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The map label for this gene is clpA [H]

Identifier: 120611896

GI number: 120611896

Start: 3570205

End: 3572556

Strand: Reverse

Name: clpA [H]

Synonym: Aave_3238

Alternate gene names: 120611896

Gene position: 3572556-3570205 (Counterclockwise)

Preceding gene: 120611897

Following gene: 120611894

Centisome position: 66.74

GC content: 66.33

Gene sequence:

>2352_bases
ATGATTGCCCAGGAACTGGAAGTCAGCTTGCACATGGCCTTTGTCGAGGCCCGCCAGCAGCGCCACGAGTTCATCACCGT
GGAGCATCTGTTGCTTGCACTGCTTGATAACCCCAGCGCAGCCGAAGTGCTGCGCGCATGCTCGGCCAACATCGAGGATC
TTCGCTCGTCGCTGGCCAATTTCATCAAGGACAACACGCCGCAGGTGGCGGGCACCGACGAGGTGGACACGCAGCCCACG
CTGGGATTCCAGCGGGTGATCCAGCGCGCCATCATGCACGTGCAGTCCACCGGCAACGGCAAGAAGGAAGTGACCGGCGC
GAACGTGCTGGTCGCCATCTTCGGCGAAAAGGATTCGCACGCCGTGTACTACCTGCACCAGCAGGGGGTGACCCGCCTGG
ACGTGGTCAACTTCATCGCCCACGGCATCAAGAAGGGCGAGCCGCCGGAGCCCGCCAAGGCCGAGAACCCCTCCGAGGCC
GAGGAGGGCGGCGCCGGCGGCGAGCGCAGCGAGAAGGCTTCCCCGCTGGAGCAGTACACCCAGAACCTCAACGTGGCCGC
CAGGGAAGGCAAGATCGATCCGCTGATCGGCCGCAACTACGAGGTCGAGCGCACCATCCAGATCCTCTGCCGCCGCCGCA
AGAACAACCCGCTGCTGGTGGGCGAGGCCGGCGTGGGCAAGACCGCGATCGCGGAGGGCCTGGCCTGGCGCATCACGCAG
AACGACGTGCCCGAGATCCTGGCCGAAGCCTCGGTCTATTCGCTGGACATGGGCGCGCTGCTGGCCGGCACCAAGTACCG
CGGCGATTTCGAGCAGCGCCTCAAGGGCGTGCTCAAGTCGCTCAAGGACAAGCCGAACGCGATCCTGTTCATCGACGAGA
TCCACACGCTGATCGGCGCGGGCGCCGCGTCGGGCGGCACGCTGGACGCGTCCAACCTGCTCAAGCCGGCGCTCTCCAGC
GGCCAGCTCAAGTGCATCGGCGCGACCACCTTCACCGAGTACCGCGGCATCTTCGAGAAGGACGCGGCCCTGTCGCGGCG
CTTCCAGAAGGTCGATGTGGTCGAGCCGACCGTGGCCGAGACGGTGGACATCCTCAAGGGCCTCAAGAGCCGCTTCGAGG
AGCACCACAGCGTGAAGTACGCCACCGCGGCGCTGCAGGCGGCGGCGGAGCTGTCGGCCAAGTACATCAACGACCGGCAC
CTGCCCGACAAGGCGATCGACGTGATCGACGAGGCCGGCGCGGCCCAGCGCATCCTGGTGGCCAGCAAGCGCAAGAAGAC
CATCGGCAAGGCCGAGATCGAGGAAATCGTGGCGAAGATCGCGCGCATCCCGCCCGCGAACGTCTCCAACGACGACCGCA
GCAAGCTGCAGACCATCGAGCGTGACCTCAAGAGCGTGGTGTTCGGCCAGGACAAGGCGCTGGAAGTGCTCGCCTCCGCG
GTCAAGATGGCGCGCTCGGGCCTGGGCAAGGGCGACAAGCCGATCGGCTCGTTCCTCTTCAGCGGCCCGACCGGCGTCGG
CAAGACCGAGGCGGCCAAGCAGCTGGCCTACATCCTGGGCATCGAGCTGATCCGCTTCGACATGTCGGAGTACATGGAGC
GCCACGCCGTGAGCCGCCTGATCGGCGCGCCCCCGGGCTACGTGGGCTTCGACCAGGGCGGCCTGCTGACCGAGGCCATC
ACGAAGAAGCCGCACGCGGTGCTGCTGCTCGACGAGATCGAGAAGGCGCACCCGGACATCTTCAACGTGCTGCTGCAGGT
GATGGACCACGGCACGCTGACGGACAACAACGGGCGCAAGGCCGACTTCCGCAACGTCATCATCATCATGACGACGAACG
CGGGCGCCGAGACCATGAACAAGGCCACCATCGGGTTCACCAACCCGCGGCAGGCCGGCGACGAGATGGCCGACATCAAG
CGCCTGTTCACGCCCGAGTTCCGCAACCGCCTCGATGCGATCGTCAACTTCAAGCCGCTGGACGAGCAGATCATCCTGCG
CGTGGTGGACAAGTTCCTGCTGCAGCTGGAGACCCAGCTCGCCGAGAAGAAGGTGGAAGTCACCTTCACCGACGCGCTGC
GCAAGCACCTGGCGAAGAAGGGCTTCGATCCGCTGATGGGCGCGCGCCCGATGCAGCGCCTGATCCAGGACACGATCCGC
CGTGCGCTGGCCGACGAGCTGCTGTTCGGCCGCCTGACCGAAGGTGGCCGCCTGACGGTGGACATCGAGGTCAAGACCGA
CGAGAAGGGCGTGGAGACGCCCGACGTGCTGCTGGACATCCAGCCGCTGCCGAAGAAGGACCGCTCGGCCAAGTCCGAGC
CGGCGGAACCCGAAGAGGCGACGGCGGACTGA

