Definition Acidovorax citrulli AAC00-1 chromosome, complete genome.
Accession NC_008752
Length 5,352,772

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The map label for this gene is icd [H]

Identifier: 120611240

GI number: 120611240

Start: 2821485

End: 2822744

Strand: Direct

Name: icd [H]

Synonym: Aave_2572

Alternate gene names: 120611240

Gene position: 2821485-2822744 (Clockwise)

Preceding gene: 120611237

Following gene: 120611242

Centisome position: 52.71

GC content: 62.14

Gene sequence:

>1260_bases
ATGACCAGCTACCAGCACATCAAGGTCCCTGCCGAAGGCCAGAAGATCACCGTCAATGCCGACATGTCCCTGAACGTGCC
GGACCAGCCCATCATTCCCTATATCGAGGGTGACGGTACCGGCTTCGACATCACCCCTGTGATGCTGAAAGTGGTGGACG
CGGCCGTGGCCAAGGCCTACGGCGGCAAGCGCAAGATCCACTGGATGGAAGTCTTCGCCGGCGAGAAGTCCACGAAGGTG
TACGGTCCCGACGTCTGGCTGCCGGAAGAAACCCTGCATGCCGTGCGCGACTACGTCGTTTCCATCAAGGGCCCGCTGAC
GACGCCCGTGGGCGGCGGCATCCGCTCGCTGAACGTGGCGCTGCGCCAGGAACTCGACCTCTACGTCTGCCTGCGCCCCA
TCCAGTACTTCAAGGGCGTTCCCTCGCCCGTGAAGGAACCCGAGAAGACCAACATGGTGATCTTCCGCGAGAACTCGGAA
GACATCTATGCCGGCATCGAGTTCGAAGCCGAGTCCGACAAGGCCAAGAAGCTCATCAAGATCCTGCAGGAGGAGTTCGG
CGTCAAGAAGATCCGCTTCCCCGAGACCTCCGGCATCGGCGTGAAGCCCGTGTCCAAGGAAGGCACGCAGCGCCTGGTGC
GCAAGGCCATCCAGTACGCCATCGACAACGACAAGCCCAGCGTGACCATCGTCCACAAGGGCAACATCATGAAGTTCACG
GAAGGCGGCTTCCGTGACTGGGCCTACGACCTGGCTGCCAGGGAATTCGGCGCCGAACTCATCGACGGCGGCCCGTGGAT
GAAGTTCAAGAACCCGCGCACCGGCAAGGAAATCACGGTCAAGGACAGCATCGCCGACGCGTTCCTGCAGCAGATCCTGC
TGCGCCCCGCCGAGTACAGCGTGATCGCCACGCTGAACCTGAACGGCGACTACGTCTCCGACGCGCTGGCAGCCCAGGTG
GGCGGCATCGGCATCGCCCCGGGCGCCAACCTGTCCGACTCCGTCGCGATGTTCGAAGCCACGCACGGCACGGCACCGAA
GTACGCCGGCAAGGACTACGTGAACCCCGGTTCCGAAATCCTTTCCGCCGAAATGATGCTGCGCCACATGGGCTGGACCG
AAGCGGCCGACATCATCATCAGCTCGATGGAAAAATCCATCCTGAGCAAGAAGGTGACCTACGACTTCGCCCGCCTGATG
GAAGGTGCGACGCAGGTGAGCTGCTCGGGCTTCGGCCAGGTGATGATCGACAACATGTGA

Upstream 100 bases:

>100_bases
GCCTACAAATTTTTATCGCTAAAATCATCGCGTTTTGTGCCTGTCGCACAGGCCGGCCGGGCGCCGCCCCGGACGCCATT
CCACCGGAGATAACCGTTCC

Downstream 100 bases:

>100_bases
TTGCCGCCGGCGGCGTCGCTTGACGTTTCGCAAGCCCTTGATCCTCCCTGGGGATCAAGGGCTTTTCCGTTTTCGGGCGG
GTCCGGCGGGCGCCACCTGG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTSYQHIKVPAEGQKITVNADMSLNVPDQPIIPYIEGDGTGFDITPVMLKVVDAAVAKAYGGKRKIHWMEVFAGEKSTKV
YGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVKEPEKTNMVIFRENSE
DIYAGIEFEAESDKAKKLIKILQEEFGVKKIRFPETSGIGVKPVSKEGTQRLVRKAIQYAIDNDKPSVTIVHKGNIMKFT
EGGFRDWAYDLAAREFGAELIDGGPWMKFKNPRTGKEITVKDSIADAFLQQILLRPAEYSVIATLNLNGDYVSDALAAQV
GGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADIIISSMEKSILSKKVTYDFARLM
EGATQVSCSGFGQVMIDNM

Sequences:

>Translated_419_residues
MTSYQHIKVPAEGQKITVNADMSLNVPDQPIIPYIEGDGTGFDITPVMLKVVDAAVAKAYGGKRKIHWMEVFAGEKSTKV
YGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVKEPEKTNMVIFRENSE
DIYAGIEFEAESDKAKKLIKILQEEFGVKKIRFPETSGIGVKPVSKEGTQRLVRKAIQYAIDNDKPSVTIVHKGNIMKFT
EGGFRDWAYDLAAREFGAELIDGGPWMKFKNPRTGKEITVKDSIADAFLQQILLRPAEYSVIATLNLNGDYVSDALAAQV
GGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADIIISSMEKSILSKKVTYDFARLM
EGATQVSCSGFGQVMIDNM
>Mature_418_residues
TSYQHIKVPAEGQKITVNADMSLNVPDQPIIPYIEGDGTGFDITPVMLKVVDAAVAKAYGGKRKIHWMEVFAGEKSTKVY
GPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVKEPEKTNMVIFRENSED
IYAGIEFEAESDKAKKLIKILQEEFGVKKIRFPETSGIGVKPVSKEGTQRLVRKAIQYAIDNDKPSVTIVHKGNIMKFTE
GGFRDWAYDLAAREFGAELIDGGPWMKFKNPRTGKEITVKDSIADAFLQQILLRPAEYSVIATLNLNGDYVSDALAAQVG
GIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADIIISSMEKSILSKKVTYDFARLME
GATQVSCSGFGQVMIDNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=384, Percent_Identity=30.9895833333333, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=26.9886363636364, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=26.9886363636364, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4758582, Length=299, Percent_Identity=28.0936454849498, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI28178838, Length=299, Percent_Identity=28.0936454849498, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=32.5966850828729, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787381, Length=411, Percent_Identity=74.2092457420924, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=25.9946949602122, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081683, Length=403, Percent_Identity=24.8138957816377, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71986051, Length=374, Percent_Identity=30.7486631016043, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=29.5081967213115, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=301, Percent_Identity=29.2358803986711, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17550882, Length=280, Percent_Identity=24.6428571428571, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324709, Length=398, Percent_Identity=27.8894472361809, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6322097, Length=366, Percent_Identity=27.0491803278689, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324291, Length=366, Percent_Identity=26.2295081967213, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24643268, Length=350, Percent_Identity=34.5714285714286, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24643270, Length=350, Percent_Identity=34.5714285714286, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=29.305912596401, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI161078635, Length=278, Percent_Identity=27.6978417266187, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI161078633, Length=278, Percent_Identity=27.6978417266187, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24650122, Length=278, Percent_Identity=27.6978417266187, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI161078637, Length=278, Percent_Identity=27.6978417266187, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI161078639, Length=278, Percent_Identity=27.6978417266187, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI20130355, Length=390, Percent_Identity=22.5641025641026, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281362242, Length=338, Percent_Identity=26.6272189349112, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24648872, Length=338, Percent_Identity=26.6272189349112, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46009; Mature: 45878

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYQHIKVPAEGQKITVNADMSLNVPDQPIIPYIEGDGTGFDITPVMLKVVDAAVAKAY
CCCCCEEECCCCCCEEEEECCEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHC
GGKRKIHWMEVFAGEKSTKVYGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVA
CCCCEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHH
LRQELDLYVCLRPIQYFKGVPSPVKEPEKTNMVIFRENSEDIYAGIEFEAESDKAKKLIK
HHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHH
ILQEEFGVKKIRFPETSGIGVKPVSKEGTQRLVRKAIQYAIDNDKPSVTIVHKGNIMKFT
HHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEC
EGGFRDWAYDLAAREFGAELIDGGPWMKFKNPRTGKEITVKDSIADAFLQQILLRPAEYS
CCCCHHHHHHHHHHHHCHHHHCCCCCEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCEE
VIATLNLNGDYVSDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEI
EEEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHH
LSAEMMLRHMGWTEAADIIISSMEKSILSKKVTYDFARLMEGATQVSCSGFGQVMIDNM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEECCC
>Mature Secondary Structure 
TSYQHIKVPAEGQKITVNADMSLNVPDQPIIPYIEGDGTGFDITPVMLKVVDAAVAKAY
CCCCEEECCCCCCEEEEECCEEECCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHC
GGKRKIHWMEVFAGEKSTKVYGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVA
CCCCEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHH
LRQELDLYVCLRPIQYFKGVPSPVKEPEKTNMVIFRENSEDIYAGIEFEAESDKAKKLIK
HHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHH
ILQEEFGVKKIRFPETSGIGVKPVSKEGTQRLVRKAIQYAIDNDKPSVTIVHKGNIMKFT
HHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEC
EGGFRDWAYDLAAREFGAELIDGGPWMKFKNPRTGKEITVKDSIADAFLQQILLRPAEYS
CCCCHHHHHHHHHHHHCHHHHCCCCCEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCEE
VIATLNLNGDYVSDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEI
EEEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHH
LSAEMMLRHMGWTEAADIIISSMEKSILSKKVTYDFARLMEGATQVSCSGFGQVMIDNM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]