gene sequence:

>2307_bases
ATGTCCATGCGCCTGACCCTGCACTACCGAATGCTCCTGCTGGCCATCGCGCTGTCGGTCGGCATCGGGGCGCTCTTCGC
GCGGGCCATCCTGACCATCCGCGACGATGAATGGAACTACGCGCGCGACGCCAACACGGCGCTCGCGCGCACGCTCGAGC
AGAGCATCGGGCGCACGCTCGACAGTTTCGACCATTCACTGGCGGGCGTGGTGGAGATCCTGGGCCGGCCCGACCTCGCC
AGCCTGCCGGCCGACGTGCAGCACGCCATGCTGTTCGACCACTCGCTGCGCAGCCGGGGCCTGGGCTCCGTGGCGGTGAT
CGACCCGGGGGGCAACGTCCTGATGTCGGCCGGCGCCACGCCCGCCAGCAAGATGCCCAACCTGGCCGACCGGGACTACT
TCCAGTTCCACATGCGCGAGAGGGACCGGGGCGTGTACGTCGGCCGGCCCATCCGGGGACGGGTGACGGGCGAGTACAGC
CTGGCGATGAGCCGCGCCTTTTTTCACCAGGACGGCAGTTTCGGCGGGGTGGTCGTGGGCACGATCCGGCTCAGCTACTT
CAACGAACTGTTCGGATCGCTCGGCCTGGGCCCCCAGAGCCTCGCCGAGATCGTCCGCACGGACGGCACGGCGGTTTCGC
GCTTTCCCGGGCAGATCCGCGGCGTCGGAGAGCCGGTGGCGCACGCCCATCTGGAGCGCCTCCTGCAGGAACGCGAAGGC
CATTTCACCGAATCCTCGGACGAGGCGCAGGACGGCATCCCGCGGCTCCACGCCTTCCGGCACGTGAGAGATTACCCGCT
CGTGGTTTCCGTGGCCCAGTCGGTGGACAGCATCCTCTCGCAATGGCAGCGCAACGCGGTGATCCTGGGGAGCTTCGCCG
CCCTGCTCATGGCGGCCTGCCTGGGCCTCGCCCTGCTGTTCGCGCGCGAGCTGGCGCGCCGGCAGAACGTGGCCGCGCAG
CTGCAGCGCGCGCAGCACGACATGCGCACCATCCTCGACAACCTGCCGTCGCTGGTCGCCTACTGGGACCGCAATCTGCG
CAACCGCTTCGCCAACCAGGCCTATCTCGACTGGCTCGGCATGACGCAGGAAGAGATCCAGGGCCGGCCCATCGAGGAGC
TGCTGCCCGCCGAGGCCTGCGAGACCGCTCGGCCGTACCTGCAGCGTGCGCTGCAGGGCCGCAGGCAGGTCTATGAACGG
TCGGTGCCGTTATCGTCGGGCGAAGTGCGGCACATGATGGTGTCCTGCGTTCCGGACATGGACGGAGCGCAGGCCCAGGG
CATCTTCGTGCAGATCGACGACCTCACCGAACGCAAGCGCATGGAAGACCTGCTCTTCGAGGAGAAGGAACTGGTCCGCC
TCACGCTGCAGTCCATCGGCGACGCCGTGCTGTGCACGGACGCCTCGGGCCACGTGACCTACATCAACCCCGTGGCAGAG
AAGATAACGGGCTGGCAGGCCTTCCACGCCGCCGGCCGGGACATCGACGAGGTCGCCCCCCTCTGCACCGCCAACGGTGT
GCCCGCGGAGCATCCGGCCCGCAGCGCGCTGTCGGGCGCGCAAGCCATACCGGCCGTGCGCGGCCTCGTGCTGCACTGTC
GCGACGGCCGCCGCATCGACGTGGAAAACAGCGTCAGCCCCATCACCGACCGGCACGGACAGATCACGGGCACCGTGATG
GTGCTGCGGGACGTGACCGAGGCGACGGCACTGGCACGCCGCATGGCCCATCTCGCGCAGCACGACATGCTGACCGACCT
GCCCAACCGGGTGCTGCTGCAGGACCGCGCCCAGCAGGCCATCGCCCAGGCACGCCGCGACGGACACGGCCTCGCCCTGA
TGTATATCGACCTCGACGGCTTCAAGCAGGTGAACGACACGCTGGGCCACGATGCCGGCGATCTGCTGCTGGTCCAGGTC
GCCCGGCGCTTCTCCCGCTGCGTGCGCCGCTCGGACACCGTCTGCCGCCAGGGCGGCGACGAGTTCATCGTGCTCCTGCC
CATCGTGGAACATCCCGAGCAGGCCTGCCACGTCGCCCGCAAGATCGTGGCCGCCTGCGAGGCGCCCTTCGACCTGCAGG
GCGAGTCGCGGCGGATCGGCCTCAGCGGCGGTATCGCGATGTTCCCGCAGCACGGCTCCAGCTTCGAGGAACTGTGCCGC
AGCGCCGACGTGGCGCTCTACACCGCCAAGCGTGCAGACAAGCAGCATTTCCGGATGTATGCGGGCCCCGAACAGGAGCC
CGAGGTCGTTCCGCCTGCAGCGCCTGCCCCCGGACCGGCGCCCTCCGGCGCGCAGCCGCCACGCTGA

Upstream 100 bases:

>100_bases
ACCGCACACCCACGGGCGGTGACAATACGGGGGAGCCCGCCGCGCCGCGGGCCACCCTCCCCCCTGCCGTTTCCGCGCGG
ACCCGTGCCGCCCGCTGCAC

Downstream 100 bases:

>100_bases
ACGCCGGGCGCAAAGGTTCCGTGGCCGGCGGCATCCGCGCCACGGCCGCGCAGCGGCTCACGCCGGGAGGGCGCCCTCCC
CGGCCGCCGCGACAAGCCGC

Product: PAS/PAC sensor-containing diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:

>768_residues
MSMRLTLHYRMLLLAIALSVGIGALFARAILTIRDDEWNYARDANTALARTLEQSIGRTLDSFDHSLAGVVEILGRPDLA
SLPADVQHAMLFDHSLRSRGLGSVAVIDPGGNVLMSAGATPASKMPNLADRDYFQFHMRERDRGVYVGRPIRGRVTGEYS
LAMSRAFFHQDGSFGGVVVGTIRLSYFNELFGSLGLGPQSLAEIVRTDGTAVSRFPGQIRGVGEPVAHAHLERLLQEREG
HFTESSDEAQDGIPRLHAFRHVRDYPLVVSVAQSVDSILSQWQRNAVILGSFAALLMAACLGLALLFARELARRQNVAAQ
LQRAQHDMRTILDNLPSLVAYWDRNLRNRFANQAYLDWLGMTQEEIQGRPIEELLPAEACETARPYLQRALQGRRQVYER
SVPLSSGEVRHMMVSCVPDMDGAQAQGIFVQIDDLTERKRMEDLLFEEKELVRLTLQSIGDAVLCTDASGHVTYINPVAE
KITGWQAFHAAGRDIDEVAPLCTANGVPAEHPARSALSGAQAIPAVRGLVLHCRDGRRIDVENSVSPITDRHGQITGTVM
VLRDVTEATALARRMAHLAQHDMLTDLPNRVLLQDRAQQAIAQARRDGHGLALMYIDLDGFKQVNDTLGHDAGDLLLVQV
ARRFSRCVRRSDTVCRQGGDEFIVLLPIVEHPEQACHVARKIVAACEAPFDLQGESRRIGLSGGIAMFPQHGSSFEELCR
SADVALYTAKRADKQHFRMYAGPEQEPEVVPPAAPAPGPAPSGAQPPR

Sequences:

>Translated_768_residues
MSMRLTLHYRMLLLAIALSVGIGALFARAILTIRDDEWNYARDANTALARTLEQSIGRTLDSFDHSLAGVVEILGRPDLA
SLPADVQHAMLFDHSLRSRGLGSVAVIDPGGNVLMSAGATPASKMPNLADRDYFQFHMRERDRGVYVGRPIRGRVTGEYS
LAMSRAFFHQDGSFGGVVVGTIRLSYFNELFGSLGLGPQSLAEIVRTDGTAVSRFPGQIRGVGEPVAHAHLERLLQEREG
HFTESSDEAQDGIPRLHAFRHVRDYPLVVSVAQSVDSILSQWQRNAVILGSFAALLMAACLGLALLFARELARRQNVAAQ
LQRAQHDMRTILDNLPSLVAYWDRNLRNRFANQAYLDWLGMTQEEIQGRPIEELLPAEACETARPYLQRALQGRRQVYER
SVPLSSGEVRHMMVSCVPDMDGAQAQGIFVQIDDLTERKRMEDLLFEEKELVRLTLQSIGDAVLCTDASGHVTYINPVAE
KITGWQAFHAAGRDIDEVAPLCTANGVPAEHPARSALSGAQAIPAVRGLVLHCRDGRRIDVENSVSPITDRHGQITGTVM
VLRDVTEATALARRMAHLAQHDMLTDLPNRVLLQDRAQQAIAQARRDGHGLALMYIDLDGFKQVNDTLGHDAGDLLLVQV
ARRFSRCVRRSDTVCRQGGDEFIVLLPIVEHPEQACHVARKIVAACEAPFDLQGESRRIGLSGGIAMFPQHGSSFEELCR
SADVALYTAKRADKQHFRMYAGPEQEPEVVPPAAPAPGPAPSGAQPPR
>Mature_767_residues
SMRLTLHYRMLLLAIALSVGIGALFARAILTIRDDEWNYARDANTALARTLEQSIGRTLDSFDHSLAGVVEILGRPDLAS
LPADVQHAMLFDHSLRSRGLGSVAVIDPGGNVLMSAGATPASKMPNLADRDYFQFHMRERDRGVYVGRPIRGRVTGEYSL
AMSRAFFHQDGSFGGVVVGTIRLSYFNELFGSLGLGPQSLAEIVRTDGTAVSRFPGQIRGVGEPVAHAHLERLLQEREGH
FTESSDEAQDGIPRLHAFRHVRDYPLVVSVAQSVDSILSQWQRNAVILGSFAALLMAACLGLALLFARELARRQNVAAQL
QRAQHDMRTILDNLPSLVAYWDRNLRNRFANQAYLDWLGMTQEEIQGRPIEELLPAEACETARPYLQRALQGRRQVYERS
VPLSSGEVRHMMVSCVPDMDGAQAQGIFVQIDDLTERKRMEDLLFEEKELVRLTLQSIGDAVLCTDASGHVTYINPVAEK
ITGWQAFHAAGRDIDEVAPLCTANGVPAEHPARSALSGAQAIPAVRGLVLHCRDGRRIDVENSVSPITDRHGQITGTVMV
LRDVTEATALARRMAHLAQHDMLTDLPNRVLLQDRAQQAIAQARRDGHGLALMYIDLDGFKQVNDTLGHDAGDLLLVQVA
RRFSRCVRRSDTVCRQGGDEFIVLLPIVEHPEQACHVARKIVAACEAPFDLQGESRRIGLSGGIAMFPQHGSSFEELCRS
ADVALYTAKRADKQHFRMYAGPEQEPEVVPPAAPAPGPAPSGAQPPR

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=313, Percent_Identity=36.4217252396166, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI145693134, Length=259, Percent_Identity=31.6602316602317, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787541, Length=186, Percent_Identity=36.0215053763441, Blast_Score=106, Evalue=7e-24,
Organism=Escherichia coli, GI87081881, Length=199, Percent_Identity=32.1608040201005, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI1786584, Length=172, Percent_Identity=32.5581395348837, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788956, Length=161, Percent_Identity=34.7826086956522, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI87082007, Length=186, Percent_Identity=33.8709677419355, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI87081974, Length=150, Percent_Identity=30.6666666666667, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787802, Length=178, Percent_Identity=30.8988764044944, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081977, Length=84, Percent_Identity=40.4761904761905, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787262, Length=184, Percent_Identity=30.9782608695652, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1787816, Length=156, Percent_Identity=30.7692307692308, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 84469; Mature: 84338

