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The map label for this gene is cobB [H]

Identifier: 120611893

GI number: 120611893

Start: 3566243

End: 3567172

Strand: Reverse

Name: cobB [H]

Synonym: Aave_3235

Alternate gene names: 120611893

Gene position: 3567172-3566243 (Counterclockwise)

Preceding gene: 120611894

Following gene: 120611892

Centisome position: 66.64

GC content: 74.3

Gene sequence:

>930_bases
ATGCAGAAAGCATCGCTCCCGATTTCTGACGGGCCCGAAGGCGCAGGCCGGGGGGAGCCCGCGCCCCTGGCGGCATCTGC
CGGCGGGGTGGACGCCCTGCTGGCCTGGGCGCGTGCCTGCCCGCGGCTGTTCGTGCTGACCGGCGCGGGCTGCAGCACGG
CATCCGGCATTCCCGACTACCGCGACGAGGGCGGTGCCTGGAAGCGCTCACCGCCGGTCACCTACCAGGCCTTCATGGGC
GACGAGGCGGTGCGCCGGCGCTACTGGGCGCGCAGCATGATCGGCTGGCGCGTCATGGGCAGCGCCGCGCCGGGCGCCGC
GCACCGTGCCCTGGCCGCGCTGGAGGCGATGGGCCGGGTGGAGATGCTGCTCACGCAGAACGTGGACGGCCTGCACACGG
CGGCGGGCCAGCAGCGGGTGATCGACCTGCACGGGCGCATCGATACGGTGCGCTGCATGGCCTGCGAGGCGCGCATGCAA
CGCGCGGACCTGCAATCGTGGCTGGAGGCGCGGAATCCGGCCTGGGCGGCCCTGGAGGCGGCCGCCGCGCCGGATGGCGA
TGCCGACCTGGACGGCCGCGACTTCTCCGCGTTCGAGTTGCCCGCATGCCCCCATTGCGGCGGCGGTCCCCTGAAGCCGG
ACGTGGTGTTCTTCGGCGAAAGCGTGCCACGGGAGCGCGTGGAGGCCGCGCGGGCGGCGCTGGCCCGGTCCGACGGATTG
CTGGTGGCCGGCTCCTCGCTGATGGTGTATTCGGGTTTCCGCTTCGTGCAGGCGGCCGCGGATGCCGGGCTGCCGGTGGC
GGCCGTGAACCGGGGCGTGACGCGCGCCGACGGGTTGATCGCGGTCAAGGTCGAGGACGACGTGGGCCGCGTGCTGGAAG
CCCTGGCGCAGGCGCTGGCACCGGCCCGAGGGGTGCCGCCGGCCGCATGA

Upstream 100 bases:

>100_bases
GGCGGCGGCCTGACGTTCGACGCGCTCTTCGCGCGGCTGGACACGCTGGGCGAAACCGCGGACGAGCGTGGCGAGGCGAT
CCTGGGGGCGCTGTACGAAT

Downstream 100 bases:

>100_bases
CCCGGCGGCACGGGCGGGTTTGCGCGACGGCGCCCGCCGATGGTGCTATGGTGACCGGATAACGCCCGGGCCGCGCCGAG
AGCGCGAGCCGGGGCCCTGA

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MQKASLPISDGPEGAGRGEPAPLAASAGGVDALLAWARACPRLFVLTGAGCSTASGIPDYRDEGGAWKRSPPVTYQAFMG
DEAVRRRYWARSMIGWRVMGSAAPGAAHRALAALEAMGRVEMLLTQNVDGLHTAAGQQRVIDLHGRIDTVRCMACEARMQ
RADLQSWLEARNPAWAALEAAAAPDGDADLDGRDFSAFELPACPHCGGGPLKPDVVFFGESVPRERVEAARAALARSDGL
LVAGSSLMVYSGFRFVQAAADAGLPVAAVNRGVTRADGLIAVKVEDDVGRVLEALAQALAPARGVPPAA

Sequences:

