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The map label for this gene is folP [H]

Identifier: 120611286

GI number: 120611286

Start: 2869049

End: 2869927

Strand: Direct

Name: folP [H]

Synonym: Aave_2618

Alternate gene names: 120611286

Gene position: 2869049-2869927 (Clockwise)

Preceding gene: 120611285

Following gene: 120611287

Centisome position: 53.6

GC content: 70.08

Gene sequence:

>879_bases
ATGCACTGGCAGACATCCCGCTTCCGTATCGACCTCTCGCGCCCCCAGGTCATGGGCATCCTGAATGTGACGCCGGACTC
CTTTTCCGACGGTGGGCGCCATGCTTCGCTGCGGGATGCCCTGCGCCGTGCCGAAGTCCTGCTGCAGGACGGCGCGGACA
TCCTGGACATCGGGGGGGAATCCACCCGCCCCGGCAGCCCGGCGGTGCCCCTGGAGGAGGAACTGGCCCGCGTGGTGCCG
GTGGTGAAGGAGGCCGTGGCCTGGCGCGTGCCCATTTCGGTGGATACCTACAAGCCCGCCGTCATGCAGGCGGTGCTGGA
CCTGGGCGCGGACATCGTCAACGACATCTGGGCCCTGCGGCAGCCGGGTGCCCTGGAAACAGTGGCGCGCCATGGAACAT
GCGGGGTGTGCCTGATGCACATGCATGGCGAACCGCAGACCATGCAGGTGCAGCCCATGGAGGGCGACGTGGTGGCTGCG
GTGCAGGCCTTCCTCGGTCGCCAGGCCGACGCCCTGCACGGCCAGGGCGTGGCCAGGGATCGCATCGTGCTGGACCCCGG
CATCGGGTTCGGCAAGACGGTGGAGCAGAATTTCGCGCTGCTGGCGCAGCAGGCGCGACTGGCCACGGACGGCCATGCCT
GGCTGGCCGGATGGTCTCGCAAGTCGTCGCTGGGTGCGGTGACCGGGCTGCCGGTACAGGACCGGCTCGTGCCCAGCGTC
GCCGCAGCGCTGCTGTCGGTAGAGCGGGGTGCCCGCATCGTGCGCGTGCACGATGTCGCGGAGACGTTCGCGGCACTCAG
GATCTGGTGCGCGGCCCGGCTACCATCGGAGGGTTCCGGCGCAAGCCGTGCTTCCGGGCCGGCGCGGCCGCAGCCATAG

Upstream 100 bases:

>100_bases
CCGCGGGGCAGTGCACTGAAACGGGGCCTCGGCCCCGTTTTTGCGTTTGCAGCTTCCCTTTTGTTTCCACGAACTTCCAC
CACGTCGGCGACCTCCCTCC

Downstream 100 bases:

>100_bases
CCGCCTTGGCGGCGCGCTCCCGCCGGAAAGCACGGGGCCAAGCCGGCAAAGCAAGAAGAAACCAGCAGGAACATGACAAT
GGCTCGCAAATATTTCGGTA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MHWQTSRFRIDLSRPQVMGILNVTPDSFSDGGRHASLRDALRRAEVLLQDGADILDIGGESTRPGSPAVPLEEELARVVP
VVKEAVAWRVPISVDTYKPAVMQAVLDLGADIVNDIWALRQPGALETVARHGTCGVCLMHMHGEPQTMQVQPMEGDVVAA
VQAFLGRQADALHGQGVARDRIVLDPGIGFGKTVEQNFALLAQQARLATDGHAWLAGWSRKSSLGAVTGLPVQDRLVPSV
AAALLSVERGARIVRVHDVAETFAALRIWCAARLPSEGSGASRASGPARPQP

Sequences:

>Translated_292_residues
MHWQTSRFRIDLSRPQVMGILNVTPDSFSDGGRHASLRDALRRAEVLLQDGADILDIGGESTRPGSPAVPLEEELARVVP
VVKEAVAWRVPISVDTYKPAVMQAVLDLGADIVNDIWALRQPGALETVARHGTCGVCLMHMHGEPQTMQVQPMEGDVVAA
VQAFLGRQADALHGQGVARDRIVLDPGIGFGKTVEQNFALLAQQARLATDGHAWLAGWSRKSSLGAVTGLPVQDRLVPSV
AAALLSVERGARIVRVHDVAETFAALRIWCAARLPSEGSGASRASGPARPQP
>Mature_292_residues
MHWQTSRFRIDLSRPQVMGILNVTPDSFSDGGRHASLRDALRRAEVLLQDGADILDIGGESTRPGSPAVPLEEELARVVP
VVKEAVAWRVPISVDTYKPAVMQAVLDLGADIVNDIWALRQPGALETVARHGTCGVCLMHMHGEPQTMQVQPMEGDVVAA
VQAFLGRQADALHGQGVARDRIVLDPGIGFGKTVEQNFALLAQQARLATDGHAWLAGWSRKSSLGAVTGLPVQDRLVPSV
AAALLSVERGARIVRVHDVAETFAALRIWCAARLPSEGSGASRASGPARPQP

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=261, Percent_Identity=49.8084291187739, Blast_Score=247, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=28.75, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31206; Mature: 31206

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHWQTSRFRIDLSRPQVMGILNVTPDSFSDGGRHASLRDALRRAEVLLQDGADILDIGGE
CCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCC
STRPGSPAVPLEEELARVVPVVKEAVAWRVPISVDTYKPAVMQAVLDLGADIVNDIWALR
CCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHCHHHHHHHHHHC
QPGALETVARHGTCGVCLMHMHGEPQTMQVQPMEGDVVAAVQAFLGRQADALHGQGVARD
CCCHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCHHHCCCCCCCC
RIVLDPGIGFGKTVEQNFALLAQQARLATDGHAWLAGWSRKSSLGAVTGLPVQDRLVPSV
EEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEECCCHHHHHHHHH
AAALLSVERGARIVRVHDVAETFAALRIWCAARLPSEGSGASRASGPARPQP
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHWQTSRFRIDLSRPQVMGILNVTPDSFSDGGRHASLRDALRRAEVLLQDGADILDIGGE
CCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCC
STRPGSPAVPLEEELARVVPVVKEAVAWRVPISVDTYKPAVMQAVLDLGADIVNDIWALR
CCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHCHHHHHHHHHHC
QPGALETVARHGTCGVCLMHMHGEPQTMQVQPMEGDVVAAVQAFLGRQADALHGQGVARD
CCCHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCHHHCCCCCCCC
RIVLDPGIGFGKTVEQNFALLAQQARLATDGHAWLAGWSRKSSLGAVTGLPVQDRLVPSV
EEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEECCCHHHHHHHHH
AAALLSVERGARIVRVHDVAETFAALRIWCAARLPSEGSGASRASGPARPQP
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]