Upstream 100 bases:

>100_bases
GGCGGGCCACCCGCTGCAATGCCTGAGCGAGCCGGTTGAATAACCGGCCCCGGGTCCCGATCTATCGTTATCCCTTCCCC
GCAAGCACAAAGGAGTTCAC

Downstream 100 bases:

>100_bases
CGGTCCCTGGCCCGCCAGGCGCCGGTGCCCTGCGGCACAGCGCCGAGCCCGCGGCCCCGCCAGGGTCCGCGGGCTTTTTT
CTTTGCGCAGGCCCCGGCGG

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANIEDLRSSLANFIKDNTPQVAGTDEVDTQPT
LGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSHAVYYLHQQGVTRLDVVNFIAHGIKKGEPPEPAKAENPSEA
EEGGAGGERSEKASPLEQYTQNLNVAAREGKIDPLIGRNYEVERTIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQ
NDVPEILAEASVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDKPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSS
GQLKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVAETVDILKGLKSRFEEHHSVKYATAALQAAAELSAKYINDRH
LPDKAIDVIDEAGAAQRILVASKRKKTIGKAEIEEIVAKIARIPPANVSNDDRSKLQTIERDLKSVVFGQDKALEVLASA
VKMARSGLGKGDKPIGSFLFSGPTGVGKTEAAKQLAYILGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAI
TKKPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAETMNKATIGFTNPRQAGDEMADIK
RLFTPEFRNRLDAIVNFKPLDEQIILRVVDKFLLQLETQLAEKKVEVTFTDALRKHLAKKGFDPLMGARPMQRLIQDTIR
RALADELLFGRLTEGGRLTVDIEVKTDEKGVETPDVLLDIQPLPKKDRSAKSEPAEPEEATAD

Sequences:

>Translated_783_residues
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANIEDLRSSLANFIKDNTPQVAGTDEVDTQPT
LGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSHAVYYLHQQGVTRLDVVNFIAHGIKKGEPPEPAKAENPSEA
EEGGAGGERSEKASPLEQYTQNLNVAAREGKIDPLIGRNYEVERTIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQ
NDVPEILAEASVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDKPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSS
GQLKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVAETVDILKGLKSRFEEHHSVKYATAALQAAAELSAKYINDRH
LPDKAIDVIDEAGAAQRILVASKRKKTIGKAEIEEIVAKIARIPPANVSNDDRSKLQTIERDLKSVVFGQDKALEVLASA
VKMARSGLGKGDKPIGSFLFSGPTGVGKTEAAKQLAYILGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAI
TKKPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAETMNKATIGFTNPRQAGDEMADIK
RLFTPEFRNRLDAIVNFKPLDEQIILRVVDKFLLQLETQLAEKKVEVTFTDALRKHLAKKGFDPLMGARPMQRLIQDTIR
RALADELLFGRLTEGGRLTVDIEVKTDEKGVETPDVLLDIQPLPKKDRSAKSEPAEPEEATAD
>Mature_783_residues
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANIEDLRSSLANFIKDNTPQVAGTDEVDTQPT
LGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSHAVYYLHQQGVTRLDVVNFIAHGIKKGEPPEPAKAENPSEA
EEGGAGGERSEKASPLEQYTQNLNVAAREGKIDPLIGRNYEVERTIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQ
NDVPEILAEASVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDKPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSS
GQLKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVAETVDILKGLKSRFEEHHSVKYATAALQAAAELSAKYINDRH
LPDKAIDVIDEAGAAQRILVASKRKKTIGKAEIEEIVAKIARIPPANVSNDDRSKLQTIERDLKSVVFGQDKALEVLASA
VKMARSGLGKGDKPIGSFLFSGPTGVGKTEAAKQLAYILGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAI
TKKPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAETMNKATIGFTNPRQAGDEMADIK
RLFTPEFRNRLDAIVNFKPLDEQIILRVVDKFLLQLETQLAEKKVEVTFTDALRKHLAKKGFDPLMGARPMQRLIQDTIR
RALADELLFGRLTEGGRLTVDIEVKTDEKGVETPDVLLDIQPLPKKDRSAKSEPAEPEEATAD