>Translated_309_residues
MQKASLPISDGPEGAGRGEPAPLAASAGGVDALLAWARACPRLFVLTGAGCSTASGIPDYRDEGGAWKRSPPVTYQAFMG
DEAVRRRYWARSMIGWRVMGSAAPGAAHRALAALEAMGRVEMLLTQNVDGLHTAAGQQRVIDLHGRIDTVRCMACEARMQ
RADLQSWLEARNPAWAALEAAAAPDGDADLDGRDFSAFELPACPHCGGGPLKPDVVFFGESVPRERVEAARAALARSDGL
LVAGSSLMVYSGFRFVQAAADAGLPVAAVNRGVTRADGLIAVKVEDDVGRVLEALAQALAPARGVPPAA
>Mature_309_residues
MQKASLPISDGPEGAGRGEPAPLAASAGGVDALLAWARACPRLFVLTGAGCSTASGIPDYRDEGGAWKRSPPVTYQAFMG
DEAVRRRYWARSMIGWRVMGSAAPGAAHRALAALEAMGRVEMLLTQNVDGLHTAAGQQRVIDLHGRIDTVRCMACEARMQ
RADLQSWLEARNPAWAALEAAAAPDGDADLDGRDFSAFELPACPHCGGGPLKPDVVFFGESVPRERVEAARAALARSDGL
LVAGSSLMVYSGFRFVQAAADAGLPVAAVNRGVTRADGLIAVKVEDDVGRVLEALAQALAPARGVPPAA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=254, Percent_Identity=44.4881889763779, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI6912664, Length=265, Percent_Identity=32.8301886792453, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI13787215, Length=246, Percent_Identity=32.9268292682927, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI300795542, Length=263, Percent_Identity=30.0380228136882, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI300797577, Length=270, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI300797597, Length=132, Percent_Identity=32.5757575757576, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI308199517, Length=275, Percent_Identity=29.4545454545455, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71990482, Length=260, Percent_Identity=40.3846153846154, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71990487, Length=262, Percent_Identity=40.0763358778626, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17567771, Length=262, Percent_Identity=35.8778625954198, Blast_Score=178, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17505510, Length=259, Percent_Identity=24.7104247104247, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571445, Length=258, Percent_Identity=47.2868217054264, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI28571443, Length=218, Percent_Identity=45.4128440366972, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI28571441, Length=218, Percent_Identity=45.4128440366972, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI17137536, Length=261, Percent_Identity=29.1187739463602, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 32222; Mature: 32222

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKASLPISDGPEGAGRGEPAPLAASAGGVDALLAWARACPRLFVLTGAGCSTASGIPDY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCC
RDEGGAWKRSPPVTYQAFMGDEAVRRRYWARSMIGWRVMGSAAPGAAHRALAALEAMGRV
CCCCCCCCCCCCCEEHHHHCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHH
EMLLTQNVDGLHTAAGQQRVIDLHGRIDTVRCMACEARMQRADLQSWLEARNPAWAALEA
HHHHHCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AAAPDGDADLDGRDFSAFELPACPHCGGGPLKPDVVFFGESVPRERVEAARAALARSDGL
HCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCE
LVAGSSLMVYSGFRFVQAAADAGLPVAAVNRGVTRADGLIAVKVEDDVGRVLEALAQALA
EEECCCEEEECCHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHC
PARGVPPAA
CCCCCCCCC
>Mature Secondary Structure
MQKASLPISDGPEGAGRGEPAPLAASAGGVDALLAWARACPRLFVLTGAGCSTASGIPDY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCC
RDEGGAWKRSPPVTYQAFMGDEAVRRRYWARSMIGWRVMGSAAPGAAHRALAALEAMGRV
CCCCCCCCCCCCCEEHHHHCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHH
EMLLTQNVDGLHTAAGQQRVIDLHGRIDTVRCMACEARMQRADLQSWLEARNPAWAALEA
HHHHHCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AAAPDGDADLDGRDFSAFELPACPHCGGGPLKPDVVFFGESVPRERVEAARAALARSDGL
HCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCE
LVAGSSLMVYSGFRFVQAAADAGLPVAAVNRGVTRADGLIAVKVEDDVGRVLEALAQALA
EEECCCEEEECCHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHC
PARGVPPAA
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA