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The map label for this gene is argA [H]

Identifier: 120611222

GI number: 120611222

Start: 2802360

End: 2803706

Strand: Reverse

Name: argA [H]

Synonym: Aave_2553

Alternate gene names: 120611222

Gene position: 2803706-2802360 (Counterclockwise)

Preceding gene: 120611223

Following gene: 120611220

Centisome position: 52.38

GC content: 66.59

Gene sequence:

>1347_bases
ATGTCCGCTGTCTTCAATTTCACCTTCGTGCCCTGGTTCCGGTCGGTGGCGCCCTACATCCACAAGTTCCGCCACCAGAC
CTTCGTGATCGCGCTCACGGGCGAGGCCATCGCGGCAGGCAAGCTGCAGGCGATCGCGCAGGACCTGGCGATGATCCAGG
CCATGGGGGTGAAAATCGTGCTGGTGCACGGTTTCCGGCCCCAGGTGAACGAGCAATTGGCGGCCAAGGGGCATGCGGCG
CGGTATTCGCACGGCATCCGCATCACGGATTCGGTGGCGCTGGACTGCGCGCAGGAGGCGGCCGGGCAACTGCGCTACGA
GATCGAGGCCGCGTTCAGCCAGGGCCTGCCCAACACGCCCATGGCGGGTTCCACCGTGCGCGTGATCTCGGGCAACTTCA
TCACCGCGCGCCCCGTGGGCATCGTGGACGGCGTGGACTTCAAGCATTCGGGACTGGTGCGCAAGGTGGACGTGGCGGGC
ATCCGCCGGTCGCTGGAGATGGACGCGCTGGTGCTGATCTCGCCTTTCGGCTTCTCACCCACCGGCGAGGCCTTCAATCT
CACGATGGAGGAAGTAGCGACGTCCGTCTCCATCGCGCTCAAGGCGGACAAGCTTGTCTTCGTCTGCGAGGTGCCGGGCA
TCCGCACCGACCCCGACCAGCCCGAGAGCGAGGACAACCCCATCGACACCGAACTGCCGCTGGCGCAGGCGCGGCAGATG
CTGGCGCGCGTGCCCCCGGGCCAGAAGCCGACGGACACGGCGTTCTACCTGCAGCACTGCGTGAAGGCGTGCCAGAACGG
CGTGGAACGCAGCCACATCATTCCGTTCGCGGTGGACGGCGCGCTGCTGCTGGAAATCTACGTGCACGACGGCATCGGCA
CCATGGTGGTGGACGAAAAGCTCGAGGAACTGCGCGAGGCCACGCCGGACGACGTGGGCGGCATCCTGCAGCTCATCGAG
CCGTTCGAGAAGGACGGCACGCTGGTCAAGCGCGACCGCACCGAGATCGAGCGCGACGTCGCCAACTACACCATCATCGA
GCACGACGGCGTGATCTTCGGCTGCGCCGCGCTCTACCCGTATCCGGAAGCCGGCACGGCCGAGATGGCCGCCGTCACGG
TGTCGCCGCAGAGCCAGGGCACGGGCGACGGGGAAAAGCTGCTCAAGCGCATCGAGCAGCGCGCCCGCGCCATGGGCCTG
AAGAGCCTGTTCGTGCTCACCACCCGCACGATGCACTGGTTCATCAAGCGCGGCTTCCAGCCGGTGGATCCGGACTGGCT
GCCCGAGGCCCGCAAGAAGAAATACAACTGGGACCGCCGCAGCCAGGTGCTGGTCAAGACGCTCTGA

Upstream 100 bases:

>100_bases
CGACGATAATCCGGCGCGCACCGCACGGCGCCCGCCTTCCCGACAACCACCGCCTGCCCGACCGCGCAGGCTTCCGGCCC
CGCCCCTTCATCTTCCCGCC

Downstream 100 bases:

>100_bases
GCCCAGGGGTGATGGTCAGCCCCTGACAGCGGGGGCTGCGCCCTCCAGGGCCCAGCGTGCAGCCAGCGTGCCGACCCGGG
CGATCGCGGCATCGCGCTGC

Product: N-acetylglutamate synthase

Products: NA

Alternate protein names: N-acetylglutamate synthase; AGS; NAGS [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSAVFNFTFVPWFRSVAPYIHKFRHQTFVIALTGEAIAAGKLQAIAQDLAMIQAMGVKIVLVHGFRPQVNEQLAAKGHAA
RYSHGIRITDSVALDCAQEAAGQLRYEIEAAFSQGLPNTPMAGSTVRVISGNFITARPVGIVDGVDFKHSGLVRKVDVAG
IRRSLEMDALVLISPFGFSPTGEAFNLTMEEVATSVSIALKADKLVFVCEVPGIRTDPDQPESEDNPIDTELPLAQARQM
LARVPPGQKPTDTAFYLQHCVKACQNGVERSHIIPFAVDGALLLEIYVHDGIGTMVVDEKLEELREATPDDVGGILQLIE
PFEKDGTLVKRDRTEIERDVANYTIIEHDGVIFGCAALYPYPEAGTAEMAAVTVSPQSQGTGDGEKLLKRIEQRARAMGL
KSLFVLTTRTMHWFIKRGFQPVDPDWLPEARKKKYNWDRRSQVLVKTL

Sequences:

>Translated_448_residues
MSAVFNFTFVPWFRSVAPYIHKFRHQTFVIALTGEAIAAGKLQAIAQDLAMIQAMGVKIVLVHGFRPQVNEQLAAKGHAA
RYSHGIRITDSVALDCAQEAAGQLRYEIEAAFSQGLPNTPMAGSTVRVISGNFITARPVGIVDGVDFKHSGLVRKVDVAG
IRRSLEMDALVLISPFGFSPTGEAFNLTMEEVATSVSIALKADKLVFVCEVPGIRTDPDQPESEDNPIDTELPLAQARQM
LARVPPGQKPTDTAFYLQHCVKACQNGVERSHIIPFAVDGALLLEIYVHDGIGTMVVDEKLEELREATPDDVGGILQLIE
PFEKDGTLVKRDRTEIERDVANYTIIEHDGVIFGCAALYPYPEAGTAEMAAVTVSPQSQGTGDGEKLLKRIEQRARAMGL
KSLFVLTTRTMHWFIKRGFQPVDPDWLPEARKKKYNWDRRSQVLVKTL
>Mature_447_residues
SAVFNFTFVPWFRSVAPYIHKFRHQTFVIALTGEAIAAGKLQAIAQDLAMIQAMGVKIVLVHGFRPQVNEQLAAKGHAAR
YSHGIRITDSVALDCAQEAAGQLRYEIEAAFSQGLPNTPMAGSTVRVISGNFITARPVGIVDGVDFKHSGLVRKVDVAGI
RRSLEMDALVLISPFGFSPTGEAFNLTMEEVATSVSIALKADKLVFVCEVPGIRTDPDQPESEDNPIDTELPLAQARQML
ARVPPGQKPTDTAFYLQHCVKACQNGVERSHIIPFAVDGALLLEIYVHDGIGTMVVDEKLEELREATPDDVGGILQLIEP
FEKDGTLVKRDRTEIERDVANYTIIEHDGVIFGCAALYPYPEAGTAEMAAVTVSPQSQGTGDGEKLLKRIEQRARAMGLK
SLFVLTTRTMHWFIKRGFQPVDPDWLPEARKKKYNWDRRSQVLVKTL

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

Organism=Escherichia coli, GI1789181, Length=440, Percent_Identity=45.2272727272727, Blast_Score=402, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6320913, Length=204, Percent_Identity=25.9803921568627, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR001048
- InterPro:   IPR010167 [H]

Pfam domain/function: PF00696 AA_kinase; PF00583 Acetyltransf_1 [H]

EC number: =2.3.1.1 [H]

Molecular weight: Translated: 49337; Mature: 49206

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVFNFTFVPWFRSVAPYIHKFRHQTFVIALTGEAIAAGKLQAIAQDLAMIQAMGVKIV
CCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEE
LVHGFRPQVNEQLAAKGHAARYSHGIRITDSVALDCAQEAAGQLRYEIEAAFSQGLPNTP
EEECCCCCHHHHHHHCCCHHHHCCCEEEEHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCC
MAGSTVRVISGNFITARPVGIVDGVDFKHSGLVRKVDVAGIRRSLEMDALVLISPFGFSP
CCCCEEEEEECCEEEECCCCEECCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEECCCCCC
TGEAFNLTMEEVATSVSIALKADKLVFVCEVPGIRTDPDQPESEDNPIDTELPLAQARQM
CCCCEEEEHHHHHHHHEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
LARVPPGQKPTDTAFYLQHCVKACQNGVERSHIIPFAVDGALLLEIYVHDGIGTMVVDEK
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEEEEECCCCHHHHHHH
LEELREATPDDVGGILQLIEPFEKDGTLVKRDRTEIERDVANYTIIEHDGVIFGCAALYP
HHHHHHCCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCEEEEECCCEEEEEEHHCC
YPEAGTAEMAAVTVSPQSQGTGDGEKLLKRIEQRARAMGLKSLFVLTTRTMHWFIKRGFQ
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCC
PVDPDWLPEARKKKYNWDRRSQVLVKTL
CCCCCCCCHHHHHCCCCCHHHCEEEECC
>Mature Secondary Structure 
SAVFNFTFVPWFRSVAPYIHKFRHQTFVIALTGEAIAAGKLQAIAQDLAMIQAMGVKIV
CCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEE
LVHGFRPQVNEQLAAKGHAARYSHGIRITDSVALDCAQEAAGQLRYEIEAAFSQGLPNTP
EEECCCCCHHHHHHHCCCHHHHCCCEEEEHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCC
MAGSTVRVISGNFITARPVGIVDGVDFKHSGLVRKVDVAGIRRSLEMDALVLISPFGFSP
CCCCEEEEEECCEEEECCCCEECCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEECCCCCC
TGEAFNLTMEEVATSVSIALKADKLVFVCEVPGIRTDPDQPESEDNPIDTELPLAQARQM
CCCCEEEEHHHHHHHHEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
LARVPPGQKPTDTAFYLQHCVKACQNGVERSHIIPFAVDGALLLEIYVHDGIGTMVVDEK
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEEEEECCCCHHHHHHH
LEELREATPDDVGGILQLIEPFEKDGTLVKRDRTEIERDVANYTIIEHDGVIFGCAALYP
HHHHHHCCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCEEEEECCCEEEEEEHHCC
YPEAGTAEMAAVTVSPQSQGTGDGEKLLKRIEQRARAMGLKSLFVLTTRTMHWFIKRGFQ
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCC
PVDPDWLPEARKKKYNWDRRSQVLVKTL
CCCCCCCCHHHHHCCCCCHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]