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=334, Percent_Identity=29.940119760479, Blast_Score=153, Evalue=7e-37,
Organism=Escherichia coli, GI1787109, Length=749, Percent_Identity=62.0827770360481, Blast_Score=967, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=405, Percent_Identity=45.9259259259259, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=250, Percent_Identity=55.2, Blast_Score=269, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6323002, Length=291, Percent_Identity=48.4536082474227, Blast_Score=260, Evalue=7e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 85746; Mature: 85746

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANIEDLRSSLAN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
FIKDNTPQVAGTDEVDTQPTLGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSH
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEEECCCCCC
AVYYLHQQGVTRLDVVNFIAHGIKKGEPPEPAKAENPSEAEEGGAGGERSEKASPLEQYT
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHH
QNLNVAAREGKIDPLIGRNYEVERTIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQ
HCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEECC
NDVPEILAEASVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDKPNAILFIDEIHTLIGA
CCHHHHHHHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHC
GAASGGTLDASNLLKPALSSGQLKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVAE
CCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
TVDILKGLKSRFEEHHSVKYATAALQAAAELSAKYINDRHLPDKAIDVIDEAGAAQRILV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHH
ASKRKKTIGKAEIEEIVAKIARIPPANVSNDDRSKLQTIERDLKSVVFGQDKALEVLASA
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VKMARSGLGKGDKPIGSFLFSGPTGVGKTEAAKQLAYILGIELIRFDMSEYMERHAVSRL
HHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAPPGYVGFDQGGLLTEAITKKPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRK
HCCCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCC
ADFRNVIIIMTTNAGAETMNKATIGFTNPRQAGDEMADIKRLFTPEFRNRLDAIVNFKPL
CCCCCEEEEEECCCCCHHHCCCEECCCCCHHCCHHHHHHHHHHCHHHHHHHHHHCCCCCC
DEQIILRVVDKFLLQLETQLAEKKVEVTFTDALRKHLAKKGFDPLMGARPMQRLIQDTIR
CHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
RALADELLFGRLTEGGRLTVDIEVKTDEKGVETPDVLLDIQPLPKKDRSAKSEPAEPEEA
HHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
TAD
CCC
>Mature Secondary Structure
MIAQELEVSLHMAFVEARQQRHEFITVEHLLLALLDNPSAAEVLRACSANIEDLRSSLAN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
FIKDNTPQVAGTDEVDTQPTLGFQRVIQRAIMHVQSTGNGKKEVTGANVLVAIFGEKDSH
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEEECCCCCC
AVYYLHQQGVTRLDVVNFIAHGIKKGEPPEPAKAENPSEAEEGGAGGERSEKASPLEQYT
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHH
QNLNVAAREGKIDPLIGRNYEVERTIQILCRRRKNNPLLVGEAGVGKTAIAEGLAWRITQ
HCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHCCCEEEECC
NDVPEILAEASVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDKPNAILFIDEIHTLIGA
CCHHHHHHHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHC
GAASGGTLDASNLLKPALSSGQLKCIGATTFTEYRGIFEKDAALSRRFQKVDVVEPTVAE
CCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
TVDILKGLKSRFEEHHSVKYATAALQAAAELSAKYINDRHLPDKAIDVIDEAGAAQRILV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHH
ASKRKKTIGKAEIEEIVAKIARIPPANVSNDDRSKLQTIERDLKSVVFGQDKALEVLASA
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VKMARSGLGKGDKPIGSFLFSGPTGVGKTEAAKQLAYILGIELIRFDMSEYMERHAVSRL
HHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAPPGYVGFDQGGLLTEAITKKPHAVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRK
HCCCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCC
ADFRNVIIIMTTNAGAETMNKATIGFTNPRQAGDEMADIKRLFTPEFRNRLDAIVNFKPL
CCCCCEEEEEECCCCCHHHCCCEECCCCCHHCCHHHHHHHHHHCHHHHHHHHHHCCCCCC
DEQIILRVVDKFLLQLETQLAEKKVEVTFTDALRKHLAKKGFDPLMGARPMQRLIQDTIR
CHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
RALADELLFGRLTEGGRLTVDIEVKTDEKGVETPDVLLDIQPLPKKDRSAKSEPAEPEEA
HHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
TAD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]