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMRLTLHYRMLLLAIALSVGIGALFARAILTIRDDEWNYARDANTALARTLEQSIGRTL
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
DSFDHSLAGVVEILGRPDLASLPADVQHAMLFDHSLRSRGLGSVAVIDPGGNVLMSAGAT
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCCC
PASKMPNLADRDYFQFHMRERDRGVYVGRPIRGRVTGEYSLAMSRAFFHQDGSFGGVVVG
CHHHCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEH
TIRLSYFNELFGSLGLGPQSLAEIVRTDGTAVSRFPGQIRGVGEPVAHAHLERLLQEREG
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCHHCCCCCHHHHHHHHHHHHHHCC
HFTESSDEAQDGIPRLHAFRHVRDYPLVVSVAQSVDSILSQWQRNAVILGSFAALLMAAC
CCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHH
LGLALLFARELARRQNVAAQLQRAQHDMRTILDNLPSLVAYWDRNLRNRFANQAYLDWLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MTQEEIQGRPIEELLPAEACETARPYLQRALQGRRQVYERSVPLSSGEVRHMMVSCVPDM
CCHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
DGAQAQGIFVQIDDLTERKRMEDLLFEEKELVRLTLQSIGDAVLCTDASGHVTYINPVAE
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECHHHH
KITGWQAFHAAGRDIDEVAPLCTANGVPAEHPARSALSGAQAIPAVRGLVLHCRDGRRID
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCEEC
VENSVSPITDRHGQITGTVMVLRDVTEATALARRMAHLAQHDMLTDLPNRVLLQDRAQQA
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IAQARRDGHGLALMYIDLDGFKQVNDTLGHDAGDLLLVQVARRFSRCVRRSDTVCRQGGD
HHHHHCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EFIVLLPIVEHPEQACHVARKIVAACEAPFDLQGESRRIGLSGGIAMFPQHGSSFEELCR
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEECCCCCCHHHHHHC
SADVALYTAKRADKQHFRMYAGPEQEPEVVPPAAPAPGPAPSGAQPPR
CCCEEEEEHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SMRLTLHYRMLLLAIALSVGIGALFARAILTIRDDEWNYARDANTALARTLEQSIGRTL
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
DSFDHSLAGVVEILGRPDLASLPADVQHAMLFDHSLRSRGLGSVAVIDPGGNVLMSAGAT
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCCC
PASKMPNLADRDYFQFHMRERDRGVYVGRPIRGRVTGEYSLAMSRAFFHQDGSFGGVVVG
CHHHCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEH
TIRLSYFNELFGSLGLGPQSLAEIVRTDGTAVSRFPGQIRGVGEPVAHAHLERLLQEREG
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCHHCCCCCHHHHHHHHHHHHHHCC
HFTESSDEAQDGIPRLHAFRHVRDYPLVVSVAQSVDSILSQWQRNAVILGSFAALLMAAC
CCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHH
LGLALLFARELARRQNVAAQLQRAQHDMRTILDNLPSLVAYWDRNLRNRFANQAYLDWLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MTQEEIQGRPIEELLPAEACETARPYLQRALQGRRQVYERSVPLSSGEVRHMMVSCVPDM
CCHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
DGAQAQGIFVQIDDLTERKRMEDLLFEEKELVRLTLQSIGDAVLCTDASGHVTYINPVAE
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECHHHH
KITGWQAFHAAGRDIDEVAPLCTANGVPAEHPARSALSGAQAIPAVRGLVLHCRDGRRID
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCEEC
VENSVSPITDRHGQITGTVMVLRDVTEATALARRMAHLAQHDMLTDLPNRVLLQDRAQQA
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IAQARRDGHGLALMYIDLDGFKQVNDTLGHDAGDLLLVQVARRFSRCVRRSDTVCRQGGD
HHHHHCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EFIVLLPIVEHPEQACHVARKIVAACEAPFDLQGESRRIGLSGGIAMFPQHGSSFEELCR
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEECCCCCCHHHHHHC
SADVALYTAKRADKQHFRMYAGPEQEPEVVPPAAPAPGPAPSGAQPPR
CCCEEEEEHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]